{001}-textured Pb(Zr, Ti)O₃ thin films on stainless steel by pulsed laser deposition

In this work, we report nearly single oriented {001}-textured ferroelectric PbZr0.52Ti0.48O3 thin films grown by pulsed laser deposition onto AISI 304 stainless steel substrates. Pt, Al2O3, and LaNiO3 buffer layers promote the PbZr0.52Ti0.48O3 {001} texture and protect the substrate against oxidation during deposition. The dominant {001} texture of the PbZr0.52Ti0.48O3 layer was confirmed using x-ray and electron backscatter diffraction. Before poling, the films exhibit a permittivity of about 350 at 1 kHz and a dielectric loss below 5%. The films display a remanent polarization of about 16.5 μC cm⁻² and a high coercive field of up to Ec ¼ 135.9 kV cm⁻¹. The properties of these PbZr0.52Ti0.48O3 thin films on stainless steel are promising for various MEMS applications such as transducers or energy harvesters

Étude de la marqueterie d’un secrétaire à gradin du xviiie siècle

Le secrétaire à gradin (inv. V4081) conservé au musée du Louvre a fait l’objet d’une restauration en 2013 dans les ateliers du Centre de recherche et de restauration des musées de France (C2RMF), au pavillon de Flore. L’intervention s’est accompagnée d’une importante étude matérielle de la partie polychromée de la marqueterie. Les procédés de mise en œuvre de la couche picturale et de la couche de corne qui la protège ont nécessité d’adapter la méthodologie par le couplage de multiples techniques d’examens et d’analyses. Le recoupement de l’ensemble des données a permis de caractériser finement les matériaux utilisés pour deux interventions distinctes de polychromies et de mieux cerner les dates de leur mise en œuvre.The Louvre’s drop-front secretary desk with drawers (inv. V4081) was restored in 2013 in the workshops of the Centre de Recherche et de Restauration des Musées de France (C2RMF), in the Pavillon de Flore. The restoration went hand in hand with a detailed material study of the polychromed part of the marquetry. The manner of applying the layer of pigment and the veneer of horn that protected it required the methodology to be adapted through the interaction of multiple tests and analysis techniques. By cross-referencing all the data obtained, the materials used for the two separate polychromy procedures were distinguished and dated more precisely

Itinéraire culturel de Belen: consolidation de l’ identité culturelle du quartier de Belén comme moyen de revitalisation urbaine

El interés del proyecto radica en la revitalización de entornos de importancia y carácter patrimonial dentro de la ciudad de Bogotá, más específicamente dentro del barrio Belén. Este barrio ha sido testigo de gran parte de la evolución y crecimiento de la ciudad desde su fundación en 1580, y desde entonces, ha sido un lugar donde gran parte de la vida urbana toma parte. El valor patrimonial de este barrio no radica en sus construcciones o entorno físico -dado que sus cualidades arquitectónicas originales han sido alteradas en gran manera y modificadas para servir a los distintos estilos de vida que han estado tomando lugar dentro del barrio y la ciudad con el paso del tiempo-, sino en su vida comunal, costumbres únicas, las actividades tradicionales y manifestaciones culturales que toman lugar en esta comunidad. Tal autenticidad ha valido al barrio el sobrenombre entre los residentes de “un pueblo dentro de Bogotá”, y es esta autenticidad y estos valores patrimoniales que intentan preservarse, protegiendo el barrio y su comunidad del inminente desarrollo de bienes raíces y los procesos de gentrificación que han estado afectando fuertemente esta parte de la ciudad. El proyecto está clasificado dentro de la línea Arquitectónica, con enfoque en Patrimonio y énfasis en Paisaje, Lugar y Territorio. Se desarrollará una serie de intervenciones arquitectónicas dentro del marco de una propuesta urbana que ayude a promover la economía local de estos barrios, promueva la actividad turística y mejore la calidad de vida de los habitantes

Superficie de respuesta aplicada al tratamiento de aguas residuales acoplando DSA y fotocatálisis

