Infinite time aggregation for the critical Patlak-Keller-Segel model in R2

We analyze the two-dimensional parabolic-elliptic Patlak-Keller-Segel model in the whole Euclidean space R2. Under the hypotheses of integrable initial data with finite second moment and entropy, we first show local in time existence for any mass of "free-energy solutions", namely weak solutions with some free energy estimates. We also prove that the solution exists as long as the entropy is controlled from above. The main result of the paper is to show the global existence of free-energy solutions with initial data as before for the critical mass 8 Π/Χ. Actually, we prove that solutions blow-up as a delta dirac at the center of mass when t→∞ keeping constant their second moment at any time. Furthermore, all moments larger than 2 blow-up as t→∞ if initially bounded

A Quest for Justice in Cuzco, Peru:Race and Evidence in the Case of Mercedes Ccorimanya Lavilla

The life of Mercedes Ccorimanya Lavilla renders a telling portrait of the pursuit of justice in Cuzco, Peru, revealing how courts of law can be key sites in the production and negotiation of racial and gender taxonomies. Mercedes (who was gang-raped as a young woman) illustrates the near-heroic efforts necessary to mount and pursue rape charges in Peruvian courts, where rape victims largely manage the construction of evidence in lieu of the state. In the following article, I reconstruct the social circumstances and legal institutional setting surrounding the rape trial of Mercedes Ccorimanya Lavilla through the use of historical and ethnographic materials. In arguing that race mutually defines women's sexuality in rural Peru, I show how (in order to achieve a conviction) Mercedes had to develop a strategy in which she instrumentally employed the languages of race to distance herself from her own indigeneity, as well as that of her alleged attackers

Análisis de la evolución jurisprudencial del Consejo de Estado sobre la acción de tutela contra providencias judiciales en Colombia

El Consejo de Estado, como órgano de cierre de la jurisdicción contencioso administrativa, tiene el mismo nivel jerárquico que la Corte Constitucional, según lo dispuesto en el artículo 116 de la Constitución Política de Colombia. La Corte Constitucional y el Consejo de Estado son órganos de la rama judicial autónomos e independientes. No obstante, la Corte ha conocido acerca de las acciones de tutela contra los fallos proferidos por el Consejo de Estado. Lo anterior ha ocasionado un conflicto de jurisdicciones entre estos dos cuerpos colegiados. Actualmente, en sus últimos fallos, el Consejo de Estado ha expresado que es procedente interponer esta acción contra una de sus providencias cuando estas vulneren derechos fundamentale

La crisis financiera del sistema público de pensiones en España

Both Colombia and Spain are states that face overcrowding of the elderly in their pension system, according to the figures presented at the II World Assembly on Aging in Madrid (UN, 2002), which discussed issues of a considerable increase in the population of older adults, not only in Developed countries, but in all countries of the world.  This increase in the elderly population has caused financial problems to the different pension systems in the world with respect to sustainability and the funds available to guarantee the right to a pension for older persons of retirement age. In Spain, especially, it is said that there is an imminent crisis in the Public Pension System. With the following article, it is aim to analyze the Spanish public pension system, describing its components and the incidence of its changes since the 1978 constitution.Tanto Colombia como España son Estados que afrontan sobrepoblación de adultos mayores según las cifras expuestas en la II Asamblea Mundial sobre Envejecimiento de Madrid (ONU, 2002), donde se discutieron temas sobre el aumento considerable de la población de los adultos mayores, no sólo en los países desarrollados sino en todos los países del mundo.  Este aumento en la población de adultos mayores ha ocasionado problemas financieros a los diferentes sistemas pensionales del mundo con respecto a la sostenibilidad y a los fondos con los que se cuenta para garantizar el derecho a una pensión a los adultos mayores en edad de jubilación, especialmente en España, donde se habla de una crisis en el Sistema Público de Pensiones. Con el siguiente artículo, se analiza el sistema público de pensiones español, haciendo una descripción de sus componentes y la incidencia de sus cambios desde la Constitución de 1978

Rickettsia felis Infection, Tunisia

We report, for the first time, serologic evidence of Rickettsia felis and R. aeschlimannii infections acquired in Tunisia from 1998 to 2003. We found that most patients with antibodies against both R. conorii and R. typhi had serologic evidence of R. felis infection

Neurobiology of suicide: do biomarkers exist?

Clinical risk factors have a low predictive value on suicide. This may explain the increasing interest in potential neurobiological correlates and specific heritable markers of suicide vulnerability. This review aims to present the current neurobiological findings that have been shown to be implicated in suicide completers and to discuss how postmortem studies may be useful in characterizing these individuals. Data on the role of the main neurobiological systems in suicidality, such as the neurotransmitter families, hypothalamic-pituitary-adrenal axis, neurotrophic factors, and polyamines, are exposed at the different biochemical, genetic, and epigenetic levels. Some neuroanatomic and neuropathological aspects as well as their in vivo morphological and functional neuroimaging correlates are also described. Except for the serotoninergic system, particularly with respect to the polymorphism of the gene coding for the serotonin transporter (5-HTTLPR) and brain-derived neurotrophic factor, data did not converge to produce a univocal consensus. The possible limitations of currently published studies are discussed, as well as the scope for long-term prospective studies

GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways

International audienceBACKGROUND:In spite of the recent discovery of genetic mutations in most myelodysplasic (MDS) patients, the pathophysiology of these disorders still remains poorly understood, and only few in vivo models are available to help unravel the disease.METHODS:We performed global specific gene expression profiling and functional pathway analysis in purified Sca1+ cells of two MDS transgenic mouse models that mimic human high-risk MDS (HR-MDS) and acute myeloid leukemia (AML) post MDS, with NRASD12 and BCL2 transgenes under the control of different promoters MRP8NRASD12/tethBCL-2 or MRP8[NRASD12/hBCL-2], respectively.RESULTS:Analysis of dysregulated genes that were unique to the diseased HR-MDS and AML post MDS mice and not their founder mice pointed first to pathways that had previously been reported in MDS patients, including DNA replication/damage/repair, cell cycle, apoptosis, immune responses, and canonical Wnt pathways, further validating these models at the gene expression level. Interestingly, pathways not previously reported in MDS were discovered. These included dysregulated genes of noncanonical Wnt pathways and energy and lipid metabolisms. These dysregulated genes were not only confirmed in a different independent set of BM and spleen Sca1+ cells from the MDS mice but also in MDS CD34+ BM patient samples.CONCLUSIONS:These two MDS models may thus provide useful preclinical models to target pathways previously identified in MDS patients and to unravel novel pathways highlighted by this study

The Attitudes to Ageing Questionnaire:Mokken Scaling Analysis

BACKGROUND:Hierarchical scales are useful in understanding the structure of underlying latent traits in many questionnaires. The Attitudes to Ageing Questionnaire (AAQ) explored the attitudes to ageing of older people themselves, and originally described three distinct subscales: (1) Psychosocial Loss (2) Physical Change and (3) Psychological Growth. This study aimed to use Mokken analysis, a method of Item Response Theory, to test for hierarchies within the AAQ and to explore how these relate to underlying latent traits. METHODS:Participants in a longitudinal cohort study, the Lothian Birth Cohort 1936, completed a cross-sectional postal survey. Data from 802 participants were analysed using Mokken Scaling analysis. These results were compared with factor analysis using exploratory structural equation modelling. RESULTS:Participants were 51.6% male, mean age 74.0 years (SD 0.28). Three scales were identified from 18 of the 24 items: two weak Mokken scales and one moderate Mokken scale. (1) 'Vitality' contained a combination of items from all three previously determined factors of the AAQ, with a hierarchy from physical to psychosocial; (2) 'Legacy' contained items exclusively from the Psychological Growth scale, with a hierarchy from individual contributions to passing things on; (3) 'Exclusion' contained items from the Psychosocial Loss scale, with a hierarchy from general to specific instances. All of the scales were reliable and statistically significant with 'Legacy' showing invariant item ordering. The scales correlate as expected with personality, anxiety and depression. Exploratory SEM mostly confirmed the original factor structure. CONCLUSIONS:The concurrent use of factor analysis and Mokken scaling provides additional information about the AAQ. The previously-described factor structure is mostly confirmed. Mokken scaling identifies a new factor relating to vitality, and a hierarchy of responses within three separate scales, referring to vitality, legacy and exclusion. This shows what older people themselves consider important regarding their own ageing

Bibliometric analysis of academic journal recommendations and requirements for surgical and anesthesiologic adverse events reporting.

BACKGROUND Standards for reporting surgical adverse events vary widely within the scientific literature. Failure to adequately capture adverse events hinders efforts to measure the safety of healthcare delivery and improve the quality of care. The aim of the present study is to assess the prevalence and typology of perioperative adverse event reporting guidelines among surgery and anesthesiology journals. MATERIALS AND METHODS In November 2021, three independent reviewers queried journal lists from the SCImago Journal & Country Rank (SJR) portal (www.scimagojr.com), a bibliometric indicator database for surgery and anesthesiology academic journals. Journal characteristics were summarized using SCImago, a bibliometric indicator database extracted from Scopus journal data. Quartile 1 (Q1) was considered the top quartile and Q4 bottom quartile based on the journal impact factor. Journal author guidelines were collected to determine whether adverse event reporting recommendations were included and, if so, the preferred reporting procedures. RESULTS Of 1,409 journals queried, 655 (46.5%) recommended surgical adverse event reporting. Journals most likely to recommend adverse event reporting were: 1) by category surgery (59.1%), urology (53.3%), and anesthesia (52.3%); 2) in top SJR quartiles (i.e. more influential); 3) by region, based in Western Europe (49.8%), North America (49.3%), and the Middle East (48.3%). CONCLUSIONS Surgery and anesthesiology journals do not consistently require or provide recommendations on perioperative adverse event reporting. Journal guidelines regarding adverse event reporting should be standardized and are needed to improve the quality of surgical adverse event reporting with the ultimate goal of improving patient morbidity and mortality