295 research outputs found
Immunological imbalance between IFN-³ and IL-10 levels in the sera of patients with the cardiac form of Chagas disease
- Author
- Abel LC
- Ana M Castro
- Bahia-Oliveira LM
- Briere F
- Camargo ME
- Cerban FM
- Cordeiro FD
- Correa-Oliveira R
- Daniela A D'Ávila
- Dutra WO
- Dutra WO
- Dutra WO
- Egler Chiari
- Eliane D Gontijo
- Fanger MW
- Ferreira RC
- Gaze ST
- Giordanengo L
- Gomes JA
- Gomes JA
- Guedes PM
- Higuchi ML
- Holscher C
- Kawano Y
- Lúcia MC Galvão
- Michailowsky V
- Moretti E
- Morgan J
- Paulo MM Guedes
- Perez-Fuentes R
- Perez-Fuentes R
- Ribeirao M
- Silva JS
- Talvani A
- Tibbetts RS
- Voller A
- Ward LS
- Watthanakulpanich D
- Zhang L
- Publication venue
- Instituto Oswaldo Cruz, Ministério da Saúde
- Publication date
- 01/02/2009
- Field of study
The immune response is crucial for protection against disease; however, immunological imbalances can lead to heart and digestive tract lesions in chagasic patients. Several studies have evaluated the cellular and humoral immune responses in chagasic patients in an attempt to correlate immunological findings with clinical forms of Chagas disease. Moreover, immunoglobulins and cytokines are important for parasitic control and are involved in lesion genesis. Here, cytokine and IgG isotype production were studied, using total epimastigote antigen on sera of chagasic patients with indeterminate (IND, n = 27) and cardiac (CARD, n = 16) forms of the disease. Samples from normal, uninfected individuals (NI, n = 30) were use as controls. The results showed that sera from both IND and CARD patients contained higher levels of Trypanosoma cruzi-specific IgG1 (IgG1) antibodies than sera from NI. No difference in IgG2 production levels was observed between NI, IND and CARD patients, nor was a difference in IL-10 and IFN-³ production detected in the sera of IND, CARD and NI patients. However, IND patients displayed a positive correlation between IL-10 and IFN-³ levels in serum, while CARD patients showed no such correlation, indicating an uncontrolled inflammatory response in CARD patients. These findings support the hypothesis that a lack of efficient regulation between IFN-³ and IL-10 productions in CARD patients may lead to cardiac immunopathology.CNP
The striking geographical pattern of gastric cancer mortality in Spain: environmental hypotheses revisited
- Author
- A Cayuela
- A Chao
- A García-Sánchez
- A García-Sánchez
- A Senra-Varela
- B Perez-Gomez
- B Sahún
- Beatriz Pérez-Gómez
- C Calvo-Revuelta
- CA Gonzalez
- CA Gonzalez
- CA Gonzalez
- CA Gonzalez
- CP Howson
- D Corella
- D Spiegelhalter
- DB Resnik
- DM Parkin
- E Fernandez
- Elena Boldo
- Enrique Vidal
- G Lopez-Abente
- G López-Abente
- G López-Abente
- Gonzalo López-Abente
- GR Macenlle
- Greenpeace
- GW Evans
- H Shibata
- IARC
- IARC
- J Besag
- J Ferlay
- J Franco
- J Sandor
- J Vioque
- Javier García-Pérez
- JH Barrett
- JJ Beaumont
- JM Sanz Anquela
- K Salnikow
- KD Crew
- LC da Motta
- LM Brown
- M Reynolds
- MA Bulbulyan
- Marina Pollán
- ME Craanen
- MM Morales-Suarez-Varela
- MS Karpeh
- N Aragones
- N Lunet
- N Lunet
- Nuria Aragonés
- O Nyren
- P Correa
- P Correa
- P Elliott
- P Jakszyn
- P Jakszyn
- PA Lauren
- PA Lauren
- PT Campbell
- R Ladeiras-Lopes
- Rebeca Ramis
- RJ García-Villanueva
- S Cordier
- S Kapaj
- S Richardson
- S Tsugane
- S Wall
- TG Rossman
- Virginia Lope
- W Gilks
- X Puig
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
