30 research outputs found
The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbasi B.
- Abbasi-Kangevari M.
- Abbasi-Kangevari Z.
- Abbastabar H.
- Abd-Elsalam S.
- Abdelmasseh M.
- Abdoli A.
- Abebe H.
- Abedi A.
- Abidi H.
- Abolhassani H.
- Abu-Gharbieh E.
- Abubaker Ali H.
- Achappa B.
- Acuna J. M.
- Adedeji I. A.
- Adegboye O. A.
- Adnani Q. E. S.
- Advani S. M.
- Afzal M. S.
- Aghaie Meybodi M.
- Ahadinezhad B.
- Ahinkorah B. O.
- Ahmad S.
- Ahmadi S.
- Ahmed M. B.
- Ahmed Rashid T.
- Ahmed Salih Y.
- Aiman W.
- Akalu G. T.
- Al Hamad H.
- Al-Maweri S. A.
- Al-Raddadi R. M.
- Alahdab F.
- AlAmodi A. A.
- Alanezi F. M.
- Alanzi T. M.
- Alem A. Z.
- Alem D. T.
- Alemayehu Y.
- Alhalaiqa F. N.
- Alhassan R. K.
- Ali S.
- Alicandro G.
- Alipour V.
- Aljunid S. M.
- Alkhayyat M.
- Alluri S.
- Almasri N. A.
- Almustanyir S.
- Alvarez E. M.
- Alvis-Guzman N.
- Ameyaw E. K.
- Amini S.
- Amu H.
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background: In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15–39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods: Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15–39 years to define adolescents and young adults. Findings: There were 1·19 million (95% UI 1·11–1·28) incident cancer cases and 396 000 (370 000–425 000) deaths due to cancer among people aged 15–39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59·6 [54·5–65·7] per 100 000 person-years) and high-middle SDI countries (53·2 [48·8–57·9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14·2 [12·9–15·6] per 100 000 person-years) and middle SDI (13·6 [12·6–14·8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23·5 million (21·9–25·2) DALYs to the global burden of disease, of which 2·7% (1·9–3·6) came from YLDs and 97·3% (96·4–98·1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation: Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Funding: Bill & Melinda Gates Foundation, American Lebanese Syrian Associated Charities, St Baldrick's Foundation, and the National Cancer Institute
The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbasi Behzad
- Abbasi-Kangevari Mohsen
- Abbasi-Kangevari Zeinab
- Abbastabar Hedayat
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdoli Amir
- Abebe Haimanot
- Abedi Aidin
- Abidi Hassan
- Abolhassani Hassan
- Abu-Gharbieh Eman
- Abubaker Ali Hiwa
- Achappa Basavaprabhu
- Acuna Juan Manuel
- Adedeji Isaac Akinkunmi
- Adegboye Oyelola A
- Adnani Qorinah Estiningtyas Sakilah
- Advani Shailesh M
- Afzal Muhammad Sohail
- Aghaie Meybodi Mohamad
- Ahadinezhad Bahman
- Ahinkorah Bright Opoku
- Ahmad Sajjad
- Ahmadi Sepideh
- Ahmed Rashid Tarik
- Ahmed Salih Yusra
- Ahmed Muktar Beshir
- Aiman Wajeeha
- Akalu Gizachew Taddesse
- Al Hamad Hanadi
- Al-Maweri Sadeq Ali
- Al-Raddadi Rajaa M
- Alahdab Fares
- AlAmodi Abdulhadi A
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Alem Adugnaw Zeleke
- Alem Dejene Tsegaye
- Alemayehu Yosef
- Alhalaiqa Fadwa Naji
- Alhassan Robert Kaba
- Ali Saqib
- Alicandro Gianfranco
- Alipour Vahid
- Aljunid Syed Mohamed
- Alkhayyat Motasem
- Alluri Sunitha
- Almasri Nihad A
- Almustanyir Sami
- Alvarez Elysia M
- Alvis-Guzman Nelson
- Ameyaw Edward Kwabena
- Amini Saeed
- Amu Hubert
- Ancuceanu Robert
- Andrei Catalina Liliana
- Andrei Tudorel
- Ansari Fereshteh
