Synchronous genitourinary lichen sclerosus signals a distinct urinary microbiome profile in men with urethral stricture disease.

PurposeAlterations in the urinary microbiome have been associated with urological diseases. The microbiome of patients with urethral stricture disease (USD) remains unknown. Our objective is to examine the microbiome of USD with a focus on inflammatory USD caused by lichen sclerosus (LS).MethodsWe collected mid-stream urine samples from men with LS-USD (cases; n = 22) and non-LS USD (controls; n = 76). DNA extraction, PCR amplification of the V4 hypervariable region of the 16S rRNA gene, and sequencing was done on the samples. Operational taxonomic units (OTUs) were defined using a > 97% sequence similarity threshold. Alpha diversity measurements of diversity, including microbiome richness (number of different OTUs) and evenness (distribution of OTUs) were calculated and compared. Microbiome beta diversity (difference between microbial communities) relationships with cases and controls were also assessed.ResultsFifty specimens (13 cases and 37 controls) produced a 16S rRNA amplicon. Mean sample richness was 25.9 vs. 16.8 (p = 0.076) for LS-USD vs. non-LS USD, respectively. LS-USD had a unique profile of bacteria by taxonomic order including Bacillales, Bacteroidales and Pasteurellales enriched urine. The beta variation of observed bacterial communities was best explained by the richness.ConclusionsMen with LS-USD may have a unique microbiologic richness, specifically inclusive of Bacillales, Bacteroidales and Pasteurellales enriched urine compared to those with non-LS USD. Further work will be required to elucidate the clinical relevance of these variations in the urinary microbiome

External Subsidies and Lasting Peace

Third parties are thought to face a trade-off in that those actions most likely to bring peace in the short run appear least likely to ensure its long-run stability. Yet the trade-off between conflict management and conflict resolution may be overstated. Analyzing an iterated three-player bargaining model with both information and commitment problems, we first demonstrate two conditions under which third parties may produce lasting peace through conditional subsidies, even without addressing underlying informational or commitment problems. Second, we illustrate this possibility by analyzing the impact of US foreign aid on patterns of conflict and peace between Israel and her neighbors. Our analysis indicates that the termination of the rivalry between Israel and Egypt was most likely not brought about by the Camp David accords or peacekeeping operations, but by sustained foreign aid provision. We discuss the implications for both this conflict and conflict management more broadly. </jats:p

Textstrukturen und weibliche Subjektivität in Texten von Leslie Kaplan

Zu Beginn der 80er Jahre macht sich in Frankreich eine innovative Prosaliteratur bemerkbar, die sich sowohl von der vorangegangenen theorieorientierten Avantgarde als auch vom konventionellen Roman unterscheidet. Die Autorin Leslie Kaplan hat diese von der Literaturkritik provisorisch als autre roman bezeichnete Strömung maßgeblich mitgeprägt. Ihre frühen Texte stehen mit ihrer experimentellen, nicht-narrativen Form noch deutlich unter dem Einfluss der theoriefreudigen 70er Jahre. Allmählich vollzieht sie jedoch die für die innovative Literatur der 80er als charakteristisch geltende \u27Rückkehr zum Erzählen\u27. Die Arbeit beschäftigt sich mit der Frage, welche Impulse Leslie Kaplan aus den feministischen Debatten der 70er Jahre bezieht. Untersucht werden die literaturästhetischen Erklärungen der Autorin, sowie die drei frühen Texte L\u27excès-l\u27usine (1982), Le criminel (1985) und Le Pont de Brooklyn (1987). Mit ihrem literarischen Programm eines \u27Schreibens ohne Machtausübung\u27 knüpft Kaplan implizit an die Diskussionen und Erkenntnisse der feministischen Kritik an, so eine These der Arbeit. Die literarischen Texte Kaplans kreisen um den Entwurf weiblicher Subjektivität, was ebenfalls ein zentrales Thema der Neuen Frauenliteratur war. Weibliche Subjektivität ist in den drei Texten als Offenheit entworfen. In L\u27excès-l\u27usine ist Offenheit noch negativ konstruiert als eine schmerzhafte Selbstauflösung, in Le criminel als ein Schwanken zwischen lustvoller Selbstentgrenzung und bedrohlichem Selbstverlust und in Le Pont de Brooklyn schließlich uneingeschränkt positiv als Aufgeschlossenheit und Fähigkeit, sich selbst in Frage zu stellen. Die Konstruktion einer nicht-hierarchischen Erzählstruktur erscheint dabei als Voraussetzung für den Entwurf von freien, selbstbestimmten weiblichen Figuren