<p>Abstract</p> <p>Background</p> <p>Gastric cancer is decreasing in most countries. While socioeconomic development is the main factor to which this decline has been attributed, enormous differences among countries and within regions are still observed, with the main contributing factors remaining elusive. This study describes the geographic distribution of gastric cancer mortality at a municipal level in Spain, from 1994-2003.</p> <p>Methods</p> <p>Smoothed relative risks of stomach cancer mortality were obtained, using the Besag-York-Molliè autoregressive spatial model. Maps depicting relative risk (RR) estimates and posterior probabilities of RR being greater than 1 were plotted.</p> <p>Results</p> <p>From 1994-2003, 62184 gastric cancer deaths were registered in Spain (7 percent of all deaths due to malignant tumors). The geographic pattern was similar for both sexes. RRs displayed a south-north and coast-inland gradient, with lower risks being observed in Andalusia, the Mediterranean coastline, the Balearic and Canary Islands and the Cantabrian seaboard. The highest risk was concentrated along the west coast of Galicia, broad areas of the Castile & Leon Autonomous community, the province of Cáceres in Extremadura, Lleida and other areas of Catalonia.</p> <p>Conclusion</p> <p>In Spain, risk of gastric cancer mortality displays a striking geographic distribution. With some differences, this persistent and unique pattern is similar across the sexes, suggesting the implication of environmental exposures from sources, such as diet or ground water, which could affect both sexes and delimited geographic areas. Also, the higher sex-ratios found in some areas with high risk of smoking-related cancer mortality in males support the role of tobacco in gastric cancer etiology.</p
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alda Junior WL
- Alexander J
- Aliev T
- Almeida N
- Alver B
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Anjos TS
- Antonelli L
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Aranyi A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arora S
- Asawatangtrakuldee C
- Asghar MI
- Askew A
- Assran Y
- Ata M
- Atac M
- Atramentov O
- Attikis A
- Auffray E
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Babb J
- Bacchetta N
- Bachtis M
- Baden A
- Baeni L
- Baesso P
- Baffioni S
- Bagliesi G
- Bai Y
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Bakken JA
- Balazs M
- Ball AH
- Ball G
- Ban Y
- Banerjee S
- Banerjee S
- Bansal S
- Banzuzi K
- Barbagli G
- Barberis E
- Barbone L
- Bardak C
- Barfuss AF
- Bargassa P
- Barge D
- Baringer P
- Barker A
- Barnes VE
- Barnett BA
- Barney D
- Barone L
- Barrett M
- Bartalini P
- Barth C
- Basegmez S
- Basso L
- Battilana C
- Baty C
- Bauer G
- Bauerdick LAT
- Baumgartel D
- Baur U
- Bayshev I
- Bazterra VE
- Bean A
- Beauceron S
- Beaudette F
- Beaupere N
- Bedjidian M
- Beernaert K
- Behrenhoff W
- Behrens U
- Belforte S
- Beliy N
- Belknap D
- Bell AJ
- Bell KW
- Bellan P
- Bellan R
- Bellato M
- Bellinger JN
- Belotelov I
- Belyaev A
- Belyaev A
- Benaglia A
- Bencze G
- Bendavid J
- Benedetti D
- Benelli G
- Benhabib L
- Beni N
- Benucci L
- Benussi L
- Benvenuti AC
- Beranek S
- Beretvas A
- Bergauer T
- Berger J
- Bergholz M
- Beri SB
- Bernardes CA
- Bernardini J
- Bernet C
- Berry D
- Berry E
- Berryhill J
- Bertl W
- Berzano U
- Besancon M
- Betchart B
- Bethani A
- Betts RR
- Beuselinck R
- Bhat PC
- Bhatnagar V
- Bhattacharya S
- Bhattacharya S
- Bhatti A
- Bialas W
- Bialkowska H
- Bian JG
- Bianchi G
- Bianchini L
- Bianco S
- Biasini M
- Biino C
- Bilei GM
- Bilin B
- Bilinskas MJ
- Bilki B
- Bilmis S
- Biselli A
- Bisello D
- Bitioukov S
- Blekman F
- Blobel V
- Bloch D
- Bloch I
- Bloch P
- Bloom K
- Bluj M
- Blumenfeld B
- Blyweert S
- Bobrovskyi S
- Boccali T
- Bocci A
- Bochenek J
- Bodek A
- Bodin D
- Boimska B
- Boldizsar L
- Bolla G
- Bolognesi S
- Bolton T
- Bonacorsi D
- Bonato A
- Bondu O
- Bontenackels M
- Boos E
- Bornheim A
- Borras K
- Borrello L
- Bortignon P
- Bortoletto D
- Bose S
- Bose T
- Bostock F
- Botta C
- Boudoul G
- Boulahouache C
- Boumediene D
- Bourilkov D
- Boutemeur M
- Boutle S
- Braibant-Giacomelli S
- Branca A
- Branson JG
- Breedon R
- Breto G
- Breuker H
- Brew C
- Brigliadori L
- Brigljevic V
- Brinkerhoff A
- Broccolo G
- Brochero Cifuentes JA
- Brom JM
- Brona G
- Brooke JJ
- Broutin C
- Brown RM
- Brownson E
- Brun H
- Bruno G
- Bryer AG
- Buchmann MA
- Buchmuller O
- Bunkowski K
- Bunn J
- Buontempo S
- Burgmeier A
- Burkett K
- Busson P
- Busza W
- Butler JN
- Butler PH
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- Butz E
- Bylsma B