- Ansari-Moghaddam Alireza
- Anvari Davood
- Anyasodor Anayochukwu Edward
- Arab-Zozani Morteza
- Arabloo Jalal
- Argaw Ayele Mamo
- Ariffin Hany
- Arshad Muhammad
- Arulappan Judie
- Aryannejad Armin
- Asemi Zatollah
- Asghari Jafarabadi Mohammad
- Atashzar Mohammad Reza
- Atorkey Prince
- Atreya Alok
- Attia Sameh
- Aujayeb Avinash
- Ausloos Marcel
- Avila-Burgos Leticia
- Awedew Atalel Fentahun
- Ayala Quintanilla Beatriz Paulina
- Ayele Alemu Degu
- Ayen Solomon Shitu
- Azab Mohammed A
- Azadnajafabad Sina
- Azami Hiva
- Azangou-Khyavy Mohammadreza
- Azari Jafari Amirhossein
- Azarian Ghasem
- Azzam Ahmed Y
- Bahadory Saeed
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- Wubishet Befikadu Legesse
- Xu Rixing
- Xu Suowen
- Yahyazadeh Jabbari Seyed Hossein
- Yang Lin
- Yaya Sanni
- Yazdi-Feyzabadi Vahid
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- Yehualashet Sisay Shewasinad
- Yeshaneh Alex
- Yeshaw Yigizie
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- Yu Chuanhua
- Yunusa Ismaeel
- Zadnik Vesna
- Zahir Mazyar
- Zahirian Moghadam Telma
- Zamani Mohammad
- Zamanian Maryam
- Zandian Hamed
- Zare Fariba
- Zastrozhin Mikhail Sergeevich
- Zastrozhina Anasthasia
- Zhang Jianrong
- Zhang Zhi-Jiang
- Ziapour Arash
- Zoladl Mohammad
- Šekerija Mario
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe
The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
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- Isfahani HM
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- Islam RM
- Islami F
- Ismail NE
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- Iwagami M
- Jabbari SHY
- Jafari AA
- Jaiswal A
- Jakovljevic M
- Jalili M
- Jalilian S
- Jamshidi E
- Jang S-I
- Jani CT
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- Javaheri T
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- Kahe F
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- Kauppila JH
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- Kebede AG
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- Kejela GG
- Keramati M
- Keykhaei M
- Khajuria H
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- Khan AAK
- Khan EA
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- Khan MN
- Khanali J
- Khaneghah AM
- Khatab K
- Khatatbeh MM
- Khatib MN
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- Khezeli M
- Khodadost M
- Kim MS
- Kim YJ
- Kisa A
- Kisa S
- Klugar M
- Klugarova J
- Kocarnik JM
- Kolahi A-A
- Kolkhir P
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- Koyanagi A
- Krishan K
- Krishnamoorthy Y
- Kugbey N
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- Kumar GA
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- Lo C-H
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- Mafi AR
- Magdeldin S
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- Makki A
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- Mansouri B
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- Masoudi S
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- Mathews E
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- Melese A
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- Menezes RG
- Mengesha SD
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- Mentis A-FA
- Mera-Mamian AYM
- Meretoja TJ
- Merid MW
- Merin LJ
