8 research outputs found
The H-ATOMIC Criteria for the Etiologic Classification of Patients with Intracerebral Hemorrhage
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2016
- Field of study
Background and Purpose
There are no generally accepted criteria for the etiologic classification of intracerebral hemorrhage
(ICH). For this reason, we have developed a set of etiologic criteria and have
applied them to a large number of patients to determine their utility.
Methods
The H-ATOMIC classification includes 7 etiologic categories: Hypertension, cerebral Amyloid
angiopathy, Tumour, Oral anticoagulants, vascular Malformation, Infrequent causes
and Cryptogenic. For each category, the etiology is scored with three degrees of certainty:
Possible(3), Probable(2) and Definite(1). Our aim was to perform a basic study consisting of
neuroimaging, blood tests, and CT-angio when a numerical score (SICH) suggested an
underlying structural abnormality. Combinations of >1 etiologic category for an individual
patient were acceptable. The criteria were evaluated in a multicenter and prospective study
of consecutive patients with spontaneous ICH.
Results
Our study included 439 patients (age 70.8 ± 14.5 years; 61.3% were men). A definite etiology
was achieved in 176 (40.1% of the patients: Hypertension 28.2%, cerebral Amyloid
angiopathy 0.2%, Tumour 0.2%, Oral anticoagulants 2.2%, vascular Malformation 4.5%,
Infrequent causes 4.5%). A total of 7 patients (1.6%) were cryptogenic. In the remaining
58.3% of the patients, ICH was attributable to a single (n = 56, 12.7%) or the combination of
2 (n = 200, 45.5%) possible/probable etiologies. The most frequent combinations of etiologies
involved possible hypertension with possible CAA (H3A3, n = 38) or with probable CAA
(H3A2, n = 29), and probable hypertension with probable OA (H2O2, n = 27). The most frequent category with any degree of certainty was hypertension (H1+2+3 = 80.6%) followed
by cerebral amyloid angiopathy (A1+2+3 = 30.9%).
Conclusions
According to our etiologic criteria, only about 40% patients received a definite diagnosis,
while in the remaining patients ICH was attributable to a single possible/probable etiology or
to more than one possible/probable etiology. The use of these criteria would likely help in
the management of patients with ICH.This work was supported by Ministery of Health-Instituto de Salud Carlos III: RETICS (Redes temáticas de Investigación Cooperativa) INVICTUS RD012/0014 (JM-F, PC-R, AM-D, LP-S, RD-M), FEDER (Fondo Europeo de Desarrollo Regional)
Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)
- Author
- Abora Rial-Villavecchia
- Adriana Sánchez Serrano
- Adrián Sousa
- Aina Gomila Grange
- Ainhoa Sanjuan López
- Ainhoa Urrutia Losada
- Alberto Gato Díez
- Alberto Romero-Palacios
- Alberto Serrano Martínez
- Alejandra Duarte Borges
- Alejandro Araujo
- Alexander Rombauts
- Alexandra de la Vega
- Alexandre Pérez González
- Alfonso Cabello Úbeda
- Alfonso Lluna Carrascosa
- Alicia Hernández Torres
- Almudena Hernández Milian
- Ana Alberich Conesa
- Ana Correa Ruiz
- Ana Escoresca
- Ana Ferrer Ribera
- Ana Isabel Mariño Callejo
- Ana Isabel Peláez Ballesta
- Ana Such Diaz
- Andrea Martín Plata
- André Barbosa Ventura
- Andrés Ruiz Sancho
- Ane Andrés Eisenhofer
- Anonymous
- Antonia Alcaraz
- Antonia Sepúlveda Berrocal
- Antonio José Ruiz Reina
- Antonio Plata Ciezar
- Araceli González-Cuevas
- Arantzazu Mera Fidalgo
- Ariadna De Genover Gil
- Aroa Villoslada Gelabert
- Aychel Elena Roura Piloto
- Beatriz Diaz Pollan
- Beatriz Dietl
- Beatriz Pérez-Monte Mínguez
- Beatriz Sobrino Diaz
- Beigel
- Belén Loeches Yagüe
- Berenguer
- Bhimraj
- Blanca Alonso Martínez
- Blanca Martínez Cifre
- Blanca Pinilla
- Borja Gracia-Tello
- Campochiaro
- Capra
- Carlos Bea Serrano
- Carlos Dueñas Gutiérrez
- Carlos Enrique Sabbagh Fajardo
- Carlota Gudiol
- Carmen Aguayo Jiménez
- Carmen Herrero Rodríguez
- Carmen Infante
- Carmen Yllera
- Carolina Roldán Fontana
- Channappanavar
- Chen
- Chen
- Chiara Fanciulli
- Clara Martínez Montes
- Clara Muñoz Aguirre
- Claudia González Rico
- Claudia Álvarez-Pouso
- Claudio Bueno
- Concepción García-García
- Concepción Gonzalo
- Cristina Badía
- Cristina Cervera Acedo
- Cristina Díez
- Cristina Lojo Cruz
