519 research outputs found
Prompt high-energy emission from gamma-ray bursts in the internal shock model
The prompt GRB emission is thought to arise from electrons accelerated in
internal shocks propagating within a highly relativistic outflow. The launch of
Fermi offers the prospect of observations with unprecedented sensitivity in
high-energy (>100 MeV) gamma-rays. The aim is to explore the predictions for HE
emission from internal shocks, taking into account both dynamical and radiative
aspects, and to deduce how HE observations constrain the properties of the
relativistic outflow. The emission is modeled by combining a time-dependent
radiative code with a dynamical code giving the evolution of the physical
conditions in the shocked regions.Synthetic lightcurves and spectra are
compared to observations. The HE emission deviates significantly from
analytical estimates, which tend to overpredict the IC component, when the time
dependence and full cross-sections are included. The exploration of the
parameter space favors the case where the dominant process in the BATSE range
is synchrotron emission. The HE component becomes stronger for weaker magnetic
fields. The HE lightcurve can display a prolonged pulse duration due to IC
emission, or even a delayed peak compared to the BATSE range.Alternatively,
having dominant IC emission in the BATSE range requires most electrons to be
accelerated into a steep power-law distribution and implies strong 2nd order IC
scattering. In this case, the BATSE and HE lightcurves are very similar. The
combined dynamical and radiative approach allows a firm appraisal of GRB HE
prompt emission. A diagnostic procedure is presented to identify from
observations the dominant emission process and derive constrains on the bulk
Lorentz factor, particle density and magnetic field of the outflow.Comment: 28 pages, 20 figures, accepted for publication in A&
Bacterial and Phytoplankton Responses to Nutrient Amendments in a Boreal Lake Differ According to Season and to Taxonomic Resolution
Nutrient limitation and resource competition in bacterial and phytoplankton communities may appear different when considering different levels of taxonomic resolution. Nutrient amendment experiments conducted in a boreal lake on three occasions during one open water season revealed complex responses in overall bacterioplankton and phytoplankton abundance and biovolume. In general, bacteria were dominant in spring, while phytoplankton was clearly the predominant group in autumn. Seasonal differences in the community composition of bacteria and phytoplankton were mainly related to changes in observed taxa, while the differences across nutrient treatments within an experiment were due to changes in relative contributions of certain higher- and lower-level phylogenetic groups. Of the main bacterioplankton phyla, only Actinobacteria had a treatment response that was visible even at the phylum level throughout the season. With increasing resolution (from 75 to 99% sequence similarity) major responses to nutrient amendments appeared using 454 pyrosequencing data of 16S rRNA amplicons. This further revealed that OTUs (defined by 97% sequence similarity) annotated to the same highly resolved freshwater groups appeared to occur during different seasons and were showing treatment-dependent differentiation, indicating that OTUs within these groups were not ecologically coherent. Similarly, phytoplankton species from the same genera responded differently to nutrient amendments even though biovolumes of the majority of taxa increased when both nitrogen and phosphorus were added simultaneously. The bacterioplankton and phytoplankton community compositions showed concurrent trajectories that could be seen in synchronous succession patterns over the season. Overall, our data revealed that the response of both communities to nutrient changes was highly dependent on season and that contradictory results may be obtained when using different taxonomic resolutions
Melting of PCM in a thermal energy storage unit: Numerical investigation and effect of nanoparticle enhancement
The present paper describes the analysis of the melting process in a single vertical shell-and-tube latent heat thermal energy storage (LHTES), unit and it is directed at understanding the thermal performance of the system. The study is realized using a computational fluid-dynamic (CFD) model that takes into account of the phase-change phenomenon by means of the enthalpy method. Fluid flow is fully resolved in the liquid phase-change material (PCM) in order to elucidate the role of natural convection. The unsteady evolution of the melting front and the velocity and temperature fields is detailed. Temperature profiles are analyzed and compared with experimental data available in the literature. Other relevant quantities are also monitored, including energy stored and heat flux exchanged between PCM and HTF. The results demonstrate that natural convection within PCM and inlet HTF temperature significantly affects the phase-change process. Thermal enhancement through the dispersion of highly conductive nanoparticles in the base PCM is considered in the second part of the paper. Thermal behavior of the LHTES unit charged with nano-enhanced PCM is numerically analyzed and compared with the original system configuration. Due to increase of thermal conductivity, augmented thermal performance is observed: melting time is reduced of 15% when nano-enhanced PCM with particle volume fraction of 4% is adopted. Similar improvements of the heat transfer rate are also detecte
Framing Ethnic Variations in Alcohol Outcomes from Biological Pathways to Neighborhood Context
Background
Health disparities research seeks to eliminate disproportionate negative health outcomes experienced in some racial/ethnic minority groups. This brief review presents findings on factors associated with drinking and alcohol‐related problems in racial/ethnic groups. Methods
Those discussed are as follows: (i) biological pathways to alcohol problems, (ii) gene × stress interactions, (iii) neighborhood disadvantage, stress, and access to alcohol, and (iv) drinking cultures and contexts. Results
These factors and their interrelationships are complex, requiring a multilevel perspective. Conclusions
The use of interdisciplinary teams and an epigenetic focus are suggested to move the research forward. The application of multilevel research to policy, prevention, and intervention programs may help prioritize combinations of the most promising intervention targets
Mechanistic investigation of Rh(i)-catalysed asymmetric Suzuki–Miyaura coupling with racemic allyl halides
Understanding how catalytic asymmetric reactions with racemic starting materials can operate would enable new enantioselective cross-coupling reactions that give chiral products. Here we propose a catalytic cycle for the highly enantioselective Rh(I)-catalysed Suzuki–Miyaura coupling of boronic acids and racemic allyl halides. Natural abundance 13C kinetic isotope effects provide quantitative information about the transition-state structures of two key elementary steps in the catalytic cycle, transmetallation and oxidative addition. Experiments with configurationally stable, deuterium-labelled substrates revealed that oxidative addition can happen via syn- or anti-pathways, which control diastereoselectivity. Density functional theory calculations attribute the extremely high enantioselectivity to reductive elimination from a common Rh complex formed from both allyl halide enantiomers. Our conclusions are supported by analysis of the reaction kinetics. These insights into the sequence of bond-forming steps and their transition-state structures will contribute to our understanding of asymmetric Rh–allyl chemistry and enable the discovery and application of asymmetric reactions with racemic substrates
How to Teach Entrepreneurship to Communication and Creative Industries Students
This handbook has been written as a result of work undertaken in the "CreBiz - Business Development Laboratory Study Module for Creative Industries" project. The objective of creating the study module is to enhance the business knowledge of undergraduate and graduate students of arts, humanities and media and communications, i.e. individuals, who have potential to be (self) employed after their graduation in the field of creative industries. Special focus in the study module is given to the latent entrepreneurial propensities, i.e. personal qualities and skills of the individual that would enable students to pursue an entrepreneurial career when given the opportunity or incentive to new venture creation
A single sub-km Kuiper Belt object from a stellar Occultation in archival data
The Kuiper belt is a remnant of the primordial Solar System. Measurements of
its size distribution constrain its accretion and collisional history, and the
importance of material strength of Kuiper belt objects (KBOs). Small, sub-km
sized, KBOs elude direct detection, but the signature of their occultations of
background stars should be detectable. Observations at both optical and X-ray
wavelengths claim to have detected such occultations, but their implied KBO
abundances are inconsistent with each other and far exceed theoretical
expectations. Here, we report an analysis of archival data that reveals an
occultation by a body with a 500 m radius at a distance of 45 AU. The
probability of this event to occur due to random statistical fluctuations
within our data set is about 2%. Our survey yields a surface density of KBOs
with radii larger than 250 m of 2.1^{+4.8}_{-1.7} x 10^7 deg^{-2}, ruling out
inferred surface densities from previous claimed detections by more than 5
sigma. The fact that we detected only one event, firmly shows a deficit of
sub-km sized KBOs compared to a population extrapolated from objects with r>50
km. This implies that sub-km sized KBOs are undergoing collisional erosion,
just like debris disks observed around other stars.Comment: To appear in Nature on December 17, 2009. Under press embargo until
1800 hours London time on 16 December. 19 pages; 7 figure
Effects of sub-lethal concentrations of mupirocin on global transcription in Staphylococcus aureus 8325-4 and a model for escape from inhibition
Staphylococcus aureus is a major pathogen in both hospital and community settings causing infections ranging from mild skin and wound infections to life-threatening systemic illness. Gene expression changes due to the stringent response have been studied in Staphylococcus aureus using lethal concentrations of mupirocin but no studies have investigated the effects of sub-lethal concentrations. S. aureus 8325-4
was exposed to sub-inhibitory concentrations of mupirocin. The production of ppGpp was determined via HPLC and the effects on global transcription were studied by
RNAseq analysis. Growth inhibition had occurred after 1 h of treatment and metabolic
analysis revealed that the stringent response alarmone ppGpp was detected and GTP
concentrations decreased. Transcriptome profiles showed that global transcriptional
alterations were similar to those for S. aureus after treatment with lethal concentrations
of mupirocin including the repression of genes involved in transcription, translation and replication machineries. Furthermore, up-regulation for genes involved in stress responses, amino acid biosynthesis and transport as well as for some virulence factor
genes was observed. However, ppGpp was not detectable after 12 or 24 h and cell growth had resumed although some transcriptional changes remained. Sub-lethal
concentrations of mupirocin induce the stringent response but cells adapt and resume growth once ppGpp levels decrease
Ecosystem responses to increased organic carbon concentration: comparing results based on longterm monitoring and whole-lake experimentation
Recent increases in terrestrial dissolved organic carbon (DOC) concentrations in northern inland waters have many ecological consequences. We examined available data on carbon cycles and food webs of 2 boreal headwater lakes in southern Finland. Basic limnology and catchment characteristics of a pristine lake, Valkea-Kotinen (VK), were monitored over the past 25 years while the lake has undergone browning and DOC increased from similar to 11 to 13 mg L-1. Pronounced changes in the early 2000s represent a regime shift in DOC concentration and color. Lake Alinen Mustajarvi (AM) was manipulated for 2 years by additions of labile DOC (cane sugar), raising the DOC concentration from similar to 10 to 12 mg L-1, but not changing light conditions. The 2 different approaches both revealed increased concentrations and efflux of carbon dioxide (CO2) from the lakes and thus net heterotrophy and changes in the pelagic community structure following an increase in DOC concentration. Long-term monitoring of VK revealed a decline in phytoplankton primary production (PP) along with browning, which was reflected in retarded growth of young (1-2-year-old) perch. In the experimentally manipulated lake (AM), PP was not affected, and the growth of young perch was more variable. The results suggested the importance of a pathway from labile DOC via benthic invertebrates to perch. Although provided with this extra resource, the food chain based on DOC proved inefficient. Long-term monitoring and whole-lake experimentation are complementary approaches for revealing how freshwater ecosystems respond to climate and/or atmospheric deposition-induced changes, such as browning.Peer reviewe
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