WPŁYW KOMPLEKSOWEGO POSTĘPOWANIA LECZNICZEGO NA POSTAWĘ RÓWNOWAŻNĄ PACJENTÓW Z DOLEGLIWOŚCIAMI BÓLOWYMI KRĘGOSŁUPA W ODCINKU LĘDŹWIOWO-KRZYŻOWYM

I n t r o d u c t i o n . The series of changes in biomechanics of spine and patient's balanced posture is observed when the symptoms associated with lumbosacral spine's ailments occur. As a result of involuntary and unconscious taking the weight off the "affected" side, there is a shift of the center of gravity onto the unaffected side which, in turn, is a reason for intensification of existing ailments or occurrence of new ones. T h e a i m of this thesis is to assess the balanced posture in patients with lumbosacral spine ailments before and after rehabilitation. M a t e r i a l s a n d m e t h o d s . The study was conducted on the group of 33 patients suffering with lumbosacral spine ailments aged 60-70. The assessment of balanced posture was prepared by means of the TecnoBody PK 252 platform during patients’ stay in 21 Military Health Resort Rehabilitation Hospital in Busko Zdrój. Every patient underwent a comprehensive 21-days treatment consisting of the application of kinesiotherapy, physical therapy and balne otherapy. R e s u l t s . The comprehensive health resort rehabilitation treatment influenced the improvement of balanced posture parameters i.e. standard deviation forwardsbackwards, standard deviation right-left, area of ellipse, perimeter and average speed of postural sways in patients aged suffering from lumbosacral spine ailments. C o n c l u s i o n s : 1. The comprehensive health resort and rehabilitation treatment in 21 Military Health Resort Rehabilitation Hospital influenced the improvement of balanced posture parameters in patients aged 60-70 suffering from lumbosacral spine ailments. 2. Significant differences occur as far as the assessment of balanced posture is concerned in patients aged 60-70 suffering from lumbosacral spine ailments with open and closed eyes. The differences are noticeable both before and after the treatment.W s t ę p . W momencie wystąpienia objawów klinicznych związanych z dolegliwościami bólowymi odcinka lędźwiowo krzyżowego obserwuje się szereg zMarta Hałas et al.mian w biomechanice kręgosłupa oraz postawie równoważnej pacjenta. W wyniku mimowolnego i nieświadomego odciążenia strony „zajętej” dochodzi do przemieszczenia środka ciężkości w stronę niezajętą, co z kolei jest powodem nasilania istniejących dolegliwości lub powodem wystąpienia nowych. C e l e m p r a c y jest ocena postawy równoważnej pacjentów z dolegliwościami bólowymi kręgosłupa w odcinku lędźwiowo-krzyżowym przed i po postępowaniu rehabilitacyjnym. M a t e r i a ł i m e t o d y . Badania przeprowadzono na grupie 33 osób z dolegliwościami bólowymi kręgosłupa w odcinku lędźwiowo-krzyżowym w wieku 60-70 lat. Oceny postawy równoważnej dokonano na platformie TecnoBody PK 252 w trakcie pobytu w 21 Wojskowym Szpitalu w Busku Zdroju. U każdego pacjenta zastosowane zostało kompleksowe 21 dniowe postępowanie lecznicze polegające na stosowaniu kinezyterapii, fizykoterapii oraz balneologii. Oceny postawy równoważnej dokonano przed rozpoczęciem terapii i bezpośrednio po jej zakończeniu. Wy n i k i . Kompleksowe leczenie uzdrowiskoworehabilitacyjne wpłynęło na poprawę parametrów postawy równoważnej tj: odchylenie standardowe przód-tył, odchylenie standardowe prawa-lewa, pole elipsy, perymetr oraz średnia prędkość wychyleń posturalnych u pacjentów w wieku 60-70 lat z dolegliwościami bólowymi kręgosłupa w odcinku lędźwiowo-krzyżowym. Wn i o s k i : 1. Kompleksowe leczenie uzdrowiskowo-rehabilitacyjnego w 21 WSzUR, ma wpływ na poprawę parametrów opisujących postawę równoważną u pacjentów w wieku 60-70 lat z pacjentów z dolegliwościami bólowymi kręgosłupa w odcinku lędźwiowo-krzyżowym. 2. Występują istotne różnice w ocenie postawy równoważnej pacjentów z dolegliwościami bólowymi kręgosłupa w odcinku lędźwiowo-krzyżowym w wieku 60-70 lat z oczami otwartymi i oczami zamkniętymi. Zarówno przed rozpoczęciem leczenia, jak i po zakończonym leczeniu.

