747 research outputs found
Selective optical broadcasting in reconfigurable multiprocessor interconnects - art. no. 61850J
Speeding up multiprocessor machines with reconfigurable optical interconnects - art. no. 61240K
Accretion disk in the eclipsing binary AU Mon
We analyze the CoRoT and V-passband ground-based light curves of the
interacting close binary AU Mon, assuming that there is a geometrically and
optically thick accretion disk around the hotter and more massive star, as
inferred from photometric and spectroscopic characteristics of the binary. Our
model fits the observations very well and provides estimates for the orbital
elements and physical parameters of the components and of the accretion disk.Comment: Accepted for publication in MNRA
Expanding the measurement of culture with a sample of two billion humans
This is the final version. Available on open access from the Royal Society via the DOI in this recordData accessibility:
Data and code will be available at the paper’s repository on OSF (http://doi.org/10.17605/OSF.IO/A2BTR) and in a public repository in Github (https://github.com/measuring-culture). The data description is provided in electronic supplementary material [85].Culture has played a pivotal role in human evolution. Yet, the ability of social scientists to study culture is limited by the currently available measurement instruments. Scholars of culture must regularly choose between scalable but sparse survey-based methods or restricted but rich ethnographic methods. Here, we demonstrate that massive online social networks can advance the study of human culture by providing quantitative, scalable and high-resolution measurement of behaviourally revealed cultural values and preferences. We employ data across nearly 60 000 topic dimensions drawn from two billion Facebook users across 225 countries and territories. We first validate that cultural distances calculated from this measurement instrument correspond to traditional survey-based and objective measures of cross-national cultural differences. We then demonstrate that this expanded measure enables rich insight into the cultural landscape globally at previously impossible resolution. We analyse the importance of national borders in shaping culture and compare subnational divisiveness with gender divisiveness across countries. Our measure enables detailed investigation into the geopolitical stability of countries, social cleavages within small- and large-scale human groups, the integration of migrant populations and the disaffection of certain population groups from the political process, among myriad other potential future applications.European Union Horizon 2020Comunidad de Madrid-SpainFundacion BBVASpanish Ministry of Education with the FPU programm
Impact of sequence variation in the ul128 locus on production of human cytomegalovirus in fibroblast and epithelial cells
The human cytomegalovirus (HCMV) virion envelope contains a complex consisting of glycoproteins gH and gL plus proteins encoded by the UL128 locus (UL128L): pUL128, pUL130, and pUL131A. UL128L is necessary for efficient infection of myeloid, epithelial, and endothelial cells but limits replication in fibroblasts. Consequently, disrupting mutations in UL128L are rapidly selected when clinical isolates are cultured in fibroblasts. In contrast, bacterial artificial chromosome (BAC)-cloned strains TB40-BAC4, FIX, and TR do not contain overt disruptions in UL128L, yet no virus reconstituted from them has been reported to acquire mutations in UL128L in vitro. We performed BAC mutagenesis and reconstitution experiments to test the hypothesis that these strains contain subtle mutations in UL128L that were acquired during passage prior to BAC cloning. Compared to strain Merlin containing wild-type UL128L, all three strains produced higher yields of cell-free virus. Moreover, TB40-BAC4 and FIX spread cell to cell more rapidly than wild-type Merlin in fibroblasts but more slowly in epithelial cells. The differential growth properties of TB40-BAC4 and FIX (but not TR) were mapped to single-nucleotide substitutions in UL128L. The substitution in TB40-BAC4 reduced the splicing efficiency of UL128, and that in FIX resulted in an amino acid substitution in UL130. Introduction of these substitutions into Merlin dramatically increased yields of cell-free virus and increased cell-to-cell spread in fibroblasts but reduced the abundance of pUL128 in the virion and the efficiency of epithelial cell infection. These substitutions appear to represent mutations in UL128L that permit virus to be propagated in fibroblasts while retaining epithelial cell tropism
An asteroseismic study of the beta Cephei star 12 Lacertae: multisite spectroscopic observations, mode identification and seismic modelling
We present the results of a spectroscopic multisite campaign for the beta
