College Republicans and Conservative Social Identity

Through participant-observation and interviews, I explore the conservative social identity of College Republicans at a midsize, midtier public university in the United States. Using the concepts of repertoires and frames, I analyze how individuals make claims to political social identities. Specifically, I show that symbolic appeals to the free market were an essential aspect of the conservative repertoire at my field site. Furthermore, the shifting and contradictory frames used by the College Republicans in this study demonstrate that their discursive political practices were not primarily about policy preferences; they were about affirming a conservative social identity. Understanding how stated policy preferences and identity intertwine in everyday political talk has important implications for American democracy

Hollywood, Bike Messengers, and the New Economy

The sociological study of popular cinema provides an analytic entry point for exploring how economic realities are given meaning through cultural products. In this paper, I compare how two Hollywood movies about bike messengers, Quicksilver and Premium Rush, position their main characters in relationship to the new economy. Both films provide commentaries on work and social class, but, as products of unique socio-historical periods, I argue that their commentaries differ significantly. Produced in the 1980s, Quicksilver uses messengering as a form of middle-class redemption, allowing the protagonist to return to the world of capitalist finance. By contrast, as a product of the Great Recession, Premium Rush offers a utopian vision of self-determination for low-wage service workers at the same time that it reifies the uncertainty, unpredictability, and riskiness that increasingly characterize American labor. I also show that both films converge in their portrayal of women and working-class blacks

Parkour, the affective appropriation of urban space, and the real/virtual dialectic

Parkour is a new sport based on athletically and artistically overcoming urban obstacles. In this paper, I argue that the real world practices of parkour are dialectically intertwined with the virtual worlds made possible by information and communication technologies. My analysis of parkour underscores how globalized ideas and images available through the Internet and other media can be put into practice within specific locales. Practitioners of parkour, therefore, engage their immediate, physical world at the same time that they draw upon an imagination enabled by their on-screen lives. As such, urban researchers need to consider the ways that virtual worlds can change and enhance how individuals understand and utilize the material spaces of the city. EMPLACEMENT IN A VIRTUAL WORLD With the increasing integration of information and communication technologies (ICTs) into our lives, more and more of our daily interactions take place "on screen&quot

Grazing Collisions of Black Holes via the Excision of Singularities

We present the first simulations of non-headon (grazing) collisions of binary black holes in which the black hole singularities have been excised from the computational domain. Initially two equal mass black holes $m$ are separated a distance $\approx10m$ and with impact parameter $\approx2m$. Initial data are based on superposed, boosted (velocity $\approx0.5c$) solutions of single black holes in Kerr-Schild coordinates. Both rotating and non-rotating black holes are considered. The excised regions containing the singularities are specified by following the dynamics of apparent horizons. Evolutions of up to $t \approx 35m$ are obtained in which two initially separate apparent horizons are present for $t\approx3.8m$. At that time a single enveloping apparent horizon forms, indicating that the holes have merged. Apparent horizon area estimates suggest gravitational radiation of about 2.6% of the total mass. The evolutions end after a moderate amount of time because of instabilities.Comment: 2 References corrected, reference to figure update

Pratos e mais pratos: louças domésticas, divisões culturais e limites sociais no Rio de Janeiro, século XIX

Reply to ten comments on a paper published in the last issue of this journal. The discussion follows along six main lines: History museums, identity, ideology and the category of nation; the need of material collections and their modalities: patrimonial, operational, virtual; theater versus laboratory; visitors and their ambiguities; Public History: the museum and the academy.Resposta aos comentários de dez especialistas que contribuíram no debate de texto publicado no último número desta revista. A discussão orientou-se segundo seis tópicos principais: museus históricos, identidade, ideologia e a categoria de nação; a necessidade de acervos materiais e suas modalidades: acervo patrimonial, operacional, virtual; teatro versus laboratório; o público e suas ambigüidades; História Pública: o museu e a Academia

Properties of the Binary Black Hole Merger GW150914

On September 14, 2015, the Laser Interferometer Gravitational-Wave Observatory (LIGO) detected a gravitational-wave transient (GW150914); we characterize the properties of the source and its parameters. The data around the time of the event were analyzed coherently across the LIGO network using a suite of accurate waveform models that describe gravitational waves from a compact binary system in general relativity. GW150914 was produced by a nearly equal mass binary black hole of masses 36+5−4M⊙ and 29+4−4M⊙; for each parameter we report the median value and the range of the 90% credible interval. The dimensionless spin magnitude of the more massive black hole is bound to be <0.7 (at 90% probability). The luminosity distance to the source is 410+160−180  Mpc, corresponding to a redshift 0.09+0.03−0.04 assuming standard cosmology. The source location is constrained to an annulus section of 610  deg2, primarily in the southern hemisphere. The binary merges into a black hole of mass 62+4−4M⊙ and spin 0.67+0.05−0.07. This black hole is significantly more massive than any other inferred from electromagnetic observations in the stellar-mass regime

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Appropriating the city: space, theory, and bike messengers

Over the last 30 years, social theorists have increasingly emphasized the importance of space. However, in empirical research, the dialectical relationship between social interaction and the physical environment is still a largely neglected issue. Using the theory of structuration, I provide a concrete example of why and how space matters in the cultural analysis of an urban social world. I argue that bike messengers—individuals who deliver time-sensitive materials in downtown cores of major cities—cannot be understood outside an analysis of space. Specifically, I connect the cultural significance of messenger practices to the emplacement of those practices inside the urban environment