THE INFLUENCE OF THE COMPREHENSIVE TREATMENT PROCEDURE ON BALANCED POSTURE IN PATIENTS WITH LUMBOSACRAL SPINE AILMENTS

I n t r o d u c t i o n. The series of changes in biomechanics of spine and patient's balanced posture is observed when the symptoms associated with lumbosacral spine's ailments occur. As a result of involuntary and unconscious taking the weight off the "affected" side, there is a shift of the center of gravity onto the unaffected side which, in turn, is a reason for intensification of existing ailments or occurrence of new ones. T h e a i m of this thesis is to assess the balanced posture in patients with lumbosacral spine ailments before and after rehabilitation. M a t e r i a l s a n d m e t h o d s. The study was conducted on the group of 33 patients suffering with lumbosacral spine ailments aged 60-70. The assessment of balanced posture was prepared by means of the TecnoBody PK 252 platform during patients’ stay in 21 Military Health Resort Rehabilitation Hospital in Busko Zdrój. Every patient underwent a comprehensive 21-days treatment consisting of the application of kinesiotherapy, physical therapy and balne otherapy. R e s u l t s. The comprehensive health resort rehabilitation treatment influenced the improvement of balanced posture parameters i.e. standard deviation forwardsbackwards, standard deviation right-left, area of ellipse, perimeter and average speed of postural sways in patients aged suffering from lumbosacral spine ailments. C o n c l u s i o n s : 1. The comprehensive health resort and rehabilitation treatment in 21 Military Health Resort Rehabilitation Hospital influenced the improvement of balanced posture parameters in patients aged 60-70 suffering from lumbosacral spine ailments. 2. Significant differences occur as far as the assessment of balanced posture is concerned in patients aged 60-70 suffering from lumbosacral spine ailments with open and closed eyes. The differences are noticeable both before and after the treatment.W s t ę p. W momencie wystąpienia objawów klinicznych związanych z dolegliwościami bólowymi odcinka lędźwiowo krzyżowego obserwuje się szereg zMarta Hałas et al.mian w biomechanice kręgosłupa oraz postawie równoważnej pacjenta. W wyniku mimowolnego i nieświadomego odciążenia strony „zajętej” dochodzi do przemieszczenia środka ciężkości w stronę niezajętą, co z kolei jest powodem nasilania istniejących dolegliwości lub powodem wystąpienia nowych. C e l e m p r a c y jest ocena postawy równoważnej pacjentów z dolegliwościami bólowymi kręgosłupa w odcinku lędźwiowo-krzyżowym przed i po postępowaniu rehabilitacyjnym. M a t e r i a ł i m e t o d y. Badania przeprowadzono na grupie 33 osób z dolegliwościami bólowymi kręgosłupa w odcinku lędźwiowo-krzyżowym w wieku 60-70 lat. Oceny postawy równoważnej dokonano na platformie TecnoBody PK 252 w trakcie pobytu w 21 Wojskowym Szpitalu w Busku Zdroju. U każdego pacjenta zastosowane zostało kompleksowe 21 dniowe postępowanie lecznicze polegające na stosowaniu kinezyterapii, fizykoterapii oraz balneologii. Oceny postawy równoważnej dokonano przed rozpoczęciem terapii i bezpośrednio po jej zakończeniu. Wy n i k i. Kompleksowe leczenie uzdrowiskoworehabilitacyjne wpłynęło na poprawę parametrów postawy równoważnej tj: odchylenie standardowe przód-tył, odchylenie standardowe prawa-lewa, pole elipsy, perymetr oraz średnia prędkość wychyleń posturalnych u pacjentów w wieku 60-70 lat z dolegliwościami bólowymi kręgosłupa w odcinku lędźwiowo-krzyżowym. Wn i o s k i : 1. Kompleksowe leczenie uzdrowiskowo-rehabilitacyjnego w 21 WSzUR, ma wpływ na poprawę parametrów opisujących postawę równoważną u pacjentów w wieku 60-70 lat z pacjentów z dolegliwościami bólowymi kręgosłupa w odcinku lędźwiowo-krzyżowym. 2. Występują istotne różnice w ocenie postawy równoważnej pacjentów z dolegliwościami bólowymi kręgosłupa w odcinku lędźwiowo-krzyżowym w wieku 60-70 lat z oczami otwartymi i oczami zamkniętymi. Zarówno przed rozpoczęciem leczenia, jak i po zakończonym leczeniu.

