Simulating classroom lessons:an agent-based attempt

This is an interim report on a project to construct an agent-based simulation that reproduces some of the interactions between students and their teacher in classroom lessons. In a pilot study, the activities of 67 students and 7 teachers during 40 lessons were recorded using a data collection instrument that currently captures 17 student states and 15 teacher states. These data enabled various conceptual models to be explored, providing empirical values and distributions for the model parameters. Using these data, a lesson can be ‘played back’ using a visualization program implemented in NetLogo. A visualization and simulation can be viewed side-by-side and their outputs compared in various ways, e.g. overall class state-transition matrices or individual student state trajectories. The main challenges are the formulation of descriptive rules, establishing what metrics to use to compare lessons, and determining how to validate a simulation

Livestock Protection Tools for California Ranchers

Conflicts between livestock and predators are perhaps inevitable, especially on extensively managed rangelands This publication helps producers evaluate livestock lethal and non-lethal protection tools that may fit their site-specific needs

Proteomic profiling of high risk medulloblastoma reveals functional biology

Genomic characterization of medulloblastoma has improved molecular risk classification but struggles to define functional biological processes, particularly for the most aggressive subgroups. We present here a novel proteomic approach to this problem using a reference library of stable isotope labeled medulloblastoma-specific proteins as a spike-in standard for accurate quantification of the tumor proteome. Utilizing high-resolution mass spectrometry, we quantified the tumor proteome of group 3 medulloblastoma cells and demonstrate that high-risk MYC amplified tumors can be segregated based on protein expression patterns. We cross-validated the differentially expressed protein candidates using an independent transcriptomic data set and further confirmed them in a separate cohort of medulloblastoma tissue samples to identify the most robust proteogenomic differences. Interestingly, highly expressed proteins associated with MYC-amplified tumors were significantly related to glycolytic metabolic pathways via alternative splicing of pyruvate kinase (PKM) by heterogeneous ribonucleoproteins (HNRNPs). Furthermore, when maintained under hypoxic conditions, these MYC-amplified tumors demonstrated increased viability compared to non-amplified tumors within the same subgroup. Taken together, these findings highlight the power of proteomics as an integrative platform to help prioritize genetic and molecular drivers of cancer biology and behavior

A future workforce of food-system analysts

A programme developed across five UK universities aims to equip graduate professionals with the skills, tools and capabilities to better understand and manage food-system complexity for food security, for the environment and for enterprise.<br/

The global oscillation network group site survey. II. Results

The Global Oscillation Network Group (GONG) Project will place a network of instruments around the world to observe solar oscillations as continuously as possible for three years. The Project has now chosen the six network sites based on analysis of survey data from fifteen sites around the world. The chosen sites are: Big Bear Solar Observatory, California; Mauna Loa Solar Observatory, Hawaii; Learmonth Solar Observatory, Australia; Udaipur Solar Observatory, India; Observatorio del Teide, Tenerife; and Cerro Tololo Interamerican Observatory, Chile. Total solar intensity at each site yields information on local cloud cover, extinction coefficient, and transparency fluctuations. In addition, the performance of 192 reasonable components analysis. An accompanying paper describes the analysis methods in detail; here we present the results of both the network and individual site analyses. The selected network has a duty cycle of 93.3%, in good agreement with numerical simulations. The power spectrum of the network observing window shows a first diurnal sidelobe height of 3 × 10⁻⁴ with respect to the central component, an improvement of a factor of 1300 over a single site. The background level of the network spectrum is lower by a factor of 50 compared to a single-site spectrum

Proteomic profiling of high risk medulloblastoma reveals functional biology

Genomic characterization of medulloblastoma has improved molecular risk classification but struggles to define functional biological processes, particularly for the most aggressive subgroups. We present here a novel proteomic approach to this problem using a reference library of stable isotope labeled medulloblastoma-specific proteins as a spike-in standard for accurate quantification of the tumor proteome. Utilizing high-resolution mass spectrometry, we quantified the tumor proteome of group 3 medulloblastoma cells and demonstrate that high-risk MYC amplified tumors can be segregated based on protein expression patterns. We cross-validated the differentially expressed protein candidates using an independent transcriptomic data set and further confirmed them in a separate cohort of medulloblastoma tissue samples to identify the most robust proteogenomic differences. Interestingly, highly expressed proteins associated with MYC-amplified tumors were significantly related to glycolytic metabolic pathways via alternative splicing of pyruvate kinase (PKM) by heterogeneous ribonucleoproteins (HNRNPs). Furthermore, when maintained under hypoxic conditions, these MYC-amplified tumors demonstrated increased viability compared to non-amplified tumors within the same subgroup. Taken together, these findings highlight the power of proteomics as an integrative platform to help prioritize genetic and molecular drivers of cancer biology and behavior

Yttrium complexes of Arsine, Arsenide, and Arsinidene Ligands

Deprotonation of the yttrium–arsine complex [Cp′3Y{As(H)2Mes}] (1) (Cp′=η5-C5H4Me, Mes=mesityl) by nBuLi produces the μ-arsenide complex [{Cp′2Y[μ-As(H)Mes]}3] (2). Deprotonation of the As[BOND]H bonds in 2 by nBuLi produces [Li(thf)4]2[{Cp′2Y(μ3-AsMes)}3Li], [Li(thf)4]2[3], in which the dianion 3 contains the first example of an arsinidene ligand in rare-earth metal chemistry. The molecular structures of the arsine, arsenide, and arsinidene complexes are described, and the yttrium–arsenic bonding is analyzed by density functional theory

ESA Voyage 2050 white paper:A Polarized View of the Hot and Violent Universe

Since the birth of X-ray Astronomy, spectacular advances have been seen in the imaging, spectroscopic and timing studies of the hot and violent X-ray Universe, and further leaps forward are expected in the future. On the other hand, polarimetry is very much lagging behind: after the measurements of the Crab Nebula and Scorpius X-1, obtained by OSO-8 in the 70s, no more observations have been performed in the classical X-ray band, even if some interesting results have been obtained in hard X-rays and in soft gamma-rays. The NASA/ASI mission IXPE, scheduled for the launch in 2021, is going to provide for the first time imaging X-ray polarimetry in the 2-8 keV band thanks to its photoelectric polarimeter, coupled with ~25'' angular resolution X-ray mirrors. Its orders of magnitude improvement in sensitivity with respect to the OSO-8 Bragg polarimeter implies scientifically meaningful polarimetric measurements for at least the brightest specimens of most classes of X-ray sources. In 2027, the Chinese-led mission eXTP should also be launched. In addition to timing and spectroscopic instruments, eXTP will have on board photoelectric polarimeters very similar to those of IXPE, but with a total effective area 2-3 times larger. Building on IXPE results, eXTP will increase the number of sources for which significant polarimetric measurements could be obtained. However, further progresses, such as exploring a broader energy range, considering a larger effective area, improving the angular resolution, and performing wide-field polarization measurements, are needed to reach a mature phase for X-ray polarimetry. In the first part of this White Paper we will discuss a few scientific cases in which a next generation X-ray Polarimetry mission can provide significant advances. In the second part, a possible concept for a medium-class Next Generation X-ray Polarimetry (NGXP) mission will be sketched

Hermeneutics and Nature

This paper contributes to the on-going research into the ways in which the humanities transformed the natural sciences in the late Eighteenth and early Nineteenth Centuries. By investigating the relationship between hermeneutics -- as developed by Herder -- and natural history, it shows how the methods used for the study of literary and artistic works played a crucial role in the emergence of key natural-scientific fields, including geography and ecology