8 research outputs found
Deep-scattering layer, gas-bladder density, and size estimates using a two-frequency acoustic and optical probe
© 2016 International Council for the Exploration of the Sea. All rights reserved.Estimating the biomass of gas-bladdered organisms in the mesopelagic ocean is a simple first step to understanding ecosystem structure. An existing two-frequency (38 and 120 kHz) acoustic and optical probe was lowered to 950 m to estimate the number and size of gas-bladders. In situ target strengths from 38 and 120 kHz and their difference were compared with those of a gas-bladder resonance-scattering model. Predicted mean equivalent spherical radius gas-bladder size varied with depth, ranging from 2.1 mm (shallow) to 0.6 mm (deep). Density of night-time organisms varied throughout the water column and were highest (0.019 m-3) in the 200-300 m depth range. Predictions of 38 kHz volume-backscattering strength (Sv) from the density of gas-bladdered organisms could explain 88% of the vessel's 38 kHz Sv at this location (S 40.9, E 166.7). Catch retained by trawls highlighted the presence of gas-bladdered fish of a similar size range but different densities while optical measurements highlighted the depth distribution and biomass of gas-inclusion siphonophores. Organism behaviour and gear selectivity limits the validation of acoustic estimates. Simultaneous optical verification of multifrequency or broadband acoustic targets at depth are required to verify the species, their size and biomass
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Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1)
Congenital fibrosis of the extraocular muscles type 1 (CFEOM1; OMIM #135700) is an autosomal dominant strabismus disorder associated with defects of the oculomotor nerve. We show that individuals with CFEOM1 harbor heterozygous missense mutations in a kinesin motor protein encoded by KIF21A. We identified six different mutations in 44 of 45 probands. The primary mutational hotspots are in the stalk domain, highlighting an important new role for KIF21A and its stalk in the formation of the oculomotor axis