The dialectical experience of the fear of missing out for U.S. American iGen emerging adult college students

FoMO, the fear of missing out, is a salient and significant experience with personal and relational consequences. This study qualitatively analyzed 35 interviews with iGen emerging adult college students about their experiences with FoMO. Framed by relational dialectics theory 2.0 (Baxter, L. A. (2011). Voicing relationships: A dialogic perspective. Sage), we found two relational-level contradictions, connection and disconnection and inclusion and exclusion, which are illuminated by the cultural-level interplay of the discourses of ‘carpe diem’ and ‘investment in the future.’ Findings indicate that through the discourse of carpe diem, participants attempt to increase the power awarded to relational and personal resources and expand what it means to invest in the future. Implications of these findings related to well-being and academic success are discussed and practical applications for institutions of higher education such as team-based learning and more holistic professional development programs are presented

Everolimus-induced Symmetrical Drug-related Intertriginous and Flexural Exanthema

Abstract is missing (Short communication

HaloSat: Early results on the mass of the Milkyway halo

International audienceHaloSat is the first NASA SMD CubeSat funded through the ROSES Astrophysics Research and Analysis Program. HaloSat's goal is test the hypothesis that the 'missing baryons' reside in hot dilute halos of visible galaxies. This is performed by performing an all-sky survey and measuring Oxygen line emission from the halo of the Milkyway. Halo gas is predicted to have temperatures near a million degrees and is can be separated and traced by an experiment with large grasp and energy resolution < 100 eV in the vicinity of the emission lines of O VII and O VIII. HaloSat was deployed from the International Space Station in mid-July and began routine science operations in October. We present initial scientific results, including observations of the Cygnus loop and Crab Nebula, which demonstrate instrument performance and contribute to the in-orbit energy scale calibration, and selected high latitude regions

Global monitoring of the impact of the COVID-19 pandemic through online surveys sampled from the Facebook user base

Simultaneously tracking the global impact of COVID-19 is challenging because of regional variation in resources and reporting. Leveraging self-reported survey outcomes via an existing international social media network has the potential to provide standardized data streams to support monitoring and decision-making worldwide, in real time, and with limited local resources. The University of Maryland Global COVID-19 Trends and Impact Survey (UMD-CTIS), in partnership with Facebook, has invited daily cross-sectional samples from the social media platform's active users to participate in the survey since its launch on April 23, 2020. We analyzed UMD-CTIS survey data through December 20, 2020, from 31,142,582 responses representing 114 countries/territories weighted for nonresponse and adjusted to basic demographics. We show consistent respondent demographics over time for many countries/territories. Machine Learning models trained on national and pooled global data verified known symptom indicators. COVID-like illness (CLI) signals were correlated with government benchmark data. Importantly, the best benchmarked UMD-CTIS signal uses a single survey item whereby respondents report on CLI in their local community. In regions with strained health infrastructure but active social media users, we show it is possible to define COVID-19 impact trajectories using a remote platform independent of local government resources. This syndromic surveillance public health tool is the largest global health survey to date and, with brief participant engagement, can provide meaningful, timely insights into the global COVID-19 pandemic at a local scale

Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.

Phagocytosis is required for a broad range of physiological functions, from pathogen defense to tissue homeostasis, but the mechanisms required for phagocytosis of diverse substrates remain incompletely understood. Here, we developed a rapid magnet-based phenotypic screening strategy, and performed eight genome-wide CRISPR screens in human cells to identify genes regulating phagocytosis of distinct substrates. After validating select hits in focused miniscreens, orthogonal assays and primary human macrophages, we show that (1) the previously uncharacterized gene NHLRC2 is a central player in phagocytosis, regulating RhoA-Rac1 signaling cascades that control actin polymerization and filopodia formation, (2) very-long-chain fatty acids are essential for efficient phagocytosis of certain substrates and (3) the previously uncharacterized Alzheimer's disease-associated gene TM2D3 can preferentially influence uptake of amyloid-β aggregates. These findings illuminate new regulators and core principles of phagocytosis, and more generally establish an efficient method for unbiased identification of cellular uptake mechanisms across diverse physiological and pathological contexts