187 research outputs found
Composite Accretion Disk and White Dwarf Photosphere Analyses of the FUSE and HST Observations of EY Cygni
We explore the origin of FUSE and HST STIS far UV spectra of the dwarf nova,
EY Cyg, during its quiescence using \emph{combined} high gravity photosphere
and accretion disk models as well as model accretion belts. The best-fitting
single temperature white dwarf model to the FUSE plus HST STIS spectrum of EY
Cygni has TK, log , with an Si abundance of 0.1 x
solar and C abundance of 0.2 x solar but the distance is only 301 pc. The
best-fitting composite model consists of white dwarf with TK,
log , plus an accretion belt with TK covering 27% of
the white dwarf surface with V km/s. The accretion belt
contributes 63% of the FUV light and the cooler white dwarf latitudes
contribute 37%. This fit yields a distance of 351 pc which is within 100 pc of
our adopted distance of 450 pc. EY Cyg has very weak C {\sc iv} emission and
very strong N {\sc v} emission, which is atypical of the majority of dwarf
novae in quiescence. We also conducted a morphological study of the
surroundings of EY Cyg using direct imaging in narrow nebular filters from
ground-based telescopes. We report the possible detection of nebular material^M
associated with EY Cygni. Possible origins of the apparently large N {\scv}/C
{\sc iv} emission ratio are discussed in the context of nova explosions,
contamination of the secondary star and accretion of nova abundance-enriched
matter back to the white dwarf via the accretion disk or as a descendant of a
precursor binary that survived thermal timescale mass transfer. The scenario
involving pollution of the secondary by past novae may be supported by the
possible presence of a nova remnant-like nebula around EY Cyg.Comment: To appear in AJ, Oct. 2004. 5 figures, including 2 color ones (2D
pictures
An International Ultraviolet Explorer Archival Study of Dwarf Novae in Outburst
We present a synthetic spectral analysis of nearly the entire far ultraviolet
International Ultraviolet Explorer (IUE) archive of spectra of dwarf novae in
or near outburst. The study includes 46 systems of all dwarf nova subtypes both
above and below the period gap. The spectra were uniformly analyzed using
synthetic spectral codes for optically thick accretion disks and stellar
photospheres along with the best-available distance measurements or estimates.
We present newly estimated accretion rates and discuss the implications of our
study for disk accretion physics and CV evolution.Comment: Accepted for publication in the ApJ, Part
Far Ultraviolet Observations of the Dwarf Novae SS Aur and RU Peg in Quiescence
We have analyzed the Far Ultraviolet Spectrocopic Explorer (FUSE) spectra of
two U Gem-Type dwarf novae, SS Aur and RU Peg, observed 28 days and 60 days
(respectively) after their last outburst. In both systems the FUSE spectra (905
- 1182 A) reveal evidence of the underlying accreting white dwarf exposed in
the far UV. Our grid of theoretical models yielded a best-fitting photosphere
to the FUSE spectra with Teff=31,000K for SS Aur and Teff=49,000K for RU Peg.
This work provides two more dwarf nova systems with known white dwarf
temperatures above the period gap where few are known. The absence of CIII
(1175 A) absorption in SS Aur and the elevation of N above solar suggests the
possibility that SS Aur represents an additional accreting white dwarf where
the surface C/N ratio derives from CNO processing. For RU Peg, the modeling
uncertainties prevent any reliable conclusions about the surface abundances and
rotational velocity.Comment: AJ, Oct. 200
Head Impact Exposure in Youth Football: Elementary School Ages 9–12 Years and the Effect of Practice Structure
Head impact exposure in youth football has not been well-documented, despite children under the age of 14 accounting for 70% of all football players in the United States. The objective of this study was to quantify the head impact exposure of youth football players, age 9–12, for all practices and games over the course of single season. A total of 50 players (age = 11.0 ± 1.1 years) on three teams were equipped with helmet mounted accelerometer arrays, which monitored each impact players sustained during practices and games. During the season, 11,978 impacts were recorded for this age group. Players averaged 240 ± 147 impacts for the season with linear and rotational 95th percentile magnitudes of 43 ± 7 g and 2034 ± 361 rad/s(2). Overall, practice and game sessions involved similar impact frequencies and magnitudes. One of the three teams however, had substantially fewer impacts per practice and lower 95th percentile magnitudes in practices due to a concerted effort to limit contact in practices. The same team also participated in fewer practices, further reducing the number of impacts each player experienced in practice. Head impact exposures in games showed no statistical difference. While the acceleration magnitudes among 9–12 year old players tended to be lower than those reported for older players, some recorded high magnitude impacts were similar to those seen at the high school and college level. Head impact exposure in youth football may be appreciably reduced by limiting contact in practices. Further research is required to assess whether such a reduction in head impact exposure will result in a reduction in concussion incidence
Head Impact Exposure in Youth and Collegiate American Football
The relationship between head impact and subsequent brain injury for American football players is not well defined, especially for youth. The objective of this study is to quantify and assess Head Impact Exposure (HIE) metrics among youth and collegiate football players. This multiseason study enrolled 639 unique athletes (354 collegiate; 285 youth, ages 9–14), recording 476,209 head impacts (367,337 collegiate; 108,872 youth) over 971 sessions (480 collegiate; 491 youth). Youth players experienced 43 and 65% fewer impacts per competition and practice, respectively, and lower impact magnitudes compared to collegiate players (95th percentile peak linear acceleration (PLA, g) competition: 45.6 vs 61.9; 95th percentile PLA practice: 42.6 vs 58.8; 95th percentile peak rotational acceleration (PRA, rad∙s–2) competition: 2262 vs 4422; 95th percentile PRA practice: 2081 vs 4052; 95th percentile HITsp competition: 25.4 vs 32.8; 95th percentile HITsp practice: 23.9 vs 30.2). Impacts during competition were more frequent and of greater magnitude than during practice at both levels. Quantified comparisons of head impact frequency and magnitude between youth and collegiate athletes reveal HIE differences as a function of age, and expanded insight better informs the development of age-appropriate guidelines for helmet design, prevention measures, standardized testing, brain injury diagnosis, and recovery management
The Dwarf Novae During Quiescence
We present a synthetic spectral analysis of nearly the entire FUV IUE archive
of spectra of DNe in or near quiescence. We have examined all of the systems
for which S/N permitted an analysis. The study includes 53 systems of all DN
subtypes both above and below the period gap. The spectra were uniformly
analyzed using synthetic spectral codes for optically thick accretion disks and
stellar photospheres along with the best-available distance measurements or
estimates. We present newly determined approximate WD temperatures or upper
limits and estimated accretion rates. The average temperature of WDs in DNe
below the period gap is ~18,000K. For WDs in DNe above the period gap, the
average WD temperature is ~26,000K. There is a flux component, in addition to a
WD photosphere, which contributes >60% of the flux in the FUV in 53% of the
quiescent DNe in this study. We find that for 41% of the DNe in our sample, a
WD photosphere provides >60% of the FUV flux. Accretion rates estimated from
the FUV alone for the sample of DNe during quiescence ranged from 10^-12
Msun/yr to 10^-10 Msun/yr.The additional flux component is almost certainly not
an optically thick accretion disk since, according to the disk instability
model, the disk should be optically thin and too cool during DN quiescence to
be a significant FUV continuum emitter. Among the candidates for the second
component of FUV light are the quiescent inner disk, a hot equatorial accretion
belt, and a hot rotating ring. The implications of our study for disk accretion
physics and CV evolution are discussed.Comment: 36 pages, 3 tables, 8 figures, final accepted version of manuscrip
Investigating the Host Binding Signature on the Plasmodium falciparum PfEMP1 Protein Family
The Plasmodium falciparum erythrocyte membrane protein 1
(PfEMP1) family plays a central role in antigenic variation and cytoadhesion of
P. falciparum infected erythrocytes. PfEMP1
proteins/var genes are classified into three main
subfamilies (UpsA, UpsB, and UpsC) that are hypothesized to have different roles
in binding and disease. To investigate whether these subfamilies have diverged
in binding specificity and test if binding could be predicted by adhesion domain
classification, we generated a panel of 19 parasite lines that primarily
expressed a single dominant var transcript and assayed binding
against 12 known host receptors. By limited dilution cloning, only UpsB and UpsC
var genes were isolated, indicating that UpsA
var gene expression is rare under in vitro
culture conditions. Consequently, three UpsA variants were obtained by rosette
purification and selection with specific monoclonal antibodies to create a more
representative panel. Binding assays showed that CD36 was the most common
adhesion partner of the parasite panel, followed by ICAM-1 and TSP-1, and that
CD36 and ICAM-1 binding variants were highly predicted by adhesion domain
sequence classification. Binding to other host receptors, including CSA, VCAM-1,
HABP1, CD31/PECAM, E-selectin, Endoglin, CHO receptor “X”, and
Fractalkine, was rare or absent. Our findings identify a category of larger
PfEMP1 proteins that are under dual selection for ICAM-1 and CD36 binding. They
also support that the UpsA group, in contrast to UpsB and UpsC
var genes, has diverged from binding to the major
microvasculature receptor CD36 and likely uses other mechanisms to sequester in
the microvasculature. These results demonstrate that CD36 and ICAM-1 have left
strong signatures of selection on the PfEMP1 family that can be detected by
adhesion domain sequence classification and have implications for how this
family of proteins is specializing to exploit hosts with varying levels of
anti-malaria immunity
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research
Finishing the euchromatic sequence of the human genome
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
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