1,704 research outputs found
An examination of two-year and four-year continuing education curriculum in post-secondary hospitality management programs
The purpose of this study was to examine continuing education in foodservice management and higher education focuses on how academic programs view continuing education. Four specific areas were focused upon in this study (1) operational issues in continuing education, (2) program design of continuing education, (3) academic practices related to continuing education, and (4) subject areas of foodservice which could be a part of a continuing education program; When possible, importance and performance scores were calculated, allowing for a robust analysis. The analysis includes general descriptive statistics such as frequencies and means and appropriate inferential statistics
Polymeric IgA and immune complex concentrations in IgA-related renal disease
Polymeric IgA and immune complex concentrations in IgA-related renal disease. Polymeric IgA (PIgA) and immune complex concentrations in IgA-related renal disease were measured in cross sectional and longitudinal studies to establish the relationship between these parameters and both mucosal infection and renal dysfunction. These studies were performed in 50 patients with IgA nephropathy (IgAN), 17 patients with Henoch Schönlein purpura nephritis (HSPN), 11 control patients with IgA negative, diffuse mesangial proliferative glomerulonephritis (DMPGN) and 50 healthy controls. Total PIgA (PIgAT) and PIgA subclass concentrations were measured using a secretory component binding enzyme immunoassay and isotype specific immune complex concentrations were measured using conglutinin (K) binding immunoassays. In cross sectional studies patients with IgAN were found to have increased concentrations of PIgAT, PIgA1, K-IgA1 and K-IgA2 compared to controls. In the longitudinal studies controls and patients had significant increases in PIgAT and PIgA1 concentrations during infection. However, in patients with IgAN, the increases were greater, persisted for longer, and PIgA2 concentrations were also increased. K-IgA1 and K-IgA2 concentrations increased significantly during episodes of infection in IgAN patients in contrast to controls. Patients with HSPN had results similar to those of IgAN patients. No significant correlation was found between PIgA or K-IgA concentrations, and either serum creatinine concentrations or the degree of hematuria. The results indicate that patients with IgA-related renal disease have abnormal regulation of PIgA and immune complexed IgA, and that these abnormalities are exaggerated during mucosal infection
PATHOLOGICAL CHANGES IN 37 HUMAN RENAL HOMOTRANSPLANTS TREATED WITH IMMUNOSUPPRESSIVE DRUGS
Pathological changes in thirtyâseven human renal homotransplants are described. All the patients had been treated with Imuran, prednisone and actinomycin C; ten had also received local Xâirradiation to the transplant. Fifteen of the transplants were from patients in a rejection phase. Most of these kidneys were enlarged because of interstitial oedema and several were speckled with petechial hemorrhages. There was fibrinoid necrosis of afferent arterioles and interlobular arteries in twelve of the transplants, and the peritubular capillaries were disrupted in ten. Swelling of the arteriolar endothelial cells, fibrinoâplatelet and fibrous intimal thickening of interlobular arteries were also common. In most of the transplants there was a light infiltration with small lymphocytes, plasma cells and a few larger pyroninophilic cells. Similar changes were present in the pelvis and ureter. Twelve of the transplants came from patients whose last rejection episode had been clinically reversed 14 to 117 days previously. AH these kidneys were enlarged because of compensatory hypertrophy. Seven showed some intimal thickening of the interlobular arteries and in three there was fibrinoid necrosis of arteriolar walls. Tubular atrophy, interstitial fibrosis and a light cellular infiltration were also common changes. Only one kidney appeared normal. Three transplants came from patients who had not experienced clinical evidence of a rejection episode. One showed acute tubular necrosis due to prolonged ischemia at the time of transplantation; one was almost normal; the third showed vascular lesions suggestive of old unrecognised rejection. Seven transplants had either not functioned or developed some complication necessitating their early removal. One of these was infarcted due to obstruction of the venous drainage; two showed massive acute tubular necrosis due to ischaemia; two, which were incompatible with their hosts on the basis of ABO blood groups, failed to excrete urine and showed distension of the arterioles and glomerular capillaries with erythrocytes; one bled uncontrollably from the pelvis; one came from a patient who died at twelve hours from hyperkalemia and hyponatremia during a massive postâoperative diuresis. This work was aided by grants Aâ6283, Aâ6344, HEâ07735, AMâ07772, AIâ01452, and OGâ27 from the U.S. Public Health Service, and by a grant from the Medical Research Council. The necropsies on cases described in this paper were either performed or supervised by Drs Coral Cotterall, Doris Courington, Carol Ewing, R. B. Hill, J. Jamroz, D. W. King, D. M. Lang, Martha La Via, Elizabeth Macintyre, N. McGrath, J. C. Maisel, C. G. Massion, D. R. Meekin, H. B. Neustein, S. Ryan, and D. E. Smith. We would like to thank all these pathologists for making this study possible. We are particularly grateful to Dr D. T. Rowlands, who supervised some of the necropsies, for his helpful coâoperation throughout this study. Expert assistance in preparing the sections and photomicrographs was given by Miss Jane Rendall. © 1965 BJU International Compan
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Schistosomiasis Morbidity Hotspots: Roles of the Human Host, the Parasite and Their Interface in the Development of Severe Morbidity.
Schistosomiasis is the second most important human parasitic disease in terms of socioeconomic impact, causing great morbidity and mortality, predominantly across the African continent. For intestinal schistosomiasis, severe morbidity manifests as periportal fibrosis (PPF) in which large tracts of macro-fibrosis of the liver, visible by ultrasound, can occlude the main portal vein leading to portal hypertension (PHT), sequelae such as ascites and collateral vasculature, and ultimately fatalities. For urogenital schistosomiasis, severe morbidity manifests as pathology throughout the urinary system and genitals, and is a definitive cause of squamous cell bladder carcinoma. Preventative chemotherapy (PC) programmes, delivered through mass drug administration (MDA) of praziquantel (PZQ), have been at the forefront of schistosomiasis control programmes in sub-Saharan Africa since their commencement in Uganda in 2003. However, despite many successes, 'biological hotspots' (as distinct from 'operational hotspots') of both persistent high transmission and morbidity remain. In some areas, this failure to gain control of schistosomiasis has devastating consequences, with not only persistently high infection intensities, but both "subtle" and severe morbidity remaining prevalent. These hotspots highlight the requirement to revisit research into severe morbidity and its mechanisms, a topic that has been out of favor during times of PC implementation. Indeed, the focality and spatially-structured epidemiology of schistosomiasis, its transmission persistence and the morbidity induced, has long suggested that gene-environmental-interactions playing out at the host-parasite interface are crucial. Here we review evidence of potential unique parasite factors, host factors, and their gene-environmental interactions in terms of explaining differential morbidity profiles in the human host. We then take the situation of schistosomiasis mansoni within the Albertine region of Uganda as a case study in terms of elucidating the factors behind the severe morbidity observed and the avenues and directions for future research currently underway within a new research and clinical trial programme (FibroScHot)
Recommended from our members
Schistosomiasis Morbidity Hotspots: Roles of the Human Host, the Parasite and Their Interface in the Development of Severe Morbidity.
Schistosomiasis is the second most important human parasitic disease in terms of socioeconomic impact, causing great morbidity and mortality, predominantly across the African continent. For intestinal schistosomiasis, severe morbidity manifests as periportal fibrosis (PPF) in which large tracts of macro-fibrosis of the liver, visible by ultrasound, can occlude the main portal vein leading to portal hypertension (PHT), sequelae such as ascites and collateral vasculature, and ultimately fatalities. For urogenital schistosomiasis, severe morbidity manifests as pathology throughout the urinary system and genitals, and is a definitive cause of squamous cell bladder carcinoma. Preventative chemotherapy (PC) programmes, delivered through mass drug administration (MDA) of praziquantel (PZQ), have been at the forefront of schistosomiasis control programmes in sub-Saharan Africa since their commencement in Uganda in 2003. However, despite many successes, 'biological hotspots' (as distinct from 'operational hotspots') of both persistent high transmission and morbidity remain. In some areas, this failure to gain control of schistosomiasis has devastating consequences, with not only persistently high infection intensities, but both "subtle" and severe morbidity remaining prevalent. These hotspots highlight the requirement to revisit research into severe morbidity and its mechanisms, a topic that has been out of favor during times of PC implementation. Indeed, the focality and spatially-structured epidemiology of schistosomiasis, its transmission persistence and the morbidity induced, has long suggested that gene-environmental-interactions playing out at the host-parasite interface are crucial. Here we review evidence of potential unique parasite factors, host factors, and their gene-environmental interactions in terms of explaining differential morbidity profiles in the human host. We then take the situation of schistosomiasis mansoni within the Albertine region of Uganda as a case study in terms of elucidating the factors behind the severe morbidity observed and the avenues and directions for future research currently underway within a new research and clinical trial programme (FibroScHot)
Seasonal distribution of genetic types of planktonic foraminifer morphospecies in the Santa Barbara Channel and its paleoceanographic implications
We present data on the temporal distribution of planktonic foraminifer genotypes (small subunit (SSU) ribosomal (r) RNA gene) and morphospecies (sediment traps) collected during 1999 in the Santa Barbara Channel. The sampling was undertaken with special emphasis on paleoceanographically important morphospecies, predominantly Globigerina bulloides. We found the same genotype of G. bulloides (type IId) in all the changing hydrographic regimes associated with this region throughout the annual cycle with the exception of January, when we recorded the additional presence of the high-latitude G. bulloides type IIa. We identified three new genotypes: Neogloboquadrina dutertrei type Ic, N. pachyderma dextral type II, and Turborotalita quinqueloba type IId. Our data suggest that G. bulloides type IId and possibly even the new genotypes listed above may be associated specifically with the complex hydrography or other environmental features characteristic of this area. Since G. bulloides type IId occurs throughout the year and its peak fluxes are related to different hydrographic regimes, we argue that the physical properties of the water column are not the major factor influencing the distribution and growth of this genotype. In sediment trap samples we found a skewed coiling ratio for G. bulloides (most likely representing type IId), which is related neither to sea surface temperature nor to genotypic difference. This study illustrates the necessity to map both the spatial and temporal distribution of the genetic types, especially in areas of paleoceanographic interest, where geochemical and paleontological proxies are being calibrated
Aki associated with macroscopic glomerular hematuria: Clinical and pathophysiologic consequences
Hematuria is a common finding in various glomerular diseases. This article reviews the clinical data on glomerular
hematuria and kidney injury, as well as the pathophysiology of hematuria-associated renal damage. Although
glomerular hematuria has been considered a clinical manifestation of glomerular diseases without real
consequences on renal function and long-term prognosis, many studies performed have shown a relationship
between macroscopic glomerular hematuria and AKI and have suggested that macroscopic hematuria-associated
AKI is related to adverse long-term outcomes. Thus, up to 25% of patients with macroscopic hematuriaâ
associated AKI do not recover baseline renal function. Oral anticoagulation has been associated with glomerular
macrohematuriaârelated kidney injury. Several pathophysiologic mechanisms may account for the tubular injury
found on renal biopsy specimens. Mechanical obstruction by red blood cell casts was thought to play a role. More
recent evidence points to cytotoxic effects of oxidative stress induced by hemoglobin, heme, or iron released from
red blood cells. These mechanisms of injury may be shared with hemoglobinuria or myoglobinuria-induced AKI.
