Effects of different deoxidization methods on high-temperature physical properties of high-strength low-alloy steels

This study was aimed at examining the effects of different deoxidization methods on the physical properties of metallic melts by measuring the changes in the kinematic viscosity, electrical resistivity, surface tension, and density of the metallurgical melts during the heating and cooling processes. Our results indicate that high-temperature physical properties are consistently affected by specific elements and compounds. © 2020 Ke-lin Zhang et al., published by De Gruyter 2020.2019010701011382National Natural Science Foundation of China, NSFC: U1532268, 51671149The authors gratefully acknowledge support from the National Natural Science Foundation of China (U1532268, 51671149), Wuhan Science and Technology Program (Grant No. 2019010701011382), and the 111 project

RETINAL VESSELS DIGITAL MORPHOMETRY IN ANALYSIS OF LASER TREATMENT RESULTS IN RETINOPATHY OF PREMATURITY

Purpose. Quantification of morphometric parameters of segments of retinal vessels of the central fundus zone, vessels of the 2nd order and peripheral vessels in the vicinity of the avascular zone to detect early signs and dynamics of stage II and III regression in retinopathy of prematurity (ROP) in different periods after laser treatment (LT).Material and methods. There were examined 50 preterm infants (100 eyes) with the type 2 (a high risk of progression) of the ROP stage II and III before and in different periods after pattern laser photocoagulation. The morphometric analysis of obtained digital images of the retina in children with ROP was performed using the retinal camera «RetCam 3» (Clarity Medisal Systems, Inc.,USA) in mode of the software «ROP-MORRNOMETRY».Results. Statistically significant differences in the diameter of retinal vessels throughout their length and the tortuosity factor of arteries in the central fundus zone in the follow-up of 1 and 2 months after laser treatment were not revealed, indicating a robust ROP regression.Conclusions. Clinical applications of data obtained in the performed study allows to optimize the postoperative monitoring of premature infants with ROP, minimizing the quantity of repeated diagnostic tests

ИСПОЛЬЗОВАНИЕ СИСТЕМНОГО ТРОМБОЛИЗИСА ДЛЯ ЛЕЧЕНИЯ ОСТРОЙ ИШЕМИИ КОНЕЧНОСТЕЙ

ABSTRACT. Treatment of acute limb ischemia remains a serious problem in vascular surgery. There are both surgical and conservative therapies. Systemic thrombolysis is one of supplementing methods, and in some cases, it is the method of choice, especially when surgical therapy is not possible. The paper presents our experience of systemic thrombolytic therapy in the treatment of acute limb ischemia. РЕЗЮМЕ. Лечение острой ишемии конечностей остается серьезной проблемой в ангиохирургии. Существуют как хирургические, так и консервативные методы лечения. Один из методов, дополняющий, а в ряде случаев являющийся и методом выбора — системный тромболизис, особенно когда выполнение оперативного лечения невозможно. В статье представлен наш опыт использования системной тромболитической терапии в лечении острой ишемии конечностей.

Inhomogeneous Superconductivity in Condensed Matter and QCD

Inhomogeneous superconductivity arises when the species participating in the pairing phenomenon have different Fermi surfaces with a large enough separation. In these conditions it could be more favorable for each of the pairing fermions to stay close to its Fermi surface and, differently from the usual BCS state, for the Cooper pair to have a non zero total momentum. For this reason in this state the gap varies in space, the ground state is inhomogeneous and a crystalline structure might be formed. This situation was considered for the first time by Fulde, Ferrell, Larkin and Ovchinnikov, and the corresponding state is called LOFF. The spontaneous breaking of the space symmetries in the vacuum state is a characteristic feature of this phase and is associated to the presence of long wave-length excitations of zero mass. The situation described here is of interest both in solid state and in elementary particle physics, in particular in Quantum Chromo-Dynamics at high density and small temperature. In this review we present the theoretical approach to the LOFF state and its phenomenological applications using the language of the effective field theories.Comment: RevTex, 83 pages, 26 figures. Submitted to Review of Modern Physic

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.Peer reviewe

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC

2016 ESC on Acute and Chronic H