Cries and whispers: exhuming and narrating defeat in Spain today

In this paper, I will reflect on the impact in contemporary Spain of the production, circulation and consumption of narratives and images of Civil War terror and suffering, specifically those resulting from the opening of mass graves from the Francoist repression. This sharing of narratives has to be seen in the context of a broader and highly controversial process of reconsideration of the Civil War as a traumatic past. At a time when Spanish society is engaged in important debates regarding the singularity or plurality of our identity and the structure of our territorial organization, these exhumations are bringing to light rather disturbing information regarding our past, our present, and probably our future as well. The excavation of these “crime scenes” in various parts of the country is provoking heated discussions and performances in family contexts, politics, historiography, the media, the arts, and the public sphere in general. For example, the public display of skeletons, skulls and bone fragments bearing the marks of violence – from “perimortem” tortures to bullet wounds and coups de grâce – is bringing back tragic stories that, for many relatives but also for civil society at large, were for decades mostly silenced, told in whispers, imperfectly transmitted in limited family circles, or simply ignored. The screen of silence, fear and self-censorship has been particularly strong in local, rural contexts. Exhumation and narration are inextricably entwined. Exhumations elicit storytelling; conversely, their meaning and social impact depend on the available repertoire of competing “memory plots".Peer reviewe

Using magnetic resonance imaging to measure head muscles: An innovative method to opportunistically determine muscle mass and detect sarcopenia

Background Sarcopenia is associated with multiple adverse outcomes. Traditional methods to determine low muscle mass for the diagnosis of sarcopenia are mainly based on dual-energy X-ray absorptiometry (DXA), whole-body magnetic resonance imaging (MRI) and bioelectrical impedance analysis. These tests are not always available and are rather time consuming and expensive. However, many brain and head diseases require a head MRI. In this study, we aim to provide a more accessible way to detect sarcopenia by comparing the traditional method of DXA lean mass estimation versus the tongue and masseter muscle mass assessed in a standard brain MRI. Methods The H70 study is a longitudinal study of older people living in Gothenburg, Sweden. In this cross-sectional analysis, from 1203 participants aged 70 years at baseline, we included 495 with clinical data and MRI images available. We used the appendicular lean soft tissue index (ALSTI) in DXA images as our reference measure of lean mass. Images from the masseter and tongue were analysed and segmented using 3D Slicer. For the statistical analysis, the Spearman correlation coefficient was used, and concordance was estimated with the Kappa coefficient. Results The final sample consisted of 495 participants, of which 52.3% were females. We found a significant correlation coefficient between both tongue (0.26) and masseter (0.33) with ALSTI (P < 0.001). The sarcopenia prevalence confirmed using the alternative muscle measure in MRI was calculated using the ALSTI (tongue = 2.0%, masseter = 2.2%, ALSTI = 2.4%). Concordance between sarcopenia with masseter and tongue versus sarcopenia with ALSTI as reference has a Kappa of 0.989 (P < 0.001) for masseter and a Kappa of 1 for the tongue muscle (P < 0.001). Comorbidities evaluated with the Cumulative Illness Rating Scale were significantly associated with all the muscle measurements: ALSTI (odds ratio [OR] 1.16, 95% confidence interval [CI] 1.07–1.26, P < 0.001), masseter (OR 1.16, 95% CI 1.07–1.26, P < 0.001) and tongue (OR 1.13, 95% CI 1.04–1.22, P = 0.002); the higher the comorbidities, the higher the probability of having abnormal muscle mass. Conclusions ALSTI was significantly correlated with tongue and masseter muscle mass. When performing the sarcopenia diagnostic algorithm, the prevalence of sarcopenia calculated with head muscles did not differ from sarcopenia calculated using DXA, and almost all participants were correctly classified using both methods.publishedVersio

Redefining the role of urban studies Early Career Academics in the post-COVID-19 university

We are an international collective of Early Career Academics (ECAs) who met throughout 2020 to explore the implications of COVID-19 on precarious academics. With this intervention, our aims are to voice commonly shared experiences and concerns and to reflect on the extent to which the pandemic offers opportunities to redefine Higher Education and research institutions, in a context of ongoing precarity and funding cuts. Specifically, we explore avenues to build solidarity across institutions and geographies, to ensure that the conduct of urban research, and support offered to ECAs, allows for more inclusivity, diversity, security and equitability. *The Urban ECA Collective emerged from a workshop series described in this article which intended to foster international solidarity among self-defined early career academics working within urban research.ITESO, A.C

