Planetary Bistatic Radar

Planetary radar observations offer the potential for probing the properties of characteristics of solid bodies throughout the inner solar system and at least as far as the orbit of Saturn. In addition to the direct scientific value, precise orbital determinations can be obtained from planetary radar observations, which are in turn valuable for mission planning or spacecraft navigation and planetary defense. The next-generation Very Large Array would not have to be equipped with a transmitter to be an important asset in the world's planetary radar infrastructure. Bistatic radar, in which one antenna transmits (e.g., Arecibo or Goldstone) and another receives, are used commonly today, with the Green Bank Telescope (GBT) serving as a receiver. The improved sensitivity of the ngVLA relative to the GBT would improve the signal-to-noise ratios on many targets and increase the accessible volume specifically for asteroids. Goldstone-ngVLA bistatic observations would have the potential of rivaling the sensitivity of Arecibo, but with much wider sky access.Comment: 11 pages, 2 figures, To be published in the ASP Monograph Series, "Science with a Next-Generation VLA", ed. E. J. Murphy (ASP, San Francisco, CA

Interactions within the mammalian DNA methyltransferase family

BACKGROUND: In mammals, epigenetic information is established and maintained via the postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Dnmt1 is required for maintenance methylation whereas Dnmt3a and Dnmt3b are responsible for de novo methylation. Contrary to Dnmt3a or Dnmt3b, the isolated C-terminal region of Dnmt1 is catalytically inactive, despite the presence of the sequence motifs typical of active DNA methyltransferases. Deletion analysis has revealed that a large part of the N-terminal domain is required for enzymatic activity. RESULTS: The role played by the N-terminal domain in this regulation has been investigated using the yeast two-hybrid system. We show here the presence of an intra-molecular interaction in Dnmt1 but not in Dnmt3a or Dnmt3b. This interaction was confirmed by immunoprecipitation and was localized by deletion mapping. Furthermore, a systematic analysis of interactions among the Dnmt family members has revealed that DNMT3L interacts with the C-terminal domain of Dnmt3a and Dnmt3b. CONCLUSIONS: The lack of methylating ability of the isolated C-terminal domain of Dnmt1 could be explained in part by a physical interaction between N- and C-terminal domains that apparently is required for activation of the catalytic domain. Our deletion analysis suggests that the tertiary structure of Dnmt1 is important in this process rather than a particular sequence motif. Furthermore, the interaction between DNMT3L and the C-terminal domains of Dnmt3a and Dnmt3b suggests a mechanism whereby the enzymatically inactive DNMT3L brings about the methylation of its substrate by recruiting an active methylase

Spin state and moment of inertia of Venus

Fundamental properties of the planet Venus, such as its internal mass distribution and variations in length of day, have remained unknown. We used Earth-based observations of radar speckles tied to the rotation of Venus obtained in 2006-2020 to measure its spin axis orientation, spin precession rate, moment of inertia, and length-of-day variations. Venus is tilted by 2.6392 $\pm$ 0.0008 degrees ($1\sigma$) with respect to its orbital plane. The spin axis precesses at a rate of 44.58 $\pm$ 3.3 arcseconds per year ($1\sigma$), which gives a normalized moment of inertia of 0.337 $\pm$ 0.024 and yields a rough estimate of the size of the core. The average sidereal day on Venus in the 2006-2020 interval is 243.0226 $\pm$ 0.0013 Earth days ($1\sigma$). The spin period of the solid planet exhibits variations of 61 ppm ($\sim$20 minutes) with a possible diurnal or semidiurnal forcing. The length-of-day variations imply that changes in atmospheric angular momentum of at least $\sim$4% are transferred to the solid planet.Comment: 20 pages, 7 figures, supplementary information. Submitted to Nature Astronomy on October 14, 202

Mercury's Moment of Inertia from Spin and Gravity Data

Earth-based radar observations of the spin state of Mercury at 35 epochs between 2002 and 2012 reveal that its spin axis is tilted by (2.04 plus or minus 0.08) arc min with respect to the orbit normal. The direction of the tilt suggests that Mercury is in or near a Cassini state. Observed rotation rate variations clearly exhibit an 88-day libration pattern which is due to solar gravitational torques acting on the asymmetrically shaped planet. The amplitude of the forced libration, (38.5 plus or minus 1.6) arc sec, corresponds to a longitudinal displacement of ∼450 m at the equator. Combining these measurements of the spin properties with second-degree gravitational harmonics (Smith et al., 2012) provides an estimate of the polar moment of inertia of MercuryC/MR2 = 0.346 plus or minus 0.014, where M and R are Mercury's mass and radius. The fraction of the moment that corresponds to the outer librating shell, which can be used to estimate the size of the core, is Cm/C = 0.431 plus or minus 0.025

Detection of Large Grains in the Coma of Comet C/2001 A2 (LINEAR) from Arecibo Radar Observations

Arecibo S-band (lambda=13cm) radar observations of Comet C/2001 A2 (LINEAR) on 2001 July 7-9 showed a strong echo from large coma grains. This echo was significantly depolarized. This is the first firm detection of depolarization in a grain-coma radar echo and indicates that the largest grains are at least lambda / 2 or 2 cm in radius. The grains are moving at tens of m/s with respect to the nucleus. The non-detection of the nucleus places an upper limit of 3 km on its diameter. The broad, asymmetric echo power spectrum suggests a fan of grains that have a steep (differential number ~ a^-4) size distribution at cm-scales, though the observed fragmentation of this comet complicates that picture.Comment: 20 pages, 3 tables, 5 figures Submitted to Icaru

De novo TBR1 variants cause a neurocognitive phenotype with ID and autistic traits:report of 25 new individuals and review of the literature

TBR1, a T-box transcription factor expressed in the cerebral cortex, regulates the expression of several candidate genes for autism spectrum disorders (ASD). Although TBR1 has been reported as a high-confidence risk gene for ASD and intellectual disability (ID) in functional and clinical reports since 2011, TBR1 has only recently been recorded as a human disease gene in the OMIM database. Currently, the neurodevelopmental disorders and structural brain anomalies associated with TBR1 variants are not well characterized. Through international data sharing, we collected data from 25 unreported individuals and compared them with data from the literature. We evaluated structural brain anomalies in seven individuals by analysis of MRI images, and compared these with anomalies observed in TBR1 mutant mice. The phenotype included ID in all individuals, associated to autistic traits in 76% of them. No recognizable facial phenotype could be identified. MRI analysis revealed a reduction of the anterior commissure and suggested new features including dysplastic hippocampus and subtle neocortical dysgenesis. This report supports the role of TBR1 in ID associated with autistic traits and suggests new structural brain malformations in humans. We hope this work will help geneticists to interpret TBR1 variants and diagnose ASD probands

A Search for Technosignatures Around 11,680 Stars with the Green Bank Telescope at 1.15-1.73 GHz

We conducted a search for narrowband radio signals over four observing sessions in 2020-2023 with the L-band receiver (1.15-1.73 GHz) of the 100 m diameter Green Bank Telescope. We pointed the telescope in the directions of 62 TESS Objects of Interest, capturing radio emissions from a total of ~11,680 stars and planetary systems in the ~9 arcminute beam of the telescope. All detections were either automatically rejected or visually inspected and confirmed to be of anthropogenic nature. In this work, we also quantified the end-to-end efficiency of radio SETI pipelines with a signal injection and recovery analysis. The UCLA SETI pipeline recovers 94.0% of the injected signals over the usable frequency range of the receiver and 98.7% of the injections when regions of dense RFI are excluded. In another pipeline that uses incoherent sums of 51 consecutive spectra, the recovery rate is ~15 times smaller at ~6%. The pipeline efficiency affects calculations of transmitter prevalence and SETI search volume. Accordingly, we developed an improved Drake Figure of Merit and a formalism to place upper limits on transmitter prevalence that take the pipeline efficiency and transmitter duty cycle into account. Based on our observations, we can state at the 95% confidence level that fewer than 6.6% of stars within 100 pc host a transmitter that is detectable in our search (EIRP > 1e13 W). For stars within 20,000 ly, the fraction of stars with detectable transmitters (EIRP > 5e16 W) is at most 3e-4. Finally, we showed that the UCLA SETI pipeline natively detects the signals detected with AI techniques by Ma et al. (2023).Comment: 22 pages, 9 figures, submitted to AJ, revise

Hypothesis-driven genome-wide association studies provide novel insights into genetics of reading disabilities

Peer reviewe

Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people

The use of spoken and written language is a fundamental human capacity. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30 to 80% depending on the trait. The genetic architecture is complex, heterogeneous, and multifactorial, but investigations of contributions of single-nucleotide polymorphisms (SNPs) were thus far underpowered. We present a multicohort genome-wide association study (GWAS) of five traits assessed individually using psychometric measures (word reading, nonword reading, spelling, phoneme awareness, and nonword repetition) in samples of 13,633 to 33,959 participants aged 5 to 26 y. We identified genome-wide significant association with word reading (rs11208009, P = 1.098 x 10(-8)) at a locus that has not been associated with intelligence or educational attainment. All five reading-/language-related traits showed robust SNP heritability, accounting for 13 to 26% of trait variability. Genomic structural equation modeling revealed a shared genetic factor explaining most of the variation in word/nonword reading, spelling, and phoneme awareness, which only partially overlapped with genetic variation contributing to nonword repetition, intelligence, and educational attainment. A multivariate GWAS of word/nonword reading, spelling, and phoneme awareness maximized power for follow-up investigation. Genetic correlation analysis with neuroimaging traits identified an association with the surface area of the banks of the left superior temporal sulcus, a brain region linked to the processing of spoken and written language. Heritability was enriched for genomic elements regulating gene expression in the fetal brain and in chromosomal regions that are depleted of Neanderthal variants. Together, these results provide avenues for deciphering the biological underpinnings of uniquely human traits.Peer reviewe