- Cabrera A
- Cabrillo IJ
- Caebergs T
- Cakir A
- Calabria C
- Calderon De La Barca Sanchez M
- Calderon A
- Cali IA
- Calligaris L
- Callner J
- Calvert B
- Calvo E
- Campagnari C
- Campbell A
- Camporesi T
- Capiluppi P
- Caponeri B
- Cappello G
- Cardaci M
- Carlin R
- Carlsmith D
- Carrillo Moreno S
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- Cartiglia N
- Carvalho W
- Casal B
- Casimiro Linares E
- Castaldi R
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- Castilla-Valdez H
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- Cavallari F
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- Ceard L
- Ceballos GG
- Cepeda M
- Cerati GB
- Cerci DS
- Cerci S
- Cerizza G
- Cerminara G
- Cerrada M
- Chabert EC
- Chadwick M
- Chakaberia I
- Chamizo Llatas M
- Chan M
- Chang P
- Chang S
- Chang YH
- Chang YH
- Chang YW
- Chanon N
- Chao Y
- Charaf O
- Charlot C
- Chasco M
- Chasserat J
- Chatrchyan S
- Chatterjee A
- Chauhan S
- Checchia P
- Chen GM
- Chen HS
- Chen J
- Chen KF
- Chen KH
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- Chen Z
- Cherepanov V
- Chertok M
- Chetluru V
- Cheung HWK
- Chhibra SS
- Chierici R
- Chiochia V
- Chiorboli M
- Chlebana F
- Cho Y
- Choi M
- Choi S
- Choi Y
- Choi YK
- Chou JP
- Choudhary BC
- Choudhury RK
- Choudhury S
- Christiansen T
- Chuang SH
- Chung J
- Chung YS
- Chwalek T
- Ciesielski R
- Cihangir S
- Cimmino A
- Cipriano PMR
- Cirino G
- Cittolin S
- Ciulli V
- Civinini C
- Claes DR
- Clare R
- Clarida W
- Clement E
- Clerbaux B
- Cline D
- CMS Collaboration
- Cockerill DJA
- Codispoti G
- Colafranceschi S
- Colaleo A
- Cole JE
- Colino N
- Collard C
- Colling D
- Conetti S
- Contardo D
- Conte E
- Contreras-Campana C
- Contreras-Campana E
- Conway J
- Conway R
- Cooper SI
- Cooper W
- Cornelis T
- Correa Martins Junior M
- Cortezon EP
- Cossutti F
- Costa M
- Costa S
- Costantini S
- Coughlan JA
- Cousins R
- Covarelli R
- Cox B
- Cox PT
- Creanza D
- Cremaldi LM
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- Cuevas J
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- Cumalat JP
- Cuplov V
- Cure B
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- Cutajar M
- Cutts D
- Cwiok M
- Czellar S
- D'Agnolo RT
- D'Alessandro R
- D'Alfonso M
- D'Enterria D
- D'Hondt J
- Da Costa EM
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- Dahmes B
- Dahms T
- Dallavalle GM
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- Damiao DD
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- Danielson T
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- Daskalakis G
- Dasu S
- Daubie E
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- David A
- Davids M
- Davies G
- de Barbaro P
- De Benedetti A
- De Boer W
- de Cassagnac RG
- De Cosa A
- de Fatis TT
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- De Jeneret JD
- De La Cruz B
- De La Cruz-Burelo E
- De Lentdecker G
- De Mattia M
- de Monchenault GH
- De Oliveira Martins C
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- de Troconiz JF
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- De Wolf EA
- Deisher A
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- del Arbol PMR
- Del Re D
- Delaere C
- Delgado Peris A
- Deliomeroglu M
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- Dimitrov A
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- Dirkes G
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- Ecklund KM
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- Edelmaier CJ
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- Farrell C
- Fasanella D
- Fassi F
- Faure JL
- Favaro C
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- Fedi G
- Fehling D
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- Ferapontov A
- Ferencek D
- Ferguson T
- Ferguson W
- Fernandez Bedoya C
- Fernandez Menendez J
- Fernandez Perez Tomei TR
- Fernandez Ramos JP
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- Ferrando A
- Ferri F
- Ferro C
- Field RD
- Finger M
- Finger M
- Fiore L
- Fiorendi S
- Fiori F
- Fisher M
- Fisk I
- Flacher H
- Flanagan W
- Flix J
- Florez C
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- Flucke G
- Flugge G
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- Fonseca De Souza S
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- Fouz MC
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- Furic IK
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- Gaddi A
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- Georgiou G
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- Gerber CE
- Gershtein Y
- Gerwig H
- Geurts FJM
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- Hatakeyama K
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- Hebbeker T
- Hebda P
- Hegeman J
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- Heidemann C
- Heikkinen A
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- Heister A
- Hektor A
- Held H
- Heltsley B
- Henderson C
- Heo SG
- Heracleous N
- Heredia-de La Cruz I
- Hermanns T
- Hernandez JM
- Herndon M
- Herve A
- Hesari H
- Heyburn B
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- Hindrichs O
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- Iashvili I
- Iaydjiev P
- Ignatenko M
- Iii RPK
- Iiyama Y
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- Ille B
- Incandela J
- Ingram Q
- Innocente V
- Iorio AOM
- Isildak B
- Issah M
- Ivanov A
- Ivanov Y
- Jabeen S
- Jackson J
- Jafari A
- Jain S
- Jain S
- Jain S
- Jang DW
- Janot P
- Janssen X
- Janulis M
- Jarrin EC
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- Jarvis C
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- Jenkins M
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- Jeong C
- Jessop C
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- Jindal M
- Jindal P
- Jindariani S
- Jo HY
- Jo M
- John JS
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- Josa MI
- Joshi U
- Juillot P
- Jun SY
- Jung H
- Jussen R
- Justus C
- Kaadze K
- Kachanov V
- Kadastik M
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- Wood J
- Wood JS
- Worm SD
- Wright D
- Wrochna G
- Wu W
- Wuerthwein F
- Wulz C-E
- Wyslouch B
- Xiao H
- Xie S
- Xu M
- Yagil A
- Yalvac M
- Yang F
- Yang M
- Yang Y
- Yang ZC
- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
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- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
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- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
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- Anastassov A
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- Andreev Y
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- Antunes JR
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- Wissing C
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- Wood JS
- Worm SD
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- Wyslouch B
- Xiao H
- Xie S
- Xu M
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- Yang F
- Yang M
- Yang Y
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- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
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- Wissing C
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- Wulz C-E
- Wyslouch B
- Xiao H
- Xie S
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- Yang M
- Yang Y
- Yang ZC
- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
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- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
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- Ziebarth EB
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- Zito G
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
The azimuthal anisotropy of charged particles in PbPb collisions at
nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS
detector at the LHC over an extended transverse momentum (pt) range up to
approximately 60 GeV. The data cover both the low-pt region associated with
hydrodynamic flow phenomena and the high-pt region where the anisotropies may
reflect the path-length dependence of parton energy loss in the created medium.
The anisotropy parameter (v2) of the particles is extracted by correlating
charged tracks with respect to the event-plane reconstructed by using the
energy deposited in forward-angle calorimeters. For the six bins of collision
centrality studied, spanning the range of 0-60% most-central events, the
observed v2 values are found to first increase with pt, reaching a maximum
around pt = 3 GeV, and then to gradually decrease to almost zero, with the
decline persisting up to at least pt = 40 GeV over the full centrality range
measured.Comment: Replaced with published version. Added journal reference and DO
Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Adair A
- Adam N
- Adam W
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- Adiguzel A
- Adler V
- Adzic P
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
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- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
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- Alcaraz Maestre J
- Alda Junior WL
- Aldaya Martin M
- Alexander J
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- Yilmaz Y
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- Zielinski M
- Zito G
- Zou W
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
A search for new physics is performed in events with two same-sign isolated
leptons, hadronic jets, and missing transverse energy in the final state. The
analysis is based on a data sample corresponding to an integrated luminosity of
4.98 inverse femtobarns produced in pp collisions at a center-of-mass energy of
7 TeV collected by the CMS experiment at the LHC. This constitutes a factor of
140 increase in integrated luminosity over previously published results. The
observed yields agree with the standard model predictions and thus no evidence
for new physics is found. The observations are used to set upper limits on
possible new physics contributions and to constrain supersymmetric models. To
facilitate the interpretation of the data in a broader range of new physics
scenarios, information on the event selection, detector response, and
efficiencies is provided.Comment: Published in Physical Review Letter
Compressed representation of a partially defined integer function over multiple arguments
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullin S
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- Cepeda M
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- Choudhary BC
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- Christiansen T
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- Chuang SH
- Chwalek T
- Ciesielski R
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- Cimmino A
- Cipriano PMR
- Cittolin S
- Ciulli V
- Civinini C
- Claes DR
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- Clarida W
- Clement E
- Clerbaux B
- Cline D
- CMS Collaboration
- Coarasa Perez JA
- Cockerill DJA
- Colafranceschi S
- Colaleo A
- Cole JE
- Colino N
- Collard C
- Colling D
- Contardo D
- Conte E
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- Correa Martins Junior M
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- Costantini S
- Costanza F
- Couderc F
- Coughlan JA
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- Covarelli R
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- Cox PT
- Creanza D
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- Publication venue
- Publication date
- 01/01/2013
- Field of study
In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
Measurement of jet fragmentation into charged particles in pp and PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
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- Sola V
- Solano A
- Somalwar S
- Son DC
- Son T
- Song S
- Sonmez N
- Sonnenschein L
- Sordini V
- Souza MHG
- Spagnolo P
- Spalding WJ
- Spanier S
- Sparrow A
- Speer T
- Sperka D
- Sphicas P
- Spiegel L
- Spiga D
- Spiridonov A
- Spiropulu M
- Sprenger D
- Squillacioti P
- Squires M
- St John J
- Stadie H
- Stahl A
- Staiano A
- Starodumov A
- Staykova Z
- Steggemann J
- Stein M
- Steinbrueck G
- Stenson K
- Stephans GSF
- Stickland D
- Stieger B
- Stober FM
- Stoeckli F
- Stolin V
- Stone R
- Stoye M
- Stoykova S
- Stoynev S
- Strauss J
- Stringer R
- Strobbe N
- Strom D
- Stuart D
- Sturdy J
- Suarez I
- Suarez RG
- Sudano E
- Sudhakar K
- Sulak L
- Sulimov V
- Sultanov G
- Sumorok K
- Sumowidagdo S
- Sun W
- Sung K
- Surat UE
- Svintradze I
- Svyatkovskiy A
- Swanson J
- Swartz M
- Symonds P
- Szillasi Z
- Szleper M
- Sznajder A
- Tadel M
- Takahashi M
- Tali B
- Tambe N
- Tan P
- Tao J
- Tapper A
- Taroni S
- Tatarinov A
- Taurok A
- Tauscher L
- Taylor L
- Tcholakov V
- Temple J
- Tenchini R
- Teng H
- Teo WD
- Teodorescu L
- Teyssier D
- Thea A
- Theofilatos K
- Thom J
- Thomas L
- Thomas S
- Thompson J
- Thomsen J
- Thyssen F
- Tiko A
- Timciuc V
- Tinti G
- Tiras E
- Titov M
- Tkaczyk S
- Tlisov D
- To W
- Toback D
- Tomalin IR
- Tonelli G
- Tonjes MB
- Tonwar SC
- Topakli H
- Topaksu AK
- Torassa E
- Toropin A
- Torre P
- Tosi M
- Tosi S
- Tourtchanovitch L
- Traczyk P
- Tran NV
- Travaglini R
- Trayanov R
- Treille D
- Tricomi A
- Tripathi M
- Trocino D
- Trocsanyi ZL
- Troendle D
- Tropiano A
- Troshin S
- Tsamalaidze Z
- Tsang KV
- Tschudi Y
- Tsirou A
- Tu Y
- Tucker J
- Tully C
- Tumasyan A
- Tuo S
- Tuominen E
- Tuominiemi J
- Tuovinen E
- Tupputi S
- Turkewitz J
- Turner M
- Tuuva T
- Tuve C
- Twedt E
- Tytgat M
- Tyurin N
- Tzeng YM
- Ujvari B
- Ulmer KA
- Ulrich R
- Ungaro D
- Uplegger L
- Urscheler C
- Uvarov L
- Uzunian A
- Vaandering EW
- Valls N
- Valuev V
- Van Doninck W
- Van Haevermaet H
- Van Hove P
- Van Mechelen P
- Van Mulders P
- Van Onsem GP
- Van Remortel N
- Van Spilbeeck A
- Vander Velde C
- Vanelderen L
- Vanini S
- Vanlaer P
- Vardanyan I
- Varela J
- Varelas N
- Vargas JER
- Vartak A
- Vaughan J
- Vavilov S
- Vazquez Valencia F
- Veelken C
- Veeraraghavan V
- Velasco M
- Velicanu D
- Velkovska J
- Venditti R
- Venturi A
- Verdier P
- Verdini PG
- Veres GI
- Vergili LN
- Vergili M
- Verwilligen P
- Verzetti M
- Veszpremi V
- Vesztergombi G
- Veverka J
- Vidal R
- Vila I
- Vilar Cortabitarte R
- Villasenor-Cendejas LM
- Villella I
- Vinogradov A
- Virdee T
- Viret S
- Vischia P
- Vishnevskiy D
- Vitulo P
- Vlasov E
- Vlimant JR
- Vodopiyanov I
- Vogel H
- Volkov A
- Volobouev I
- Volodko A
- Volpe R
- Vorobiev I
- Vorobyev A
- Vorobyev A
- Voutilainen M
- Vuosalo C
- Vutova M
- Wagner P
- Wagner SR
- Wagner-Kuhr J
- Wakefield S
- Wallny R
- Walsh R
- Walsh S
- Waltenberger W
- Walzel G
- Wan X
- Wang J
- Wang J
- Wang M
- Wang S
- Wang X
- Wang Z
- Wardle N
- Wasserbaech S
- Wayand S
- Wayne M
- Weber H
- Weber HA
- Weber M
- Weber M
- Wehrli L
- Weiler T
- Weinberg M
- Wendland L
- Weng Y
- Wenger EA
- Werner JS
- West C
- Wetzel J
- Whitbeck A
- Whitmore J
- Whyntie T
- Wickramage N
- Widl E
- Wilken R
- Wilkinson R
- Williams G
- Williams T
- Willmott C
- Wimpenny S
- Winer BL
- Winn D
- Winstrom L
- Wissing C
- Wittich P
- Wittmer B
- Woehri HK
- Wolf M
- Wolf R
- Womersley WJ
- Won S
- Wood D
- Wood J
- Wood JS
- Worm SD
- Wright D
- Wrochna G
- Wu W
- Wuerthwein F
- Wulz C-E
- Wyslouch B
- Xiao H
- Xie S
- Xu M
- Yagil A
- Yalvac M
- Yang F
- Yang M
- Yang Y
- Yang ZC
- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Zielinski M
- Zito G
- Zotto P
- Zou W
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Jet fragmentation in pp and PbPb collisions at a centre-of-mass energy of
2.76 TeV per nucleon pair was studied using data collected with the CMS
detector at the LHC. Fragmentation functions are constructed using
charged-particle tracks with transverse momenta pt > 4 GeV for dijet events
with a leading jet of pt > 100 GeV. The fragmentation functions in PbPb events
are compared to those in pp data as a function of collision centrality, as well
as dijet-pt imbalance. Special emphasis is placed on the most central PbPb
events including dijets with unbalanced momentum, indicative of energy loss of
the hard scattered parent partons. The fragmentation patterns for both the
leading and subleading jets in PbPb collisions agree with those seen in pp data
at 2.76 TeV. The results provide evidence that, despite the large parton energy
loss observed in PbPb collisions, the partition of the remaining momentum
within the jet cone into high-pt particles is not strongly modified in
comparison to that observed for jets in vacuum.Comment: Submitted to the Journal of High Energy Physic
Giardia Flagellar Motility Is Not Directly Required to Maintain Attachment to Surfaces
- Author
- A Vahrmann
- B Piva
- C Branche
- CA Gilchrist
- CD Silflow
- CH Sun
- D Axelrod
- D Magne
- David J. Richter
- DB Keister
- DE Feely
- DE Feely
- DE Feely
- DS Friend
- DV Holberton
- DV Holberton
- DV Holberton
- E Nohynkova
- E Ortega-Barria
- EB Babiychuk
- EF Smith
- EM Narcisi
- FD Gillin
- FD Gillin
- G Correa
- HG Elmendorf
- Jonathan K. Pham
- K Roxstrom-Lindquist
- KA Wemmer
- KJ Livak
- KS Ralston
- L Campanati
- L Savioli
- L. David Sibley
- M Benchimol
- MC Sousa
- ME Weiland
- ML Carpenter
- ML Ginger
- MS Sagolla
- P Pathuri
- P Tumova
- PA Flanagan
- PF Perez
- PM Inge
- R Sapiro
- RD Adam
- RM Mariante
- S Ghosh
- S Gourguechon
- SC Dawson
- SC Dawson
- SC Dawson
- Scott C. Dawson
- SK Dutcher
- SL Erlandsen
- SR Davis-Hayman
- Susan A. House
- TE Nash
- U Rescher
- V Gaechter
- V Gerke
- WM Kattenbach
- WR Hansen
- WR Hansen
- Publication venue
- Public Library of Science
- Publication date
- 01/08/2011
- Field of study
Giardia trophozoites attach to the intestinal microvilli (or inert surfaces) using an undefined “suction-based” mechanism, and remain attached during cell division to avoid peristalsis. Flagellar motility is a key factor in Giardia's pathogenesis and colonization of the host small intestine. Specifically, the beating of the ventral flagella, one of four pairs of motile flagella, has been proposed to generate a hydrodynamic force that results in suction-based attachment via the adjacent ventral disc. We aimed to test this prevailing “hydrodynamic model” of attachment mediated by flagellar motility. We defined four distinct stages of attachment by assessing surface contacts of the trophozoite with the substrate during attachment using TIRF microscopy (TIRFM). The lateral crest of the ventral disc forms a continuous perimeter seal with the substrate, a cytological indication that trophozoites are fully attached. Using trophozoites with two types of molecularly engineered defects in flagellar beating, we determined that neither ventral flagellar beating, nor any flagellar beating, is necessary for the maintenance of attachment. Following a morpholino-based knockdown of PF16, a central pair protein, both the beating and morphology of flagella were defective, but trophozoites could still initiate proper surface contacts as seen using TIRFM and could maintain attachment in several biophysical assays. Trophozoites with impaired motility were able to attach as well as motile cells. We also generated a strain with defects in the ventral flagellar waveform by overexpressing a dominant negative form of alpha2-annexin::GFP (D122A, D275A). This dominant negative alpha2-annexin strain could initiate attachment and had only a slight decrease in the ability to withstand normal and shear forces. The time needed for attachment did increase in trophozoites with overall defective flagellar beating, however. Thus while not directly required for attachment, flagellar motility is important for positioning and orienting trophozoites prior to attachment. Drugs affecting flagellar motility may result in lower levels of attachment by indirectly limiting the number of parasites that can position the ventral disc properly against a surface and against peristaltic flow
Transcriptional Changes in Schistosoma mansoni during Early Schistosomula Development and in the Presence of Erythrocytes
- Author
- A Loukas
- A Loukas
- A Sher
- AD Aragon
- AJ Simpson
- Alex Loukas
- AP Mountford
- AP Mountford
- BH Kalinna
- BW van Balkom
- CA Peck
- CM Fitzsimmons
- CR Caffrey
- Donald P. McManus
- DP McManus
- EJ Pearce
- Elodie Ghedin
- ER James
- ER Jolly
- FC Cardoso
- G Payares
- G Payares
- Geoffrey N. Gobert
- GN Gobert
- GN Gobert
- GN Gobert
- GN Gobert
- GN Gobert
- GP Dillon
- GR Newport
- H You
- J Deng
- J Jang-Lee
- JA Clegg
- Jason Mulvenna
- JH McKerrow
- JK Lazdins
- JM Correnti
- JP Salter
- JS Morey
- L Moertel
- LG Pacifico
- Luke Moertel
- M Berriman
- Mai H. Tran
- Malcolm K. Jones
- MD Wright
- ME Morales
- MH Tran
- MJ Doenhoff
- MK Jones
- MR Kasschau
- O Emanuelsson
- OL Goldring
- PF Basch
- PJ Skelly
- PS Coulson
- R Correa-Oliveira
- R DeMarco
- R El Ridi
- R Moqbel
- R Perez-Sanchez
- RA Wilson
- S Braschi
- S Braschi
- S Verjovski-Almeida
- SA Bustin
- SG Forrester
- T Kawamoto
- TA Don
- TA Patterson
- WM Kemp
- Y Zhou
- YL Lin
- Z Zhou
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2009
- Field of study
Schistosome blood flukes cause more mortality and morbidity than any other human worm infection, but current control methods primarily rely on a single drug. There is a desperate need for new approaches to control this parasite, including vaccines. People become infected when the free-swimming larva, the cercaria, enters through the skin and becomes the schistosomulum. Schistosomula are susceptible to immune responses during their first few days in the host before they become adult parasites. We characterised the genes that these newly transformed parasites switch on when they enter the host to identify molecules that are critical for survival in the human host. Some of these highly up-regulated genes can be targeted for future development of new vaccines and drugs
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