Biópsia pulmonar percutânea em equinos

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EVIDÊNCIAS DE INFLAMAÇÃO DAS VIAS AÉREAS RESPIRATÓRIAS INFERIORES, EM POTROS PSI SAUDÁVEIS, ANTES DO INÍCIO DOS TREINAMENTOS

Obstruções do trato respiratório inferiorapresentam grande impacto no potencial atlético decavalos de corrida. Doença Inflamatória das ViasAéreas (DIVA) constitui achado comum em cavalosde corrida jovens. Esse estudo testou a hipótesede que a inflamação do trato respiratório inferiorpoderia iniciar ainda na vida no haras. Sete diferentesharas foram visitados, e 119 potros sobreanoforam investigados. As vias aéreas inferiores foramavaliadas através de exame clínico e endoscópico,e citologia do aspirado traqueal. Entre os potrosconsiderados clinicamente saudáveis, 90,76% evidenciarammuco traqueo-bronquial e os perfis citológicosevidenciaram reação inflamatória presente.A presente investigação confirma a presença deinflamação pulmonar em potros PSI antes do iníciodo treinamento, representando um risco potencial àcapacidade atlética futura.Lower respiratory airway obstruction has a major impact in racehorse athletic potential. Inflammatory Airway Disease (IAD) is a common finding in young racehorses. This study tested the hypothesis that lower airway inflammation could initiate in farm life. Seven different breeding farms were visited, and 119 yearlings were investigated. Lower airways were evaluated by clinical examination, endoscopy and cytology of the tracheal aspirate. From those yearlings considered clinically healthy, 90,76% evidenced tracheobronchial mucus and some showing cytological profile of inflammatory reaction. Then, the present investigation confirms the occurrence of inflammatory condition of the lower respiratory airways in thoroughbred yearlings before training has commenced, representing a potential risk for the future athletic performance in young racehorses

EXAME GASTROSCÓPICO APÓS ADMINISTRAÇÃO ORAL DE ANTI-INFLAMATÓRIOS NÃO ESTEROIDAIS EM CÃES

O objetivo deste estudo foi o de avaliar os efeitos gástricos decorrentes da administração oral do carprofeno e vedaprofeno em cães. Para isso, 21 cães foram divididos aleatoriamente em 3 grupos (n=7). O Grupo I, recebeu a dose terapêutica de 2,2 mg/kg de carprofeno oral; o Grupo II recebeu vedaprofeno via oral, na dose terapêutica de 0,5 mg/kg, e ao Grupo III foi administrado placebo via oral, com intervalos entre doses de 12 em 12 horas, durante 30 dias consecutivos. Os cães foram submetidos a endoscopia gástrica antes da administração dos medicamentos, 10 e 30 dias após o início do tratamento. Foram avaliados, diariamente, quanto às alterações de comportamento e exames físicos. Concluise que o carprofeno e o vedaprofeno, podem ser administrados via oral, em dose terapêutica, durante o período de 30 dias consecutivos, causando mínimas alterações gástricas em cães. Gastroscopic examination after oral administration of non steroids antiinflammatory in dogs Abstract An evaluation of the gastric side effects caused by the administration of carpofren and vedaprofen to dogs has been carried out in the present research work. A total of 21 dogs were randomized in 3 groups (n = 7). To Group I carprofen was administered orally at a dose of 2.2mg/kg. To Group II, vedaprofen was administered orally at a dose of 0.5 mg/kg. Group III received a placebo orally. In all three groups, the administration of both the drugs and the placebo took place twice a day, at each 12 hours interval, for a period of 30 days. The animals were then observed for behavioral changes and submitted to physical exams dayly. Following these observations, it was possible to conclude that capofren and vedaprofen could be adminitered orally to dogs, at therapeutic dose rates, for 30 consecutive days, without clinical evidence of side effects in the gastric tract

LAMINITE EM PORCAS DESCARTADAS PROVENIENTES DE GRANJAS COMERCIAIS DE SUÍNOS DO SUL DO BRASIL

Although laminitis has been reported in pigs, distal phalanx rotation detected by radiography has not been described yet in this species. Accordingly, this paper describes three cases of laminitis in sows from a Brazilian commercial swine unit, and a preliminary study on laminitis in culled sows from a slaughterhouse, based on radiographic evaluation. A farrow-to-finish unit located in a central swine production area in southern Brazil showed a history of locomotor alterations in sows. Three lame sows were selected for examination. They displayed typical clinical signs of laminitis. Their feet were radiographed, and all three showed distal phalanx deviation in at least one digit. In order to find out the possibility of laminitis occurrence in other farms, thirteen hind and five front feet from lame sows were collected in a slaughterhouse, and radiographed in lateromedial position. Eleven sows (61%) showed distal phalanx rotation of the third or the fourth digit, whereas eight of them (44%) showed this alteration in both digits. Osteolysis in five sows (28%) and periosteal proliferation in another four sows (11%) were observed. In conclusion, laminitis with distal phalanx rotation is present in Brazilian herds, and radiographic analysis may be an important diagnosis tool for the disease in vivo or at slaughterhouses.Embora a laminite tenha sido relatada em suínos, a rotação de falange distal detectada por radiografia ainda não foi descrita nessa espécie. O presente trabalho descreve três casos de laminite em porcas provenientes de uma granja comercial de suínos bem como relata um estudo preliminar sobre laminite em porcas de descarte em abatedouro, baseado em avaliações radiográficas. Uma granja de ciclo completo localizada em uma área de exploração suinícola do sul do Brasil mostrou histórico de alterações locomotoras em porcas. Três porcas com claudicação foram selecionadas para exame. Elas apresentavam sinais clínicos típicos de laminite. Seus membros foram radiografados e todas apresentaram rotação de falange distal em pelo menos um dígito. Para verificar a presença de laminite em outros rebanhos da região, treze membros pélvico e cinco membros torácicos de matrizes suínas foram colhidos em um abatedouro e radiografados em posição latero-medial. Onze porcas (61%) mostraram rotação de falange distal no terceiro ou no quarto dígito, enquanto oito delas (44%) mostraram essa alteração em ambos os dígitos. Foram observadas osteólises em cinco (28%) porcas e proliferação periosteal em quatro porcas (11%). Em conclusão, a laminite está presente em rebanhos suínos brasileiros, e a análise radiográfica constitui-se em uma importante ferramenta para o diagnóstico da doença in vivo ou em abatedouros

Detecção de anticorpos contra o vírus da arterite eqüina (EVAV) e herpes vírus eqüino tipo 1 (EHV-1) em cavalos de carroceiros de Curitiba e Região Metropolitana, Paraná, Brazil

Approximately 1,500 cart horses with low access to veterinary assistance and their owners traffic daily through Curitiba and surroundings to collect recycling material, including paper, metal, plastic and glass. Viral diseases transmitted by aerosol are ofimportance in equine medicine of exposed populations which share the common airspace. Accordingly, the purpose of the present study was to evaluate the occurrence of antibodies against equine viral arteritis virus (EVAV) and equine herpesvirus type 1 (EHV-1) incart horses of Curitiba and surroundings. A total of 97 samples were collected from crossbred cart horses, 51 males and 46 females, with average age of 15.3 years (from 4 months to 22 years) from April 2005 to June 2006, from Curitiba and São José dos Pinhais, Southern Brazil. All 97 samples tested were negative for EVAV. However, one horse from Curitiba (1/25) and four fromSão José dos Pinhais (4/72) were found positive for EHV-1, performing a total of five horses (4.1%). These results demonstrated lower rates of EVAV and EHV-1 when compared to other studies in purebred horse populations or horses used for other purposes. In conclusion, despite cart horses undergo daily traffic in urban areas with low access to veterinary assistance,they seem less exposed to the infection risk of equine viral arteritis virus and equine herpesvirus type 1 when compared to horses utilized for sports, exposition and reproduction.Aproximadamente 1.500 cavalos de carroceiros com baixo acesso à assistência veterinária e seus proprietários trafegam diariamente pela Região Metropolitana de Curitiba para coleta de materialreciclável, incluindo papel, metal, plástico e vidro. Doenças virais transmitidas por aerossol são de importância na medicina eqüina de populações expostas que compartilham o mesmo ambiente. O propósito deste estudo foi de avaliar a ocorrência de anticorposcontra o vírus da arterite eqüina (EVAV) e o herpes vírus eqüino tipo 1 (EHV-1) em cavalos de carroceiros de Curitiba e Região Metropolitana. Um total de 97 amostras de sangue foram coletadas de cavalos de carroceiros sem raça definida sendo 51 machos e 46 fêmeas, média de 15,3 anos de idade de abril de 2005 a junho de 2006 em Curitiba e São José dos Pinhais. Todas as 97 amostras testadas foram negativas para EVAV. Entretanto, um cavalo de Curitiba (1/25) e quatro de São José dos Pinhais (4/72) foram positivos para EHV-1, com total de cinco cavalos (4.1%). Os resultados demonstraram taxas mais baixas de EVAV e EHV-1 quando comparados com outros estudos em cavalospuros ou para outros propósitos. Em conclusão, apesar dos cavalos de carroceiros realizarem tráfego diário em centros urbanos e terem pouco acesso à assistência veterinária, estes parecem estar menos expostos ao risco de infecção por EVAV e EHV-1 quando comparados com cavalos utilizados para esportes,exposições e reprodução

Mechanistic insights into a hydrate contribution to the Paleocene-Eocene carbon cycle perturbation from coupled thermohydraulic simulations

During the Paleocene-Eocene Thermal Maximum (PETM), the carbon isotopic signature (δ13C) of surface carbon-bearing phases decreased abruptly by at least 2.5 to 3.0‰. This carbon isotope excursion (CIE) has been attributed to widespread methane hydrate dissociation in response to rapid ocean warming. We ran a thermohydraulic modeling code to simulate hydrate dissociation due to ocean warming for various PETM scenarios. Our results show that hydrate dissociation in response to such warming can be rapid but suggest that methane release to the ocean is modest and delayed by hundreds to thousands of years after the onset of dissociation, limiting the potential for positive feedback from emission-induced warming. In all of our simulations at least half of the dissociated hydrate methane remains beneath the seabed, suggesting that the pre-PETM hydrate inventory needed to account for all of the CIE is at least double that required for isotopic mass balance

On the Origin and Trigger of the Notothenioid Adaptive Radiation

Adaptive radiation is usually triggered by ecological opportunity, arising through (i) the colonization of a new habitat by its progenitor; (ii) the extinction of competitors; or (iii) the emergence of an evolutionary key innovation in the ancestral lineage. Support for the key innovation hypothesis is scarce, however, even in textbook examples of adaptive radiation. Antifreeze glycoproteins (AFGPs) have been proposed as putative key innovation for the adaptive radiation of notothenioid fishes in the ice-cold waters of Antarctica. A crucial prerequisite for this assumption is the concurrence of the notothenioid radiation with the onset of Antarctic sea ice conditions. Here, we use a fossil-calibrated multi-marker phylogeny of nothothenioid and related acanthomorph fishes to date AFGP emergence and the notothenioid radiation. All time-constraints are cross-validated to assess their reliability resulting in six powerful calibration points. We find that the notothenioid radiation began near the Oligocene-Miocene transition, which coincides with the increasing presence of Antarctic sea ice. Divergence dates of notothenioids are thus consistent with the key innovation hypothesis of AFGP. Early notothenioid divergences are furthermore congruent with vicariant speciation and the breakup of Gondwana

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected