526 research outputs found
Ritanserin as an adjunct to lithium and haloperidol for the treatment of medication-naive patients with acute mania: a double blind and placebo controlled trial
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/06/2003
- Field of study
BACKGROUND: Bipolar disorder is a lifelong episodic condition characterized by mood swings between mania and depression. Several lines of evidence suggest that serotonin is likely to play a pivotal role in the pathophysiology of bipolar disorder. Ritanserin, a 5-HT(2 )receptor antagonist, has been reported to have antipsychotic activity. In this 6-week double blind, placebo controlled study involving moderate to severe manic patients, we assessed the effects of ritanserin plus haloperidol in combination with lithium. METHODS: 45 patients aged between 21–43 were eligible to participate as they met the DSM-IV criteria for a current manic episode, on the basis of a clinical interview by an academician psychiatrist. In addition, a score of at least 20 points on the Young Mania rating Scale was required representing moderate to severe mania. Patients were randomly allocated lithium (1–1.2 mEq/L) + haloperidol (10 mg/day)+ ritanserin (10 mg/day) (Group A) or lithium (1–1.2 mEq/L)+ haloperidol (10 mg/day) + placebo (Group B) for a 6-week, double-blind, placebo-controlled study. Patients were assessed by a third year psychiatry resident at baseline and 3, 7, 14, 21, 28 and 42 days after the medication started. All patients entered the hospital were not previously under any medication. The mean decrease in the Young Mania Rating Scale score from baseline was used as the main outcome measure of response of mania to treatment. The extrapyramidal symptoms were assessed using the Extrapyramidal Symptoms Rating Scale. Side effects were systematically recorded throughout the study and were assessed using a checklist. RESULTS: Young Mania Rating Scale total scores improved with ritanserin. The difference between the two protocols was significant as indicated by the effect of group and the between-subjects factor (F = 5.02, d.f. = 1, P = 0.03). The means Extrapyramidal Symptoms Rating Scale scores for the placebo group were higher than the ritanserin group and the difference was significant in day 42. The difference between the two groups in the frequency of side effects was not significant CONCLUSIONS: The efficacy of ritanserin to obtain a better improvement in patients with mania seems to support the 5-HT hypothesis of bipolar disorder
Generalization of the normal-exponential model: exploration of a more accurate parametrisation for the signal distribution on Illumina BeadArrays
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A descriptive study of medical educators' views of problem-based learning
- Author
- C Macnee
- CH Major
- CJ Eagle
- DF Wood
- DH Dolmans
- DM Irby
- DT Vernon
- E Rideout
- FM Wolf
- G Maudsley
- HG Schmidt
- HS Barrows
- JA Colliver
- JA Colliver
- JA Colliver
- JA Colliver
- K Hecker
- L Berkson
- LH Distlehorst
- M Albert
- M Silver
- MA Albanese
- Mohsen Tavakol
- N Glasgow
- PF Shanley
- R Watson
- Reg Dennick
- Sina Tavakol
- SM Loyens
- WA Reid
- WK Davis
- YH Carter
- Publication venue
- BioMed Central
- Publication date
- 04/11/2009
- Field of study
Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation
- Author
- A Karadag
- AA Dlugosz
- AW Studebaker
- B Ancrile
- B Elenbaas
- CH Squarize
- CV Clevenger
- DC Ng
- DJ Gough
- DL Silver
- DM Watson
- F Ciardiello
- FD Lubin
- FM Ausubel
- G Niu
- GJ Clark
- GZ Cheng
- H Yu
- Hao Ho
- HC Chen
- HD Soule
- HH Ho
- J Azare
- J Bromberg
- J Debnath
- J Turkson
- J Yang
- J Yang
- Jacqueline Bromberg
- JE Darnell Jr
- JF Bromberg
- JF Bromberg
- JI Pulai
- K Giehl
- Katrina Podsypanina
- Kenneth Leslie
- KM Imbalzano
- KS Chan
- KS Selander
- KW Nettles
- L Naldini
- L Wallner
- LH Wang
- LH Wang
- LH Wang
- LI McKay
- Lionel Ivashkiv
- M Berishaj
- Marjan Berishaj
- MD Inda
- MS Boguski
- N Diaz
- NE Kohl
- NJ Sullivan
- OW Petersen
- P Bhat-Nakshatri
- P Sansone
- PG Coulie
- PJ Keely
- Q Xu
- R Arulanandam
- R Chiarle
- R Galien
- S Paschoud
- S Yamashita
- Sizhi P Gao
- SP Gao
- T Clair
- T Kishimoto
- TN Dechow
- VA Spencer
- VM Weaver
- VM Weaver
- W Xiao
- W Zhao
- X Ling
- Z Wen
- ZT Schafer
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts.
- Author
- A Rapisarda
- Adrian L. Harris
- Anthony L. Sinn
- C Frezza
- Cecilia M. Devlin
- CW Lu
- Dean Singleton
- ED Michelakis
- ED Michelakis
- Francesca Buffa
- G Bergers
- Harriet E. Gee
- Helen Turley
- HS Friedman
- Jayne Silver
- JC Morris
- JF Groot de
- JH Park
- Ji-Liang Li
- JJ Raizer
- JW Kim
- KM Anderson
- KR Pechman
- Krishan Kumar
- L Dubois
- LH Stockwin
- M Emdadul Haque
- M Falkenberg
- M Prestele
- Melanie Huffman
- Mircea Ivan
- NG Larsson
- O Keunen
- P Swietach
- RA Harris
- RC Scarpulla
- Russell Leek
- S Davies
- SC Winter
- Simon Wigfield
- SM Wigfield
- T Rzymski
- W Wick
- WG Kaelin Jr
- X Tang
- Y Cao
- Y Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
Inhibition of vascular endothelial growth factor increases response rates to chemotherapy and progression-free survival in glioblastoma. However, resistance invariably occurs, prompting the urgent need for identification of synergizing agents. One possible strategy is to understand tumor adaptation to microenvironmental changes induced by antiangiogenic drugs and test agents that exploit this process. We used an in vivo glioblastoma-derived xenograft model of tumor escape in presence of continuous treatment with bevacizumab. U87-MG or U118-MG cells were subcutaneously implanted into either BALB/c SCID or athymic nude mice. Bevacizumab was given by intraperitoneal injection every 3 days (2.5 mg/kg/dose) and/or dichloroacetate (DCA) was administered by oral gavage twice daily (50 mg/kg/dose) when tumor volumes reached 0.3 cm(3) and continued until tumors reached approximately 1.5-2.0 cm(3). Microarray analysis of resistant U87 tumors revealed coordinated changes at the level of metabolic genes, in particular, a widening gap between glycolysis and mitochondrial respiration. There was a highly significant difference between U87-MG-implanted athymic nude mice 1 week after drug treatment. By 2 weeks of treatment, bevacizumab and DCA together dramatically blocked tumor growth compared to either drug alone. Similar results were seen in athymic nude mice implanted with U118-MG cells. We demonstrate for the first time that reversal of the bevacizumab-induced shift in metabolism using DCA is detrimental to neoplastic growth in vivo. As DCA is viewed as a promising agent targeting tumor metabolism, our data establish the timely proof of concept that combining it with antiangiogenic therapy represents a potent antineoplastic strategy
Evaluation of long noncoding RNA MALAT1 as a candidate blood-based biomarker for the diagnosis of non-small cell lung cancer
- Author
- A Jemal
- A Schmermund
- B Ning
- Beate Pesch
- C Becker
- CL Andersen
- CS Zhu
- D Zheng
- Daniel Gilbert Weber
- DG Weber
- DG Weber
- EM Reis
- F Bianchi
- F Xie
- Georg Johnen
- H Tani
- HI Pass
- J Vandesompele
- Jens Kollmeier
- JL Guthrie
- K Panzitt
- K Tano
- Karl-Heinz Jöckel
- KM Foss
- LA Matheson
- LH Schmidt
- LH Sobin
- M Boeri
- M Eissmann
- M Kruhoffer
- MW Pfaffl
- N Silver
- OA Kent
- Oleksandr Bryk
- P Goldstraw
- P Gresner
- P Ji
- P Ulivi
- PA Davoren
- PJ Zhang
- PL Mai
- R Lin
- S Ren
- SF Häusler
- Swaantje Casjens
- T Arita
- T Gutschner
- T Gutschner
- T Kogure
- TD Schmittgen
- Thomas Brüning
- V Ambros
- VR Falkenberg
- Y Fradet
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogana T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Aranda CP
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin J-F
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnault C
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Asfandiyarov R
- Ask S
- Asman B
- Asner D
- Asquith L
- Assamagan K
- Astbury A
- Astvatsatourov A
- Atoian G
- Aubert B
- Auge E
- Augsten K
- Aurousseau M
- Austin N
- Avolio G
- Avramidou R
- Axen D
- Ay C
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Bachy G
- Backes M
- Backhaus M
- Badescu E
- Bagnaia P
- Bahinipati S
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker MD
- Baker OK
- Baker S
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barajas CAC
- Barak L
- Baranov SP
- Barashkou A
