FORMING TOLERANCE IN STUDENTS MAJORING IN PEDAGOGY IN MULTICULTURAL EDUCATIONAL SPACE OF THE HIGHER EDUCATION INSTITUTION

Abstract. The article is devoted to the search for the solution of the problem of forming tolerance in students majoring in pedagogy. The multicultural and multinational nature of society in the Republic of Tatarstan, the intensification of the process of educational migration made the issues of multicultural education and upbringing of the younger generation timely. The solution of this problem is connected with the level of tolerance formation in teaching taff. Studies conducted at the Kazan Federal University show that at present this level cannot be considered sufficient for effective interaction with students, which affects the quality of education and upbringing. The given problem has determined the research purpose: to reveal potential of pedagogical disciplines in forming tolerance in studentsmajoring in pedagogy. The authors used the following methods of research: analysis of psychological and educational literature on the content characteristics of tolerance and aspects of its formation; the analysis of educational standards and programs of disciplines; systematization; synthesis. On the basis of theoretical analysis of available research and the authors’ own experience of working with students, the problem field of research was determined: forming students' tolerance in the multicultural environment of the higher education institution by creating organizational and pedagogicalconditions and selecting the means for their implementation. The means of implementing the organizational and pedagogical conditions offered by the authors are the disciplines of the basic and profiling components studied in the process of teaching students majoring in pedagogy. The data can be recommended to university lecturers, as well as to students for self-educational activities..Keywords: tolerance, the potential of pedagogical disciplines, mechanisms, organizational and pedagogical conditions, technologies

The case study technologies as the means of competency building approach realization in higher education of Russia

© Canadian Center of Science and Education. The problem of increasing education efficiency in Russian high school under the condition of well-organized educational process with using “Case-study” technology is considered in the article. The article is devoted to the methodology of case study, and especially its implementation in Kazan Federal University, the Institute of Philology and Intercultural Communication. The experiment was held in two groups (experimental and control) diagnosing communicative, social, occupational and educational cognitive motives and motives of self-actualization, avoiding failure and prestige. The study was conducted in such disciplines as “English Language”, “Training and education in the field of foreign languages”. To measure the number of observed qualities of student’s personality the diagnostic technique level of formation of students learning motivation was selected. The resulting figures revealed a positive trend from the use of case technology in the classroom with students

Formation of general cultural competencies of students in the educational space of the University

Worldwide basic social institution which carries out human adaptation to changing conditions is a system of education. The article discusses the role and place of liberal education in the training of future specialists. This article discusses the process of formation of common cultural competencies of students in the higher education system. The authors present a theoretical basis research problems and results of experimental studies on the implementation of the competency approach in accordance with the new educational standards in the integration of the national education system in the world educational space

Teaching Idiomatic English in Esp. Class

More and more researches illustrate a great role of idioms in foreign language education. While a great deal of these researches focuses on the positive impact idioms play in learning foreign languages, there is a need for more empirical research aimed at teaching idiomatic language, which requires effective teaching techniques. The authors of this paper made an attempt to meet this challenge. In this study, the research objective defined by the authors is to prove that humorous stories (anecdotes) promote the acquisition of idioms easily and efficiently. The leading research method was a three-stage experiment. To successfully conduct the experiment, there was compiled a list of ninety frequently used English idioms. Twenty two MA students volunteered to participate in this experiment. The obtained results indicated that the linguistic phenomena are “well-digested”™ when they are presented in the appealing way in the classroom. The paper discusses issues and practices of the techniques implemented in this study for teaching idiomatic English in ESP class and offers general recommendations for foreign language educators

Analysis of financial stability of insurance organizations of the Republic of Belarus

The article shows the importance of insurance development in the formation of the financial system of society. The method of assessing the financial stability of insurers on the basis of relative indicators is presented. The work of four insurance organizations operating in the Republic of Belarus was analyzed: BRUSP «Belgosstrakh», ZASO «Belneftestrakh», ZASO «TASK», ZASO «Kupala». Measures are proposed to improve the financial and economic activity of insurers.В статье показано значение развития страхования в формировании финансовой системы общества. Представлена методика оценки финансовой устойчивости страховщиков на основе относительных показателей. Проанализирована работа четырех страховых организаций, функционирующих в Республике Беларусь: БРУСП «Белгосстрах», ЗАСО «Белнефтестрах», ЗАСО «ТАСК», ЗАСО «Купала». Предложены мероприятия, призванные улучшить финансово-хозяйственную деятельность страховщиков

The role of individual protein kinase C isoforms in mouse mast cell function and their targeting by the immunomodulatory parasitic worm product, ES-62

ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, has been shown to modulate the immune system through subversion of signal transduction pathways operating in various immune system cells. With respect to human bone marrow-derived mast cells (BMMCs), ES-62 was previously shown to inhibit FcϵRI-mediated mast cell functional responses such as degranulation and pro-inflammatory cytokine release through a mechanism involving the degradation of PKC-α. At the same time, it was noted that the worm product was able to degrade certain other PKC isoforms but the significance of this was uncertain. In this study, we have employed PKC isoform KO mice to investigate the role of PKC-α, -β -ϵ, and -θ in mouse BMMCs in order to establish their involvement in mast cell-mediated responses and also, if their absence impacts on ES-62’s activity. The data obtained support that in response to antigen cross-linking of IgE bound to FcϵRI, pro-inflammatory cytokine release is controlled in part by a partnership between one conventional and one novel isoform with PKC-α and -θ acting as positive regulators of IL-6 and TNF-α production, while PKC-β and ϵ act as negative regulators of such cytokines. Furthermore, ES-62 appears to target certain other PKC isoforms in addition to PKC-α to inhibit cytokine release and this may enable it to more efficiently inhibit mast cell responses

Ovarian VEGF165b expression regulates follicular development, corpus luteum function and fertility

Angiogenesis and vascular regression are critical for the female ovulatory cycle. They enable progression and regression of follicular development, and corpora lutea formation and regression. Angiogenesis in the ovary occurs under the control of the vascular endothelial growth factor-A (VEGFA) family of proteins, which are generated as both pro-(VEGF165) and anti(VEGF165b)-angiogenic isoforms by alternative splicing. To determine the role of the VEGF165b isoforms in the ovulatory cycle, we measured VEGF165b expression in marmoset ovaries by immunohistochemistry and ELISA, and used transgenic mice over-expressing VEGF165b in the ovary. VEGF165b was expressed in the marmoset ovaries in granulosa cells and theca, and the balance of VEGF165b:VEGF165 was regulated during luteogenesis. Mice over-expressing VEGF165b in the ovary were less fertile than wild-type littermates, had reduced secondary and tertiary follicles after mating, increased atretic follicles, fewer corpora lutea and generated fewer embryos in the oviduct after mating, and these were more likely not to retain the corona radiata. These results indicate that the balance of VEGFA isoforms controls follicle progression and luteogenesis, and that control of isoform expression may regulate fertility in mammals, including in primates

Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner

Following platelet adhesion and primary activation at sites of vascular injury, secondary platelet activation is induced by soluble platelet agonists, such as ADP, ATP, thrombin and thromboxane. Zinc ions are also released from platelets and damaged cells and have been shown to act as a platelet agonist. However, the mechanism of zinc-induced platelet activation is not well understood. Here we show that exogenous zinc gains access to the platelet cytosol and induces full platelet aggregation that is dependent on platelet protein tyrosine phosphorylation, PKC and integrin αIIbβ3 activity and is mediated by granule release and secondary signalling. ZnSO4 increased the binding affinity of GpVI, but not integrin α2β1. Low concentrations of ZnSO4 potentiated platelet aggregation by collagen-related peptide (CRP-XL), thrombin and adrenaline. Chelation of intracellular zinc reduced platelet aggregation induced by a number of different agonists, inhibited zinc-induced tyrosine phosphorylation and inhibited platelet activation in whole blood under physiologically relevant flow conditions. Our data are consistent with a transmembrane signalling role for zinc in platelet activation during thrombus formation

Vascular endothelial growth factor-A 165 b ameliorates outer-retinal barrier and vascular dysfunction in the diabetic retina

Diabetic retinopathy (DR) is one of the leading causes of blindness in the developed world. Characteristic features of DR are retinal neurodegeneration, pathological angiogenesis and breakdown of both the inner and outer retinal barriers of the retinal vasculature and retinal pigmented epithelial (RPE)–choroid respectively. Vascular endothelial growth factor (VEGF-A), a key regulator of angiogenesis and permeability, is the target of most pharmacological interventions of DR. VEGF-A can be alternatively spliced at exon 8 to form two families of isoforms, pro- and anti-angiogenic. VEGF-A165a is the most abundant pro-angiogenic isoform, is pro-inflammatory and a potent inducer of permeability. VEGF-A165b is anti-angiogenic, anti-inflammatory, cytoprotective and neuroprotective. In the diabetic eye, pro-angiogenic VEGF-A isoforms are up-regulated such that they overpower VEGF-A165b. We hypothesized that this imbalance may contribute to increased breakdown of the retinal barriers and by redressing this imbalance, the pathological angiogenesis, fluid extravasation and retinal neurodegeneration could be ameliorated. VEGF-A165b prevented VEGF-A165a and hyperglycaemia-induced tight junction (TJ) breakdown and subsequent increase in solute flux in RPE cells. In streptozotocin (STZ)-induced diabetes, there was an increase in Evans Blue extravasation after both 1 and 8 weeks of diabetes, which was reduced upon intravitreal and systemic delivery of recombinant human (rh)VEGF-A165b. Eight-week diabetic rats also showed an increase in retinal vessel density, which was prevented by VEGF-A165b. These results show rhVEGF-A165b reduces DR-associated blood–retina barrier (BRB) dysfunction, angiogenesis and neurodegeneration and may be a suitable therapeutic in treating DR