Cephei star 12 (DD) Lacertae. Our study is based on more than thousand
high-resolution high S/N spectra gathered with 8 different telescopes in a time
span of 11 months. In addition we make use of numerous archival spectroscopic
measurements. We confirm 10 independent frequencies recently discovered from
photometry, as well as harmonics and combination frequencies. In particular,
the SPB-like g-mode with frequency 0.3428 1/d reported before is detected in
our spectroscopy. We identify the four main modes as (l1,m1) = (1, 1), (l2,m2)
= (0, 0), (l3,m3) = (1, 0) and (l4,m4) = (2, 1) for f1 = 5.178964 1/d, f2 =
5.334224 1/d, f3 = 5.066316 1/d and f4 = 5.490133 1/d, respectively. Our
seismic modelling shows that f2 is likely the radial first overtone and that
the core overshooting parameter alpha_ov is lower than 0.4 local pressure scale
heights.Comment: 16 pages, 11 figures, accepted in MNRA
CoRoT high-precision photometry of the B0.5 IV star HD 51756
OB stars are important constituents for the ecology of the Universe, and
there are only a few studies on their pulsational properties detailed enough to
provide important feedback on current evolutionary models. Our goal is to
analyse and interpret the behaviour present in the CoRoT light curve of the
B0.5 IV star HD 51756 observed during the second long run of the space mission,
and to determine the fundamental stellar parameters from ground-based
spectroscopy gathered with the CORALIE and HARPS instruments after checking for
signs of variability and binarity, thus making a step further in mapping the
top of the Beta Cep instability strip. We compare the newly obtained
high-resolution spectra with synthetic spectra of late O-type and early B-type
stars computed on a grid of stellar parameters. We match the results with
evolutionary tracks to estimate stellar parameters. We use various time series
analysis tools to explore the nature of the variations present in the light
curve. Additional calculations are carried out based on distance and historical
position measurements of the components to impose constraints on the binary
orbit. We find that HD 51756 is a wide binary with both a slow (v sin i \approx
28 km s^-1) and a fast (v sin i \approx 170 km s^-1) early-B rotator whose
atmospheric parameters are similar (T_eff \approx 30000 K and log g \approx
3.75). We are unable to detect pulsation in any of the components, and we
interpret the harmonic structure in the frequency spectrum as sign of
rotational modulation, which is compatible with the observed and deduced
stellar parameters of both components. The non-detection of pulsation modes
provides a feedback on the theoretical treatment, given that non-adiabatic
computations applied to appropriate stellar models predict the excitation of
both pressure and gravity modes for the fundamental parameters of this star.Comment: Accepted for publication in Astronomy and Astrophysics on 14/01/2011,
11 pages, 9 figures, 4 table
Protein Design Using Continuous Rotamers
Optimizing amino acid conformation and identity is a central problem in computational protein design. Protein design algorithms must allow realistic protein flexibility to occur during this optimization, or they may fail to find the best sequence with the lowest energy. Most design algorithms implement side-chain flexibility by allowing the side chains to move between a small set of discrete, low-energy states, which we call rigid rotamers. In this work we show that allowing continuous side-chain flexibility (which we call continuous rotamers) greatly improves protein flexibility modeling. We present a large-scale study that compares the sequences and best energy conformations in 69 protein-core redesigns using a rigid-rotamer model versus a continuous-rotamer model. We show that in nearly all of our redesigns the sequence found by the continuous-rotamer model is different and has a lower energy than the one found by the rigid-rotamer model. Moreover, the sequences found by the continuous-rotamer model are more similar to the native sequences. We then show that the seemingly easy solution of sampling more rigid rotamers within the continuous region is not a practical alternative to a continuous-rotamer model: at computationally feasible resolutions, using more rigid rotamers was never better than a continuous-rotamer model and almost always resulted in higher energies. Finally, we present a new protein design algorithm based on the dead-end elimination (DEE) algorithm, which we call iMinDEE, that makes the use of continuous rotamers feasible in larger systems. iMinDEE guarantees finding the optimal answer while pruning the search space with close to the same efficiency of DEE. Availability: Software is available under the Lesser GNU Public License v3. Contact the authors for source code
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