212 research outputs found
Muted change in Atlantic overturning circulation over some glacial-aged Heinrich events
Heinrich events—surges of icebergs into the North Atlantic Ocean—punctuated the last glacial period. The events are associated with millennial-scale cooling in the Northern Hemisphere. Fresh water from the melting icebergs is thought to have interrupted the Atlantic meridional overturning circulation, thus minimizing heat transport into the northern North Atlantic. The northward flow of warm water passes through the Florida Straits and is reflected in the distribution of seawater properties in this region. Here we investigate the northward flow through this region over the past 40,000 years using oxygen isotope measurements of benthic foraminifera from two cores on either side of the Florida Straits. These measurements allow us to estimate water density, which is related to flow through the thermal wind balance. We infer a substantial reduction of flow during Heinrich Event 1 and the Younger Dryas cooling, but little change during Heinrich Events 2 and 3, which occurred during an especially cold phase of the last glacial period. We speculate that because glacial circulation was already weakened before the onset of Heinrich Events 2 and 3, freshwater forcing had little additional effect. However, low-latitude climate perturbations were observed during all events. We therefore suggest that these perturbations may not have been directly caused by changes in heat transport associated with Atlantic overturning circulation as commonly assumed
DeepBrain: Functional Representation of Neural In-Situ Hybridization Images for Gene Ontology Classification Using Deep Convolutional Autoencoders
This paper presents a novel deep learning-based method for learning a
functional representation of mammalian neural images. The method uses a deep
convolutional denoising autoencoder (CDAE) for generating an invariant, compact
representation of in situ hybridization (ISH) images. While most existing
methods for bio-imaging analysis were not developed to handle images with
highly complex anatomical structures, the results presented in this paper show
that functional representation extracted by CDAE can help learn features of
functional gene ontology categories for their classification in a highly
accurate manner. Using this CDAE representation, our method outperforms the
previous state-of-the-art classification rate, by improving the average AUC
from 0.92 to 0.98, i.e., achieving 75% reduction in error. The method operates
on input images that were downsampled significantly with respect to the
original ones to make it computationally feasible
The Effect of Supplementing Mannan Oligosaccharide or Finely Ground Fiber, during the Summer on Body Temperature, Performance, and Blood Metabolites of Finishing Steers
Crossbred beef steers (12 pens, n=96) were used to determine the effect of adding Agrimos or 5% ground (1 in.) wheat straw compared to a control on body temperature, panting score and performance. Th ere were no differences in final BW, ADG, and DMI among treatments. Feed conversion was increased for cattle fed 5% additional ground straw when compared to control and Agrimos. Hot carcass weight, dressing %, LM area, and marbling score were not different among treatments. Cattle fed the control had greater 12th rib fat depth and USDA yield grade than cattle fed straw or Agrimos. Both average and maximum body temperatures were slightly greater for cattle fed Agrimos than for cattle fed control or added straw. Panting scores were decreased slightly for cattle fed the extra straw when compared to control and Agrimos. The addition of Agrimos or wheat straw to the diet had minimal effects on heat stress measures
Science and Ideology in Economic, Political, and Social Thought
This paper has two sources: One is my own research in three broad areas: business cycles, economic measurement and social choice. In all of these fields I attempted to apply the basic precepts of the scientific method as it is understood in the natural sciences. I found that my effort at using natural science methods in economics was met with little understanding and often considerable hostility. I found economics to be driven less by common sense and empirical evidence, then by various ideologies that exhibited either a political or a methodological bias, or both. This brings me to the second source: Several books have appeared recently that describe in historical terms the ideological forces that have shaped either the direct areas in which I worked, or a broader background. These books taught me that the ideological forces in the social sciences are even stronger than I imagined on the basis of my own experiences.
The scientific method is the antipode to ideology. I feel that the scientific work that I have done on specific, long standing and fundamental problems in economics and political science have given me additional insights into the destructive role of ideology beyond the history of thought orientation of the works I will be discussing
The Atacama Cosmology Telescope: Cosmology from Galaxy Clusters Detected via the Sunyaev-Zel'dovich Effect
We present constraints on cosmological parameters based on a sample of
Sunyaev-Zel'dovich-selected galaxy clusters detected in a millimeter-wave
survey by the Atacama Cosmology Telescope. The cluster sample used in this
analysis consists of 9 optically-confirmed high-mass clusters comprising the
high-significance end of the total cluster sample identified in 455 square
degrees of sky surveyed during 2008 at 148 GHz. We focus on the most massive
systems to reduce the degeneracy between unknown cluster astrophysics and
cosmology derived from SZ surveys. We describe the scaling relation between
cluster mass and SZ signal with a 4-parameter fit. Marginalizing over the
values of the parameters in this fit with conservative priors gives sigma_8 =
0.851 +/- 0.115 and w = -1.14 +/- 0.35 for a spatially-flat wCDM cosmological
model with WMAP 7-year priors on cosmological parameters. This gives a modest
improvement in statistical uncertainty over WMAP 7-year constraints alone.
Fixing the scaling relation between cluster mass and SZ signal to a fiducial
relation obtained from numerical simulations and calibrated by X-ray
observations, we find sigma_8 = 0.821 +/- 0.044 and w = -1.05 +/- 0.20. These
results are consistent with constraints from WMAP 7 plus baryon acoustic
oscillations plus type Ia supernoava which give sigma_8 = 0.802 +/- 0.038 and w
= -0.98 +/- 0.053. A stacking analysis of the clusters in this sample compared
to clusters simulated assuming the fiducial model also shows good agreement.
These results suggest that, given the sample of clusters used here, both the
astrophysics of massive clusters and the cosmological parameters derived from
them are broadly consistent with current models.Comment: 12 pages, 7 figures. Submitted to Ap
Sushi in the United States, 1945-1970
Sushi first achieved widespread popularity in the United States in
the mid-1960s. Many accounts of sushi’s US establishment foreground
the role of a small number of key actors, yet underplay
the role of a complex web of large-scale factors that provided the
context in which sushi was able to flourish. This article critically
reviews existing literature, arguing that sushi’s US popularity
arose from contingent, long-term, and gradual processes. It examines
US newspaper accounts of sushi during 1945–1970, which
suggest the discursive context for US acceptance of sushi was
considerably more propitious than generally acknowledged.
Using California as a case study, the analysis also explains
conducive social and material factors, and directs attention to
the interplay of supply- and demand-side forces in the favorable
positioning of this “new” food. The article argues that the US
establishment of sushi can be understood as part of broader
public acceptance of Japanese cuisine
The Earth BioGenome Project 2020: Starting the clock.
© The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Lewin, H. A., Richards, S., Lieberman Aiden, E., Allende, M. L., Archibald, J. M., Bálint, M., Barker, K. B., Baumgartner, B., Belov, K., Bertorelle, G., Blaxter, Mark L., Cai, J., Caperello, N. D., Carlson, K., Castilla-Rubio, J. C., Chaw, S-M., Chen, L., Childers, A. K., Coddington, J. A., Conde, D. A., Corominas, M., Crandall, K. A., Crawford, A. J., DiPalma, F., Durbin, R., Ebenezer, T. E., Edwards, S. V., Fedrigo, O., Flicek, P., Formenti, G., Gibbs, R. A., Gilbert, M. Thomas P., Goldstein, M. M., Graves, J. M., Greely, H. T., Grigoriev, I. V., Hackett, K. J., Hall, N., Haussler, D., Helgen, K. M., Hogg, C. J., Isobe, S., Jakobsen, K. S., Janke, A., Jarvis, E. D., Johnson, W. E., Jones, S. J. M., Karlsson, E. K., Kersey, P. J., Kim, J-H., Kress, W. J., Kuraku, S., Lawniczak, M. K. N., Leebens-Mack, J. H., Li, X., Lindblad-Toh, K., Liu, X., Lopez, J. V., Marques-Bonet, T., Mazard, S., Mazet, J. A. K., Mazzoni, C. J., Myers, E. W., O’Neill, R. J., Paez, S., Park, H., Robinson, G. E., Roquet, C., Ryder, O. A., Sabir, J. S. M., Shaffer, H. B., Shank, T. M., Sherkow, J. S., Soltis, P. S., Tang, B., Tedersoo, L., Uliano-Silva, M., Wang, K., Wei, X., Wetzer, R., Wilson, J. L., Xu, X., Yang, H., Yoder, A. D., Zhang, G. The Earth BioGenome Project 2020: starting the clock. Proceedings of the National Academy of Sciences of the United States of America, 119(4), (2022): e2115635118, https://doi.org/10.1073/pnas.2115635118.November 2020 marked 2 y since the launch of the Earth BioGenome Project (EBP), which aims to sequence all known eukaryotic species in a 10-y timeframe. Since then, significant progress has been made across all aspects of the EBP roadmap, as outlined in the 2018 article describing the project’s goals, strategies, and challenges (1). The launch phase has ended and the clock has started on reaching the EBP’s major milestones. This Special Feature explores the many facets of the EBP, including a review of progress, a description of major scientific goals, exemplar projects, ethical legal and social issues, and applications of biodiversity genomics. In this Introduction, we summarize the current status of the EBP, held virtually October 5 to 9, 2020, including recent updates through February 2021. References to the nine Perspective articles included in this Special Feature are cited to guide the reader toward deeper understanding of the goals and challenges facing the EBP
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