Application of auxological methods, including dental age estimation, in the assessment of delayed puberty in girls in gynecological practice

Developmental gynecology uses methods practiced in auxology — the science of human ontogenetic development. An important and jointly used concept in gynecology and auxology is the concept of developmental age, which, unlike calendar age, is a measure of the biological maturity of the organism, indicating the stage of advancement in the development of certain features or body systems. Developmental age assessment methods include: a) morphological (somatic) age — body height and weight, b) secondary sex characteristics — breast in girls, genitalia (penis and testes) in boys, and pubic hair in both sexes, c) bone age — hand and wrist x-ray, and d) dental age. An important marker of developmental age is also age at menarche, treated as a late indicator of puberty in girls. All of these methods are useful in the context of assessing regularity and disorders of puberty, such as delayed puberty. The paper discusses developmental age assessment methods that can be used to diagnose delayed puberty as well as the causes of delayed puberty in girls. It should be emphasized that in assessing the process of physical development of a given individual, the cooperation of specialists in the field of developmental gynecology, pediatrics, auxology, dentistry, endocrinology, and dietetics would be the most desirable

Arsenic (As) and breast cancer risk

The study was conducted to determine the correlations between serum concentration of arsenic (As) with increased or decreased predisposition to breast and ovarian cancer

Sexual activity among young women. Medical and legal aspects

Objectives: Two main aims of the study were: (1) to examine whether age of sexual debut and patterns of sexual behavior have changed over the past decades among young Polish women and (2) to consider the medical and legal aspects regarding juvenile patients who are sexually active. Materials and methods: Two hundred women, born within two consecutive decades (1975-1995) in the Wielkopolska region (Poland) were asked to fill in a questionnaire concerning the following: age at sexual initiation and the contraceptive method used at the time, preferred forms of sexual activity, current contraceptive methods. Statistical analysis was performed using the Statistica 9.0 software [StatSoft]. Statistical evaluation was based on the chisquare test and analysis of covariance (ANCOVA). Results: The average age of sexual initiation decreased significantly between the two studied cohorts of women and ranged from 18.9 for women born between 1975 and 1984 (cohort I) and 17.6 for women born between 1985 and 1995 (cohort II), regardless of the place of residence. The percentage of women who had their first sexual intercourse by the age of 15 years was 0 % in cohort I and 8.2% in cohort II. Other characteristics of sexual activity were similar across the studied cohorts of women. Condom use during the first sexual intercourse was the preferred form of contraception (59.2%). 65% women have reported current contraceptive use. As for the preferred type of intercourse, all women (100%) chose vaginal sex. The most frequent number of sexual intercourses per month was 7 or more (41.7%). Conclusions: The age of sexual debut among Polish women has decreased significantly over the last decades. Premature initiation is believed to increase the risk of unplanned pregnancy, STDs and emotional stress. Polish medical and legal circles lack unequivocal stand on how to deal with juvenile patients who are sexually active, expect to receive advice from a gynecologist, a gynecologic examination and prescribed contraceptives

HPV genotypes in the oral cavity/oropharynx of children and adolescents: cross-sectional survey in Poland

Human papillomaviruses (HPVs) are a very complex group of pathogenic viruses, with more than 80 types, causing human infection. Given the prevalence of HPV infection and its relationship with the development of cervical and many other cancers, HPV vaccine development has been a major public health initiative worldwide in the last decade. The aim of the presented study was to identify HPV DNA by MY-PCR in 4,150 school children and adolescents, aged 10–18 years in the Wielkopolska region, Poland. All individuals were asked to fill in extensive questionnaires; further normal, oral squamous cells were collected from each pupil. Cellular DNA was isolated and used as a MY-PCR template to estimate the incidence of HPV-active infection. Forty five subjects (1.08% of the sample) were carriers of oropharyngeal HPVs. HPV status and variables of interest, such as age, gender, socioeconomical status, and risk factors (smoking and sexual intercourse history, alcohol consumption) were not correlated. The presence of HPVs in the oral cavity was cumulated in several schools of the region. DNA sequencing of MY-PCR products revealed only four HPV genotypes. The most frequent genotype was HPV11 (38/45 HPV-positive cases), while other more rare genotypes were HPV6 (3/45), HPV12 (3/45), and HPV57 (1/45). Conclusion: Our findings presented herein, reveal a relatively low prevalance of oropharyngeal HPVs in Polish adolescents and fill an important gap in the knowledge of oral HPV infections of children above 10 years and adolescents

Genetic predisposition to in situ and invasive lobular carcinoma of the breast.

Invasive lobular breast cancer (ILC) accounts for 10-15% of all invasive breast carcinomas. It is generally ER positive (ER+) and often associated with lobular carcinoma in situ (LCIS). Genome-wide association studies have identified more than 70 common polymorphisms that predispose to breast cancer, but these studies included predominantly ductal (IDC) carcinomas. To identify novel common polymorphisms that predispose to ILC and LCIS, we pooled data from 6,023 cases (5,622 ILC, 401 pure LCIS) and 34,271 controls from 36 studies genotyped using the iCOGS chip. Six novel SNPs most strongly associated with ILC/LCIS in the pooled analysis were genotyped in a further 516 lobular cases (482 ILC, 36 LCIS) and 1,467 controls. These analyses identified a lobular-specific SNP at 7q34 (rs11977670, OR (95%CI) for ILC = 1.13 (1.09-1.18), P = 6.0 × 10(-10); P-het for ILC vs IDC ER+ tumors = 1.8 × 10(-4)). Of the 75 known breast cancer polymorphisms that were genotyped, 56 were associated with ILC and 15 with LCIS at P<0.05. Two SNPs showed significantly stronger associations for ILC than LCIS (rs2981579/10q26/FGFR2, P-het = 0.04 and rs889312/5q11/MAP3K1, P-het = 0.03); and two showed stronger associations for LCIS than ILC (rs6678914/1q32/LGR6, P-het = 0.001 and rs1752911/6q14, P-het = 0.04). In addition, seven of the 75 known loci showed significant differences between ER+ tumors with IDC and ILC histology, three of these showing stronger associations for ILC (rs11249433/1p11, rs2981579/10q26/FGFR2 and rs10995190/10q21/ZNF365) and four associated only with IDC (5p12/rs10941679; rs2588809/14q24/RAD51L1, rs6472903/8q21 and rs1550623/2q31/CDCA7). In conclusion, we have identified one novel lobular breast cancer specific predisposition polymorphism at 7q34, and shown for the first time that common breast cancer polymorphisms predispose to LCIS. We have shown that many of the ER+ breast cancer predisposition loci also predispose to ILC, although there is some heterogeneity between ER+ lobular and ER+ IDC tumors. These data provide evidence for overlapping, but distinct etiological pathways within ER+ breast cancer between morphological subtypes

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms