169 research outputs found
TOI-150: A transiting hot Jupiter in the TESS southern CVZ
We report the detection of a hot Jupiter ($M_{p}=1.75_{-0.17}^{+0.14}\
M_{J}R_{p}=1.38\pm0.04\ R_{J}\log
g=4.152^{+0.030}_{-0.043}\beta=-79.59^{\circ}$). We confirm the
planetary nature of the candidate TOI-150.01 using radial velocity observations
from the APOGEE-2 South spectrograph and the Carnegie Planet Finder
Spectrograph, ground-based photometric observations from the robotic
Three-hundred MilliMeter Telescope at Las Campanas Observatory, and Gaia
distance estimates. Large-scale spectroscopic surveys, such as APOGEE/APOGEE-2,
now have sufficient radial velocity precision to directly confirm the signature
of giant exoplanets, making such data sets valuable tools in the TESS era.
Continual monitoring of TOI-150 by TESS can reveal additional planets and
subsequent observations can provide insights into planetary system
architectures involving a hot Jupiter around a star about halfway through its
main-sequence life.Comment: 13 pages, 3 figures, 2 tables, accepted to ApJ
Mid-IR Luminosities and UV/Optical Star Formation Rates at z<1.4
UV continuum and mid-IR emission constitute two widely used star formation
indicators at intermediate and high redshifts. We study 2430 galaxies with
z<1.4 in the Extended Groth Strip with MIPS 24 mic observations from FIDEL,
spectroscopy from DEEP2, and UV, optical, and near-IR photometry from AEGIS.
The data are coupled with stellar population models and Bayesian SED fitting to
estimate dust-corrected SFRs. In order to probe the dust heating from stellar
populations of various ages, the derived SFRs were averaged over various
timescales--from 100 Myr for "current" SFR to 1--3 Gyr for long-timescale SFRs.
These SED-based UV/optical SFRs are compared to total infrared luminosities
extrapolated from 24 mic observations. We find that for the blue, actively star
forming galaxies the correlation between the IR luminosity and the UV/optical
SFR shows a decrease in scatter when going from shorter to longer SFR-averaging
timescales. We interpret this as the greater role of intermediate age stellar
populations in heating the dust than what is typically assumed. This holds over
the entire redshift range. Many so-called green valley galaxies are simply
dust-obscured actively star-forming galaxies. However, there exist 24
mic-detected galaxies, some with L>10^11 L_sun, yet with little current star
formation. For them a reasonable amount of dust absorption of stellar light is
sufficient to produce the observed levels of IR. In our sample optical and
X-ray AGNs do not contribute on average more than ~50% to the mid-IR
luminosity, and we see no evidence for a large population of "IR excess"
galaxies (Abridged).Comment: Accepted for publication in ApJ. Content identical to arXiv version
1. No color figure
Percepción de la ciberseguridad: : ciberdelitos, normas legales y políticas de seguridad
The objective of the study is to establish a relationship between cybersecurity, cybercrimes, current legal regulations and cybersecurity policies associated with electronic and computer media in Panama, an online form was applied remotely during the months of June-July year 2022, to the faculty coordinators and professors who belong to the School of Informatics for Educational and Business Management in eight academic units, and who have specialized studies in the area of ??Administration of Information Centers, Auditing and Security of Information Systems. A percentage 92.59% responded to this instrument, which compiled the results of the years of academic benefits and services, teaching category and academic-professional training in the specialty area, as well as information related to cybersecurity policies and backups of important information. As a conclusive aspect, it was determined that 96.96% of the respondents fully agree that teaching actions are required in terms of cybersecurity policies applied to the use and management of computer equipment, technological resources and digital media.Con el objetivo de establecer una relación entre la ciberseguridad, los ciberdelitos, las normas legales vigentes y las políticas de ciberseguridad asociados a los medios electrónicos e informáticos en Panamá, se aplicó un formulario en línea de manera remota durante los meses de junio-julio del año 2022, a los coordinadores de facultad y profesores que pertenecen a la Escuela de Informática para la Gestión Educativa y Empresarial en ocho unidades académicas, que cuentan con estudios especializados en el área de Administración de Centros de Información, Auditoría y Seguridad de Sistemas de Información. El 92.59% respondieron dicho instrumento, el cual recopiló los resultados de los años de prestaciones y servicios académicos, categoría docente y la formación académico-profesional en el área de especialidad, así como información relacionada con políticas de ciberseguridad y respaldos de información importante. Como aspecto concluyente, se determinó que el 96.96% de los encuestados está totalmente de acuerdo que se requieren de acciones de docencia en materia de políticas de ciberseguridad aplicadas al uso y manejo de los equipos informáticos, recursos tecnológicos y medios de comunicación digital
Percepción de la ciberseguridad:
Con el objetivo de establecer una relación entre la ciberseguridad, los ciberdelitos, las normas legales vigentes y las políticas de ciberseguridad asociados a los medios electrónicos e informáticos en Panamá, se aplicó un formulario en línea de manera remota durante los meses de junio-julio del año 2022, a los coordinadores de facultad y profesores que pertenecen a la Escuela de Informática para la Gestión Educativa y Empresarial en ocho unidades académicas, que cuentan con estudios especializados en el área de Administración de Centros de Información, Auditoría y Seguridad de Sistemas de Información. El 92.59% respondieron dicho instrumento, el cual recopiló los resultados de los años de prestaciones y servicios académicos, categoría docente y la formación académico-profesional en el área de especialidad, así como información relacionada con políticas de ciberseguridad y respaldos de información importante. Como aspecto concluyente, se determinó que el 96.96% de los encuestados está totalmente de acuerdo que se requieren de acciones de docencia en materia de políticas de ciberseguridad aplicadas al uso y manejo de los equipos informáticos, recursos tecnológicos y medios de comunicación digital
The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment
The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in
operation since July 2014. This paper describes the second data release from
this phase, and the fourteenth from SDSS overall (making this, Data Release
Fourteen or DR14). This release makes public data taken by SDSS-IV in its first
two years of operation (July 2014-2016). Like all previous SDSS releases, DR14
is cumulative, including the most recent reductions and calibrations of all
data taken by SDSS since the first phase began operations in 2000. New in DR14
is the first public release of data from the extended Baryon Oscillation
Spectroscopic Survey (eBOSS); the first data from the second phase of the
Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2),
including stellar parameter estimates from an innovative data driven machine
learning algorithm known as "The Cannon"; and almost twice as many data cubes
from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous
release (N = 2812 in total). This paper describes the location and format of
the publicly available data from SDSS-IV surveys. We provide references to the
important technical papers describing how these data have been taken (both
targeting and observation details) and processed for scientific use. The SDSS
website (www.sdss.org) has been updated for this release, and provides links to
data downloads, as well as tutorials and examples of data use. SDSS-IV is
planning to continue to collect astronomical data until 2020, and will be
followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14
happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov
2017 (this is the "post-print" and "post-proofs" version; minor corrections
only from v1, and most of errors found in proofs corrected
Galaxy Zoo: Quantifying Morphological Indicators of Galaxy Interaction
We use Galaxy Zoo 2 visual classifications to study the morphological
signatures of interaction between similar-mass galaxy pairs in the Sloan
Digital Sky Survey. We find that many observable features correlate with
projected pair separation; not only obvious indicators of merging, disturbance
and tidal tails, but also more regular features, such as spiral arms and bars.
These trends are robustly quantified, using a control sample to account for
observational biases, producing measurements of the strength and separation
scale of various morphological responses to pair interaction. For example, we
find that the presence of spiral features is enhanced at scales < 70 h^-1 kpc,
probably due to both increased star formation and the formation of tidal tails.
On the other hand, the likelihood of identifying a bar decreases significantly
in pairs with separations < 30 h^-1 kpc, suggesting that bars are suppressed by
close interactions between galaxies of similar mass. We go on to show how
morphological indicators of physical interactions provide a way of
significantly refining standard estimates for the frequency of close pair
interactions, based on velocity offset and projected separation. The presence
of loosely wound spiral arms is found to be a particularly reliable signal of
an interaction, for projected pair separations up to ~100 h^-1 kpc. We use this
indicator to demonstrate our method, constraining the fraction of low-redshift
galaxies in truly interacting pairs, with M_* > 10^9.5 M_Sun and mass ratio <
4, to be between 0.4 - 2.7 per cent.Comment: Accepted to MNRAS on November 12, 201
Structure Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors
There is an urgent need for new treatments for Chagas disease, a parasitic infection which mostly impacts South and Central America. We previously reported on the discovery of GSK3494245/DDD01305143, a preclinical candidate for visceral leishmaniasis which acted through inhibition of the Leishmania proteasome. A related analogue, active against Trypanosoma cruzi, showed suboptimal efficacy in an animal model of Chagas disease, so alternative proteasome inhibitors were investigated. Screening a library of phenotypically active analogues against the T. cruzi proteasome identified an active, selective pyridazinone, the development of which is described herein. We obtained a cryo-EM co-structure of proteasome and a key inhibitor and used this to drive optimization of the compounds. Alongside this, optimization of the absorption, distribution, metabolism, and excretion (ADME) properties afforded a suitable compound for mouse efficacy studies. The outcome of these studies is discussed, alongside future plans to further understand the series and its potential to deliver a new treatment for Chagas disease.</p
An ultrahot Neptune in the Neptune desert
About 1 out of 200 Sun-like stars has a planet with an orbital period shorter than one day: an ultrashort-period planet. All of the previously known ultrashort-period planets are either hot Jupiters, with sizes above 10 Earth radii (R⊕), or apparently rocky planets smaller than 2 R⊕. Such lack of planets of intermediate size (the ‘hot Neptune desert’) has been interpreted as the inability of low-mass planets to retain any hydrogen/helium (H/He) envelope in the face of strong stellar irradiation. Here we report the discovery of an ultrashort-period planet with a radius of 4.6 R⊕ and a mass of 29 M⊕, firmly in the hot Neptune desert. Data from the Transiting Exoplanet Survey Satellite revealed transits of the bright Sun-like star LTT 9779 every 0.79 days. The planet’s mean density is similar to that of Neptune, and according to thermal evolution models, it has a H/He-rich envelope constituting 9.0^(+2.7)_(−2.9)% of the total mass. With an equilibrium temperature around 2,000 K, it is unclear how this ‘ultrahot Neptune’ managed to retain such an envelope. Follow-up observations of the planet’s atmosphere to better understand its origin and physical nature will be facilitated by the star’s brightness (V_(mag) = 9.8)
The Future of Rheumatoid Arthritis and Hand Surgery - Combining Evolutionary Pharmacology and Surgical Technique
Rheumatoid arthritis is a systemic autoimmune disease of uncertain aetiology, which is characterized primarily by synovial inflammation with secondary skeletal destructions
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