Joint Power Control and Structural Health Monitoring in Industry 4.0 Scenarios using Eclipse Arrowhead and Web of Things

The integration of legacy IoT ecosystems in Industry 4.0 scenarios requires human effort to adapt single devices. This process would highly benefit from features like device lookup, loose coupling and late binding. In this paper, we tackle the issue of integrating legacy monitoring systems and actuation systems in an industrial scenario, by looking into the Web of Things (WoT) as a communication standard and the Eclipse Arrowhead Framework (AHF) as a service orchestrator. More specifically, we propose a general architectural approach to enable closed-loop automation between the above mentioned legacy systems by leveraging the adaptation of the WoT to the AHF. Then, we develop a rule-based engine that enables the control of the actuation based on sensor values. Finally, we present a proof-of-concept use case where we integrate a Structural Health Monitoring (SHM) scenario with a power control actuation subsystem using the developed component

D1R/GluN1 complexes in the striatum integrate dopamine and glutamate signalling to control synaptic plasticity and cocaine-induced responses.

Convergent dopamine and glutamate signalling onto the extracellular signal-regulated kinase (ERK) pathway in medium spiny neurons (MSNs) of the striatum controls psychostimulant-initiated adaptive processes underlying long-lasting behavioural changes. We hypothesised that the physical proximity of dopamine D1 (D1R) and glutamate NMDA (NMDAR) receptors, achieved through the formation of D1R/NMDAR complexes, may act as a molecular bridge that controls the synergistic action of dopamine and glutamate on striatal plasticity and behavioural responses to drugs of abuse. We found that concomitant stimulation of D1R and NMDAR drove complex formation between endogenous D1R and the GluN1 subunit of NMDAR. Conversely, preventing D1R/GluN1 association with a cell-permeable peptide (TAT-GluN1C1) left individual D1R and NMDAR-dependent signalling intact, but prevented D1R-mediated facilitation of NMDAR-calcium influx and subsequent ERK activation. Electrophysiological recordings in striatal slices from mice revealed that D1R/GluN1 complexes control the D1R-dependent enhancement of NMDAR currents and long-term potentiation in D1R-MSN. Finally, intra-striatal delivery of TAT-GluN1C1 did not affect acute responses to cocaine but reduced behavioural sensitization. Our findings uncover D1R/GluN1 complexes as a major substrate for the dopamine-glutamate interaction in MSN that is usurped by addictive drugs to elicit persistent behavioural alterations. They also identify D1R/GluN1 complexes as molecular targets with a therapeutic potential for the vast spectrum of psychiatric diseases associated with an imbalance between dopamine and glutamate transmission

Elevated transaminases as a predictor of coma in a patient with anorexia nervosa: a case report and review of the literature

<p>Abstract</p> <p>Introduction</p> <p>Liver injury is a frequent complication associated with anorexia nervosa, and steatosis of the liver is thought to be the major underlying pathology. However, acute hepatic failure with transaminase levels over 1000 IU/mL and deep coma are very rare complications and the mechanism of pathogenesis is largely unknown.</p> <p>Case presentation</p> <p>A 37-year-old Japanese woman showed features of acute liver failure and hepatic coma which were not associated with hypoglycemia or hyper-ammonemia. Our patient's consciousness was significantly improved with the recovery of liver function and normalization of transaminase levels after administration of nutritional support.</p> <p>Conclusions</p> <p>Our case report demonstrates that transaminase levels had an inverse relationship with the consciousness of our patient, although the pathogenesis of coma remains largely unknown. This indicates that transaminase levels can be one of the key predictors of impending coma in patients with anorexia nervosa. Therefore, frequent monitoring of transaminase levels combined with rigorous treatment of the underlying nutritional deficiency and psychiatric disorder are necessary to prevent this severe complication.</p

MeV-scale sterile neutrino decays at the Fermilab Short-Baseline Neutrino program

Nearly-sterile neutrinos with masses in the MeV range and below would be produced in the beam of the Short-Baseline Neutrino (SBN) program at Fermilab. In this article, we study the potential for SBN to discover these particles through their subsequent decays in its detectors. We discuss the decays which will be visible at SBN in a minimal and non-minimal extension of the Standard Model, and perform simulations to compute the parameter space constraints which could be placed in the absence of a signal. We demonstrate that the SBN programme can extend existing bounds on well constrained channels such as N → νl+l− and N → l±π∓ while, thanks to the strong particle identification capabilities of liquid-Argon technology, also place bounds on often neglected channels such as N → νγ and N → νπ0. Furthermore, we consider the phenomenological impact of improved event timing information at the three detectors. As well as considering its role in background reduction, we note that if the light-detection systems in SBND and ICARUS can achieve nanosecond timing resolution, the effect of finite sterile neutrino mass could be directly observable, providing a smoking-gun signature for this class of models. We stress throughout that the search for heavy nearly-sterile neutrinos is a complementary new physics analysis to the search for eV-scale oscillations, and would extend the BSM programme of SBN while requiring no beam or detector modifications

Leptonic CP Violation and Neutrino Mass Models

We discuss leptonic mixing and CP violation at low and high energies, emphasizing possible connections between leptogenesis and CP violation at low energies, in the context of lepton flavour models. Furthermore we analyse weak basis invariants relevant for leptogenesis and for CP violation at low energies. These invariants have the advantage of providing a simple test of the CP properties of any lepton flavour model.Comment: 26 pages, no figures, submitted to the Focus Issue on `Neutrino Physics` edited by F. Halzen, M. Lindner and A. Suzuki, to be published in New Journal of Physic

High intensity neutrino oscillation facilities in Europe

The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the Fréjus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of μ+ and μ− beams in a storage ring. The far detector in this case is a 100 kt magnetized iron neutrino detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular He6 and Ne18, also stored in a ring. The far detector is also the MEMPHYS detector in the Fréjus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the physics reach of each facility, in particular for the measurement of CP violation in the lepton sector, and estimated the cost of construction. These have demonstrated that the best facility to build is the Neutrino Factory. However, if a powerful proton driver is constructed for another purpose or if the MEMPHYS detector is built for astroparticle physics, the Super Beam also becomes very attractive

Measurement of the muon decay spectrum with the ICARUS liquid Argon TPC

Examples are given which prove the ICARUS detector quality through relevant physics measurements. We study the muon decay energy spectrum from a sample of stopping muon events acquired during the test run of the ICARUS T600 detector. This detector allows the spatial reconstruction of the events with fine granularity, hence, the precise measurement of the range and dE/dx of the muon with high sampling rate. This information is used to compute the calibration factors needed for the full calorimetric reconstruction of the events. The Michel rho parameter is then measured by comparison of the experimental and Monte Carlo simulated muon decay spectra, obtaining rho = 0.72 +/- 0.06(stat.) +/- 0.08(syst.). The energy resolution for electrons below ~50 MeV is finally extracted from the simulated sample, obtaining (Emeas-Emc)/Emc = 11%/sqrt(E[MeV]) + 2%.Comment: 16 pages, 8 figures, LaTex, A4. Some text and 1 figure added. Final version as accepted for publication in The European Physical Journal

Simultaneous multi-frequency observation of the unknown redshift blazar PG 1553+113 in March-April 2008

The blazar PG 1553+113 is a well known TeV gamma-ray emitter. In this paper, we determine its spectral energy distribution using simultaneous multi-frequency data in order to study its emission processes. An extensive campaign was carried out between March and April 2008, where optical, X-ray, high-energy (HE) gamma-ray, and very-high-energy (VHE) gamma-ray data were obtained with the KVA, Abastumani, REM, RossiXTE/ASM, AGILE and MAGIC telescopes, respectively. This is the first simultaneous broad-band (i.e., HE+VHE) gamma-ray observation, though AGILE did not detect the source. We combine data to derive source's spectral energy distribution and interpret its double peaked shape within the framework of a synchrotron self compton modelComment: 5 pages, 2 figures, publishe