Genetic architecture of subcortical brain structures in 38,851 individuals

Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease

Novel genetic loci underlying human intracranial volume identified through genome-wide association

Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five novel loci for intracranial volume and confirmed two known signals. Four of the loci are also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρgenetic=0.748), which indicated a similar genetic background and allowed for the identification of four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, Parkinson’s disease, and enriched near genes involved in growth pathways including PI3K–AKT signaling. These findings identify biological underpinnings of intracranial volume and provide genetic support for theories on brain reserve and brain overgrowth

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Drivers of Children's Travel Satisfaction

The purpose of this thesis is twofold: Firstly, it explores the reasons parents state for choosing the car to take their children to school; Secondly, it investigates how the characteristics of the journey relate to children’s wellbeing, mood, and cognitive performance. This thesis consists of three papers (Papers I, II, and III). Participating in Paper I were 245 parents of schoolchildren aged between 10 and 15 in Värmland County, Sweden. These parents answered a questionnaire wherein they stated to what degree certain statements correlated with their decision to choose the car. In Paper II, 237 children in grade 4 (aged 10-11), in the City of Staffanstorp, Sweden, recorded all their journeys in a diary over one school week, also reporting on their travel mode, current mood while travelling, activities on arrival, and experiences vis-à-vis those activities. Participating in Paper III was a sample of 345 children aged between 10 and 15 attending five public schools in Värmland County, Sweden. These children rated their current mood, filled out the Satisfaction with Travel Scale (capturing the travel experience), reported details about their journeys, and took a word fluency test. Parents’ wish to accompany their children to school, and the convenience of the car, both impact upon the travel mode decision. In addition, parents also seem to choose the car regardless of the distance between home and school. The findings further reveal that the mood children are in varies with how they travel and where they go, and that there is a difference between boys’ and girls’ experiences. Children who travel by car experience the lowest degree of quality and activation, something which is maintained throughout the school day (especially for girls). Social activities during travel bring a higher degree of quality and excitement, while solitary activities bring more stress. The findings further show that using a smartphone, or doing a combination of activities during the journey, results in better cognitive performance. Thus, it is concluded that the mode choice that parents make for their children correlates with those children’s mood and experience. Specifically, where and how children travel, what they do when they travel, and how long they travel for affect their experiences, mood, and/or cognitive performance.The aim of this thesis is twofold. Firstly, it explores parents’ stated reasons for choosing the car for their children’s school journeys. Secondly, it investigates the relationship between the characteristics of a journey (i.e. travel mode, travel time, and activities conducted while travelling) and children’s wellbeing (through domain-specific satisfaction), current mood, and cognitive performance. The overall findings show that parents value the car both for its convenience and for the possibility of accompanying their children. Parents also use the car regardless of the distance between home and school. Travel affects children in various ways; for instance, doing certain activities while traveling can help boost cognitive performance and make children feel happy and excited. Notably, being passive during the journey makes children feel stressed and those who travel to school by car are the most tired during the school day. This implies that parents’ travel mode choice affects children’s wellbeing and cognitive performance. These insights are important when it comes to addressing current challenges relating to children’s day-to-day travel: How they experience their day-to-day travel may contribute toward how children travel in the future.Den här avhandlingen har två delsyften. Först undersöks vilka skäl föräldrar anger för varför deväljer att skjutsa sina barn till skolan med bil. Ett andra syfte är att undersöka hur detta val påverkarbarns mentala hälsa via självskattad upplevelse av skolresan och hur de känner sig vid ankomst(humör). Ytterligare ett syfte är att undersöka hur upplevelsen av skolresan påverkar hur barnenpresterar när de kommer till skolan. Avhandlingen innehåller tre artiklar. I Artikel I deltog 245föräldrar till barn i årskurs 4, 6 och 8 i värmländska skolor. Föräldrarna angav i vilken utsträckningolika skäl påverkar deras val att skjutsa barnen till skolan med bil. I artikel II deltog 237 barn (varav101 flickor) från årskurs 4 i Staffanstorp, Skåne. Barnen förde resdagbok över alla resor de gjordeunder en vecka. I dagboken beskrev de vart de reste, vilka färdmedel de använt, deras humör underresan (som skattades som ledsen-glad och trött-pigg), vilka aktiviteter de ägnat sig åt vidslutdestinationen samt deras upplevelser av dessa aktiviteter. I Artikel III deltog 345 barn frånårskurs 4, 6 och 8 i Värmland. Istället för resdagbok skattade barnen sitt humör, hur nöjda de varmed resan genom att fylla i Satisfaction with Travel Scale adapted for Children (STS-C), resedetaljersamt gjorde ett ordflödestest direkt vid ankomst i skolan. Resultaten visar bland annat att föräldrars önskan att spendera tid med sina barn och praktiskaaspekter med bil ligger till grund för valet av bil. Huruvida det är ett långt eller kort avstånd tillskolan påverkar inte valet att använda bil. Barns humör varierar beroende på hur de reser(färdmedel) och vart de reser (destination). En skillnad observerades också mellan flickor ochpojkar och mellan olika årskurser där t.ex. fickor påverkades mer negativt av att resa med bil änpojkar. Barn som reser med bil till skolan är minst nöjda (upplevde en lägre grad av kvalitet) ochpå sämre humör (är känslomässigt mindre aktiva) vilket också håller i sig under skoldagen. Att ägnasig åt sociala aktiviteter (konversera med vänner och familj) under resan bidrar till en högre upplevdkvalitet och mer upprymdhet medan barn som ägnat sig åt aktiviteter utan sällskap upplever enhögre grad av stress. Resultaten visar också att barn som använder sin smartphone eller kombinerarolika aktiviteter under resan presterar bättre på kognitivt test

Experiences of Everyday Travel : Through the Lens of a Child

The purpose of this thesis was to investigate how children experience their everyday travel. More specifically how do certain travel characteristics influence children’s current mood, experiences of their everyday travel, and their cognitive performance. The thesis consists of two papers (Papers I and II). In Paper I, 206 children (101 girls) in grade 4 (aged 10), in the city of Staffanstorp in Sweden, recorded all their journeys in a diary during one school week, along with reports of their travel mode, their current mood while travelling (ranging from very sad to very happy and from very tired to very alert), their activities on arrival, and their experiences regarding those activities. In Paper II, a sample of 344 children (165 girls) between the ages of 10 and 15 was taken at five public schools in Värmland County, Sweden. The children rated their current mood, filled out the Satisfaction with Travel Scale (capturing the travel experience), reported details about their journeys, and took a word-fluency test. The findings show that children’s immediate affective experiences (current mood) vary with how they travel and where they go, and that there is a difference between boys’ and girls’ experiences. Children who travel by car experience the lowest degree of quality and activation, something which is also maintained throughout the school day (as the case with activation). Social activities during travel add to higher degree of quality and excitement, while solitary activities bring more stress. The findings further show that using a smartphone or doing a combination of activities during the journey results in better cognitive performance, as do longer traveling times. It is concluded that where and how children travel, what they do when traveling, and for how long they travel all affect children’s travel experiences, mood, and/or cognitive performance. This thesis sheds light on a neglected research area – which is the experiences of travel – through the lens of a child.The purpose of this licentiate thesis is to examine how children experience their everyday travel. More specifically, do travel mode, travel time, and travel activities influence children’s experiences of their everyday travel, how they feel, and how they perform at school. In Paper 1 we investigate whether children’s moods, while travelling, vary with travel mode and destination. In Paper 2 we investigate whether children’s experiences of travel and current mood vary with travel mode, traveling time, and activities during travel. We also investigate whether the travel experience affects cognitive performance. The overall findings of the two studies suggest that where and how children travel, what they do when traveling, and for how long they travel all affect children’s travel experiences, moods, and cognitive performance. These novel findings bring important knowledge of the impact of a journey. Children are the next generation of traveler; how they experience their day-to-day travel may contribute toward their future travel behavior and influence how societies travel in the future