Relatório de estágio em monitorização de ensaios clínicos

Mestrado em Biomedicina FarmacêuticaEste relatório descreve a minha experiência de 9 meses enquanto estagiária nos Laboratórios Pfizer, Lda.,uma das indústrias farmacêutica mais especializada em pesquisa biomédica. Este estágio decorreu em dois formatos: formação multidisciplinar e monodisciplinar. A formação multidisciplinar teve como objectivo obter uma perspectiva mais alargada das diferentes unidades de uma indústria farmacêutica, envolvendo deste modo a participação em diferentes unidades desta empresa. A formação monodisciplinar concentrou-se na área de monitorização de ensaios clínicos, decorrendo na unidade de ensaios clínicos – Country Clinical Operations – com o objectivo de adquirir experiência e competências na condução de ensaios clínicos. O estágio multidisciplinar permitiu-me adquirir competências em diferentes unidades da companhia e perceber qual a sua função dentro da companhia. O estágio monodisciplinar permitiu-me compreender com maior profundidade o papel do monitor na condução de ensaios clínicos e o quão importante é para garantir a segurança, direitos e bem-estar dos participantes nos ensaios clínicos e garantir a integridade dos dados recolhidos. Permitiu me também contactar com locais de ensaio e perceber quais os desafios que temos de ultrapassar para voltarmos a ser um país de interesse para a condução de ensaios clínicos.This report describes my 9-month experience as an intern at Laboratórios Pfizer,Lda., one of the most specialized companies of biomedical research in the world. This internship took place in two formats: multidisciplinary and monodosciplinary training. Multidisciplinary training had the objective of obtaining a broad perspective of the different units of the company involving the participation in these different units. The Monodisciplinary training carried out in the Clinical Country Operations unit was focused in monitoring clinical trials. The objective was to obtain experience and skills in the conduction of clinical trials. Multidisciplinary internship allowed me acquire skills in each unit where I spent time and realize what are the functions of each unit in the company. Monodisciplinary internship allowed me to deeply understand the monitor’s responsibilities in conducting clinical trials, and how important is to ensure the rights, safety and welfare of subjects participating in clinical trials and assure the quality, reliability and integrity of data collected. It also allowed me to contact with study sites and understand what are the challenges that we need to overcome and become again an eligible country to conduct clinical trials

Relato da organização de um serviço dedicado à Covid19: Assegurar a proteção dos profissionais face à exposição ocupacional

info:eu-repo/semantics/publishedVersio

MAMMALS IN PORTUGAL : A data set of terrestrial, volant, and marine mammal occurrences in P ortugal

Mammals are threatened worldwide, with 26% of all species being includedin the IUCN threatened categories. This overall pattern is primarily associatedwith habitat loss or degradation, and human persecution for terrestrial mam-mals, and pollution, open net fishing, climate change, and prey depletion formarine mammals. Mammals play a key role in maintaining ecosystems func-tionality and resilience, and therefore information on their distribution is cru-cial to delineate and support conservation actions. MAMMALS INPORTUGAL is a publicly available data set compiling unpublishedgeoreferenced occurrence records of 92 terrestrial, volant, and marine mam-mals in mainland Portugal and archipelagos of the Azores and Madeira thatincludes 105,026 data entries between 1873 and 2021 (72% of the data occur-ring in 2000 and 2021). The methods used to collect the data were: live obser-vations/captures (43%), sign surveys (35%), camera trapping (16%),bioacoustics surveys (4%) and radiotracking, and inquiries that represent lessthan 1% of the records. The data set includes 13 types of records: (1) burrowsjsoil moundsjtunnel, (2) capture, (3) colony, (4) dead animaljhairjskullsjjaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8),observation in shelters, (9) photo trappingjvideo, (10) predators dietjpelletsjpine cones/nuts, (11) scatjtrackjditch, (12) telemetry and (13) vocalizationjecholocation. The spatial uncertainty of most records ranges between 0 and100 m (76%). Rodentia (n=31,573) has the highest number of records followedby Chiroptera (n=18,857), Carnivora (n=18,594), Lagomorpha (n=17,496),Cetartiodactyla (n=11,568) and Eulipotyphla (n=7008). The data setincludes records of species classified by the IUCN as threatened(e.g.,Oryctolagus cuniculus[n=12,159],Monachus monachus[n=1,512],andLynx pardinus[n=197]). We believe that this data set may stimulate thepublication of other European countries data sets that would certainly contrib-ute to ecology and conservation-related research, and therefore assisting onthe development of more accurate and tailored conservation managementstrategies for each species. There are no copyright restrictions; please cite thisdata paper when the data are used in publications.info:eu-repo/semantics/publishedVersio

Mammals in Portugal: a data set of terrestrial, volant, and marine mammal occurrences in Portugal

Mammals are threatened worldwide, with ~26% of all species being included in the IUCN threatened categories. This overall pattern is primarily associated with habitat loss or degradation, and human persecution for terrestrial mammals, and pollution, open net fishing, climate change, and prey depletion for marine mammals. Mammals play a key role in maintaining ecosystems functionality and resilience, and therefore information on their distribution is crucial to delineate and support conservation actions. MAMMALS IN PORTUGAL is a publicly available data set compiling unpublished georeferenced occurrence records of 92 terrestrial, volant, and marine mammals in mainland Portugal and archipelagos of the Azores and Madeira that includes 105,026 data entries between 1873 and 2021 (72% of the data occurring in 2000 and 2021). The methods used to collect the data were: live observations/captures (43%), sign surveys (35%), camera trapping (16%), bioacoustics surveys (4%) and radiotracking, and inquiries that represent less than 1% of the records. The data set includes 13 types of records: (1) burrows | soil mounds | tunnel, (2) capture, (3) colony, (4) dead animal | hair | skulls | jaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8), observation in shelters, (9) photo trapping | video, (10) predators diet | pellets | pine cones/nuts, (11) scat | track | ditch, (12) telemetry and (13) vocalization | echolocation. The spatial uncertainty of most records ranges between 0 and 100 m (76%). Rodentia (n =31,573) has the highest number of records followed by Chiroptera (n = 18,857), Carnivora (n = 18,594), Lagomorpha (n = 17,496), Cetartiodactyla (n = 11,568) and Eulipotyphla (n = 7008). The data set includes records of species classified by the IUCN as threatened (e.g., Oryctolagus cuniculus [n = 12,159], Monachus monachus [n = 1,512], and Lynx pardinus [n = 197]). We believe that this data set may stimulate the publication of other European countries data sets that would certainly contribute to ecology and conservation-related research, and therefore assisting on the development of more accurate and tailored conservation management strategies for each species. There are no copyright restrictions; please cite this data paper when the data are used in publications

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved