BATU BARA Rencana Detail Tata Ruang, Kawasan Perkotaan Kuala Tanjung BWP SELATAN

Sektor Industri merupakan salah satu sektor penggerak perekonomian nasional yang memiliki kontribusi tinggi dalam membentuk nilai tambah faktor-faktor produksi. KI Kuala Tanjung juga merupakan satu dari 14 Kawasan Industri Prioritas yang ditetapkan dalam RPJMN 2015-2019, dan menjadi Prioritas Strategis Nasional berdasarkan Peraturan Presiden Nomor 3 Tahun 2016 Tentang Percepatan Pelaksanaan Proyek Strategis Nasional yang telah diubah dengan Perpes 56 Tahun 2018 tentang Perubahan Kedua Atas Peraturan Presiden Nomor 3 Tahun 2016 Tentang Percepatan Pelaksanaan Proyek Strategis Nasional. Oleh karena itu, wilayah sekitar Kawasan Industri (KI) Kuala Tanjung perlu diarahkan perkembangannya untuk mendukung kegiatan industri di dalam kawasan agar berjalan komprehensif.Dalam rangka mendukung kebijakan nasional pembangunan 14 kawasan industri (KI) yang ditetapkan dalam RPJMN 2014-2019 dan mengembangkan kawasan penyangga pertumbuhan yang selaras dan terintegrasi dengan KI Kuala Tanjung, Direktorat Jenderal Tata Ruang melalui Direktorat Penataan Kawasan pada tahun anggaran 2019 akan melaksanakan penyusunan Rencana Detail Tata Ruang di sekitar Kawasan Industri Kuala Tanjung berupa Penyusunan Materi Teknis Rencana Detail Tata Ruang (RDTR) dan Peraturan Zonasi (PZ) beserta Kajian Lingkungan Hidup Strategis (KLHS).Dalam penetapan Kawasan Industri (KI) Kuala Tanjung, Pemerintah memiliki tujuan untuk membangun pusat-pusat kegiatan ekonomi yang baru yang berada di luar Pulau Jawa yang memastikan Kawasan Industri (KI) Kuala Tanjung bisa berfungsi secara selaras dengan kawasan di sekitarnya dan kegiatan yang berkembang di sekitar Kawasan Industri (KI) Kuala Tanjung adalah kegiatan yang tidak kontraproduktif dengan kegiatan dalam Kawasan Industri Kuala Tanjung itu sendiri

Acceptability of Tenofovir Gel as a Vaginal Microbicide Among Women in a Phase I Trial: A Mixed-Methods Study

Objectives: In this phase I safety trial of tenofovir gel, a candidate vaginal microbicide for human immunodeficiency virus (HIV) prevention, a mixed-methods design was used to gather acceptability data among women participants. The impact of acceptability factors on use of the gel and the relationship between qualitative and quantitative acceptability data are explored. Methods: Participants included low-risk, HIV-uninfected, and clinically stable HIV-infected women. Participants were enrolled into cohorts stratified by HIV serostatus, sexual activity, gel concentration, and frequency of use. Quantitative data were collected via interviewer-administered structured questionnaires. Qualitative data were collected via semistructured small group discussions. Results: Although 94% of participants stated they would “probably” or “definitely” use tenofovir gel, a range of responses emerged on multiple domains relevant to microbicide acceptability during the qualitative discussions. Lubrication, leakage, sexual pleasure, and the possibility of covert use were central to women's qualitative assessments of tenofovir gel. Conclusions: Quantitative results indicate that tenofovir vaginal gel was acceptable to almost all users, while qualitative findings indicate that acceptability is complex, varies among users, and is likely shaped by a variety of contextual factors that manufacturers will need to consider to optimize use-effectiveness. Because of the differences in the qualitative and quantitative responses, the authors argue that future trials of candidate microbicides should include strategic collection of mixed-methods microbicide acceptability data

RENCANA DETAIL TATA RUANG KECAMATAN TULIS MASA DEPAN INVESTASI KABUPATEN BATANG

U ntuk mempercepat pelaksanaan berusaha di Indonesia, Pemerintah pada tanggal 21 Juni 2018 telah mengeluarkan Peraturan Presiden Nomor 24 Tahun 2018 tentang Pelayanan Perizinan Berusaha Terintegrasi Secara Elektronik melalui penyederhanaan regulasi dan mempermudah birokrasi perizinan dengan menyatukan pengajuan, proses, dan pengeluaran perizinan berusaha melalui sistem pengelolaan perizinan terpadu secara elektronik atau Online Single Submission (OSS). Bagi daerah yang belum memiliki Rencana Detail Tata Ruang (RDTR), investor atau pelaku usaha diwajibkan mengajukan Izin Lokasi melalui Sistem OSS. Sedangkan bagi wilayah yang telah memiliki RDTR atau berada dalam Kawasan Ekonomi Khusus (KEK), Kawasan Industri (KI), Kawasan Strategis Pariwisata Nasional (KSPN), dan Kawasan Perdagangan Bebas dan Pelabuhan Bebas (KPBPB), tidak memerlukan Izin Lokasi dalam melakukan kegiatan berusaha. Oleh karena itu, penyelesaian RDTR menjadi sangat signifikan dalam membantu realisasi investasi karena bisa mempersingkat waktu izin pemanfaatan lahan.. Untuk itu, Kementerian Agraria dan Tata Ruang/ BPN akan mempercepat penyusunan RDTR sebagai dasar perizinan pemanfaatan ruang dengan mengutamakan kabupaten dan kota tujuan investasi dalam mendukung kemudahan berusaha melalui pelaksanaan perizinan investasi terpadu secara daring atau OSS. Salah satu kabupaten/kota yang akan disusun rencana rinci tata ruangnya adalah Kabupaten Batang, Provinsi Jawa Tengah

Selective Inhibition of p300 HAT Blocks Cell Cycle Progression, Induces Cellular Senescence, and Inhibits the DNA Damage Response in Melanoma Cells

Epigenetic events, including covalent post-translational modifications of histones, have been demonstrated to have critical roles in tumor development and progression. The transcriptional coactivator p300/CBP possesses both histone acetyltransferase (HAT) activity and scaffolding properties that directly influence the transcriptional activation of targeted genes. We have used a potent and specific inhibitor of p300/CBP HAT activity, C646, in order to evaluate the functional contributions of p300/CBP HAT to tumor development and progression. Here we report that C646 inhibits the growth of human melanoma and other tumor cells and promotes cellular senescence. Global assessment of the p300 HAT transcriptome in human melanoma identified functional roles in promoting cell cycle progression, chromatin assembly, and activation of DNA repair pathways through direct transcriptional regulatory mechanisms. In addition, C646 is shown to promote sensitivity to DNA damaging agents, leading to the enhanced apoptosis of melanoma cells after combination treatment with cisplatin. Together, our data suggest that p300 HAT activity mediates critical growth regulatory pathways in tumor cells and may serve as a potential therapeutic target for melanoma and other malignancies by promoting cellular responses to DNA damaging agents that are currently ineffective against specific cancers

Detection of solar-like oscillations from Kepler photometry of the open cluster NGC 6819

Asteroseismology of stars in clusters has been a long-sought goal because the assumption of a common age, distance and initial chemical composition allows strong tests of the theory of stellar evolution. We report results from the first 34 days of science data from the Kepler Mission for the open cluster NGC 6819 -- one of four clusters in the field of view. We obtain the first clear detections of solar-like oscillations in the cluster red giants and are able to measure the large frequency separation and the frequency of maximum oscillation power. We find that the asteroseismic parameters allow us to test cluster-membership of the stars, and even with the limited seismic data in hand, we can already identify four possible non-members despite their having a better than 80% membership probability from radial velocity measurements. We are also able to determine the oscillation amplitudes for stars that span about two orders of magnitude in luminosity and find good agreement with the prediction that oscillation amplitudes scale as the luminosity to the power of 0.7. These early results demonstrate the unique potential of asteroseismology of the stellar clusters observed by Kepler.Comment: 5 pages, 4 figures, accepted by ApJ (Lett.

A multi-national peer support intervention: the UPSIDES pilot phase

Objective. Using Peer Support in Developing Empowering Mental Health Services (UPSIDES) is evaluating implementation of a peer support worker (PSW) intervention at six recruiting sites (Germany, India, Israel, Tanzania, and Uganda) (ISRCTN26008944). The aim of this study is to evaluate the pre-trial pilot phase. Method. The initial training to prepare individuals for the PSW role and the implementation of the peer support (PS) intervention was evaluated using a multi-method design comprising six focus groups (FG; n=22) and questionnaires capturing the perspectives of service users, PSWs, peer trainers, and mental health staff members (n=21). Results. Findings were organised across eleven key implementation themes: organisational culture, PSW training, PSW role definition, staff willingness and ability to work with PSWs, resource availability, financial arrangements, support for PSW well-being, PSW access to a peer network, acceptance, preparation, and other challenges. Discussion. The following recommendations are made, based on this pilot phase: the PS training should train on practical skills using role-playing exercises; PSWs should work in teams, including role reflection with colleagues (intervision) or with a highly experienced coach (supervision); necessary resources and tools for networking should be provided; and continuous awareness-raising about PS is needed

The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019

Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe