Educational Provision for Newly Arrived Unaccompanied Sanctuary Seekers aged 15-16

Local Authorities in England are rarely able to find a school place for newly arrived unaccompanied sanctuary seekers when the young person arrives in their locality aged 15-16. Criticisms regarding this exclusionary practice are plentiful; that said, it has been argued the dominance of debate regarding access to mainstream education for pupils aged 15-16 obfuscates critical analysis of the educational needs of this group. Focussed on a bespoke Local Authority educational offer for fewer than twenty newly arrived unaccompanied sanctuary seekers aged 15-16, this paper analyses the essence of this offer in relation to social inclusion. Analysed in relation to the category, structure and level/function of the young people’s social inclusion, this paper draws on interview and focus group data to shine a light on the efficacious elements of the offer which point to ways forward for mainstream schools

Observational Constraints on Interstellar Grain Alignment

We present new multicolor photo-polarimetry of stars behind the Southern Coalsack. Analyzed together with multiband polarization data from the literature, probing the Chamaeleon I, Musca, rho Opiuchus, R CrA and Taurus clouds, we show that the wavelength of maximum polarization (lambda_max) is linearly correlated with the radiation environment of the grains. Using Far-Infrared emission data, we show that the large scatter seen in previous studies of lambda_max as a function of A_V is primarily due to line of sight effects causing some A_V measurements to not be a good tracer of the extinction (radiation field strength) seen by the grains being probed. The derived slopes in lambda_max vs. A_V, for the individual clouds, are consistent with a common value, while the zero intercepts scale with the average values of the ratios of total-to-selective extinction (R_V) for the individual clouds. Within each cloud we do not find direct correlations between lambda_max and R_V. The positive slope in consistent with recent developments in theory and indicating alignment driven by the radiation field. The present data cannot conclusively differentiate between direct radiative torques and alignment driven by H_2 formation. However, the small values of lambda_max(A_V=0), seen in several clouds, suggest a role for the latter, at least at the cloud surfaces. The scatter in the lambda_max vs. A_V relation is found to be associated with the characteristics of the embedded Young Stellar Objects (YSO) in the clouds. We propose that this is partially due to locally increased plasma damping of the grain rotation caused by X-rays from the YSOs.Comment: Accepted for publication in the Astrophysical Journa

Phase II study of irinotecan in combination with temozolomide (TEMIRI) in children with recurrent or refractory medulloblastoma: a joint ITCC and SIOPE brain tumor study

BackgroundThis multicenter phase II study investigated temozolomide + irinotecan (TEMIRI) treatment in children with relapsed or refractory medulloblastoma.MethodsPatients received temozolomide 100–125 mg/m2/day (days 1–5) and irinotecan 10 mg/m2/day (days 1–5 and 8–12) every 3 weeks. The primary endpoint was tumor response within the first 4 cycles confirmed ≥4 weeks and assessed by an external response review committee (ERRC). In a 2-stage Optimum Simon design, ≥6 responses in the first 15 evaluable patients were required within the first 4 cycles for continued enrollment; a total of 19 responses from the first 46 evaluable patients was considered successful.ResultsSixty-six patients were treated. Seven responses were recorded during stage 1 and 15 in the first 46 ERRC evaluated patients (2 complete responses and 13 partial responses). The objective response rate during the first 4 cycles was 32.6% (95% confidence interval [CI], 19.5%–48.0%). Median duration of response was 27.0 weeks (7.7–44.1 wk). In 63 patients evaluated by local investigators, the objective response rate was 33.3% (95% CI, 22.0%–46.3%), and 68.3% (95% CI, 55.3%–79.4%) experienced clinical benefit. Median survival was 16.7 months (95% CI, 13.3–19.8). The most common grade 3 treatment-related nonhematologic adverse event was diarrhea (7.6%). Grade 3/4 treatment-related hematologic adverse events included neutropenia (16.7%), thrombocytopenia (12.1%), anemia (9.1%), and lymphopenia (9%).ConclusionsThe planned study primary endpoint was not met. However, its tolerability makes TEMIRI a suitable candidate chemotherapy backbone for molecularly targeted agents in future trials in this setting

Optical polarization and near IR photometry of the proto-planetary nebula Hen 3-1475

We present BVRI CCD aperture polarization and near-infrared photometry of the proto-planetary nebula Hen 3-1475. Its intrinsic polarization is high and shows a strong spectral dependence. The position angles in all bands are perpendicular to the axis of the observed bipolar structure. A Monte Carlo code is used to model the intrinsic polarization of \hhe. Using disk dimensions and other constraints suggested by previous works, we are able to reproduce the observations with an optically thick disk composed by grains with a power-law size distribution ranging from 0.06 to 0.22 um. We also reliably estimate the foreground polarization from hundreds of stars contained in the CCD images. It is parallel to the intrinsic polarization of Hen 3-1475. Possible implications of this result are discussed. From IR observations, we estimate a interstellar reddening, A(V), of about 3.2.Comment: ApJ accepted, 16 pages, 6 figure

Estudi ambiental del cicle de vida del formatge Denominació d'Origen Protegida Mahón-Menorca

Aquest projecte pretén analitzar l'impacte associat a les diferents fases del cicle de vida del formatge D.O.P. Mahón-Menorca des de la producció de la llet fins la posterior comercialització, passant pel procés de fabricació del producte. Per així donar resposta a la preocupació i demanda ciutadana en relació a les pràctiques empresarials sostenibles amb el medi ambient. L'estudi es duu a terme per sectors, a fi de poder comparar en termes d'impacte ambiental el pes associat a cada fase del procés. Per tal d'assolir aquesta fi, s'ha fet ús de fonts primàries extretes d'un extens treball de camp i fonts secundàries. Els principals resultats mostren que el sector primari és dels tres sectors que contribueix més al Canvi Climàtic assumint un 90% de les emissions de CO2 generades. Els punts crítics destacables del sector secundari els trobem a les fases d'envelliment i del sector terciari es centren en el transport, essent aquest molt més pol·luent respecte l'embalatge.Este proyecto pretende analizar el impacto asociado a las diferentes fases del ciclo de vida del queso D.O.P. Mahón-Menorca desde la producción de la leche hasta la posterior comercialización del queso, pasando por el proceso de fabricación. Para así dar respuesta a la preocupación y demanda ciudadana en relación a las prácticas empresariales y sostenibles con el medio ambiente. El estudio se lleva a cabo por sectores, a fin de poder comparar en términos de impacto ambiental el peso asociado a cada fase del proceso. Para poder obtener dichos fines, se han utilizado fuentes primarias extraídas de un extenso trabajo de campo y fuentes secundarias. Los principales resultados muestran que el sector primario es de los tres sectores el que más contribuye al Cambio Climático asumiendo un 90% de las emisiones de CO2 generadas. Los puntos críticos destacables del sector secundario los encontramos en las fases de envejecimiento y del sector terciario se centran en el transporte, siendo este el más contaminante respecto al embalaje.This project aims to calculate the impact associated with the different stages of the P.D.O. Mahón-Menorca cheese's life cycle from producing the milk until the subsequent marketing, through the manufacturing process of the product. That way we can give an answer to the citizen's worries about environmental friendly practices. To achieve this objective, primary sources has been used drawn from extensive fieldwork and secondary sources from previous studies. The main results show that the primary sector is the most contributing to Climate Change in-between the other three sectors assuming 90% of CO2 emissions. The critical points in the secondary sector are located in the stages of cheese aging and in the tertiary sector it's focused on transportation, being much more pollutant respect packaging

Progress towards sustainable control of xylella fastidiosa subsp. Pauca in olive groves of salento (apulia, italy)

Xylella fastidiosa subsp. pauca is the causal agent of “olive quick decline syndrome” in Salento (Apulia, Italy). On April 2015, we started interdisciplinary studies to provide a sustainable control strategy for this pathogen that threatens the multi-millennial olive agroecosystem of Salento. Confocal laser scanning microscopy and fluorescence quantification showed that a zinc-copper-citric acid biocomplex—Dentamet® —reached the olive xylem tissue either after the spraying of the canopy or injection into the trunk, demonstrating its effective systemicity. The biocomplex showed in vitro bactericidal activity towards all X. fastidiosa subspecies. A mid-term evaluation of the control strategy performed in some olive groves of Salento indicated that this biocomplex significantly reduced both the symptoms and X. f. subsp. pauca cell concentration within the leaves of the local cultivars Ogliarola salentina and Cellina di Nardò. The treated trees started again to yield. A1 H-NMR metabolomic approach revealed, upon the treatments, a consistent increase in malic acid and γ-aminobutyrate for Ogliarola salentina and Cellina di Nardò trees, respectively. A novel endotherapy technique allowed injection of Dentamet® at low pressure directly into the vascular system of the tree and is currently under study for the promotion of resprouting in severely attacked trees. There are currently more than 700 ha of olive groves in Salento where this strategy is being applied to control X. f. subsp. pauca. These results collectively demonstrate an efficient, simple, low-cost, and environmentally sustainable strategy to control this pathogen in Salento

European sea bass brain DLB-1 cell line is susceptible to nodavirus: A transcriptomic study

Viral diseases are responsible for high rates of mortality and subsequent economic losses in modern aquaculture. The nervous necrosis virus (NNV) produces viral encephalopathy and retinopathy (VER), which affects the fish central nervous system. It is considered one of the most serious viral diseases in marine aquaculture, the European sea bass (Dicentrarchus labrax) being amongst the most susceptible. We have evaluated the European sea bass brain derived cell line (DLB-1) susceptibility to NNV genotypes and evaluated its transcriptomic profile. DLB-1 cells supported NNV gene transcription and replication since strains belonging to the four NNV genotypes produce cytopathic effects. Afterwards, DLB-1 cells were infected with an RGNNV strain, the one which showed the highest replication, for 12 and 72 h and an RNA-seq analysis was performed to identify potential genes involved in the host-NNV interactions. Differential expression analysis showed the up-regulation of many genes related to immunity, heat-shock proteins or apoptosis but not to proteasome or autophagy processes. These data suggest that the immune response, mainly the interferon (IFN) pathway, is not powerful enough to abrogate the infection, and cells finally suffer stress and die by apoptosis liberating infective particles. GO enrichment also revealed, for the first time, the down-regulation of terms related to brain/neuron biology indicating molecular mechanisms causing the pathogenic effect of NNV. This study opens the way to understand key elements in sea bass brain and NNV interactions.Versión del edito

Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC

The uncertainty on the calorimeter energy response to jets of particles is derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the calorimeter response to single isolated charged hadrons is measured and compared to the Monte Carlo simulation using proton-proton collisions at centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009 and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter response to specific types of particles (positively and negatively charged pions, protons, and anti-protons) is measured and compared to the Monte Carlo predictions. Finally, the jet energy scale uncertainty is determined by propagating the response uncertainty for single charged and neutral particles to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3% for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table, submitted to European Physical Journal