Tolerance, adherence, and acceptability of a ketogenic 2.5:1 ratio, nutritionally complete, medium chain triglyceride-containing liquid feed in children and adults with drug-resistant epilepsy following a ketogenic diet

Objective: To investigate incorporating a ready-to-use 2.5:1 ratio liquid feed into a ketogenic diet (KD) in children and adults with drug-resistant epilepsy. Methods: Following a three-day baseline, patients (n = 19; age: 19 years [SD 13], range: 8–46 years) followed a KD for 28 days (control period), then incorporated ≥200 mL/day of a ready-to-use liquid feed, made with a ratio of 2.5 g of fat to 1 g of protein plus carbohydrate and including medium chain triglycerides ([MCTs]; 25.6% of total fat/100 mL) for 28 days as part of their KD (intervention period). Outcome measures (control vs intervention period) included gastrointestinal (GI) tolerance, adherence to KD and intervention feed, dietary intake, blood ß-hydroxybutyrate (BHB) concentration, seizure outcomes, health-related quality of life (HRQoL), acceptability and safety. Results: Compared to the control period, during the intervention period, the percentage of patients reporting no GI symptoms increased (+5% [SD 5], p = 0.02); adherence to the KD prescription was similar (p = 0.92) but higher in patients (n = 5) with poor adherence (&lt;50%) to KD during the control period (+33% [SD 26], p = 0.049); total MCT intake increased (+12.1 g/day [SD 14.0], p = 0.002), driven by increases in octanoic (C8; +8.3 g/day [SD 6.4], p &lt; 0.001) and decanoic acid (C10; +5.4 g/day [SD 5.4], p &lt; 0.001); KD ratio decreased (p = 0.047), driven by a nonsignificant increase in protein intake (+11 g/day [SD 44], p = 0.29); seizure outcomes were similar (p ≥ 0.63) but improved in patients (n = 6) with the worst seizure outcomes during the control period (p = 0.04); and HRQoL outcomes were similar. The intervention feed was well adhered to (96% [SD 8]) and accepted (≥88% of patients confirmed). Significance: These findings provide an evidence-base to support the effective management of children and adults with drug-resistant epilepsy following a KD with the use of a ready-to-use, nutritionally complete, 2.5:1 ratio feed including MCTs. Plain language summary: This study examined the use of a ready-to-use, nutritionally complete, 2.5:1 ratio (2.5 g of fat to 1 g of protein plus carbohydrate) liquid feed, including medium chain triglycerides (MCTs), into a ketogenic diet (KD) in children and adults with drug-resistant epilepsy. The results show that the 2.5:1 ratio feed was well tolerated, adhered to, and accepted in these patients. Increases in MCT intake (particularly C8 and C10) and improvements in seizure outcomes (reduced seizure burden and intensity) and KD adherence also occurred with the 2.5:1 ratio feed in patients with the worst seizures and adherence, respectively.</p

Inducing behavioural change in society through communication and education in sustainable manufacturing

The United Nations considers the mobilization of the broad public to be the essential requirement for achieving a shift towards a more sustainable development. Science can play a vital role in Education for Sustainable Development (ESD) by contributing to ESD-related research and development on the one hand, and by becoming active awareness raisers themselves in education and multiplier networks. Specifically, the use of special Learnstruments, and investment inOpen Educationformats among other educational tools, may pave the way for accelerated apprehension and appreciation of sustainable manufacturing topics among the greater populace

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes