An interferometric determination of the refractive part of optical constants for carbon and silver across soft X-ray absorption edges

International audienceInterferometric, direct determinations of the f 1 scattering factor near absorption edges in the soft x-ray range is demonstrated. The interferometric system, which is based on wave front division (no beam splitter) with plane mirrors only, produces a linear fringe pattern. The principle consists in direct measuring of the fringe shift occurring upon insertion of a sample into one interferometer arm, by means of a dedicated detection system. This provides the optical thickness, which in turn gives the f 1 factor, knowing either the sample mass per unit surface, or the sample thickness and density. With the sample being probed in transmission under near normal incidence, the determination of f 1 is not perturbed by the absorption part of the complex scattering factor. Therefore, f 1 data obtained here can be said new and independent with respect to those obtained previously, in the sense that they are obtained from a new, purely experimental technique, and are neither deduced from nor perturbed by absorption. The interferometer design used can be implemented in a very large spectral range. For demonstrating the ability of this interferometric system to provide such new f 1 data, a thin free-standing carbon foil near the K edge (from 4.1 to 4.65 nm, 302-267 eV), and a membrane-supported silver layer near an M edge (from 2.6 to 3.8 nm, 477-326 eV) were used as test objects

Internal frequency conversion extreme ultraviolet interferometer using mutual coherence properties of two high-order-harmonic sources

International audienceWe report on an innovative two-dimensional imaging extreme ultraviolet (XUV) interferometer operating at 32 nm based on the mutual coherence of two laser high order harmonics (HOH) sources, separately generated in gas. We give the first evidence that the two mutually coherent HOH sources can be produced in two independent spatially separated gas jets, allowing for probing centimeter-sized objects. A magnification factor of 10 leads to a micron resolution associated with a subpicosecond temporal resolution. Single shot interferograms with a fringe visibility better than 30% are routinely produced. As a test of the XUV interferometer, we measure a maximum electronic density of 3×10^20 cm^−3 1.1 ns after the creation of a plasma on aluminum target

Transdisciplinary Joint Seminar Studies: Conflits et Interprétations

This report details the research activity carried out from 2009 to date under the Transdisciplinary Joint Seminar Studies of the universities of Aoyama Gakuin, Franche-Comté and Tsukuba. Through study sessions and conferences as well as individual research papers, the issue of conflict and interpretation is addressed across the specific fields of study from the three distinct considerations of circulation, representation and language. 要旨本報告は2009年から現在まで「青山学院大学・フランシュコンテ大学・筑波大学異分野共同セミナー」において行われた研究活動をまとめたものである。分科会、講演、ならびに個々の論文において論じられた「循環」「表象」「言語」の考察を通じて、「衝突」と「解釈」をめぐる諸問題が検証される

A Priori Modelling of Fire Test One

Chapter 10 in the book: The Dalmarnock Fire Tests: Experiments and Modelling, Edited by G. Rein, C. Abecassis Empis and R. Carvel, Published by the School of Engineering and Electronics, University of Edinburgh, 2007. ISBN 978-0-9557497-0-4An international round-robin study of fire modelling was conducted prior to the Dalmarnock Fire Tests in order to assess the state-of-the-art of fire modelling in real scenarios. The philosophy behind the Dalmarnock Fire Tests was to provide instrumentation density suitable for comparison to field models and designed the scenario for maximum test reproducibility. Each participating team independently simulated a priori the test using a common detailed description of the compartment geometry, fuel packages, ignition source and ventilation conditions. The aim of the exercise was to forecast the test results as accurately as possible, and not to provide an engineering analysis with adequate conservative assumptions or safety factors. The modelling results and experimental measurements are compared among themselves, allowing for conclusions on the robustness, reliability and accuracy of current modelling practices. The results indicate large scatter and considerable disparity among predicted fires and also differing from the experimental data. The Dalmarnock Fire Test One was benchmarked against a second test to establish the potential experimental variability. The scatter of the simulations is much larger than the experimental error and the experimental variability. The study emphasises on the inherent difficulty of predicting fire dynamics and demonstrates that the main source of scatter is originated in the many degrees of freedom and the uncertainty in the input parameters. The conclusions from the study are made public to encourage debate and exchange of views on the topic of fire modelling

Round-robin study of a priori modelling predictions of the Dalmarnock Fire Test One

Peer-reviewed journal paper published in 2009 about the international modelling exercise conducted in 2006.An international study of fire modelling was conducted prior to the Dalmarnock Fire Test One in order to assess the state-of-the-art of fire simulations using a round-robin approach. This test forms part of the Dalmarnock Fire Tests, a series of experiments conducted in 2006 in a high-rise building. The philosophy behind the tests was to provide measurements in a realistic fire scenario involving multiple fuel packages and non-trivial fire growth, and with an instrumentation density suitable for comparison with computational fluid dynamics models. Each of the seven round-robin teams independently simulated the test scenario a priori using a common detailed description of the compartment geometry, fuel packages, ignition source and ventilation conditions. The aim of the exercise was to forecast the fire development as accurately as possible and compare the results. The aim was not to provide an engineering analysis with conservative assumptions or safety factors. Comparison of the modelling results shows a large scatter and considerable disparity among the predictions, and between predictions and experimental measurements. The scatter of the simulations is much larger than the error and variability expected in the experiments. The study emphasises on the inherent difficulty of modelling fire dynamics in complex fire scenarios like Dalmarnock, and shows that the accuracy to predict fire growth (i.e. evolution of the heat released rate) is, in general, poor

The “Goldilocks Zoneâ€? from a redox perspectiveâ€â€�Adaptive vs. deleterious responses to oxidative stress in striated muscle

Consequences of oxidative stress may be beneficial or detrimental in physiological systems. An organ system's position on the “hormetic curve� is governed by the source and temporality of reactive oxygen species (ROS) production, proximity of ROS to moieties most susceptible to damage, and the capacity of the endogenous cellular ROS scavenging mechanisms. Most importantly, the resilience of the tissue (the capacity to recover from damage) is a decisive factor, and this is reflected in the disparate response to ROS in cardiac and skeletal muscle. In myocytes, a high oxidative capacity invariably results in a significant ROS burden which in homeostasis, is rapidly neutralized by the robust antioxidant network. The up-regulation of key pathways in the antioxidant network is a central component of the hormetic response to ROS. Despite such adaptations, persistent oxidative stress over an extended time-frame (e.g., months to years) inevitably leads to cumulative damages, maladaptation and ultimately the pathogenesis of chronic diseases. Indeed, persistent oxidative stress in heart and skeletal muscle has been repeatedly demonstrated to have causal roles in the etiology of heart disease and insulin resistance, respectively. Deciphering the mechanisms that underlie the divergence between adaptive and maladaptive responses to oxidative stress remains an active area of research for basic scientists and clinicians alike, as this would undoubtedly lead to novel therapeutic approaches. Here, we provide an overview of major types of ROS in striated muscle and the divergent adaptations that occur in response to them. Emphasis is placed on highlighting newly uncovered areas of research on this topic, with particular focus on the mitochondria, and the diverging roles that ROS play in muscle health (e.g., exercise or preconditioning) and disease (e.g., cardiomyopathy, ischemia, metabolic syndrome)

Heat stress-induced protection of endothelial function against ischaemic injury is abolished by ATP-sensitive potassium channel blockade in the isolated rat heart

1. The protection conferred by heat stress (HS) against myocardial ischaemia-reperfusion injury, in terms of mechanical function preservation and infarct size reduction, is well documented and mechanisms underlying these effects have been extensively explored. However, the effect of HS on coronary circulation is less known. The aim of this study was thus to investigate the role of ATP-sensitive potassium (K(ATP)) channels in the protection against ischaemic injury afforded by HS to the coronary endothelial function. 2. Twenty-four hours after whole body hyperthermia (42°C for 15 min, H groups) or sham anaesthesia (Sham groups), isolated perfused rat hearts were subjected to a 15 min stabilization period followed by a 30 min infusion of either 0.3 μM glibenclamide (Gli, a K(ATP) channel blocker) or its vehicle (V). Hearts were then exposed to a low-flow ischaemia (30 min)-reperfusion (20 min) (I/R) or normally perfused (50 min), after which coronaries were precontracted with 0.1 μM U-46619. Finally, the response to the endothelium-dependent vasodilator, 5-hydroxytryptamine (5-HT, 10 μM) was compared to that of the endothelium-independent vasodilator, sodium nitroprusside (SNP, 3 μM). 3. In hearts from Sham-V and Sham-Gli groups, I/R selectively diminished 5-HT-induced vasodilatation without affecting the vasodilatation to SNP. In V-treated groups, prior HS preserved the vasodilatation produced by 5-HT. This HS-induced protection was abolished by Gli treatment. 4. In conclusion, these results suggest that K(ATP) channel activation contributes to the preservation of coronary endothelial function conferred by heat stress against ischaemic insult