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Barrera CO
- Barrillon P
- Bartoldus R
- Barton AE
- Bartsch D
- Bartsch V
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Battistoni G
- Bauer F
- Bawa HS
- Beare B
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck GA
- Beck HP
- Beckingham M
- Becks KH
- Beddall A
- Beddall AJ
- Bedikian S
- Bednyakov VA
- Bee CP
- Begel M
- Behera PK
- Beimforde M
- Belanger-Champagne C
- Belenguer MJ
- Bell PJ
- Bell WH
- Bella G
- Bella LA
- Bellagamba L
- Bellina F
- Bellomo M
- Belloni A
- Beloborodova O
- Belotskiy K
- Beltramello O
- Ben Ami S
- Benary O
- Benchekroun D
- Benchouk C
- Bendel M
- Benekos N
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Benslama K
- Bentvelsen S
- Beretta M
- Berge D
- Berger N
- Berghaus F
- Berglund E
- Beringer J
- Bernardet K
- Bernat P
- Bernhard R
- Bernius C
- Berry T
- Bertin A
- Bertinelli F
- Bertolucci F
- Besana MI
- Besson N
- Bethke S
- Bhimji W
- Bianchi RM
- Bianco M
- Biebel O
- Bieniek SP
- Bierwagen K
- Biesiada J
- Biglietti M
- Bilokon H
- Bindi M
- Binet S
- Bingul A
- Bini C
- Biscarat C
- Bitenc U
- Black KM
- Blair RE
- Blanchard J-B
- Blanchot G
- Blazek T
- Blocker C
- Blocki J
- Blondel A
- Blum W
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VB
- Bocchetta SS
- Bocci A
- Boddy CR
- Boehler M
- Boek J
- Boelaert N
- Boeriu OEV
- Boeser S
- Bogaerts JA
- Bogdanchikov A
- Bogouch A
- Bohm C
- Boisvert V
- Bold T
- Boldea V
- Bolnet NM
- Bona M
- Bondarenko VG
- Bondioli M
- Boonekamp M
- Boorman G
- Booth CN
- Bordoni S
- Borer C
- Borisov A
- Borissov G
- Borjanovic I
- Borroni S
- Bos K
- Boscherini D
- Bosman M
- Boterenbrood H
- Botterill D
- Bouchami J
- Boudreau J
- Bouhova-Thacker EV
- Bourdarios C
- Bousson N
- Boveia A
- Boyd J
- Boyko IR
- Bozhko NI
- Bozovic-Jelisavcic I
- Bracinik J
- Braem A
- Branchini P
- Brandenburg GW
- Brandt A
- Brandt G
- Brandt O
- Bratzler U
- Brau B
- Brau JE
- Braun HM
- Brelier B
- Bremer J
- Brenner R
- Bressler S
- Breton D
- Britton D
- Brochu FM
- Brock I
- Brock R
- Brodbeck TJ
- Brodet E
- Broggi F
- Bromberg C
- Brooijmans G
- Brooks WK
- Brown G
- Brown H
- Bruncko D
- Bruneliere R
- Brunet S
- Bruni A
- Bruni G
- Bruschi M
- BScher V
- Buanes T
- Bucci F
- Buchanan J
- Buchanan NJ
- Buchholz P
- Buckingham RM
- Buckley AG
- Buda SI
- Budagov IA
- Budick B
- Bueso XP
- Bugge L
- Buira-Clark D
- Bulekov O
- Bunse M
- Buran T
- Burckhart H
- Burdin S
- Burgess T
- Burke S
- Busato E
- Bussey P
- Buszello CP
- Butin F
- Butler B
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Caballero J
- Caforio D
- Cakir IT
- Cakir O
- Calafiura P
- Calderini G
- Calfayan P
- Calkins R
- Caloba LP
- Caloi R
- Calvet D
- Calvet S
- Camarri P
- Cambiaghi M
- Cameron D
- Camilocci ES
- Campana S
- Campanelli M
- Canale V
- Canelli F
- Canepaa A
- Cantero J
- Capasso L
- Caprini I
- Caprini M
- Capriotti D
- Capua M
- Caputo R
- Caramarcu C
- Cardarelli R
- Carli T
- Carlino G
- Carminati L
- Caron B
- Caron S
- Carter AA
- Carter JR
- Carvalho J
- Casadei D
- Casado MP
- Cascella M
- Caso C
- Castaneda-Miranda E
- Castanheira MTD
- Castillo LRF
- Castro NF
- Cataldi G
- Cataneo F
- Catinaccio A
- Catmore JR
- Cattai A
- Cattani G
- Caughron S
- Cauz D
- Cavalcanti TP
- Cavalleri P
- Cavalli D
- Cavalli-Sforza M
- Cavasinni V
- Ceradini F
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cetin SA
- Cevenini F
- Chafaq A
- Chakraborty D
- Chan K
- Chapleau B
- Chapman JD
- Chapman JW
- Chareyre E
- Charlton DG
- Chavda V
- Cheatham S
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
- Chen C
- Chen H
- Chen S
- Chen T
- Chen X
- Cheng S
- Cheong ALF
- Cheplakov A
- Chepurnov VF
- Chernyatin V
- Cheu E
- Cheung SL
- Chevalier L
- Chiefari G
- Chikovani L
- Childers JT
- Chilingarov A
- Chiodini G
- Chizhov MV
- Choudalakis G
- Chouridou S
- Christidi IA
- Christov A
- Chromek-Burckhart D
- Chu ML
- Chudoba J
- Ciapetti G
- Ciba K
- Ciftci AK
- Ciftci R
- Cinca D
- Cindro V
- Ciobotaru MD
- Cioccaa C
- Ciocio A
- Cirilli M
- Citterio M
- Ciubancan M
- Clark A
- Clark PJ
- Cleland W
- Clemens JC
- Clement B
- Clement C
- Clifft RW
- Coadou Y
- Cobal M
- Coccaro A
- Cochran J
- Codina EP
- Coe P
- Cogan JG
- Coggeshall J
- Cogneras E
- Cojocaru CD
- Colas J
- Colijn AP
- Collaboration ATLAS
- Collard C
- Collins NJ
- Collins-Tooth C
- Collot J
- Colon G
- Coniavitis E
- Conidi MC
- Consonni M
- Consorti V
- Constantinescu S
- Conta C
- Conventi F
- Cook J
- Cooke M
- Cooper BD
- Cooper-Sarkar AM
- Copic K
- Cornelissen T
- Corradi M
- Correia AMH
- Corriveau F
- Corso-Radu A
- Cortes-Gonzalez A
- Cortiana G
- Costa G
- Costa MJ
- Costanzo D
- Costin T
- Cote D
- Courneyea L
- Cowan G
- Cowden C
- Cox BE
- Cranmer K
- Cranshaw J
- Crepe-Renaudin S
- Crescioli F
- Cristinziani M
- Crosetti G
- Crupi R
- Cuciuc C-M
- Curatolo M
- Curtis CJ
- Curull XE
- Cwetanski P
- Czirr H
- Czyczula Z
- D'Auria S
- D'Onofrio M
- D'Orazio A
- Da Costa JBG
- Da Costa JGPF
- Da Silva PVM
- Da Via C
- Dabrowski W
- Dai T
- Dallapiccola C
- Daly CH
- Dam M
- Damazio DO
- Dameri M
- Damiani DS
- Danielsson HO
- Dannheim D
- Dao V
- Darbo G
- Darlea GL
- Daum C
- Dauvergne JP
- Davey W
- Davidek T
- Davidson N
- Davidson R
- Davies E
- Davies M
- Davison AR
- Davygora Y
- Dawe E
- Dawson I
- Dawson JW
- Daya-Ishmukhametova RK
- de Asmundis R
- De Castro S
- De Cecco S
- De Graat J
- De Groot N
- De Jong P
- De la Hoz SG
- De la Taille C
- De la Torre H
- De Lima JGR
- De Lotto B
- De Mora L
- De Nooij L
- De Pedis D
- De Regie JBDV
- De Renstrom PAB
- De Salvo A
- De Sanctis U
- De Santo A
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- Dean S
- Debbe R
- Dedovich DV
- Degenhardt J
- Dehchar M
- Del Papa C
- Del Peso J
- Del Prete T
- Deliyergiyev M
- Dell'Acqua A
- Dell'Asta L
- Della Pietra M
- Della Porta GZ
- della Volpe D
- Delmastro M
- Delpierre P
- Delruelle N
- Delsart PA
- Deluca C
- Demers S
- Demichev M
- Demirkoz B
- Deng J
- Deng W
- Denis RDS
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
- Dervan P
- Desch K
- Devetak E
- Deviveiros PO
- Dewhurst A
- DeWilde B
- Dhaliwal S
- Dhullipudi R
- Di Ciaccio A
- Di Ciaccio L
- Di Girolamo A
- Di Girolamo B
- Di Luise S
- Di Mattia A
- Di Micco B
- Di Nardo R
- Di Simone A
- Di Sipio R
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- Diblen F
- Diehl EB
- Dietrich J
- Dietzscha TA
- Diglio S
- Dingfelder J
- Dionisi C
- Dita P
- Dita S
- Dittus F
- Djama F
- Djobava T
- do Vale MAB
- Do ValleWemans A
- Doan TKO
- Dobbs M
- Dobinson R
- Dobos D
- Dobson E
- Dobson M
- Dodd J
- Doglioni C
- Doherty T
- Dohmae T
- Doi Y
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- Dolenc I
- Dolezal Z
- Dolgoshein BA
- Donadelli M
- Donega M
- Donini J
- Donszelmann TC
- Dopke J
- Doria A
- Dos Anjos A
- Dos Santos DR
- Dosil M
- Dotti A
- Dova MT
- Dowell JD
- Doxiadis AD
- Doyle AT
- Drasal Z
- Drees J
- Dressnandt N
- Drevermann H
- Driouichi C
- Dris M
- Dubbert J
- Dubbs T
- Dube S
- Duchovni E
- Duckeck G
- Dudarev A
- Dudziak F
- Duehrssen M
- Duerdoth IP
- Dueren M
- Duflot L
- Dufour M-A
- Dunford M
- Duxfield R
- Dwuznik M
- Dydak F
- Ebenstein WL
- Ebke J
- Eckert S
- Eckweiler S
- Edmonds K
- Edwards CA
- Edwards NC
- Ehrenfeld W
- Ehrich T
- Eifert T
- Eigen G
- Einsweiler K
- Eisenhandler E
- Ekelof T
- El Kacimi M
- El Moursli RC
- Ellert M
- Elles S
- Ellinghaus F
- Ellis K
- Ellis N
- Elmsheuser J
- Elsing M
- Emeliyanov D
- Engelmann R
- Engl A
- Epp B
- Eppig A
- Erdmann J
- Ereditato A
- Eriksson D
- Ernst J
- Ernst M
- Ernwein J
- Errede D
- Errede S
- Ertel E
- Escalier M
- Eschrich IG
- Escobar C
- Esposito B
- Etienne F
- Etienvre AI
- Etzion E
- Evangelakou D
- Evans H
- Fabbri L
- Fabre C
- Fajardo LSG
- Fakhrutdinov RM
- FalCiano S
- Fang Y
- Fanti M
- Farbin A
- Farilla A
- Farley J
- Farooque T
- Farrington SM
- Farthouat P
- Fassnacht P
- Fassouliotis D
- Fatholahzadeh B
- Favareto A
- Fayard L
- Fazio S
- Febbraro R
- Federic P
- Fedin OL
- Fedorko W
- Fehling-Kaschek M
- Feligioni L
- Fellmann D
- Felzmann CU
- Feng EJ
- Fengd C
- Fenyuk AB
- Ferencei J
- Ferland J
- Fernando W
- Ferrag S
- Ferrando BMS
- Ferrando J
- Ferrara V
- Ferrari A
- Ferrari P
- Ferrari R
- Ferrer A
- Ferrer JAV
- Ferrer ML
- Ferrere D
- Ferretti C
- Fiascaris M
- Fiedler F
- Filipcic A
- Filippas A
- Filthaut F
- Fincke-Keeler M
- Fiolhais MCN
- Fiorini L
- Firan A
- Fischer G
- Fischer P
- Fisher MJ
- Fisher SM
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- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
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- Zolnierowski Y
- Zsenei A
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Isolation and characterization of resident endogenous c-Kit⁺ cardiac stem cells from the adult mouse and rat heart
- Author
- A Linke
- AM Hierlihy
- AM Smits
- Andrew J Smith
- AP Beltrami
- AP Beltrami
- Aurora Nocera
- BE Strauer
- Bernardo Nadal-Ginard
- C Bearzi
- CA Carr
- Cheryl D Waring
- CM Martin
- D Dey
- D Torella
- D Torella
- Daniele Torella
- E Messina
- F Limana
- Fiona C Lewis
- Georgina M Ellison
- GM Ellison
- GM Ellison
- GM Ellison
- H Oh
- I Chimenti
- Iolanda Aquila
- J Sanstedt
- J Zhang
- JJ Chong
- JJ Tan
- K Malliaras
- K Matsuura
- KL Laugwitz
- L Bu
- L Lauden
- L Yang
- LH Silver
- M Sampaolesi
- N Kawaguchi
- O Bergmann
- O Pfister
- P van Vliet
- R Bolli
- R Genead
- R Koninckx
- RR Smith
- S Gil-Perotín
- T Oyama
- Valter Agosti
- WR Sperr
- X Hou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/07/2014
- Field of study
This protocol describes the isolation of endogenous c-Kit (also known as CD117)-positive (c-Kit⁺), CD45-negative (CD45⁻) cardiac stem cells (eCSCs) from whole adult mouse and rat hearts. The heart is enzymatically digested via retrograde perfusion of the coronary circulation, resulting in rapid and extensive breakdown of the whole heart. Next, the tissue is mechanically dissociated further and cell fractions are separated by centrifugation. The c-Kit⁺ CD45⁻ eCSC population is isolated by magnetic-activated cell sorting technology and purity and cell numbers are assessed by flow cytometry. This process takes ∼4 h for mouse eCSCs or 4.5 h for rat eCSCs. We also describe how to characterize c-Kit⁺ CD45⁻ eCSCs. The c-Kit⁺ CD45⁻eCSCs exhibit the defining characteristics of stem cells: they are self-renewing, clonogenic and multipotent. This protocol also describes how to differentiate eCSCs into three main cardiac lineages: functional, beating cardiomyocytes, smooth muscle, and endothelial cells. These processes take 17-20 d
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abulaitia Y
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
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- Bagiacchi P
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- Bailey DC
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- Baker OK
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- Bessidskaia O
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- Blazeka T
- Bloch I
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- Buckley AG
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- Budagov IA
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- Buescher V
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- Bulekov O
- Bundock AC
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- Busato E
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- Bustos ACF
- Buszello CP
- Butler B
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- Caforio D
- Cakir IT
- Cakir O
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- Calderini G
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- Calkins R
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- Camillocci ES
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- Caminal Armadans R
- Campana S
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- Carter JR
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- Castanheira MTD
- Castelli A
- Castillo Gimenez V
- Castillo IS
- Castillo LRF
- Castillo LRF
- Castro NF
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- Catinaccio A
- Catmore JR
- Cattai A
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- Chalupkova I
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- Chelkov GA
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- Chen Y
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- Cheng Y
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- Chernyatin V
- Cheu E
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- Chiarella V
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- Chilingarov A
- Chiodini G
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- Chow BKB
- Christidi IA
- Chromek-Burckhart D
- Chu ML
- Chudoba J
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- Coniavitis E
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- Consorti V
- Constantinescu S
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- Cortes-Gonzalez A
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- Costa G
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- Czyczula Z
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- Da Costa JGPF
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- Da Cunha Sargedas De Sousa MJ
- Da Via C
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- Dafinca A
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- Dale O
- Dallaire F
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- de Jong P
- De la Taille C
- De la Torre H
- de Lima DEF
- de Lima DEF
- De Lorenzi F
- De Mendizabal JB
- De Nooij L
- De Pedis D
- De Regie JBDV
- de Renstrom PAB
- De Salvo A
- De Sanctis U
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- Debbe R
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- Degenhardt J
- Deigaard I
- Del Peso J
- Del Prete T
- Delemontex T
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- Deliyergiyev M
- Dell'Acqua A
- Dell'Asta L
- Della Pietra M
- della Porta GZ
- della Volpe D
- Delmastro M
- Delsart PA
- Deluca C
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- Demichev M
- Demilly A
- Demirkoz B
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
- Dervan P
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- Deviveiros PO
- Dewhurst A
- Dhaliwal S
- Di Ciaccio A
- Di Ciaccio L
- Di Domenico A
- Di Donato C
- Di Girolamo A
- Di Girolamo B
- Di Mattia A
- Di Micco B
- Di Nardo R
- Di Simone A
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- Diglio S
- Dimitrievska A
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- Dita P
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- Djama F
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- do Vale MAB
- Doan TKO
- Dobos D
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- Doglioni C
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- Dohmae T
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- Dotti A
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- Dubreuil E
- Duchovni E
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- Dueren M
- Duflot L
- Duguid L
- Dunford M
- Dwuznik M
- Ebke J
- Edson W
- Edwards NC
- Ehrenfeld W
- Eifert T
- Eigen G
- Einsweiler K
- Ekelof T
- El Kacimi M
- El Moursli A
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- Ellert M
- Elles S
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- Elmsheuser J
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- Elsing M
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- Emeliyanov D
- Emeliyanov D
- Enari Y
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- Endner OC
- Endner OC
- Endo M
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- Engelmann R
- Engelmann R
- Erdmann J
- Erdmann J
- Ereditato A
- Ereditato A
- Eriksson D
- Eriksson D
- Ernis G
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- Ernst J
- Ernst J
- Ernst M
- Ernst M
- Ernwein J
- Ernwein J
- Errede D
- Errede D
- Errede S
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- Ertel E
- Ertel E
- Escalier M
- Escalier M
- Esch H
- Esch H
- Escobar C
- Escobar C
- Espinal Curull X
- Espinal Curull X
- Esposito B
- Esposito B
- Etienne F
- Etienne F
- Etienvre AI
