Metal-catalyzed 1,3-dipolar cycloaddition reactions of nitrile oxides

In the present review advances in the metal-catalyzed 1,3-dipolar cycloaddition reactions of nitrile oxides, mainly in the last decade, will be presented and discussed. An overview on the structure, preparation, dimerization and related reactions as well as the relevant aspects in the cycloaddition chemistry of nitrile oxides (including mechanistic aspects) have also been considered

A Modular Approach to Polyketide Building Blocks: Cycloadditions of Nitrile Oxides and Homoallylic Alcohols

A general approach to the diastereoselective synthesis of Δ2-isoxazolines via magnesium-mediated, hydroxyl-directed diastereoselective nitrile oxide cycloadditions of homoallylic alcohols and monoprotected homoallylic diols is disclosed. A broad spectrum of aliphatic and aromatic nitrile oxides and a variety of homoallylic alcohols participate in the cycloaddition, thus expanding the scope of polyketide building blocks that can be accessed using this strategy

Paralipomena of the Isoxazoline Carbocyclic Nucleoside Analogs

The synthetic pathway towards silyl-substituted nucleoside analogs is presented and relies upon the 1,3-dipolar cycloaddition of in situ generated nitrile oxide containing a representative silyl group. The subsequent synthetic elaborations do not damage this substituent allowing for the obtaining of the target compounds. This reliable methodology is prone to be adapted for the synthesis of silyl derivatives for several applications