Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

The Constituent Structure of Autobiographical Memory: Autobiographical Fluency in People with Chronic Epilepsy

A total of 59 people with chronic epilepsy recalled autobiographical episodes and personal facts (such as the names of friends or teachers) from various lifetime periods. Also tested was their verbal fluency and their fluency in generating items from semantic categories (animals, vegetables, US presidents, and British prime ministers). Results of a cluster analysis and a common factor analysis confirmed a dissociation between the retrieval of autobiographical information and that of nonpersonal semantic information. There was a similar dissociation between the recall of personal episodes and the recall of the personal information, but the corresponding factors were highly correlated with one another. Finally, verbal fluency performance was significantly correlated with the retrieval of personal information, personal episodes, and common objects, but not with that of public figures. The constituent structure of autobiographical fluency is extremely robust across different populations

Thermal distribution in small buildings: A review and analysis of recent literature

This report reviews and analyzes recent technical literature on two subjects relating to thermal distribution in small buildings: energy losses in ductwork and the energy consequences of zone control. Energy losses in ductwork stem from three factors: fan-induced infiltration, duct leakage, and conductive heat losses through duct walls. The first two mechanisms are intertwined, and together account for about half of all duct losses. Ducted forced-air distribution systems are found, on average, to be 60%--70% efficient. Zone control, that is, the ability to operate different zones of a building at different temperatures, is potentially an energy-conserving strategy, but field results suggest that the energy savings are far from automatic

Results from AGS E845: K sub L sup 0 yields. pi. sup 0 e sup + e sup minus , e sup + e sup minus. gamma. , e sup + e sup minus e sup + e sup minus

Results from AGS experiment 845 are reviewed. The data was collected during 1989. Final results on K{sub L}{sup 0} {yields} {pi}{sup 0}e{sup +}e{sup {minus}} and e{sup +}e{sup {minus}} {gamma} are described. Preliminary results on e{sup +}e{sup {minus}}{gamma}{gamma} and e{sup +}e{sup {minus}}e{sup +}e{sup {minus}} are discussed. 10 refs., 5 figs

Lymphatic and Other Vascular Malformative/Overgrowth Disorders Are Caused by Somatic Mutations in PIK3CA

Molecular tumour pathology - and tumour genetic

An International Collaborative Standardizing a Comprehensive Patient-Centered Outcomes Measurement Set for Colorectal Cancer

Surgical oncolog