- Etienvre AI
- Etzion E
- Etzion E
- Evans H
- Evans H
- Fabbri L
- Fabbri L
- Facini G
- Facini G
- Fajardo LSG
- Fajardo LSG
- Fakhrutdinov RM
- Fakhrutdinov RM
- Falciano S
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- Faltova J
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- Fang Y
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- Farilla A
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- Farooque T
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- Farrell S
- Farrell S
- Farrington SM
- Farrington SM
- Farthouat P
- Farthouat P
- Fassi F
- Fassi F
- Fassnacht P
- Fassnacht P
- Fassouliotis D
- Fassouliotis D
- Favareto A
- Favareto A
- Fayard L
- Fayard L
- Federic P
- Federic P
- Fedin OL
- Fedin OL
- Fedorko W
- Fedorko W
- Fehling-Kaschek M
- Fehling-Kaschek M
- Feigl S
- Feigl S
- Feligioni L
- Feligioni L
- Feng C
- Feng C
- Feng EJ
- Feng EJ
- Feng H
- Feng H
- Fenyuk AB
- Fenyuk AB
- Fernando W
- Fernando W
- Ferrag S
- Ferrag S
- Ferrando BMS
- Ferrando J
- Ferrando J
- Ferrara V
- Ferrara V
- Ferrari A
- Ferrari A
- Ferrari P
- Ferrari P
- Ferrari R
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- Ferrer A
- Ferrer A
- Ferrere D
- Ferrere D
- Ferretti C
- Ferretti C
- Fiascaris M
- Fiascaris M
- Fiedler F
- Fiedler F
- Filipcic A
- Filipcic A
- Filipuzzi M
- Filipuzzi M
- Filthaut F
- Filthaut F
- Fincke-Keeler M
- Fincke-Keeler M
- Finelli KD
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- Fiolhais MCN
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- Fiorini L
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- Firan A
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- Fischer J
- Fischer J
- Fisher MJ
- Fisher MJ
- Fitzgerald EA
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- Flechl M
- Flechl M
- Fleck I
- Fleck I
- Fleischmann P
- Fleischmann P
- Fleischmann S
- Fleischmann S
- Fletcher G
- Fletcher G
- Fletcher GT
- Fletcher GT
- Flick T
- Flick T
- Floderus A
- Floderus A
- Florez Bustos AC
- Flowerdew MJ
- Flowerdew MJ
- Formica A
- Formica A
- Forti A
- Forti A
- Fortin D
- Fortin D
- Fournier D
- Fournier D
- Fox H
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- Francavilla P
- Francavilla P
- Franchini M
- Franchini M
- Franchino S
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- Francis D
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- Franklin M
- Franklin M
- Franz S
- Franz S
- Fraternali M
- Fraternali M
- Fratin S
- Fratina S
- French ST
- French ST
- Friedrich C
- Friedrich C
- Friedrich F
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- Froidevaux D
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- Frost JA
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- Fukunaga C
- Fukunaga C
- Fulsom BG
- Fulsom BG
- Fuster J
- Fuster J
- Gabaldon C
- Gabaldon C
- Gabizon O
- Gabizon O
- Gabrielli A
- Gabrielli A
- Gabrielli A
- Gabrielli A
- Gadatsch S
- Gadatsch S
- Gadomski S
- Gadomski S
- Gagliardi G
- Gagliardi G
- Gagnon P
- Gagnon P
- Galea C
- Galea C
- Galhardo B
- Galhardo B
- Gallas EJ
- Gallas EJ
- Gallo V
- Gallo V
- Gallop BJ
- Gallop BJ
- Gallus P
- Gallus P
- Galster G
- Galster G
- Gan KK
- Gan KK
- Gandrajula RP
- Gandrajula RP
- Gao J
- Gao YS
- Gao YS
- Gaob J
- Garberson F
- Garberson F
- Garcia Navarro JE
- Garcia Navarro JE
- Garcia BRM
- Garcia C
- Garcia C
- Garcia JAB
- Garcia-Sciveres M
- Garcia-Sciveres M
- Gardner RW
- Gardner RW
- Garelli N
- Garelli N
- Garonne V
- Garonne V
- Garrido MDMC
- Gatti C
- Gatti C
- Gaudio G
- Gaudio G
- Gaur B
- Gaur B
- Gauthier L
- Gauthier L
- Gauzzi P
- Gauzzi P
- Gavrilenko IL
- Gavrilenko IL
- Gay C
- Gay C
- Gaycken G
- Gaycken G
- Gazis EN
- Gazis EN
- Ge P
- Ge P
- Gecse Z
- Gecse Z
- Gee CNP
- Gee CNP
- Geerts DAA
- Geerts DAA
- Geich-Gimbel C
- Geich-Gimbel C
- Gellerstedt K
- Gellerstedt K
- Gemme C
- Gemme C
- Gemmell A
- Gemmell A
- Genest MH
- Genest MH
- Gentile S
- Gentile S
- George M
- George M
- George S
- George S
- Gerbaudo D
- Gerbaudo D
- Gershon A
- Gershon A
- Ghazlane H
- Ghazlane H
- Ghodbane N
- Ghodbane N
- Giacobbe B
- Giacobbe B
- Giagu S
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- Giangiobbe V
- Giangiobbe V
- Giannetti P
- Giannetti P
- Gianotti F
- Gianotti F
- Gibbard B
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- Gibson SM
- Gibson SM
- Gilchriese M
- Gilchriese M
- Gillam TPS
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- Gillberg D
- Gillberg D
- Gillman AR
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- Gingrich DM
- Gingrich M
- Giokaris N
- Giokaris N
- Giordani MP
- Giordani MP
- Giordano R
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- Giorgi FM
- Giorgi FM
- Giraud PF
- Giraud PF
- Giugni D
- Giugni D
- Giuliani C
- Giuliani C
- Giunta M
- Giunta M
- Gjelsten BK
- Gjelsten BK
- Gkialas I
- Gkialas I
- Gladilin LK
- Gladilin LK
- Glasman C
- Glasman C
- Glatzer J
- Glatzer J
- Glazov A
- Glazov A
- Glonti GL
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- Goblirsch-Kolb M
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- Goddard JR
- Goddard JR
- Godfrey J
- Godfrey J
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- Godlewski J
- Goeringer C
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- Goessling C
- Goessling C
- Goldfarb S
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- Golubkov D
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- Gomes A
- Gomes A
- Gonalo R
- Goncalo R
- Gonella L
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- Gonzalez de la Hoz S
- Gonzalez de la Hoz S
- Gonzalez Parra G
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- Gonzalez BA
- Gonzalez-Sevilla S
- Gonzalez-Sevilla S
- Goossens L
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- Gorbounov PA
- Gorbounov PA
- Gordon HA
- Gordon HA
- Gorelov I
- Gorelov I
- Gorini B
- Gorini B
- Gorini E
- Gorini E
- Gorisek A
- Gorisek A
- Gornicki E
- Gornicki E
- Goshaw AT
- Goshaw AT
- Gostkin MI
- Gostkin MI
- Gouighri M
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- Goujdami D
- Goujdami D
- Goulette MP
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- Goussiou AG
- Goussiou AG
- Goy C
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- Gozpinar S
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- Grabas HMX
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- Graber L
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- Grafstroem P
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- Gramling J
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- Grassi V
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- Gratchev V
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- Gray HM
- Gray HM
- Graziani E
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- Grebenyuk OG
- Grebenyuk OG
- Greenwood ZD
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- Gregersen K
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- Griffiths J
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- Grillo AA
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- Grinstein S
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- Griso SP
- Grivaz J-F
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- Grohs JP
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- Grohsjean A
- Gross AGE
- Gross E
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- Grossi GC
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- Groth-Jensen J
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- Guest D
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- Zurzolo G
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentre−of−massframeisusedtosuppressthelargemulti−jetbackground.Thecross−sectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
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- Abdallah J
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- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or τ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, φ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
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