Who Chooses in Hartford? Regional School Choice Office Applications from Hartford-resident HPS students in 2012

These presentation slides are an abbreviated version of the full report: Dougherty, Jack, Diane Zannoni, Marissa Block, and Stephen Spirou. Who Chooses in Hartford? Report 1: Statistical Analysis of Regional School Choice Office Applicants and Non-Applicants among Hartford-Resident HPS Students in Grades 3-7, Spring 2012. Hartford, CT: Cities Suburbs Schools Project at Trinity College, May 12, 2014.http://digitalrepository.trincoll.edu/cssp_papers/46

Who Chooses in Hartford? Report 1: Statistical analysis of Regional School Choice Office applicants and non-applicants among Hartford-resident HPS students in grades 3-7, Spring 2012

Which Hartford-area families were more (or less) likely to apply for public school choice options, and how do they vary by student characteristics & achievement, school composition, and neighborhood demographics? Report 1 offers a statistical analysis of RSCO applicants versus non-applicants among 6,673 Hartford-resident students enrolled in Hartford Public Schools (HPS) — both district schools and interdistrict magnet schools — from grades 3 through 7 in Spring 2012. Overall, we found that participation in the RSCO application process was not random, but linked to student socioeconomic characteristics that often showed higher participation by more privileged families. In this sample, there were statistically significant lower levels of RSCO participation among English Language Learners and those with special needs, and generally higher levels by students with high CMT scores, and those who live in census areas with higher median household incomes and higher percentages of owner-occupied housing. The report also evaluates statistically significant differences and the magnitude of numbers of expected versus actual applicants by race and ethnicity, school performance, location, and other characteristics

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

MolProbity is a general-purpose web server offering quality validation for 3D structures of proteins, nucleic acids and complexes. It provides detailed all-atom contact analysis of any steric problems within the molecules as well as updated dihedral-angle diagnostics, and it can calculate and display the H-bond and van der Waals contacts in the interfaces between components. An integral step in the process is the addition and full optimization of all hydrogen atoms, both polar and nonpolar. New analysis functions have been added for RNA, for interfaces, and for NMR ensembles. Additionally, both the web site and major component programs have been rewritten to improve speed, convenience, clarity and integration with other resources. MolProbity results are reported in multiple forms: as overall numeric scores, as lists or charts of local problems, as downloadable PDB and graphics files, and most notably as informative, manipulable 3D kinemage graphics shown online in the KiNG viewer. This service is available free to all users at http://molprobity.biochem.duke.edu

Introspective physicalism as an approach to the science of consciousness

Most ‘theories of consciousness’ are based on vague speculations about the properties of conscious experience. We aim to provide a more solid basis for a science of consciousness. We argue that a theory of consciousness should provide an account of the very processes that allow us to acquire and use information about our own mental states – the processes underlying introspection. This can be achieved through the construction of information processing models that can account for ‘Type-C’ processes. Type-C processes can be specified experimentally by identifying paradigms in which awareness of the stimulus is necessary for an intentional action. The Shallice (1988b) framework is put forward as providing an initial account of Type-C processes, which can relate perceptual consciousness to consciously performed actions. Further, we suggest that this framework may be refined through the investigation of the functions of prefrontal cortex. The formulation of our approach requires us to consider fundamental conceptual and methodological issues associated with consciousness. The most significant of these issues concerns the scientific use of introspective evidence. We outline and justify a conservative methodological approach to the use of introspective evidence, with attention to the difficulties historically associated with its use in psychology

‘Look this way’:using gaze maintenance to facilitate the detection of children's false reports

In two experiments, we investigated whether imposing a secondary task is an effective technique for detecting child deceit. Firstly, 85 children aged 8 to 11 years old provided either a true or false report of a recent school event. At interview, some children were asked to gaze towards either the interviewer’s face (IF) or a teddy bear’s face (TF), whereas some children were given no gaze instruction. In both the IF and TF conditions, lie-tellers provided significantly fewer details than truth-tellers. 192 adult evaluators then judged the credibility of ten children’s reports from one of the three ‘gaze’ conditions with and without guidance on level of detail. Evaluators discriminated truths from lies successfully when judging children instructed to look at IF, but not when children were asked to gaze towards TF. Evaluators who received guidance demonstrated better discrimination between true and false reports than evaluators who received no such information

Evaluation of a Previously Suggested Plasma Biomarker Panel to Identify Alzheimer's Disease

There is an urgent need for biomarkers in plasma to identify Alzheimer's disease (AD). It has previously been shown that a signature of 18 plasma proteins can identify AD during pre-dementia and dementia stages (Ray et al, Nature Medicine, 2007). We quantified the same 18 proteins in plasma from 174 controls, 142 patients with AD, and 88 patients with other dementias. Only three of these proteins (EGF, PDG-BB and MIP-1δ) differed significantly in plasma between controls and AD. The 18 proteins could classify patients with AD from controls with low diagnostic precision (area under the ROC curve was 63%). Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative biomarker studies

Structural changes in commercial agriculture

The basic idea of the conference on Structural Changes in Commercial Agriculture was planted in the spring of 1964 by Earl 0. Heady. He outlined for the North Central Farm Management Research Committee his concern about the kind and amount of response to both current and prospective structural changes in the commercial farm firm. Many changes represent adjustments to technological and other innovations originating in marketing, research, and educational agencies serving farmers.https://lib.dr.iastate.edu/card_reports/1025/thumbnail.jp

Beyond cardiovascular medicine: potential future uses of icosapent ethyl

The REDUCE-IT trial demonstrated that icosapent ethyl, an ethyl ester of eicosapentaenoic acid (EPA), reduced cardiovascular events in an at-risk population by a substantial degree. While the cardiovascular protective properties of this compound are now proven, several other potential uses are being actively explored in clinical studies. These areas of investigation include cancer, inflammatory bowel disease, infections, Alzheimer’s disease, dementia, and depression. The next decade promises to deepen our understanding of the beneficial effects that EPA may offer beyond cardiovascular risk reduction