Este estudio empleó el análisis de superficie de respuesta basado en un diseño compuesto central para evaluar una celda electrolítica de flujo tipo filtro prensa, acoplada a un concentrador parabólico compuesto solar, los cuales se usaron para llevar a cabo el tratamiento de 20 l de agua residual doméstica de 742 a 756 mg l-1 en demanda química de oxígeno, y de 248 a 253 mg l-1 en carbono orgánico total. Los ánodos usados en la celda electrolítica fueron de IrPbO, IrSnO y RuPbO, recubiertos mediante la técnica de los cloruros metálicos sobre placas de Ti y activados por descomposición térmica. El concentrador parabólico compuesto solar posee un área de 1 m2 , la cual fue expuesta por cuatro horas por día, recibiendo una radiación promedio de 889 Watts m-2. La degradación de los contaminantes se vio favorecida con la adición de TiO2 a concentraciones de 100 a 150 mg l-1, con efectos poco significativos al cambiar la concentración de 0.02 a 0.06 M de Na2 SO4 del electrolito soporte. Los ensayos de la degradación fueron seguidos por el análisis del carbono orgánico total, con porcentajes de degradación de 5 a 30% al final del tratamiento, al aplicar intensidades de corriente de 10 a 30 A, con consumos energéticos desde 6 hasta 74 kW m-3

Training healthcare professionals in LGBTI cultural competencies: Exploratory findings from the Health4LGBTI pilot project

Abstract Objectives Lesbian, gay, bisexual, trans and intersex (LGBTI) people experience health inequalities and barriers to accessing healthcare at a greater rate than the general population. This paper aims to present the Health4LGBTI training course for healthcare workers and the results of its pilot implementation. Methods Funded by the European Parliament, the training course was developed by a multidisciplinary team including LGBTI organisations as part of the Health4LGBTI Project. 110 healthcare professionals from diverse medical fields attended the pilot training in six European Member States. Knowledge and attitudes were compared on the basis of a pre-post evaluation design utilising an ad hoc questionnaire. Results Knowledge scores increased after the training, irrespective of age and sexual orientation of participants. Attitudes scores generally improved, particularly in terms of inclusivity and a greater acknowledgement of LGBTI health needs and self-competence. Conclusion The Health4LGBTI training course is both feasible and effective in training healthcare professionals and support staff to improve cultural competence and thereby promoting inclusive healthcare practice. Practice Implications The Health4LGBTI training course can be implemented in different healthcare contexts. Piloting of the course provided an opportunity for healthcare professionals and for support staff to improve their knowledge of, and attitudes towards, LGBTI people

Uso de clar em fase inversa para a determinação do conteúdo de formaldeído livre em esmaltes de unhas

 Introduction: This article derives from the research titled Use of reversed-phase hplc for the determination of free formaldehyde content in nail polishes, conducted in 2015 at the Center for Applied Innovation in Competitive Technologies (ciatec). Method: The free formaldehyde content was determined in 50 samples of nail polishes of various brands marketed in León, Guanajuato, Mexico. Samples were treated according to the iso 17226-1:2003 method, with slight modifications: 2 ± 0.1 g of nail polishes were weighed in 100 ml Erlenmeyer flasks, 40 ml of 0.1 % sodium dodecyl sulfonate were added; the samples were then capped and left in a water bath at 40 °C under constant stirring for 60 minutes; they were subsequently filtered, and aliquots of each sample were taken for derivatization with 0.3 % 2,4-dinitrophenylhydrazine for 60 minutes. The analytical determination was achieved by reversed-phase hplc-diode array detection. Results: All nail polish samples tested were below the regulatory limit of 0.2 % free formaldehyde content in cosmetics. Conclusions: We obtained toxicologically relevant information on free formaldehyde in nail polishes, in addition to checking the versatility and robustness of the test method. Introducción: este artículo es producto de la investigación titulada “Uso de clar en fase inversa para la determinación del contenido de formaldehído libre en esmaltes de uñas”, desarrollada en el 2015 en el Centro de Innovación Aplicada en Tecnologías Competitivas (ciatec). Metodología: se determinó el contenido de formaldehído libre en 50 muestras de esmaltes para uñas de diversas marcas comercializadas en León, Guanajuato, México. El tratamiento de muestras se realizó de acuerdo con el método iso 17226-1:2003, con ligeras modificaciones: se pesaron 2±0,1 g de esmaltes en matraces Erlenmeyer de 100 ml, se adicionaron 40 ml de dodecil sulfonato de sodio al 0,1 %. Las muestras fueron entonces tapadas y se dejaron en baño María a 40 °c con agitación constante durante 60 minutos; posteriormente se filtraron y se tomaron alícuotas de cada muestra para su derivatización con 2,4-dinitrofenilhidracina al 0,3 % durante 60 minutos. La determinación analítica se realizó por clar en fase inversa con detección por arreglo de diodos. Resultados: se obtuvo como resultado que todas las muestras de esmaltes para uñas analizadas estuvieron por debajo del límite normativo de contenido de formaldehído libre en cosméticos de 0,2 %. Conclusiones: se obtuvo información de relevancia toxicológica sobre el formaldehído libre en los esmaltes de uñas, además de comprobar la versatilidad y robustez del método de prueba.Introdução: este artigo é produto da pesquisa intitulada “Uso de clar em fase inversa para a determinação do conteúdo de formaldeído livre em esmaltes de unhas”, desenvolvida em 2015 no Centro de Inovação Aplicada em Tecnologias Competitivas (Ciatec). Metodologia: determinou-se o conteúdo de formaldeído livre em 50 amostras de esmaltes para unhas de diversas marcas comercializadas em León, Guanajuato, México. O tratamento de amostras foi realizado de acordo com o método iso 17226-1:2003, com leves modificações: foram pesados 2±0,1 g de esmaltes em frascos Erlenmeyer de 100 ml, adicionados 40 ml de dodecil sulfonato de sódio a 0,1 %; as amostras foram então tampadas e deixadas em banho-maria a 40 °c com agitação constante durante 60 minutos; em seguida, foram filtradas e tomadas alíquotas de cada amostra para sua derivatização com 2,4- dinitrofenilhidrazina a 0,3 % durante 60 minutos. A determinação analítica foi realizada por clar em fase inversa com detecção por ajuste de diodos. Resultados: obteve-se como resultado que todas as amostras de esmaltes para unhas analisadas estiveram abaixo do limite normativo de conteúdo de formaldeído livre em cosméticos de 0,2 %. Conclusões: obteve-se informação de relevância toxicológica sobre o formaldeído livre nos esmaltes de unhas, além de comprovar a versatilidade e a solidez do método de teste

Annex C: ASCS & SACE Discovery Report

A discovery project was commissioned by DHSC to look at options for revising the Adult Social Care Survey (ASCS) and Personal Social Services Survey of Adult Carers in England (SACE), so that they are representative of the social care population (as defined in the Care Act 2014), and meaningfully reflect the experiences and outcomes of people who use care and support services and carers

Le Forum, Vol. 44 #3

https://digitalcommons.library.umaine.edu/francoamericain_forum/1105/thumbnail.jp

Genetic landscape of a large cohort of Primary Ovarian Insufficiency : New genes and pathways and implications for personalized medicine

Background Primary Ovarian Insufficiency (POI), a public health problem, affects 1-3.7% of women under 40 yield-ing infertility and a shorter lifespan. Most causes are unknown. Recently, genetic causes were identified, mostly in single families. We studied an unprecedented large cohort of POI to unravel its molecular pathophysiology.Methods 375 patients with 70 families were studied using targeted (88 genes) or whole exome sequencing with pathogenic/likely-pathogenic variant selection. Mitomycin-induced chromosome breakages were studied in patients' lymphocytes if necessary. Findings A high-yield of 29.3% supports a clinical genetic diagnosis of POI. In addition, we found strong evidence of pathogenicity for nine genes not previously related to a Mendelian phenotype or POI: ELAVL2, NLRP11, CENPE, SPATA33, CCDC150, CCDC185, including DNA repair genes: C17orf53(HROB), HELQ, SWI5 yielding high chromo-somal fragility. We confirmed the causal role of BRCA2, FANCM, BNC1, ERCC6, MSH4, BMPR1A, BMPR1B, BMPR2, ESR2, CAV1, SPIDR, RCBTB1 and ATG7 previously reported in isolated patients/families. In 8.5% of cases, POI is the only symptom of a multi-organ genetic disease. New pathways were identified: NF-kB, post-translational regulation, and mitophagy (mitochondrial autophagy), providing future therapeutic targets. Three new genes have been shown to affect the age of natural menopause supporting a genetic link.Interpretation We have developed high-performance genetic diagnostic of POI, dissecting the molecular pathogene-sis of POI and enabling personalized medicine to i) prevent/cure comorbidities for tumour/cancer susceptibility genes that could affect life-expectancy (37.4% of cases), or for genetically-revealed syndromic POI (8.5% of cases), ii) predict residual ovarian reserve (60.5% of cases). Genetic diagnosis could help to identify patients who may benefit from the promising in vitro activation-IVA technique in the near future, greatly improving its success in treating infertility.Funding Universite? Paris Saclay, Agence Nationale de Biome?decine.Copyright (c) 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)Peer reviewe