2,529 research outputs found
The Importance of Sensory Processing in Mental Health: A Proposed Addition to the Research Domain Criteria (RDoC) and Suggestions for RDoC 2.0
The time is ripe to integrate burgeoning evidence of the important role of sensory and motor functioning in mental health within the National Institute of Mental Health’s [NIMH] Research Domain Criteria [RDoC] framework (National Institute of Mental Health, n.d.a), a multi-dimensional method of characterizing mental functioning in health and disease across all neurobiological levels of analysis ranging from genetic to behavioral. As the importance of motor processing in psychopathology has been recognized (Bernard and Mittal, 2015; Garvey and Cuthbert, 2017; National Institute of Mental Health, 2019), here we focus on sensory processing. First, we review the current design of the RDoC matrix, noting sensory features missing despite their prevalence in multiple mental illnesses. We identify two missing classes of sensory symptoms that we widely define as (1) sensory processing, including sensory sensitivity and active sensing, and (2) domains of perceptual signaling, including interoception and proprioception, which are currently absent or underdeveloped in the perception construct of the cognitive systems domain. Then, we describe the neurobiological basis of these psychological constructs and examine why these sensory features are important for understanding psychopathology. Where appropriate, we examine links between sensory processing and the domains currently included in the RDoC matrix. Throughout, we emphasize how the addition of these sensory features to the RDoC matrix is important for understanding a range of mental health disorders. We conclude with the suggestion that a separate sensation and perception domain can enhance the current RDoC framework, while discussing what we see as important principles and promising directions for the future development and use of the RDoC
A Spatially Resolved Study of the Synchrotron Emission and Titanium in Tycho's Supernova Remnant with NuSTAR
We report results from deep observations (~750 ks) of Tycho's supernova
remnant (SNR) with NuSTAR. Using these data, we produce narrow-band images over
several energy bands to identify the regions producing the hardest X-rays and
to search for radioactive decay line emission from 44Ti. We find that the
hardest (>10 keV) X-rays are concentrated in the southwest of Tycho, where
recent Chandra observations have revealed high emissivity "stripes" associated
with particles accelerated to the knee of the cosmic-ray spectrum. We do not
find evidence of 44Ti, and we set limits on its presence and distribution
within the SNR. These limits correspond to a upper-limit 44Ti mass of M44 <
2.4x10^-4 M_sun for a distance of 2.3 kpc. We perform spatially resolved
spectroscopic analysis of sixty-six regions across Tycho. We map the best-fit
rolloff frequency of the hard X-ray spectra, and we compare these results to
measurements of the shock expansion and ambient density. We find that the
highest energy electrons are accelerated at the lowest densities and in the
fastest shocks, with a steep dependence of the roll-off frequency with shock
velocity. Such a dependence is predicted by models where the maximum energy of
accelerated electrons is limited by the age of the SNR rather than by
synchrotron losses, but this scenario requires far lower magnetic field
strengths than those derived from observations in Tycho. One way to reconcile
these discrepant findings is through shock obliquity effects, and future
observational work is necessary to explore the role of obliquity in the
particle acceleration process.Comment: 12 pages, 12 figures, ApJ in pres
Locating the most energetic electrons in Cassiopeia A
We present deep (2.4 Ms) observations of the Cassiopeia A supernova
remnant with {\it NuSTAR}, which operates in the 3--79 keV bandpass and is the
first instrument capable of spatially resolving the remnant above 15 keV. We
find that the emission is not entirely dominated by the forward shock nor by a
smooth "bright ring" at the reverse shock. Instead we find that the 15 keV
emission is dominated by knots near the center of the remnant and dimmer
filaments near the remnant's outer rim. These regions are fit with unbroken
power-laws in the 15--50 keV bandpass, though the central knots have a steeper
() spectrum than the outer filaments ().
We argue this difference implies that the central knots are located in the 3-D
interior of the remnant rather than at the outer rim of the remnant and seen in
the center due to projection effects. The morphology of 15 keV emission does
not follow that of the radio emission nor that of the low energy (12 keV)
X-rays, leaving the origin of the 15 keV emission as an open mystery. Even
at the forward shock front we find less steepening of the spectrum than
expected from an exponentially cut off electron distribution with a single
cutoff energy. Finally, we find that the GeV emission is not associated with
the bright features in the {\it NuSTAR} band while the TeV emission may be,
suggesting that both hadronic and leptonic emission mechanisms may be at work.Comment: 12 pages, 11 figures, accepted for publication in Ap
MADNESS: A Multiresolution, Adaptive Numerical Environment for Scientific Simulation
MADNESS (multiresolution adaptive numerical environment for scientific
simulation) is a high-level software environment for solving integral and
differential equations in many dimensions that uses adaptive and fast harmonic
analysis methods with guaranteed precision based on multiresolution analysis
and separated representations. Underpinning the numerical capabilities is a
powerful petascale parallel programming environment that aims to increase both
programmer productivity and code scalability. This paper describes the features
and capabilities of MADNESS and briefly discusses some current applications in
chemistry and several areas of physics
Innovative treatment formats, technologies, and clinician trainings that improve access to behavioral pain treatment for youth and adults
Chronic pain is prevalent across the life span and associated with significant individual and societal costs. Behavioral interventions are recommended as the gold-standard, evidence-based interventions for chronic pain, but barriers, such as lack of pain-trained clinicians, poor insurance coverage, and high treatment burden, limit patients’ ability to access evidenced-based pain education and treatment resources. Recent advances in technology offer new opportunities to leverage innovative digital formats to overcome these barriers and dramatically increase access to high-quality, evidenced-based pain treatments for youth and adults. This scoping review highlights new advances. First, we describe system-level barriers to the broad dissemination of behavioral pain treatment. Next, we review several promising new pediatric and adult pain education and treatment technology innovations to improve access and scalability of evidence-based behavioral pain treatments. Current challenges and future research and clinical recommendations are offered
Do residents’ perceptions of being well-placed and objective presence of local amenities match? A case study in West Central Scotland, UK
Background:<p></p>
Recently there has been growing interest in how neighbourhood features, such as the provision of local facilities and amenities, influence residents’ health and well-being. Prior research has measured amenity provision through subjective measures (surveying residents’ perceptions) or objective (GIS mapping of distance) methods. The latter may provide a more accurate measure of physical access, but residents may not use local amenities if they do not perceive them as ‘local’. We believe both subjective and objective measures should be explored, and use West Central Scotland data to investigate correspondence between residents’ subjective assessments of how well-placed they are for everyday amenities (food stores, primary and secondary schools, libraries, pharmacies, public recreation), and objective GIS-modelled measures, and examine correspondence by various sub-groups.<p></p>
Methods:<p></p>
ArcMap was used to map the postal locations of ‘Transport, Health and Well-being 2010 Study’ respondents (n = 1760), and the six amenities, and the presence/absence of each of them within various straight-line and network buffers around respondents’ homes was recorded. SPSS was used to investigate whether objective presence of an amenity within a specified buffer was perceived by a respondent as being well-placed for that amenity. Kappa statistics were used to test agreement between measures for all respondents, and by sex, age, social class, area deprivation, car ownership, dog ownership, walking in the local area, and years lived in current home.<p></p>
Results:<p></p>
In general, there was poor agreement (Kappa <0.20) between perceptions of being well-placed for each facility and objective presence, within 800 m and 1000 m straight-line and network buffers, with the exception of pharmacies (at 1000 m straight-line) (Kappa: 0.21). Results varied between respondent sub-groups, with some showing better agreement than others. Amongst sub-groups, at 800 m straight-line buffers, the highest correspondence between subjective and objective measures was for pharmacies and primary schools, and at 1000 m, for pharmacies, primary schools and libraries. For road network buffers under 1000 m, agreement was generally poor.<p></p>
Conclusion:<p></p>
Respondents did not necessarily regard themselves as well-placed for specific amenities when these amenities were present within specified boundaries around their homes, with some exceptions; the picture is not clear-cut with varying findings between different amenities, buffers, and sub-groups
3C 273 with NuSTAR: Unveiling the Active Galactic Nucleus
We present results from a 244 ks NuSTAR observation of 3C 273 obtained during a cross-calibration campaign with the Chandra, INTEGRAL, Suzaku, Swift, and XMM-Newton observatories. We show that the spectrum, when fit with a power-law model using data from all observatories except INTEGRAL over the 1–78 keV band, leaves significant residuals in the NuSTAR data between 30 and 78 keV. The NuSTAR 3–78 keV spectrum is well described by an exponentially cutoff power law (Γ = 1.646 ± 0.006, E_(cutoff) = 202_(-34)^(+51) keV) with a weak reflection component from cold, dense material. There is also evidence for a weak (EW = 23 ± 11 eV) neutral iron line. We interpret these features as arising from coronal emission plus reflection off an accretion disk or distant material. Beyond 80 keV INTEGRAL data show clear excess flux relative to an extrapolation of the active galactic nucleus model fit to NuSTAR. This high-energy power law is consistent with the presence of a beamed jet, which begins to dominate over emission from the inner accretion flow at 30–40 keV. Modeling the jet locally (in the NuSTAR + INTEGRAL band) as a power law, we find that the coronal component is fit by Γ_(AGN) = 1.638 ± 0.045, E_(cutoff) = 47 ± 15 keV, and jet photon index by Γ_(jet) = 1.05 ± 0.4. We also consider Fermi/LAT observations of 3C 273, and here the broadband spectrum of the jet can be described by a log-parabolic model, peaking at ~2 MeV. Finally, we investigate the spectral variability in the NuSTAR band and find an inverse correlation between flux and Γ
Standalone vertex finding in the ATLAS muon spectrometer
A dedicated reconstruction algorithm to find decay vertices in the ATLAS muon spectrometer is presented. The algorithm searches the region just upstream of or inside the muon spectrometer volume for multi-particle vertices that originate from the decay of particles with long decay paths. The performance of the algorithm is evaluated using both a sample of simulated Higgs boson events, in which the Higgs boson decays to long-lived neutral particles that in turn decay to bbar b final states, and pp collision data at √s = 7 TeV collected with the ATLAS detector at the LHC during 2011
Measurements of Higgs boson production and couplings in diboson final states with the ATLAS detector at the LHC
Measurements are presented of production properties and couplings of the recently discovered Higgs boson using the decays into boson pairs, H →γ γ, H → Z Z∗ →4l and H →W W∗ →lνlν. The results are based on the complete pp collision data sample recorded by the ATLAS experiment at the CERN Large Hadron Collider at centre-of-mass energies of √s = 7 TeV and √s = 8 TeV, corresponding to an integrated luminosity of about 25 fb−1. Evidence for Higgs boson production through vector-boson fusion is reported. Results of combined fits probing Higgs boson couplings to fermions and bosons, as well as anomalous contributions to loop-induced production and decay modes, are presented. All measurements are consistent with expectations for the Standard Model Higgs boson
The impact of electronic records on patient safety : a qualitative study
BACKGROUND: Our aim was to explore NHS staff perceptions and experiences of the impact on patient safety of introducing a maternity system. METHODS: Qualitative semi-structured interviews were conducted with 19 members of NHS staff who represented a variety of staff groups (doctors, midwives, health care assistants), staff grades (consultant and midwife grades) and wards within a maternity unit. Participants represented a single maternity unit at a NHS teaching hospital in the North of England. Interviews were conducted during the first 12 months of the system being implemented and were analysed thematically. RESULTS: Participants perceived there to be an elevated risk to patient safety during the system's implementation. The perceived risks were attributed to a range of social and technical factors. For example, poor system design and human error which resulted in an increased potential for missing information and inputting error. CONCLUSIONS: The first 12 months of introducing the maternity system was perceived to and in some cases had already caused actual risk to patient safety. Trusts throughout the NHS are facing increasing pressure to become paperless and should be aware of the potential adverse impacts on patient safety that can occur when introducing electronic systems. Given the potential for increased risk identified, recommendations for further research and for NHS trusts introducing electronic systems are proposed
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