Yardbird cello: adapting the language of Charlie Parker to the cello through solo transcription and analysis

This paper examines the musical and technical demands of adapting the bebop melodic language of saxophonist Charlie Parker to the cello. String players have tended to avoid this musical language due to its non-idiomatic nature. A staple of jazz performers\u27 repertory however, bebop tunes remain standard works of study for any student of jazz improvisation. This paper examines the challenges for the cellist\u27s left hand in playing Parker\u27s melodies and improvisations. It also suggests possible bowing solutions that allow the player to emulate his articulation. Further, it examines issues of musical timing and various learning techniques for the application of this style. I approached this material using the process of transcription to internalize aspects of the musical style. The appendix includes my transcriptions of six of Parker\u27s recorded solos edited for the cello in low register, high register, and scordatura editions. The recordings examined in this paper are Dexterity, Scrapple from the Apple, Parker\u27s Mood, Embraceable You, Dewey Square, and My Little Suede Shoes

Evaluation of a Simulation-Based Training Program on Childhood Trauma with Occupational Therapy Students

An educational and simulation-based training model, the Professional ACEs-Informed Training for Health Professionals designed for allied health students was evaluated using a pre-and-post design. The training model emphasizes trauma-informed care and uses social simulation to educate and train students with skills to address adverse childhood experiences. This study evaluated occupational therapy students’ (N=70) levels of self-efficacy and knowledge of trauma-informed care at both pre- and post-training. Analysis of variance results indicated a statistically significant improvement in students’ levels of general self-efficacy and knowledge from pre- to post-assessment (p \u3c .01). These results are suggestive of the usefulness of brief didactics combined with simulation to educate occupational therapy students on adverse childhood experiences and trauma-informed care

The inequality factor: skewness and kurtosis as a measure of set-class cohesion

Building on current set-theoretic research, including similarity measures and maximal evenness, as well as findings in diatonic set theory and our own work on salience, we examine the interval-class content of set classes based on internal consistency (related to cohesion and regularity) and inconsistency (skewness). By systematically comparing one member tone of a set to the others, we posit abstract hierarchies between members based on salience, rather than the presence of specific interval classes or tonal function. Quantifying these factors allows us to hypothesize (1) what gives certain set classes the potential to function in a tonal way; (2) a set-class-sensitive method to gauge the level of dissonance in a composition (without presuppositions about the quality of specific interval classes); and (3) how different set classes might be deployed compositionally in order to achieve a variety of results. © 2014 Taylor & Francis

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Effect of TiO2 Nanoparticles and UV Radiation on Extracellular Enzyme Activity of Intact Heterotrophic Biofilms

When introduced into the aquatic environment, TiO2 NP are likely to settle from the water column, which results in increased exposure of benthic communities. Here, we show that the activity of two extracellular enzymes of intact heterotrophic biofilms, beta-glucosidase (carbon-cycling) and l-leucin aminopeptidase (nitrogen-cycling), was reduced following exposure to surface functionalized TiO2 NP and UV radiation, depending on the particles' coating. This reduction was partially linked to ROS production. Alkaline phosphatase (phosphorus-cycling) activity was not affected, however in contrast, an alkaline phosphatase isolated from E. coli was strongly inhibited at lower concentrations of TiO2 NP than the intact biofilms. These results indicate that enzymes present in the biofilm matrix are partly protected against exposure to TiO2 NP and UV radiation. Impairment of extracellular enzymes which mediate the uptake of nutrients from water may affect ecosystem function

Effect of TiO₂ Nanoparticles and UV Radiation on Extracellular Enzyme Activity of Intact Heterotrophic Biofilms

When introduced into the aquatic environment, TiO₂ NP are likely to settle from the water column, which results in increased exposure of benthic communities. Here, we show that the activity of two extracellular enzymes of intact heterotrophic biofilms, β-glucosidase (carbon-cycling) and l-leucin aminopeptidase (nitrogen-cycling), was reduced following exposure to surface functionalized TiO₂ NP and UV radiation, depending on the particles’ coating. This reduction was partially linked to ROS production. Alkaline phosphatase (phosphorus-cycling) activity was not affected, however in contrast, an alkaline phosphatase isolated from <i>E. coli</i> was strongly inhibited at lower concentrations of TiO₂ NP than the intact biofilms. These results indicate that enzymes present in the biofilm matrix are partly protected against exposure to TiO₂ NP and UV radiation. Impairment of extracellular enzymes which mediate the uptake of nutrients from water may affect ecosystem function

Chemical Aspects of Nanoparticle Ecotoxicology

Nanoecotoxicology strives to understand the processes and mechanisms by which engineered nanoparticles (ENP) may exert toxic effects on aquatic organisms. Detailed knowledge of the chemical reactions of nanoparticles in the media and of their interactions with organisms is required to understand these effects. The processes of agglomeration of nanoparticles, of dissolution and release of toxic metal ions, and of production of reactive oxygen species (ROS) are considered in this article. Important questions concern the role of uptake of nanoparticles in various organisms, in contrast to uptake of ions released from nanoparticles and to nanoparticle attachment to organism surfaces. These interactions are illustrated for effects of silver nanoparticles (AgNP), cerium oxide (CeO2 NP) and titanium dioxide (TiO2 NP), on aquatic organisms, including algae, biofilms, fish cells and fish embryos

PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane

Supplementary information is available on the Nature Neuroscience website.Despite their low abundance, phosphoinositides are critical regulators of intracellular signaling and membrane compartmentalization. However, little is known of phosphoinositide function at the postsynaptic membrane. Here we show that continuous synthesis and availability of phosphatidylinositol-(3,4,5)-trisphosphate (PIP3) at the postsynaptic terminal is necessary for sustaining synaptic function in rat hippocampal neurons. This requirement was specific for synaptic, but not extrasynaptic, AMPA receptors, nor for NMDA receptors. PIP3 downregulation impaired PSD-95 accumulation in spines. Concomitantly, AMPA receptors became more mobile and migrated from the postsynaptic density toward the perisynaptic membrane within the spine, leading to synaptic depression. Notably, these effects were only revealed after prolonged inhibition of PIP3 synthesis or by direct quenching of this phosphoinositide at the postsynaptic cell. Therefore, we conclude that a slow, but constant, turnover of PIP3 at synapses is required for maintaining AMPA receptor clustering and synaptic strength under basal conditions.This work was supported by grants from the US National Institute of Mental Health (J.A.E. and J.R.M.), the Dana Foundation (J.A.E.) and the Spanish Ministry of Science and Innovation (J.A.E.). M.F.-M. and S.K. are supported by postdoctoral contracts, and M.R. by a predoctoral fellowship, from the Spanish Ministry of Science and Innovation.Peer reviewe