The temperature dependence of hysteretic processes in Co nanowires arrays

In this paper, the temperature dependence of the hysteretic processes of Co nanowires, squarelly ordered in an array prepared by electrodeposition in nanopores of alumina membranes was analyzed. Both the magnetostatic interactions induced in the nanowires arrays and the thermal stresses (radial, azimuthal and axial stresses), which appear during the cooling of the system (nanowire and alumina template) from room temperature to 3 K was evaluated. The analysis of thermal induced stresses provides useful informations concerning the magnetic anisotropy in the Co nanowires. The temperature dependence of the remanent magnetization and coercitive field as an effect of the induced thermal stresses and magnetostatic interactions between nanowires was studied

From monoclonal antibodies to chimeric antigen receptors for the treatment of human malignancies

Monoclonal antibodies (mAbs) and their directly derived cell-based application known as chimeric antigen receptors (CARs) ensue from the need to develop novel therapeutic strategies that retain high anti-tumor activity, but carry reduced toxicity compared to conventional chemo- and radiotherapies. In this concise review article, we will summarize the application of antibodies designed to target antigens expressed by tumor cells, and the transition from these antibodies to the generation of CARs

New oral anticoagulants and their reversal agents

Atrial fibrillation is a commonly encountered pathology in medical practice, and its prevalence has shown a continuous rise over the past years. Atrial fibrillation has a significant impact on patients\u27 quality of life, not only due to the standard anticoagulant treatment with vitamin K antagonists that require close monitoring and dose adjustment, but also due to the fragile equilibrium between hemorrhagic and thrombotic risks. The introduction of new oral anticoagulants (NOACs) in the treatment guidelines for atrial fibrillation has improved the quality of life, as NOACs do not require close monitoring or dose adjustments. However, even if the safety profile of the NOACs regarding the hemorrhagic risk is superior to vitamin K antagonists, the problem raised by an unexpected hemorrhage (e.g. severe hemorrhage after an accident) and the need for efficient hemostasis in a chronic anticoagulated patient has remained unsolved. To find a solution for this problem, reversal agents for NOACs have been developed and tested, and two of them, idarucizumab and andexanet-alpha, have already been approved by the FDA, thus making NOACs increasingly appealing as a choice of anticoagulation treatment

REACTION OF SUNFLOWER GENOTYPES TO THERMAL STRESS CONDITIONS IN THE SANDY SOILS AREA OF SOUTHERN OLTENIA

The researches carried out during 2016-2017 at RDCSPS Dabuleni aimed at the behavior of biological sunflower material, created at NARDI Fundulea, under conditions of thermal water stress from the sandy soils in southern Oltenia. The results obtained at 109 sunflower genotypes underline the favorability of Romania's southern area for sunflower culture. It showed significantly distinct positive correlation between the rate of  photosynthesis in the plant, and photosynthetic active radiation (r = 0.282 **) as well as between foliar sweating rate and leaf surface temperature (0.412 **). The production was differentiated according to the genotype and the climatic conditions of the agricultural year, ranging from 2299-5180 kg / ha, with an average of 4307 kg / ha

Bioremediation of Cr(VI) polluted wastewaters by sorption on heat inactivated Saccharomyces cerevisiae biomass

The potential of heat inactivated Saccharomyces cerevisiae in the bioremoval and reduction of Cr (VI) ions from wastewaters was evaluated in terms of metal uptake in time and at equilibrium, and biosorption efficiency, by varying pH, biosorbent doses, contact time and temperature, in batch mode. During the sorption process, the heat inactivated biomass of the yeast Saccharomyces cerevisiae is capable of reducing Cr(VI) to Cr(III). Different kinetic models based on adsorption and reduction are used to represent the kinetic data of Cr(VI) bioremoval by S. cerevisiae, in explaining the biosorption mechanism of heavy metals and potential rate-controlling steps, in the perspective of full-scale process design. The results indicated some potential differences in the Cr(VI) removal mechanism at different experimental conditions. FTIR and SEM analysis were performed as well as to elucidate the mechanism of metal bioremoval by S. cerevisiae. FTIR spectra indicate that heavy metal bioremoval process doesn’t imply in this case the formation of stable covalent bonds, but it is predominantly based on chemical interactions, ion-exchange type. The SEM micrographs of Cr-loaded yeast, indicates that the surface morphology doesn’t change much after chromium ions were uptaken. This leads to the conclusion that Cr(VI) reduction occurs at the interface of the adsorbent.This paper was elaborated with the support of BRAIN project Doctoral scholarships as an investment in intelligence - ID 6681, financed by the European Social Found and Romanian Government and with the support of a grant of the Romanian National Authority for Scientific Research, CNCS - UEFISCDI, project number PN-II-ID-PCE-2011-3-0559", Contract 265/2011

EVALUATION OF THE QUALITY AND AVAILABILITY FOR IRRIGATION OF WATER FROM DIFFERENT SOURCES FROM SOUTHERN OLTENIA

The researches were carried out under the conditions of 2019 and aimed at assessing the quality and availability for irrigation of groundwater and surface water from different sources located on the territory of Dabuleni Research Development Station for Plant Culture on Sands (Dabuleni RDSPCS). The results regarding the quality of the water showed different values according to the source and climatic conditions. The average values regarding the fixed mineral residue, pH, nitrate content and ammonium ions, determined in 9 working points, show that the analyzed sources cannot be used as drinking water, but can be used for irrigation of agricultural crops. The obtained results showed the following water quality indicators: mineral residue = 475 -1350 mg / dm3; pH = 7.05 - 8.43; nitrates = 10.23 - 28.08 mg / dm3, ammonium (NH4 +) = 1.73 - 8.82 mg/dm3

THE RESEARCHS ON THE BIOCHEMICAL COMPOSITION OF POTATO TUBERS DEPENDING ON THE VARIETY AND THE WATER SUPPLY IN CONDITIONS OF SANDY SOILS IN SOUTHERN OLTENIA

Water is one of the most important factors for potato vegetation. From this point of view, potatoes has been classified among the plants sensible to water shortages, falling under our country from this point of view immediately after rice (Zanfirescu, 1977, quoted by Chichea, 2000). At CCDCPN Dăbuleni was studied an assortment of 14 potato varieties depending on the level water supply. The results show differences between the varieties studied and between levels of water supply within the same variety. They highlighted varieties: Astral, Magic, Tresor, Artemis, Robusta by a dry matter content of over 20%. The vitamin C content was more influenced by the variety in the study and less than the water supply. Best yields were obtained for varieties: Carrera (43.6 t / ha), Tresor (40.8 t / ha), Riviera (39.3 t / ha) on the ceiling irrigated at 80% of the interval active moisture

Current pharmacological treatment of painful diabetic neuropathy: A narrative review

Background and Objectives: Distal symmetrical polyneuropathy (DSPN) is one of the most common chronic complications of diabetes mellitus. Although it is usually characterized by progressive sensory loss, some patients may develop chronic pain. Assessment of DSPN is not difficult, but the biggest challenge is making the correct diagnosis and choosing the right treatment. The treatment of DSPN has three primary objectives: glycemic control, pathogenic mechanisms, and pain management. The aim of this brief narrative review is to summarize the current pharmacological treatment of painful DSPN. It also summarizes knowledge on pathogenesis-oriented therapy, which is generally overlooked in many publications and guidelines. Materials and Methods: The present review reports the relevant information available on DSPN treatment. The search was performed on PubMed, Cochrane, Semantic Scholar, Medline, Scopus, and Cochrane Library databases, including among others the terms “distal symmetrical polyneuropathy”, “neuropathic pain treatment”, “diabetic neuropathy”, “diabetes complications”, ”glycaemic control”, “antidepressants”, “opioids”, and “anticonvulsants”. Results: First-line drugs include antidepressants (selective serotonin reuptake inhibitors and tricyclic antidepressants) and pregabalin. Second- and third-line drugs include opioids and topical analgesics. While potentially effective in the treatment of neuropathic pain, opioids are not considered to be the first choice because of adverse reactions and addiction concerns. Conclusions: DSPN is a common complication in patients with diabetes, and severely affects the quality of life of these patients. Although multiple therapies are available, the guidelines and recommendations regarding the treatment of diabetic neuropathy have failed to offer a unitary consensus, which often hinders the therapeutic options in clinical practice

Mastita plasmocitară, atitudini terapeutice corecte, review asupra 17 cazuri

Spital Clinic Universitar de Urgențe “Sf. Spiridon”, Iași, Clinica III Chirurgie, Al XI-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” din Republica Moldova și cea de-a XXXIII-a Reuniune a Chirurgilor din Moldova „Iacomi-Răzeșu” 27-30 septembrie 2011Introducere: Mastita plasmocitară este o boală inflamatorie cronică rară a sțnului, de etiologie necunoscută, ce îmbracă mai multe tablouri clinice în funcție de stadiul evolutiv al bolii. Scopul lucrării este de a sublinia importanța cunoașterii atitudinii terapeutice corecte în fața acestei patologii. Material și metodă: Am evoluat tabloul complet la 17 paciente diagnosticate și tratate pentru mastita plasmocitară în Clinica III Chirurgie Iași, în perioada 2001-2010. Rezultate: Vârsta medie a pacientelor a fost 34 ani. Tabloul clinic la internare a fost dominat de masa tumorală mamară la 2 cazuri, masa tumorală si abces al sânului la 4 cazuri, abcese multiple mamare cu fistula la piele în 10 cazuri și abcese multiple ale sânului însoțite de fenomene neurologice și de vasculită periferică la 1 pacienta. S-a practicat incizie și drenaj al colectiilor în 15 cazuri (datorită refuzului exciziei largi/mastectomiei de către pacientă) și mastectomie subcutanată ca prima terapie la 2 paciente.Toate cele 15 paciente au prezentat recidive sub formă de abcese intraglandulare ce au necesitat reintervenție-incizie și drenaj în 8 cazuri, mastectomie în 5 cazuri, bicadranectomie în 1 caz și cadranectomie în 1 caz. O pacientă a prezentat evoluție postoperatorie trenantă și gravă cu recidive sub formă de abcese în vecinătatea celor deja drenate, sub antibioterapie, cu fenomene neurologice și de vasculită autoimună ce a necesitat administratrea de Prednison. La pacientele la care s-a practicat incizie-drenaj ca reintervenție, evoluția favorabilă a fost de scurtă durată, cu apariția recidiveluo în 1-9 luni. Evolutța la pacientele mastectomizate a fost favorabilă. Concluzii: Mastita plasmocitară rămâne o boală inflamatorie cronică rară,recidivantă de etiologie incertă.Multiplele recidive duc în timp la remaniere importantă a glandei ce poate preta la confuzia cu neoplasmul mamar. Singurul tratament cu viza curativă este adesea mastectomia subcutanată, greu acceptată de pacient în contextul patologiei benigne

Approximation of the critical buckling factor for composite panels

This article is concerned with the approximation of the critical buckling factor for thin composite plates. A new method to improve the approximation of this critical factor is applied based on its behavior with respect to lamination parameters and loading conditions. This method allows accurate approximation of the critical buckling factor for non-orthotropic laminates under complex combined loadings (including shear loading). The influence of the stacking sequence and loading conditions is extensively studied as well as properties of the critical buckling factor behavior (e.g concavity over tensor D or out-of-plane lamination parameters). Moreover, the critical buckling factor is numerically shown to be piecewise linear for orthotropic laminates under combined loading whenever shear remains low and it is also shown to be piecewise continuous in the general case. Based on the numerically observed behavior, a new scheme for the approximation is applied that separates each buckling mode and builds linear, polynomial or rational regressions for each mode. Results of this approach and applications to structural optimization are presented