Low Hanging Fruit: Use of Virtual Reality Driving Simulation in Department of Motor Vehicles to Assess Minimal Competence of Novice Drivers

Nationally, Departments of Motor Vehicles (DMV) license novice drivers based in part on on-road assessments. Intuitively it is assumed that such assessments are fair, reliable and valid measures of minimal driving competency. Upon further reflection, this would be difficult, given the subjectivity of a huge range of driving examiners that approach this assessment with different training backgrounds, life distractions and biases from examination to examination, the different road, traffic, lighting and weather conditions from one examination and DMV center to the next, and the minimal driving challenges in such assessments. For example, a typical on-road test involves only a 4 mile road segment with 2 left turns, 4 right turns, 1 lane change, pulling into a turn lane, and 1 speed limit change. It does not include highway driving nor defensive driving maneuvers. Additionally, such on-road assessments are both potentially dangerous and time demanding/expensive. A less expensive, safer, more challenging, objective, reliable, and valid procedure may be the use of Virtual Reality Driving Simulation (VRDS) that administers consistent and more extensive driving challenges to all examinees, which is evaluated in an objective manner based on normative data from current safe drivers. This presentation describes the experience and presents the data from a project where VRDSs were set up in two DMV facilities and a Research facility. The goals of this project were to determine whether VRDS assessments are just as reliable, discriminating and acceptable to the public as on-road assessments, and whether performance on the simulator predicts future on-road driving mishaps

Age Differences in Driving-Specific Tests of Executive Function

The purpose of the present study was to examine age differences in executive function as measured by novel driving-specific tests of executive function using a novel driving simulator. Developmental changes in executive function have been implicated as possible contributing factors to elevated crash statistics for both older adult (over age 65) and adolescent (between age 15 and 20) populations, however for different reasons. Poorer older adult driving performance has been partially attributed to general age-related cognitive decline in executive function mediated by age-related frontal-lobe atrophy and neural disconnection. Immature executive function has been implicated in poorer adolescent driving performance and is thought to be expressed in situations where the developmentally high sensitivity of the socio-emotional reward system outcompetes the regulatory influence of the under developed executive system. Using a new, high fidelity, virtual reality driving simulator, we created drivingspecific tests to assess executive function. These operational tests employed driving-relevant stimuli, with driving-relevant challenges, that required drivingrelevant responses, in a driving-relevant context. Fifteen older adult and 20 adolescent drivers completed these driving-specific executive function tests. We hypothesized that poorer older adult driving performance would be reflected on these driving specific tests of executive function due to general cognitive decline and that, given the absence of social-emotional reward, adolescents would outperform older adults. Analyses of both bivariate correlations and group comparisons generally supported these predictions

Evaluating the use of the autodiametric method for estimating fecundity of Reinhardtius hippoglossoides, a species with an unusual oocyte development strategy

The autodiametric method is a highly streamlined method for estimating fecundity of fish with determinate oocyte development pattern. Greenland halibut presents a peculiar reproductive strategy with two simultaneously cohorts one of large vitellogenic oocytes (for the current year) and another one of small vitellogenic oocytes (for the subsequent year). Results of this study showed that autodiametric method can be applied to estimate fecundity in Greenland halibut. Additionally, spatial differences in the autodiametric calibration curve were observed in the Northwest Atlantic, but did not translate into differences in fecundity at length. This is the first time that spatial differences between ACCs of the same species have been reported, what could be the result of (i) the unusual oocyte development pattern, or (ii) spatial differences in oocyte biochemistry. More research on the relative dynamics of oocyte cohorts simultaneously present in Greenland halibut ovaries and the factors (endo- or exogenous) influencing oocyte packing density could provide a better understanding of observed geographical differences.En prens

Hormonal response to lipid and carbohydrate meals during the acute postprandial period

<p>Abstract</p> <p>Background</p> <p>Optimizing the hormonal environment during the postprandial period in favor of increased anabolism is of interest to many active individuals. Data are conflicting regarding the acute hormonal response to high fat and high carbohydrate feedings. Moreover, to our knowledge, no studies have compared the acute hormonal response to ingestion of lipid and carbohydrate meals of different size.</p> <p>Methods</p> <p>We compared the hormonal response to lipid and carbohydrate meals of different caloric content during the acute postprandial period. Nine healthy men (22 ± 2 years) consumed in a random order, cross-over design one of four meals/beverages during the morning hours in a rested and fasted state: dextrose at 75 g (300 kcals), dextrose at 150 g (600 kcals), lipid at 33 g (300 kcals), lipid at 66 g (600 kcals). Blood samples were collected Pre meal, and at 0.5 hr, 1 hr, 2 hr, and 3 hr post meal. Samples were assayed for testosterone, cortisol, and insulin using ELISA techniques. Area under the curve (AUC) was calculated for each variable, and a 4 × 5 ANOVA was used to further analyze data.</p> <p>Results</p> <p>A meal × time effect (p = 0.0003) was noted for insulin, with values highest for the dextrose meals at the 0.5 hr and 1 hr times, and relatively unaffected by the lipid meals. No interaction (p = 0.98) or meal (p = 0.39) effect was noted for testosterone, nor was an interaction (p = 0.99) or meal (p = 0.65) effect noted for cortisol. However, a time effect was noted for both testosterone (p = 0.04) and cortisol (p < 0.0001), with values decreasing during the postprandial period. An AUC effect was noted for insulin (p = 0.001), with values higher for the dextrose meals compared to the lipid meals (p < 0.05). No AUC effect was noted for testosterone (p = 0.85) or cortisol (p = 0.84).</p> <p>Conclusions</p> <p>These data indicate that 1) little difference is noted in serum testosterone or cortisol during the acute postprandial period when healthy men consume lipid and dextrose meals of different size; 2) Both testosterone and cortisol experience a drop during the acute postprandial period, which is similar to what is expected based on the normal diurnal variation--feeding with lipid or dextrose meals does not appear to alter this pattern; 3) dextrose meals of either 75 g or 150 g result in a significant increase in serum insulin, in particular at 0.5 hr and 1 hr post-ingestion; 4) lipid meals have little impact on serum insulin.</p

2016 Research & Innovation Day Program

A one day showcase of applied research, social innovation, scholarship projects and activities.https://first.fanshawec.ca/cri_cripublications/1003/thumbnail.jp

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.

Funder: Funder: Fundación bancaria ‘La Caixa’ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease