63 research outputs found
H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathway.
Effects of an H3R Antagonist on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid
Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders primarily characterized by impaired social interaction and communication, and by restricted repetitive behaviors and interests. Ligands of histamine receptor 3 (H3R) are considered potential therapeutic agents for the treatment of different brain disorders and cognitive impairments. Considering this, the aim of the present study is to evaluate the actions of ciproxifan (CPX), an H3R antagonist, on the animal model of autism induced by prenatal exposure to valproic acid (VPA). Swiss mice were prenatally exposed to VPA on embryonic day 11 and assessed for social behavior, nociceptive threshold and repetitive behavior at 50 days of life. The treatment with CPX (3 mg/kg) or saline was administered 30 minutes before each behavioral test. The VPA group presented lower sociability index compared to VPA animals that were treated with CPX. Compared to the Control group, VPA animals presented a significantly higher nociceptive threshold, and treatment with CPX was not able to modify this parameter. In the marble burying test, the number of marbles buried by VPA animals was consistent with markedly repetitive behavior. VPA animals that received CPX buried a reduced amount of marbles. In summary, we report that an acute dose of CPX is able to attenuate sociability deficits and stereotypies present in the VPA model of autism. Our findings have the potential to help the investigations of both the molecular underpinnings of ASD and of possible treatments to ameliorate the ASD symptomatology, although more research is still necessary to corroborate and expand this initial data
L-histidine provokes a state-dependent memory retrieval deficit in mice re-exposed to the elevated plus-maze
A critical time window for the analgesic effect of central histamine in the partial sciatic ligation model of neuropathic pain
Ameliorating antipsychotic-induced weight gain by betahistine: Mechanisms and clinical implications
The effect of intracerebroventricular injection of histamine in visceral nociception induced by acetic acid in rats
Objective : This study was designed to investigate the role of brain
histamine and H1 and H2 receptors in mediating the central perception
of visceral pain in rats. Materials and Methods : In conscious rats
implanted with a lateral brain ventricle cannula, the effect of
intracerebroventricular (i.c.v.) injection of histamine (2.5, 10, and
40 μg), and chlorpheniramine and ranitidine at the same doses of
5, 20, and 80 μg were investigated on visceral pain. Visceral
nociception induced by intraperitoneal (i.p.) injection of acetic acid
(1 mL, 1%), and the number of complete abdominal wall muscle
contractions accompanied with stretching of hind limbs (writhes) were
counted for 1 h. Results : Histamine at doses of 10 and 40 μg and
chlorpheniramine and ranitidine at the same doses of 20 and 80 μg,
significantly decreased the numbers of writhes (P < 0.05).
Pretreatment with chlorpheniramine and ranitidine at the same dose of
80 μg, significantly prevented histamine (40 μg)-induced
antinociception (P < 0.05). Conclusion : The results of this study
suggest that brain histamine may be involved in modulation of visceral
antinociception through both central H 1 and H 2 receptors
- …