- Cristina Peláez Ballesta
- Cristina Pérez García
- Daniel Molina Morant
- Daniel Podzamczer
- Daniel Roger Zapata
- David Roa Alonso
- David Vinuesa García
- Diana Piñar Cabezos
- Efrén Sánchez Vidal
- Elena Aranda Rife
- Elena Bereciartua Bastarrica
- Elena Hellín-Valiente
- Elena Marín
- Elena Morcillo Rodríguez
- Elena Salamanca-Rivera
- Elena Trigo Esteban
- Elena Álvaro Alonso
- Eleni Patera
- Elisa Cordero-Matía
- Elisa García Vázquez
- Elizabet Petkova-Saiz
- Encarnación Moral Escudero
- Enrique Bernal Morell
- Enrique Míguez Rey
- Ester Saez de Adana Arroniz
- Esther Aznar Muñoz
- Esther Calbo
- Esther Martínez Birlanga
- Eva Jiménez González de Buitrago
- Eva León Jiménez
- Eva Pilar García Villalba
- Eva Talavera García
- Evangelia Anna María Zioga
- Fadel
- Fernando de la Calle Prieto
- Fernando Fernández Sánchez
- Francesc Escrihuela
- Francesca Gioia
- Francisco Anguita Santos
- Francisco Arnaiz de las Revillas
- Francisco Javier De la Hera Fernández
- Francisco Javier Martínez Marcos
- Francisco Javier Rodríguez Gómez
- Francisco Muñoz Beamud
- Francisco Tejerina
- Fátima Brañas Baztán
- Gabriela Abelenda-Alonso
- Gabriela Escudero López
- Galadriel Pellejero
- Gaspar Duro Ruiz
- Gemma Mut Ramon
- Gemma Muñiz Nicolás
- Guan
- Guaraldi
- Guillem Policarpo Torres
- Guillermo Cuevas Tascon
- Gurutz Orbe Narváez
- Gómez Lucía
- Harris
- Helem Haydeé Vílchez Rueda
- Helena Albendín Iglesias
- Hoffmann–La Roche
- Horby
- Hortensia Álvarez Díaz
- Ignacio Pina
- Ignacio Pérez Valero
- Ignacio Álvarez Rodríguez
- Inmaculada González-Cuello
- Inmaculada Jarrín
- Inmaculada López-Montesinos
- Inés Fernández Jiménez
- Inés Pérez Zapata
- Irene Martín Rubio
- Isabel A. Pérez Hernández
- Isabel Asschert Agüero
- Isabel Gutiérrez
- Isabel Gutiérrez Martín
- Isabel Rábago Lorite
- Isidoro Fernández Romero
- Israel Sevilla Moreno
- Itziar Arrieta-Aldea
- Iván Pelegrín Senent
- Iván Piñero
- Jara Llenas-García
- Javier De la Torre Lima
- Javier Garrido
- Javier Martin Guerra
- Jerónimo Pachón
- Jessica Souto Higueras
- Jesús Fortún Abete
- Jesús Rodríguez-Baño
- Jesús Ruiz Aragón
- Joan Gómez-Junyent
- Joel Elías Chara Cervantes
- Jon Ugalde Espiñeira
- Jordi Carratalà
- Jordi Niubó
- Jorge Calderón Parra
- Jorge Calvo
- Jorge Parra Ruiz
- Jorge Valencia de la Rosa
- Josefina García García
- Josune Goikoetxea Agirre
- José A. Oteo Revuelta
- José Antonio Iribarren Loyarte
- José Javier Castrodeza Sanz
- José Joaquin Portu Zapirain
- José Luis Sierra-Monzón
- José M. Azcona Gutiérrez
- José M. García de Lomas Guerrero
- José Manuel Tafalla Torres
- José María Reguera Iglesias
- José María Robaina Bordón
- José Miguel Cisneros
- José Ramón Arribas
- Juan Berenguer
- Juan Berenguer
- Juan Carlos Gainzarain Arana
- Juan Carlos López
- Juan Carlos Ramos Ramos
- Juan Diego Ruiz Mesa
- Juan González García
- Juan González-Moreno
- Juan Mora Delgado
- Juan Pablo Avilés Parra
- Juan Ramón Domínguez Vicent
- Juan Salillas Hernando
- Juan Torres Macho
- Judit Villar-García
- Julen Cadiñaños Loidi
- Julio García Rodríguez
- Justo Lajusticia Aisa
- Júlia Pareja Coca
- Karim Mohamed Ramírez
- Laia Lorenzo-Esteller
- Laia Raich Montiu
- Laura Castelo Corral
- Laura García Escudero
- Laura García Pereña
- Laura Guio Carrión
- Laura Parra Gómez
- Laura Rodríguez Fernández
- Le
- Leire Pérez-Latorre
- Lluis Planas Bibiloni
- Lorea Arteche Eguizabal
- Lourdes Bladé Vidal
- Lucia Boix Palop
- Lucia Suárez
- Lucia Valiente de Santis
- Lucía Ramos Merino
- Luisa González-Iglesias
- Luz Martín Carbonero
- Ma del Carmen Liébana Martos
- Ma Jesús del Amor Espín
- Ma Luisa Fernández Ávila
- Ma Teresa Pérez Rodríguez
- Maialen Ibarguren Pinilla
- Manuel Alejandro Gálvez Bobadilla
- Manuela Aguilar-Guisado
- Margarita Ramírez
- Mario Pérez Butragueño
- Mariona Tasias Pitarch
- Marta Arsuaga Vicente
- Marta Asín-Corrochano
- Marta Díaz Menéndez
- Marta Fernández Morales
- Marta Ibarrola Hierro
- Marta Jiménez Escrig
- Marta Lamata Subero
- Marta Navarro Vilasaró
- Marta Santos Peña
- Martín Guillermo
- María Antonia Ribot Sanso
- María Carmen Fariñas Álvarez
- María D. del Toro
- María Erostarbe Gallardo
- María Hernández-Bonaga
- María Isabel Guirado Torrecillas
- María Jesús Bustinduy Odriozola
- María José Ríos-Villegas
- María Lorena María Valle Feijoo Begoña Rodríguez Ferreira
- María Luisa Machado Sicilia
- María Paz García Butenegro
- María Pilar Toledano Sierra
- María Rivas-Carmenado
- María Rodríguez Mayo
- María Ruíz Campuzano
- María Soledad García de Carlos
- María Victoria Fernández-Baca
- María Yllescas
- María Ángeles Garcinuño
- Mehta
- Melchor Riera Jaume
- Mercedes Clemente Presas
- Meritxell Gavalda Manso
- Meritxell Ortega Montoliu
- Miguel Górgolas Hernández-Mora
- Miguel Pedromingo Kus
- Miguel Salvert Lletí
- Miguel Torralba González de Suso
- Miguel Ángel Morán Rodríguez
- Mikel Temprano Gogenola
- Miquel Hortos Alsina
- Miquel Pujol
- Mohamed Kallouchi
- Montserrat Sanmarti Vilamala
- Montserrat Viqueira González
- Mònica Angerri Nadal
- Mónica Liébana Gómez
- Nerea Carrasco Antón
- Nicolás Jiménez-García
- Nicolás Merchante Gutiérrez
- Nieves de la Cruz Felipe
- Nieves Valcarce Pardeiro
- Olga Meca Birlanga
- Olga Sánchez-Pernaute
- Onofre Martínez Madrid
- Oscar Sanz Peláez
- Pablo Ryan
- Paloma Albiol Viñals
- Patricia González Muñiz
- Patricia González-Ruano Pérez
- Patricia Jiménez Aguilar
- Patricia Martínez Martín
- Paula Mendoza Roy
- Paula Santibañez Sáenz
- Pedro Gil Divasson
- Pedro Martínez Pérez-Crespo
- Pedro Ángel Cuadros Tito
- Pere Comas Casanova
- Pilar Martín Dávila
- Pilar Vizcarra
- Rafae Silvariño Fernández
- Raquel Álvarez Franco
- Rebeca Longueira
- Regino Rodríguez Álvarez
- Reinaldo Espíndola Gómez
- Ricardo Gil Sánchez
- Rita Godoy Lorenzo
- Rocío Montejano Sánchez
- Rojas-Marte
- Rosa de Miguel Buckley
- Rosa Oltra Sempere
- Rosana Rouco Esteves Marques
- Rosario Castilla Ortiz
- Sabela Sánchez Trigo
- Saioa Domingo Echaburu
- Salvador Pérez-Galera
- Santiago Moreno Guillén
- Santiago Pérez Parra
- Sara Lidia Kamel Rey
- Sara Vela Bernal
- Sara Velasco Fuentes
- Sergio España Cueto
- Sergio Gilaberte Reyzábal
- Sergio Manuel Santana Báez
- Sergio Pérez Pinto
- Sergio Román Soto
- Silvana Fiorante
- Silvia García Martínez
- Silvia Suárez
- Sonia Calzado Isbert
- Sonia García Prieto
- Sonsoles Salto
- Tamara Caínzos Romero
- Teresa Aldabó
- Teresa Aldámiz-Echevarría
- Teresa Giménez
- Vanesa Alende Castro
- Vicens Díaz de Brito Fernández
- Vicente de la Rosa
- Violeta Ramos Sesma
- Virginia Almadana
- Virginia Fernández Espinilla
- Virginia Isern Fernández
- Virginia Naranjo Velasco
- Víctor Asensi
- Xabier Kortajarena Urkola
- Xavier Sanz Salvador
- Ye
- Yolanda Meije Castillo
- Yuan
- Zaira R. Palacios Baena
- Zhang
- Zuriñe Ortiz de Zárate Ibarra
- Ángel Domínguez-Castellano
- Ángeles García Flores
- Ángeles Muñoz
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/08/2020
- Field of study
Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters.
Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs).
Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001).
Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio
The H-ATOMIC criteria for the etiologic classification of patients with Intracerebral Hemorrhage
- Author
- Publication venue
- Publication date
- 15/01/2021
- Field of study
BACKGROUND AND PURPOSE: There are no generally accepted criteria for the etiologic classification of intracerebral hemorrhage (ICH). For this reason, we have developed a set of etiologic criteria and have applied them to a large number of patients to determine their utility. METHODS: The H-ATOMIC classification includes 7 etiologic categories: Hypertension, cerebral Amyloid angiopathy, Tumour, Oral anticoagulants, vascular Malformation, Infrequent causes and Cryptogenic. For each category, the etiology is scored with three degrees of certainty: Possible(3), Probable(2) and Definite(1). Our aim was to perform a basic study consisting of neuroimaging, blood tests, and CT-angio when a numerical score (SICH) suggested an underlying structural abnormality. Combinations of >1 etiologic category for an individual patient were acceptable. The criteria were evaluated in a multicenter and prospective study of consecutive patients with spontaneous ICH. RESULTS: Our study included 439 patients (age 70.8 ± 14.5 years; 61.3% were men). A definite etiology was achieved in 176 (40.1% of the patients: Hypertension 28.2%, cerebral Amyloid angiopathy 0.2%, Tumour 0.2%, Oral anticoagulants 2.2%, vascular Malformation 4.5%, Infrequent causes 4.5%). A total of 7 patients (1.6%) were cryptogenic. In the remaining 58.3% of the patients, ICH was attributable to a single (n = 56, 12.7%) or the combination of ≥2 (n = 200, 45.5%) possible/probable etiologies. The most frequent combinations of etiologies involved possible hypertension with possible CAA (H3A3, n = 38) or with probable CAA (H3A2, n = 29), and probable hypertension with probable OA (H2O2, n = 27). The most frequent category with any degree of certainty was hypertension (H1+2+3 = 80.6%) followed by cerebral amyloid angiopathy (A1+2+3 = 30.9%).CONCLUSIONS: According to our etiologic criteria, only about 40% patients received a definite diagnosis, while in the remaining patients ICH was attributable to a single possible/probable etiology or to more than one possible/probable etiology. The use of these criteria would likely help in the management of patients with ICH
Mechanical Thrombectomy in and Outside the REVASCAT Trial
- Author
- Alejandro Martínez Domeño
- Alejandro Tomasello
- Ana Rodríguez-Campello
- Angel Chamorro
- Anna Pellisé
- Antoni Dávalos
- Antonio López
- Antonio Martínez-Yélamos
- Carlos Castaño
- Carlos Molina
- Carlos Molina
- Cecile van Eendenburg
- David Cánovas
- Elena López-Cancio
- Elio Vivas
- Elisa Cuadrado-Godia
- Erik Cobo
- Ernest Palomeras
- Esteban Santamarina
- Eva Giralt
- Francisco Purroy
- Helena Quesada
- Jaume Roquer
- Jerzy Krupinski
- Joan Martí Fàbregas
- Joan Perendreu
- Joaquín Serena
- Jordi Blasco
- Jordi Estela
- Jordi Sanahuja
- Jorge Pagola
- Josep Maria Aragonés
- Josep Maria Soler Insa
- José Álvarez-Sabín
- Juan M. Macho
- Juanjo Baiges
- Júlia Saura
- Laura Dorado
- Leopoldo Guimaraens
- Lluis Cano
- Lola Cocho Calderón
- Lucia Aja
- Luis San Roman Manzanera
- M. Carme Nicolás Herrerias
- Manuel Gómez-Choco
- Mar Castellanos
- Marc Ribó
- Maria Angeles de Miquel
- Maria del Carmen Garcia
- Marta Rubiera
- Meritxell Gomis
- Miquel Gallofré
- Moisés Garcés
- Mònica Millán
- Natalia Pérez de la Ossa
- Paloma Mora
- Pere Cardona
- Pilar Coscojuela
- Pilar Otermin Vallejo
- Rafael Marés
- Raquel Delgado Mederos
- Raul Martínez
- Rebeca Marín Bueno
- Sergio Amaro
- Sonia García
- Sonia Huertas Folch
- Sònia Abilleira
- Tudor G. Jovin
- Víctor Obach
- Xabier Urra
- Xavier Ustrell
- Yolanda Silva
- Ángel Ois
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- Field of study
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cáceres
- Aguilera-Albesa Sergio
- Aguiló-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Özge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- Antolí Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz María Jesús
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart Mélodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Behillil Sylvie
- Behillill Sylvie
- Bellani Giacomo
- Belot Alexandre
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Beretta Ilaria
- Bergin Colm
- Bertholon Frédérique
- Bettini Laura Rachele
- Beudel Martijn
- Bezrodnik Liliana
- Bhavsar Krishna
- Biggs Catherine
- Biggs Catherine
- Bilbao Agurtzane
- Bilguvar Kaya
- Biondi Andrea
- Bitker Laurent
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanco Ignacio
- Blandinières Adeline
- Bleibtreu Alexandre
- Bloomfield Marketa
- Blázquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boisson Bertrand
- Bolivar-Prados Mireia
- Bolze Alexandre
- Bomers Marije
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bonfanti Paolo
- Bonneaudeau Brigitte
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels Cédric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botta Michela
- Bouadma Lila
- Bouadma Lila
- Boucherit Soraya
- Boudhabhay Idris
- Bouiller Kévin
- Boulanger Cécile
- Bourgeois Fleur Le
- Bourgeon Marilou
- Bourke Nollaig
- Bourke Nollaig
- Bourke Nollaig
- Bouscambert-Duchamp Maude
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousquet Aurore
- Bousso Philippe
- Boutolleau David
- Bouvattier Claire
- Boyarchuk Oksana
- Boyarchuk Oksana
- Bozdemir Şefika Elmas
- Bravais Juliette
- Briones M. Luisa
- Briseño-Roa Luis
- Brodin Petter
- Brodin Petter
- Brouwer Matthijs
- Bruhns Pierre
- Bruneau Léa
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bueno Maria Rita P.
- Bugiani Marianna
- Buis David
- Bukhari Huda
- Bulle Esther
- Burdet Charles
- Burdet Charles
- Burrel Sonia
- Bustamante Carlos
- Bustamante Jacinta
- Butte Manish
- Béziat Vivien
- Cannet Dorothée
- Capra Ruggero
- Carapito Raphael
- Carrabba Maria
- Carrillo Jorge
- Casanova Jean-Laurent
- Casanova Jean-Laurent
- Casari Giorgio
- Casari Giorgio
- Casari Giorgio
- Casasnovas Carlos
- Caseris Marion
- Cassaniti Irene
- Castagnoli Riccardo
- Castelle Martin
- Castelli Francesco
- Castro Mateus
- Catherinot Emilie
- Cazzaniga Marina
- Celik Jale Bengi
- Cerf-Bensussan Nadine
- Cervantes-Gonzalez Minerva
- Ceschi Alessandro
- Chahine Abir
- Chair Anissa
- Chakravorty Samya
- Chalumeau Martin
- Charbit Bruno
- Charpentier Charlotte
- Chauvineau-Grenier Angélique
- Chen Jie
- Cheng Matthew
- Chirouze Catherine
- Chirouze Catherine
- Chouchane Osoul
- Chrabieh Maya
- Christodoulou John
- Ciceri Fabio
- Citerio Giuseppe
- Clavé Pere
- Clercq Jozefien De
- Cloherty Alex
- Clotet Bonaventura
- Cobat Aurélie
- Codina Anna
- Coelho Alexandra
- Coeuret-Pellicer Mireille
- Cognasse Fabrice
- Cognasse Fabrice
- Cohen Yves
- Colobran Roger
- Colobran Roger
- Comarmond Cloé
- Combes Alain
- Comoli Patrizia
- Condino-Neto Antonio
- Condino-Neto Antonio
- Conlon Niall
- Connolly Emma
- Constantinescu Stefan
- Conti Francesca
- Contro Ernesto
- Cooper Megan
- Cordel Hugues
- Correales Luisa Paola Duarte
- Corsico Angelo
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Couffin-Cadiergues Sandrine
- Coulongeat Matthieu
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- Tanaka Junko
- Tancevski Ivan
- Tancevski Ivan
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- Tandjaoui-Lambiotte Yacine
- Tangy Frédéric
- Tangye Stuart
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- Trouillet-Assant Sophie
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- Uzunhan Yurdagul
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- Valencia-Ramos Juan
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt Michèle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel Sébastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain Cédric
- Villar-García Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- Vélez Verónica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- Yahşi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- Yükselmiş Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Íñigo-Campos Antonio
- Öz Şadiye Kübra Tüter
- Özkan Esra Akyüz
- Özçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cáceres
- Aguilera-Albesa Sergio
- Aguiló-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Özge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
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- Timsit Jean-François
- Tipu Imran
- Tolstrup Martin
- Tolstrup Martin
- Tomasoni Gabriele
- Toubert Antoine
- Toubiana Julie
- Touvier Mathilde
- Townsend Liam
- Triantafyllia Vasiliki
- Trouillet-Assant Sophie
- Trouillet-Assant Sophie
- Troya Jesús
- Troya Jesús
- Tsang Owen
- Tserel Liina
- Tso Eugene
- Tsonas Anissa
- Tsumura Miyuki
- Tual Christelle
- Tubiana Sarah
- Tubiana Sarah
- Tucci Alessandra
- Tuinman Pieter
- Turvey Stuart
- Tzourio Christophe
- Téoulé François
- Uddin K.
- Uddin Mohammed
- Ungeheuer Marie-Noëlle
- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Vabres Pierre
- Valencia-Ramos Juan
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt Michèle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel Sébastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain Cédric
- Villar-García Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- Vélez Verónica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- Yahşi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- Yükselmiş Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Íñigo-Campos Antonio
- Öz Şadiye Kübra Tüter
- Özkan Esra Akyüz
- Özçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population
Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain
- Author
- Adoración Valiente
- Adriana Hernández Belmonte
- Adriana Sánchez Serrano
- Adrián Sánchez Montalvá
- Agustín Rojas-Vieyra
- Aida Gutiérrez García
- Aina Gabarrell Pascuet
- Aina Gomila Grange
- Ainhoa Urrutia Losada
- Alba Alastrué Violeta
- Alba Bergas
- Alba Rueda López
- Albert Sabater Gil
- Alberto Arranz Caso
- Alberto Bahamonde Carrasco
- Alberto Delgado-Iribarren
- Alberto Oreja
- Alberto Serrano Martínez
- Alejandra Duarte Borges
- Alejandra Pérez García
- Alejandro Aguirre Vila-Cora
- Alejandro Callejas Díaz
- Alejandro García García
- Alejandro Suárez-Benjumea
- Alex Smithson Amat
- Alex Soriano
- Alexander Rombauts
- Alexandre Pérez González
- Alexia Costanza Espiño Álvarez
- Alexy Inciarte
- Alfonso Cabello Úbeda
- Alfredo Mican
- Alicia Hernández Torres
- Almudena Villa Martí
- Alí Martakoush
- Amparo Blasco Claramunt
- Amparo López-Bernus
- Ana Alguacil
- Ana Barrios Blandino
- Ana Camón
- Ana del Cielo Pérez Jaén
- Ana Escoresca
- Ana Fernández Cruz
- Ana Ferrer Ribera
- Ana González-Cordón
- Ana Isabel Cañabate
- Ana Isabel Peláez Ballesta
- Ana Josefa Tebar Martínez
- Ana Lérida Urteaga
- Ana Mariño Callejo
- Ana Martínez Sapiña
- Ana María Garijo Saiz
- Ana Milagro Beamonte
- Ana Such Diaz
- Ana Vegas Serrano
- Ander González Sarria
- Andrea Espigares Correa
- Andrea Pérez Rodríguez
- André Barbosa Ventura
- Andrés Canut Blasco
- Andrés Felipe Cardona Arias
- Andrés Javier Ruiz Fernández
- Anna Ferrer Santolaria
- Antonio García Pardo
- Antonio Oteo Revuelta José
- Antonio Ramos Martínez
- Antonio Rezusta López
- Arantzazu Mera Fidalgo
- Aránzazu Villasante de la Puente
- Asier Aranguren Arostegui
- Asunción Díaz
- Beatriz Dietl Gómez-Luengo
- Beatriz Loureiro Rodríguez
- Beatriz María Sanjuan
- Beatriz Mestre Gómez
- Beatriz Pérez-Monte Mínguez
- Beatriz Rodríguez-Alonso
- Beatriz Álvarez Zapatero
- Beatriz Álvarez Álvarez
- Belén Alejos
- Belén Gutiérrez-Gutiérrez
- Belén Loeches Yagüe
- Benito Almirante
- Berta Torres
- Blanca Alonso
- Blanca Martínez Cifre
- Blanca Marzo
- Camilo Sanz Zamudio
- Carlos Bea Serrano
- Carlos Iniesta
- Carlos Jesús Dueñas Gutiérrez
- Carlos Rodríguez Franco
- Carlos Ruiz Martínez
- Carlota Gudiol
- Carmen Ardanuy
- Carmen Busca Arenzana
- Carmen Herrero Rodríguez
- Carmen Infante
- Carmen Martínez Cilleros
- Carmen Quereda
- Carmen Sáez Barberá
- Carmen Yera Bergua
- Carmen Yllera Gutiérrez
- Carmina Oltra
- Carolina Hernández Carballo
- Carolina Roldán Fontana
- Cecilia Tortajada Alamilla
- Celia Salamanca
- Chen
- Chen
- Chiara Fanciulli
- Cintia María Martínez Mateu
- Clara Muñoz Aguirre
- Clara Sala Jofre
- Claudia González Rico
- Claudio Bueno
- Concepción Amador Prous
- Concepción García García
- Conchita Pérez-Jorge Peremarch
- Constanza Muñoz Hornero
- Covadonga Morcate Fernández
- Cristina Carbonell
- Cristina Cervera Acedo
- Cristina Chico Chumillas
- Cristina Díez
- Cristina Gómez-Ayerbe
- Cristina Hernán García
- Cristina Hernández Gutiérrez
- Cristina López Mestanza
- Cristina Morales García
- Cristina Moreno
- Cristina Roca
- Cristóbal Manuel Rodríguez Leal
- Cummings
- Daniel Molina Morant
- Daniel Podzamczer
- Daniel Roger Zapata
- Daniel Useros Brañas
- David Alonso Menchén
- David Roa
- David Vinuesa García
- Delia Quilez Ágreda
- Docherty
- Domingo García-Jiménez
- Eduardo Malmierca Corral
- Efrén Sánchez Vidal
- Elena Chamarro Martí
- Elena Isaba Ares
- Elena López Tizón
- Elena María Aranda Rife
- Elena Morcillo Rodríguez
- Elena Morte
- Elena Múñez Rubio
- Elena Resino Foz
- Elena Salamanca
- Elena Trigo Esteban
- Elena Álvaro Alonso
- Elisa Cordero-Matía
- Elisa García Vázquez
- Elisabet Delgado Sánchez
- Elizabet Petkova Saiz
- Elsa Izquierdo García
- Encarnación Moral Escudero
- Enrique Míguez Rey
- Enrique Peral
- Esperanza Bejarano Tello
- Esteban Martínez
- Estel Pons Viñas
- Ester Sáez de Adana Arróniz
- Esther Aznar Muñoz
- Esther Expósito Palomo
- Esther Fraile Villarejo
- Esther García Almodóvar
- Eva Jiménez González de Buitrago
- Eva María León Jiménez
- Eva María Romay Lema
- Eva Pilar García Villalba
- Eva Talavera García
- Eva Van den Eynde Otero
- Felipe Villar Álvarez
- Fernando de la Calle Prieto
- Fernando González-Romo
- Francesc Albertí
- Francesca Gioia
- Francesca Norman
- Francisco Alcántara Nicolás
- Francisco Arnaiz de las Revillas
- Francisco Javier Membrillo de Novales
- Francisco Mora Gómez
- Francisco Muñoz Beamud
- Francisco Parras
- Francisco Rodríguez Gómez
- Francisco Tejerina
- Fátima Brañas Baztán
- Félix Gutiérrez Rodero
- Gabriel Gaspar Alonso-Vega
- Gabriela Abelenda-Alonso
- Gema Barbeito Castiñeiras
- Gema Domínguez de Pablos
- Gema Muñiz
- Germán Ramírez-Olivencia
- Ginger Giorgiana Cabrera Tejada
- Goyal
- Grasselli
- Guan
- Guillermo Cuervo
- Guillermo Cuevas Tascon
- Guillermo Estrada Fernández
- Guillermo Jiménez Álvarez
- Guillermo Maestro de la Calle
- Guillermo Martín
- Harris
- Helem Haydee Vilchez
- Helena Mozas Moriñigo
- Henar Calvo Sánchez
- Hernando Knobel
- Huang
- Huang
- Héctor Meijide Míguez
- Ianire Virto Peña
- Ignacio De los Santos Gil
- Inmaculada Jarrín
- Inmaculada Jarrín
- Inmaculada Martín Pérez
- Inmaculada Poquet Catala
- Inés Fernández Jiménez
- Inés Pérez Zapata
- Inés Suárez-García
- Irene Carrillo Acosta
- Irene Díaz de la Torre
- Irene Martín Rubio
- Iris Pedrola Gorrea
- Isabel A. Pérez Hernández
- Isabel Barrio López
- Isabel Gutiérrez
- Isabel Jiménez Martínez
- Isabel Pérez-Tamayo
- Isabel Rábago Lorite
- Ismail Zakariya-Yousef Breval
- Itziar Diego Yagüe
- Ivette Abascal Cambras
- Iván Castro Hernández
- Iván Navas Clemente
- Iván Pelegrín Senent
- Iván Piñero
- Jamil Cedeño
- Jara Llenas García
- Javier Coy Coy
- Javier De la Torre Lima
- Javier Nieto Arana
- Javier Oliver Ortega
- Javier Sánchez-Lora
- Jerónimo Pachón
- Jerónimo Pachón
- Jessica Abadia Otero
- Jesús Rodriguez Baño
- Jesús Rodríguez-Baño
- Jesús Ruiz Aragón
- Jesús Santos González
- Jesús Sanz Sanz
- Jesús Sojo
- Jesús Sánchez-Gómez
- Jesús Troya García
- Jhon Rojas
- Joan Gómez-Junyent
- Joaquín López-Contreras González
- Jon Ugalde Espiñeira
- Jonathan Cámara Fernández
- Jordi Carratalà
- Jordi Carratalà
- Jordi Mancebo Cortés
- Jordi Niubó
- Jorge Alba Fernández
- Jorge Anel Pedroche
- Jorge Calderón Parra
- Jorge Calvo
- Jorge Martínez Jordán
- Jorge Parra Ruiz
- Jorge Valencia de la Rosa
- Jose David Ampuero Martinich
- Joseba Portu Zapirain
- Josefa Serralta Buades
- Josefina García García
- Josune Goikoetxea Agirre
- José Antonio Peregrina
- José Antonio Pérez de León
- José Bravo-Ferrer
- José Hernández Quero
- José Ignacio Bernardino de la Serna
- José Luis Blanco
- José Luis Díaz de Tuesta del Arco
- José Luis García Fogeda
- José Luis Velasco Garrido
- José Luís Del Pozo León
- José M. Azcona Gutiérrez
- José Manuel Vázquez Comendador
- José María Aguado
- José María Marimón Ortiz de Zárate
- José María Milicua Muñoz
- José Miguel Cisneros
- José Mª García de Lomas Guerrero
- José R. Blanco Ramos
- José Ramón Arriba
- José Ramón Arribas López
- José Román Muñoz del Rey
- José Sanz Moreno
- José Tomas Algado Rabasa
- Juan Berenguer
- Juan Berenguer
- Juan Cantón de Seoane
- Juan Carlos Abad Almendro
- Juan Carlos Gainzarain Arana
- Juan Carlos López
- Juan Carlos Ramos Ramos
- Juan Cuadros González
- Juan Emilio Losa García
- Juan Espinosa Pereiro
- Juan Pablo Avilés
- Juan Pablo Horcajada
- Juan Salillas Hernando
- Juan Torres Macho
- Judit Villar-García
- Julen Cadiñaños Loidi
- Julia Pareja Coca
- Julia Praena
- Julio García Rodríguez
- Justo Menéndez
- Júlia Sellarés
- Karim Mohamed Ramírez
- Kass
- Klein
- Kuderer
- Kwong
- Lagunas-Rangel
- Laia Lorenzo-Esteller
- Lara Montes Andújar
- Laura Castelo Corral
- Laura Iglesias Llorente
- Laura Mao Martín
- Laura Muñoz López
- Laura Prieto Pérez
- Leire Balerdi Sarasola
- Leire Pérez-Latorre
- Liang
- Lidia Martín
- Lighter
- Liu
- Lorea Arteche Eguizabal
- Lorena De la Mora
- Loreto Vidaur Tello
- Lourdes Herrera Pacheco
- Lucia Boix Palop
- Lucia Cajuela
- Lucia Suárez Pérez
- Lucio García-Fraile
- Lucy Abella Vázquez
- Lucía Fernández de Orueta
- Lucía Gómez García
- Lucía Marín-Barrera
- Lucía Ramos Merino
- Luis Alberto Nieto Fernández del Campo
- Luis E. López-Cortés
- Luis Falgueras López
- Luis Force Sanmartín
- Luis Metola Sacristán
- Luis Puente
- Luisa Sorli Redò
- Lydia Gálvez-Benítez
- Lydia Martín González
- M. Teresa Pérez-Rodríguez
- Maialen Ibarguren Pinilla
- Manuel Cervantes García
- Manuela Aguilar-Guisado
- Mar Masiá Canuto
- Mar Mosquera
- Marcelino Hayek Peraza
- Marco Antonio Sempere Alcocer
- Marcos Díez Martínez
- Marcos López Dosil
- Margarita Ramírez-Schacke
- Maria Álvarez de Castro
- Maribel Zamora Cintas
- Marina Pacheco Martínez-Atienza
- Mario Fernández-Ruiz
- Mario José Rodriguez Dominguez
- Mario Pérez Butragueño
- Marta Alvarado Blasco
- Marta Arsuaga Vicente
- Marta Díaz Menéndez
- Marta Lamata Subero
- Marta Miarons
- Marta Mora Rillo
- Marta Navarro Vilasaró
- Marta Rava
- Marta Rico Rodríguez
- Marta Robledo del Prado
- Marta Ruiz-Alguero
- Marta Santos Peña
- Marta Vizcaíno Callejón
- María Aroca Ferri
- María Aránzazu Galindo Martín
- María Carmen Fariñas Álvarez
- María Cecilia Cánepa
- María de la Luz Padilla Salazar
- María del Carmen Navarro Sáez
- María del Mar Alonso Socas
- María Dolores Avilés
- María E. García-Leoni
- María Isabel Quijano Contreras
- María Jesús Domínguez Santalla
- María José Blanco Vidal
- María José Ruiz Rodríguez
- María Larrosa
- María Lorén Vargas
- María Luisa Machado Sicilia
- María López-Jódar
- María Milagro Montero
- María Novella Mena
- María Paz García Butenegro
- María Pilar García García
- María Rexach Fumaña
- María Roca Toda Savall
- María Rodríguez Mahía
- María Simón Sacristán
- María Yllescas
- María Ángeles Domínguez
- María Ángeles Garcinuño
- Melania Íñigo Pestaña
- Melchor Riera Jaume
- Melchor Álvarez de Mon Soto
- Melissa Carreres Candela
- Merce Cardona Rivera
- Merce Sirisi
- Mercedes Clemente Presas
- Mercedes Guillamón Sánchez
- Mercedes San Franco
- Mercedes Villarreal García-Lomas
- Mercè Gurguí Ferrer
- Miguel Cervero
- Miguel Corral Saracho
- Miguel Fernández-Huerta
- Miguel Górgolas Hernández-Mora
- Miguel Pedromingo Kus
- Miguel Salavert Lletí
- Miguel Sampedro Núñez
- Miguel Torralba González de Suso
- Miguel Villamarín
- Miguel Ángel Moran Rodríguez
- Mikel del Álamo Martínez de Lagos
- Ministerio de Sanidad
- Miquel Pujol
- Mireia Puig Campmany
- Miriam Estébanez Muñoz
- Miriam García Gómez
- Miriam Latorre-Millán
- Moncef Belhassen-García
- Montaña Jiménez Álvaro
- Montserrat Laguno
- Montserrat Sanmarti Vilamala
- Mª Antonia Sepúlveda Berrocal
- Mª Carmen Sánchez Arenas
- Mª del Mar Lago Núñez
- Mª Ángeles Marcos
- Mónica González Bardanca
- Mónica Gozalo
- Mónica Liébana Gómez
- Natalia Carrasco Fons
- Natividad Benito Hernández
- Nerea Carrasco Antón
- Nicolas Merchante Gutiérrez
- Nieves Valcarce Pardeiro
- Noelia Arenal Andrés
- Nora Izko Gartzia
- Nuria Fernández
- Nuria Parra Arribas
- Nuria Rabella García
- Núria Trullen
- Olalla Martínez Macias
- Oriol Gasch Blasi
- Oscar del Río Pérez
- Oscar Sanz Peláez
- Pablo Fernández-González
- Pablo Marguenda Contreras
- Pablo Pascual Alonso
- Pablo Ryan
- Pablo Ryan
- Paloma Merino Amador
- Patricia González Muñiz
- Patricia González- Ruano
- Patricia Martínez Martín
- Patricia Pérez-Palacios
- Patricia Sorní Moreno
- Paula Runza Buznego
- Paula Santibáñez Sáenz
- Paula Sáez Escolano
- Paula Villares Fernández
- Pedro Gil Divasson
- Pere Comas Casanova
- Pere Domingo Pedrol
- Pilar Catalán
- Pilar Hernández Machín
- Pilar Retamar
- Pilar Toledano Sierra
- Pilar Vizcarra
- Rafael Cantón Moreno
- Rafael Padrós Selma
- Rafael Silvariño Fernández
- Rafael Torres Perea
- Ramón Pérez Tanoira
- Raquel Aranega
- Raquel Barrós González
- Raquel Elisa Rodríguez Tarazona
- Raquel Martínez Goñi
- Raquel Álvarez Franco
- Rebeca Izquierdo
- Remedios Alemán Valls
- Ricardo Fernández Roblas
- Richard Rojas
- Richardson
- Robert Torres Sánchez del Arco
- Roberto Güerri-Fernández
- Roberto Vates Gómez
- Rocío Martínez Avilés
- Rodrigo Alonso Navarro
- Rodrigo Sierra Rodríguez
- Roi Suárez Gil
- Rosa de Miguel Buckley
- Rosana Rouco Esteves Marques
- Ruth Brea Aparicio
- Ruth Figueroa Cerón
- Sadaf Zafar Iqubal-Mirza
- Salvador Álvarez Martin
- Sandra Pérez-Recio
- Santos Del Campo
- Sara Fernández Rodríguez
- Sara Heili Frades
- Sara Lidia Kamal
- Sara Medrano Pardo
- Sara Rodrigo González
- Sarah Caro Bragado
- Schiffrin
- Sergio España Cueto
- Sergio Gilaberte Reyzábal
- Sergio Pérez Pinto
- Silvana Fiorante
- Silvia Castañeda Espinosa
- Silvia Hernáez Crespo
- Silvia Loscos
- Silvia Paulos Viñas
- Silvia Suárez Diaz
- Silvia Valero Rovira
- Silvia Álvarez Kaelis
- Simonnet
- Singh
- Sonia Calzado Isbert
- Sonia García
- Sonia García Calvo
- Sonia Vega Molpeceres
- Susana Casas Rodríguez
- Tamara Manso Gómez
- Teresa Aldabó
- Teresa Aldámiz-Echevarría
- Teresa García Delange
- Teresa Álvarez de Espejo Montiel
- Tomás Tosco Núñez
- Valvanera Ibarra Cucalón
- Vanessa Alende Castro
- Verónica Cano Llorente
- Vicente Boix
- Vicente Ferrer Díaz de Brito Fernández
- Victoria Hernando
- Violeta Ramos Sesma
- Virginia Fernández Espinilla
- Virginia Molina Peinado
- Virginia Naranjo Velasco
- Virginia Pomar Solchaga
- Virginia Pérez Doñate
- Víctor Asensi Álvarez
- Víctor J. Moreno Cuerda
- Wadhera
- World Health Organization
- Xabier Kortajarena Urkola
- Xavier Bonfill Cosp
- Yang
- Yolanda Martínez Martínez
- Yolanda Meije
- Yolanda Posada Franco
- Young
- Zaira R. Palacios
- Zeltia Valcarce González
- Zhou
- Zhou
- Zineb Karroud
- Zuriñe Ortiz de Zárate Ibarra
- Álvaro Navarro Batet
- Álvaro Varela Plaza
- Ángeles García Flores
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study