Heme oxygenase catalyzes the conversion of heme to biliverdin and is protective in animal models of heme
toxicity. CD163, the recently identified scavenger receptor for extracellular hemoglobin, promotes the activation
of anti-inflammatory pathways, opening the gates for novel therapeutic approachesThis work was supported by FIS (Programa Miguel Servet)
to J.A.M.; ISCIII and FEDER funds CP04/00060, PS09/00447,
Sociedad Espa~nola de Nefrologia, ISCIII-RETIC REDinREN/RD06/
0016, Comunidad de Madrid/FRACM/S-BIO0283/2006, Programa
IntensificaciĂłn Actividad Investigadora (ISCIII/) to A.O.; FIS 10/
02668 and AITER (AsociaciĂłn para el Estudio y Tratamiento de las
Enfermedades Renales) to E.G. and M.P.; and ISCIII-Redes
RECAVA (RD06/0014/0035) and ISCIII funds PI10/00072 and
Fundacion Lilly to J.E
Sensory fusion in Physarum polycephalum and implementing multi-sensory functional computation
Surface electrical potential and observational growth recordings were made of a protoplasmic tube of the slime mould Physarum polycephalum in response to a multitude of stimuli with regards to sensory fusion or multisensory integration. Each stimulus was tested alone and in combination in order to evaluate for the first time the effect that multiple stimuli have on the frequency of streaming oscillation. White light caused a decrease in frequency whilst increasing the temperature and applying a food source in the form of oat flakes both increased the frequency. Simultaneously stimulating P. polycephalum with light and oat flake produced no net change in frequency, while combined light and heat stimuli showed an increase in frequency smaller than that observed for heat alone. When the two positive stimuli, oat flakes and heat, were combined, there was a net increase in frequency similar to the cumulative increases caused by the individual stimuli. Boolean logic gates were derived from the measured frequency change. © 2014
Preparing aquatic research for an extreme future: call for improved definitions and responsive, multidisciplinary approaches
© The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Aoki, L. R., Brisbin, M. M., Hounshell, A. G., Kincaid, D. W., Larson, E., Sansom, B. J., Shogren, A. J., Smith, R. S., & Sullivan-Stack, J. Preparing aquatic research for an extreme future: call for improved definitions and responsive, multidisciplinary approaches. Bioscience, 72(6), (2022): 508-520, https://doi.org/10.1093/biosci/biac020.Extreme events have increased in frequency globally, with a simultaneous surge in scientific interest about their ecological responses, particularly in sensitive freshwater, coastal, and marine ecosystems. We synthesized observational studies of extreme events in these aquatic ecosystems, finding that many studies do not use consistent definitions of extreme events. Furthermore, many studies do not capture ecological responses across the full spatial scale of the events. In contrast, sampling often extends across longer temporal scales than the event itself, highlighting the usefulness of long-term monitoring. Many ecological studies of extreme events measure biological responses but exclude chemical and physical responses, underscoring the need for integrative and multidisciplinary approaches. To advance extreme event research, we suggest prioritizing pre- and postevent data collection, including leveraging long-term monitoring; making intersite and cross-scale comparisons; adopting novel empirical and statistical approaches; and developing funding streams to support flexible and responsive data collection
Diabetic Neuropathy: A cross-sectional study of the relationships among tests of neurophysiology
OBJECTIVE â To determine the relationships among large, small, and autonomic fiber neurophysiological measures in a cross-sectional study of patients with diabetes. RESEARCH DESIGN AND METHODS â We assessed 130 individuals: 25 healthy subjects and 105 subjects with diabetes. Subjects were classified by the presence or absence of neuropathy by physical examination. All subjects underwent autonomic testing, nerve conduc-tion studies, quantitative sensory testing, and nerve-axon reflex vasodilation in addition to quantifiable neurological examination and symptom scores. Correlation and cluster analysis were used to determine relationships between and among different neurophysiological testing parameters. RESULTS â Results of neurophysiological tests were abnormal in patients with clinical evi-dence of diabetic neuropathy compared with results in healthy control subjects and in those without neuropathy (P 0.01, all tests). The correlations among individual tests varied widely, both within (r range0.5â0.9, NS to0.001) and between test groups (r range0.2â0.5, NS to0.01). A two-step hierarchical cluster analysis revealed that neurophysiological tests do not aggregate by typical âsmall, â âlarge, â or âautonomic â nerve fiber subtypes
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