Pathways From Individual Characteristics to Subjective Consequences of Sex: The Mediating Role of Risky Sexual Encounters

Objectives: This study examined associations between young adults’ psychological characteristics and psychosocial consequences of sex, and whether risky sexual encounters mediated these associations. Methods: College students (N=265; Mage=19.49) completed questionnaires concerning risky sexual relationships, behaviors, situations, and psychosocial consequences during their most recent encounter and over the last year. Results: Sexual restraint indirectly predicted positive consequences of the most recent encounter via risky sexual behaviors. Sexual restraint and permissiveness predicted positive and negative consequences over the past year via risky relationships. Conclusions: Psychological characteristics may influence the likelihood of risky sexual encounters, thereby influencing consequences. Includes supplemental Table S1

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

To dissect the genetic architecture of blood pressure and assess effects on target-organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure loci, of which 17 were novel and 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target-organ damage in multiple tissues, with minor effects in the kidney. Our findings expand current knowledge of blood pressure pathways and highlight tissues beyond the classic renal system in blood pressure regulation

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Adolescent Sexuality: Behavior and Meaning

The emerging sexuality that accompanies adolescence poses fundamental challenges for young people. These include adjusting to the altered appearance and functioning of a sexually maturing body, learning to deal with sexual desires, confronting sexual attitudes and values, experimenting with sexual behaviors, and integrating these feelings, attitudes, and experiences into a developing sense of self. The challenge is accentuated by the unfamiliar excitement of sexual arousal, the attention connected to being sexually attractive, and the new level of physical intimacy and psychological vulnerability created by sexual encounters. Adolescents’ responses to these challenges are profoundly influenced by the social and cultural context in which they live. In the United States, in contrast to many other Western nations, adolescent sexuality has typically been viewed as inappropriate and troublesome rather than as normal and healthy. In part, this reflects cultural mores about nonmarital sexual activity; in part it reflects well-justified concerns about potential negative consequences of sexual activity. Cultural proscriptions against nonmarital sex are counterbalanced by permissive attitudes reflected in the media and in the values of many adults. These competing perspectives co-mingle, creating a situation where adolescents are exposed to sexual material in settings of daily life but given inadequate preparation to behave responsibly in sexual situations. Feelings of sexual desire and love collide with social prescriptions to show restraint, setting the stage for psychological conflict and behavioral inconsistency. Despite a recognition of the subjective aspects of adolescent sexuality, the scientific literature has focused primarily on objective indicators such as having sex at certain ages, the behaviors adolescents practice, and the health-related outcomes of teen sexual activity (Moore & Rosenthal, 1993). While this approach helps define the scope of the “problem,” it fails to address the intrapsychic and interpersonal processes that influence whether intercourse occurs and whether protection is used. Understanding these subjective dimensions is key to developing effective interventions to reduce risky sexual behavior; it is also critical for grasping the meaning young people ascribe to their experiences, and the ways in which sexuality is integrated into their identities and intimate relationships (e.g., Brooks-Gunn & Paikoff , 1997). To provide an integrated picture of adolescent sexuality, we address three related issues: (1) recent trends in sexual behaviors among US adolescents; (2) individual and social factors influencing adolescent sexual behavior; and (3) how adolescents make sense of their sexual feelings and experiences. We highlight variations related to gender and ethnicity, but our scope is limited to heterosexual behavior. Wherever possible, we rely on recent national surveys for information on the attitudes and experiences of contemporary youth

Psychological profiles and adolescent adjustment: A person-centered approach

The association between young adolescents\u27 psychological profiles and their subsequent adjustment was examined in a sample of 606 adolescents (ages 12-13) drawn from the mother-child data set of the National Longitudinal Survey of Youth. Cluster analysis was used to identify distinct groups of youth based on self-regulation, proneness to risk, self-worth, and perceived academic competence. Five replicable clusters were identified corresponding to optimal, average, behavioral risk, low self-regulation, and emotional risk groups. These clusters were associated with distinct patterns of adjustment 4 years later. At ages 16-17, youth in the optimal group tended to report better academic performance, less problem behavior, and less depression than youth in the three risk groups; however, their functioning did not differ significantly from youth in the average group. The three risk groups differed in self-reported depression symptoms and academic performance but not in levels of problem behavior. Differences among the five groups persisted when demographic and contextual variables were controlled. These results support the existence of different groups of youth who follow distinct developmental trajectories and may experience different patterns of adjustment

The adolescent self-regulatory inventory (ASRI) adaptation to portuguese context

In this study we present the results of the adaptation of the Adolescent Self-Regulatory Inventory (ASRI) to Portugal. The measure was used with two samples of high school students to which ASRI was administered with Self-Regulation Scale as control measure. In the first study the measures were administered to 823 adolescents and the construct validity analysis was assessed with exploratory factor analysis. The results allow us to find an adequate structure with proper psychometric properties, in their construct and content validity, and reliability. A second study involved 435 adolescents, being tested three models using confirmatory factor analyses. The final version of the ASRI-2 presents an acceptable fit of the data in construct and concurrent validity, given its moderate or high correlation with academic success and substance use. The implications of this new approach to the self-regulation study are discussed and directions to further studies are suggested