MR Imaging of the Midfoot and Forefoot

MR imaging is the diagnostic modality of choice for the evaluation of traumatic, inflammatory and neoplastic processes affecting the midfoot and forefoot soft tissue structures including muscles, ligaments, and tendons. MR imaging is also valuable in the diagnosis of occult bony trauma, stress reaction or fractures, and osteomyelitis. Exquisite contrast resolution, noninvasiveness, and multiplanar capabilities are unique features that make MR imaging a powerful diagnostic technique. The authors employ a basic protocol using T1‐weighted, fast spin echo proton density with and without frequency‐selective fat saturation, and fast spin echo T2‐weighted sequences as well as short‐tau inversion recovery (STIR) imaging. Additional imaging following intravenous gadolinium administration is indicated when osteomyelitis and neoplastic processes are suspected. Post‐contrast fat‐suppressed T1‐weighted sequences are necessary if intravenous or intra‐articular gadolinium is utilized.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/145401/1/cpmia2502.pd

Existence theorems in the geometrically non-linear 6-parametric theory of elastic plates

In this paper we show the existence of global minimizers for the geometrically exact, non-linear equations of elastic plates, in the framework of the general 6-parametric shell theory. A characteristic feature of this model for shells is the appearance of two independent kinematic fields: the translation vector field and the rotation tensor field (representing in total 6 independent scalar kinematic variables). For isotropic plates, we prove the existence theorem by applying the direct methods of the calculus of variations. Then, we generalize our existence result to the case of anisotropic plates. We also present a detailed comparison with a previously established Cosserat plate model.Comment: 19 pages, 1 figur

Intrinsic Redshifts and the Tully-Fisher Distance Scale

The Tully-Fisher relationship (TFR) has been shown to have a relatively small observed scatter of ~ +/-0.35 mag implying an intrinsic scatter < +/-0.30 mag. However, when the TFR is calibrated from distances derived from the Hubble relation for field galaxies scatter is consistently found to be +/-0.64 to +/-0.84 mag. This significantly larger scatter requires that intrinsic TFR scatter is actually much larger than +/-0.30 mag, that field galaxies have an intrinsic TFR scatter much larger than cluster spirals, or that field galaxies have a velocity dispersion relative to the Hubble flow in excess of 1000 km s-1. Each of these potential explanations faces difficulties contradicted by available data and the results of previous studies. An alternative explanation is that the measured redshifts of galaxies are composed of a cosmological redshift component predicted from the value of the Hubble Constant and a superimposed intrinsic redshift component previously identified in other studies. This intrinsic redshift component may exceed 5000 km s-1 in individual galaxies. In this alternative scenario a possible value for the Hubble Constant is 55-60 km s-1 Mpc-1.Comment: 15 pages, Astrophysics&Space Science - Accepted for publicatio

Sedimentary cycles in a Mesoproterozoic aeolian erg-margin succession: Mangabeira Formation, Espinhaço Supergroup, Brazil

Aeolian systems were abundant and widespread in the early Proterozoic, post-2.2 Ga. However, the majority of aeolian successions of such great age are intensely deformed and are preserved only in a fragmentary state meaning that, hitherto, few attempts have been made to apply a sequence stratigraphic approach to determine mechanisms of aeolian construction, accumulation and preservation in such systems. The Mangabeira Formation is a well preserved Mesoproterozoic erg successions covering part of the São Francisco Craton, northeastern Brazil. The lower unit of the Mangabeira Formation (~ 500 m thick) comprises aeolian deposits of dune, interdune, and sand-sheet origin, as well as some of waterlain origin. These deposits are organized into vertically stacked depositional cycles, each 6 to 20 m thick, and characterized by aeolian sandsheet and waterlain deposits succeeded by aeolian dune and interdune deposits indicative of a drying-upward trend. Aeolian cross-strata exhibit a mean dip direction to the north. Each of these cycles likely arose in response to climatic oscillation from relatively humid to arid conditions, possibly related to orbital forcing. The lower unit of the Mangabeira Formation comprises up to 14 erg sequences. The accumulation and preservation of each was determined by the relative rate of water-table rise and the availability of sand for aeolian transport, both of which changed through time, resulting in the preservation of a succession of repeated drying-upward cycles

Heavy quarkonium: progress, puzzles, and opportunities

A golden age for heavy quarkonium physics dawned a decade ago, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The early years of this period were chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in 2004, which presented a comprehensive review of the status of the field at that time and provided specific recommendations for further progress. However, the broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles could only be partially anticipated. Since the release of the YR, the BESII program concluded only to give birth to BESIII; the $B$-factories and CLEO-c flourished; quarkonium production and polarization measurements at HERA and the Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the deconfinement regime. All these experiments leave legacies of quality, precision, and unsolved mysteries for quarkonium physics, and therefore beg for continuing investigations. The plethora of newly-found quarkonium-like states unleashed a flood of theoretical investigations into new forms of matter such as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the spectroscopy, decays, production, and in-medium behavior of c\bar{c}, b\bar{b}, and b\bar{c} bound states have been shown to validate some theoretical approaches to QCD and highlight lack of quantitative success for others. The intriguing details of quarkonium suppression in heavy-ion collisions that have emerged from RHIC have elevated the importance of separating hot- and cold-nuclear-matter effects in quark-gluon plasma studies. This review systematically addresses all these matters and concludes by prioritizing directions for ongoing and future efforts.Comment: 182 pages, 112 figures. Editors: N. Brambilla, S. Eidelman, B. K. Heltsley, R. Vogt. Section Coordinators: G. T. Bodwin, E. Eichten, A. D. Frawley, A. B. Meyer, R. E. Mitchell, V. Papadimitriou, P. Petreczky, A. A. Petrov, P. Robbe, A. Vair

The discovery of Hepatocyte Growth Factor (HGF) and its significance for cell biology, life sciences and clinical medicine

It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor, c-Met. In fetal stages, HGF-neutralization, or c-Met gene destruction, leads to hypoplasia of many organs, indicating that HGF signals are essential for organ development. Endogenous HGF is required for self-repair of injured livers, kidneys, lungs and so on. In addition, HGF exerts protective effects on epithelial and non-epithelial organs (including the heart and brain) via anti-apoptotic and anti-inflammatory signals. During organ diseases, plasma HGF levels significantly increased, while anti-HGF antibody infusion accelerated tissue destruction in rodents. Thus, endogenous HGF is required for minimization of diseases, while insufficient production of HGF leads to organ failure. This is the reason why HGF supplementation produces therapeutic outcomes under pathological conditions. Moreover, emerging studies delineated key roles of HGF during tumor metastasis, while HGF-antagonism leads to anti-tumor outcomes. Taken together, HGF-based molecules, including HGF-variants, HGF-fragments and c-Met-binders are available as regenerative or anti-tumor drugs. Molecular analysis of the HGF-c-Met system could provide bridges between basic biology and clinical medicine

Searches for lepton number violating K+ decays

The NA62 experiment at CERN reports a search for the lepton number violating decays K+→π−e+e+ and K+→π−μ+μ+ using a data sample collected in 2017. No signals are observed, and upper limits on the branching fractions of these decays of 2.2 x 10^-10 and 4.2 x 10^-11 are obtained, respectively, at 90% confidence level. These upper limits improve on previously reported measurements by factors of 3 and 2, respectively

Search for heavy neutral lepton production in K+ decays to positrons

A search for heavy neutral lepton (N) production in K+→e+N decays using the data sample collected by the NA62 experiment at CERN in 2017-2018 is reported. Upper limits of the extended neutrino mixing matrix element |Ue4|^2 are established at the level of 10^−9 over most of the accessible heavy neutral lepton mass range 144-462 MeV/c^2, with the assumption that the lifetime exceeds 50 ns. These limits improve significantly upon those of previous production and decay searches. The |Ue4|^2 range favoured by Big Bang Nucleosynthesis is excluded up to a mass of about 340 MeV/c^2