- Mersha AG
- Meselu BT
- Meshkat M
- Mestrovic T
- Miazgowski T
- Michalek IM
- Mijena GFW
- Miller TR
- Mir SA
- Mirinezhad SK
- Mirmoeeni S
- Mirza-Aghazadeh-Attari M
- Mirzaei H
- Mirzaei HR
- Misganaw AS
- Misra S
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- Munblit D
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- Murray CJL
- Musa J
- Nabhan AF
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- Nagaraju SP
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- Nair TS
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- Narayana AI
- Nasab EM
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- Nzoputam CI
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- Rashidi M-M
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- Rawaf DL
- Rawaf S
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- Rehman IU
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- Sahoo H
- Sajid MR
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- Salimzadeh H
- Samodra YL
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- Sankararaman S
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- Santric-Milicevic MM
- Saqib MAN
- Sarabi MM
- Sarveazad A
- Sarvi F
- Sathian B
- Satpathy M
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- Schneider IJC
- Schwarzinger M
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- Sepanlou SG
- Seylani A
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- Sha F
- Shafaat O
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- Shahabi S
- Shahid I
- Shahrbaf MA
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- Sharifi A
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- Shobeiri P
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- Silva DAS
- Silva LMLR
- Silvestris N
- Simegn W
- Singh A
- Singh AD
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- Singh H
- Singh JA
- Singh JK
- Singh P
- Singh S
- Sinha DN
- Sinke AH
- Siraj MS
- Sitas F
- Siwal SS
- Skryabin VY
- Skryabina AA
- Socea B
- Soeberg MJ
- Sofi-Mahmudi A
- Solomon Y
- Soltani RDC
- Soltani-Zangbar MS
- Song S
- Song Y
- Soodejani MT
- Sorensen RJD
- Soshnikov S
- Sotoudeh H
- Sowe A
- Sufiyan MB
- Suk R
- Suleman M
- Sultana S
- Sur D
- Swamy SN
- Syed ZQ
- Szacska M
- Tabaeian SP
- Tabares-Seisdedos R
- Tabari MAK
- Tabatabaei SM
- Tabuchi T
- Tadbiri H
- Tahbaz SV
- Taheri E
- Taheri M
- Takahashi K
- Talaat IM
- Tampa M
- Tan K-K
- Tat NY
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- Tavakoli A
- Tehrani-Banihashemi A
- Tekalegn Y
- Tesfay FH
- Thapar R
- Thavamani A
- Thomas N
- Thomas NK
- Ticoalu JHV
- Tiyuri A
- Tollosa DN
- Topor-Madry R
- Toroudi HP
- Touvier M
- Tovani-Palone MR
- Traini E
- Tran KB
- Tran MTN
- Tripathy JP
- Ukke GG
- Ullah I
- Ullah S
- Unnikrishnan B
- Vacante M
- Vaezi M
- Valdez PR
- Vardavas C
- Varniab ZS
- Varthya SB
- Vaziri S
- Velazquez DZ
- Veroux M
- Villeneuve PJ
- Violante FS
- Vladimirov SK
- Vlassov V
- Vo B
- Vos T
- Vu LG
- Wadood AW
- Waheed Y
- Walde MT
- Wamai RG
- Wang C
- Wang F
- Wang N
- Wang Y
- Ward P
- Waris A
- Westerman R
- Wickramasinghe ND
- Woldemariam M
- Woldu B
- Xiao H
- Xu R
- Xu S
- Xu X
- Yadav L
- Yang L
- Yazdanpanah F
- Yeshaw Y
- Yismaw Y
- Yonemoto N
- Younis MZ
- Yousefi Z
- Yousefian F
- Yu C
- Yu Y
- Yunusa I
- Zahir M
- Zaki N
- Zaman BA
- Zangiabadian M
- Zare F
- Zare I
- Zareshahrabadi Z
- Zarrintan A
- Zastrozhin MS
- Zeineddine MA
- Zhang D
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhou L
- Zodpey S
- Zoladl M
- Publication venue
- Publication date
- 20/08/2022
- Field of study
Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbasi-kangevari Mohsen
- Abd-rabu Rami
- Abidi Hassan
- Abu-gharbieh Eman
- Acuna Juan Manuel
- Adhikari Sangeet
- Advani Shailesh M
- Afzal Muhammad Sohail
- Aghaie Meybodi Mohamad
- Ahinkorah Bright Opoku
- Ahmad Sajjad
- Ahmadi Ali
- Ahmadi Sepideh
- Ahmed Haroon
- Ahmed Luai A
- Ahmed Muktar Beshir
- Al Hamad Hanadi
- Al-raddadi Rajaa M
- Alahdab Fares
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Alhalaiqa Fadwa Alhalaiqa Naji
- Alimohamadi Yousef
- Alipour Vahid
- Aljunid Syed Mohamed
- Alkhayyat Motasem
- Almustanyir Sami
- Alvand Saba
- Alvis-guzman Nelson
- Amini Saeed
- Ancuceanu Robert
- Anoushiravani Amir
- Anoushirvani Ali Arash
- Ansari-moghaddam Alireza
- Arabloo Jalal
- Aryannejad Armin
- Asghari Jafarabadi Mohammad
- Athari Seyyed Shamsadin
- Ausloos Floriane
- Ausloos Marcel
- Awedew Atalel Fentahun
- Awoke Mamaru Ayenew
- Ayana Tegegn Mulatu
- Azadnajafabad Sina
- Azami Hiva
- Azangou-khyavy Mohammadreza
- Azari Jafari Amirhossein
- Badiye Ashish D
- Bagherieh Sara
- Bahadory Saeed
- Baig Atif Amin
- Baker Jennifer L
- Banach Maciej
- Barrow Amadou
- Berhie Alemshet Yirga
- Besharat Sima
- Bhagat Devidas S
- Bhagavathula Akshaya Srikanth
- Bhala Neeraj
- Bhattacharyya Krittika
- Bhojaraja Vijayalakshmi S
- Bibi Sadia
- Bijani Ali
- Biondi Antonio
- Bjørge Tone
- Bodicha Belay Boda Abule
- Braithwaite Dejana
- Brenner Hermann
- Calina Daniela
- Cao Chao
- Cao Yin
- Carreras Giulia
- Carvalho Felix
- Cerin Ester
- Chakinala Raja Chandra
- Cho William C S
- Chu Dinh-toi
- Conde Joao
- Costa Vera Marisa
- Cruz-martins Natália
- Dadras Omid
- Dai Xiaochen
- Dandona Lalit
- Dandona Rakhi
- Danielewicz Anna
- Demeke Feleke Mekonnen
- Demissie Getu Debalkie
- Desai Rupak
- Dhamnetiya Deepak
- Dianatinasab Mostafa
- Diaz Daniel
- Didehdar Mojtaba
- Doaei Saeid
- Doan Linh Phuong
- Dodangeh Milad
- Eghbalian Fatemeh
- Ejeta Debela Debela
- Ekholuenetale Michael
- Ekundayo Temitope Cyrus
- El Sayed Iman
- Elhadi Muhammed
- Enyew Daniel Berhanie
- Eyayu Tahir
- Ezzeddini Rana
- Fakhradiyev Ildar Ravisovich
- Farooque Umar
- Farrokhpour Hossein
- Farzadfar Farshad
- Fatehizadeh Ali
- Fattahi Hamed
- Fattahi Nima
- Fereidoonnezhad Masood
- Fernandes Eduarda
- Fetensa Getahun
- Filip Irina
- Fischer Florian
- Foroutan Masoud
- Gaal Peter Andras
- Gad Mohamed M
- Gallus Silvano
- Garg Tushar
- Getachew Tamiru
- Ghamari Seyyed-hadi
- Ghashghaee Ahmad
- Ghith Nermin
- Gholamalizadeh Maryam
- Gholizadeh Navashenaq Jamshid
- Gizaw Abraham Tamirat
- Glasbey James C
- Golechha Mahaveer
- Goleij Pouya
- Gonfa Kebebe Bekele
- Gorini Giuseppe
- Guha Avirup
- Gupta Sapna
- Gupta Veer Bala
- Gupta Vivek Kumar
- Haddadi Rasool
- Hafezi-nejad Nima
- Haj-mirzaian Arvin
- Halwani Rabih
- Haque Shafiul
- Hariri Sanam
- Hasaballah Ahmed I
- Hassanipour Soheil
- Hay Simon I
- Herteliu Claudiu
- Holla Ramesh
- Hosseini Mohammad-salar
- Hosseinzadeh Mehdi
- Hostiuc Mihaela
- Househ Mowafa
- Huang Junjie
- Humayun Ayesha
- Iavicoli Ivo
- Ilesanmi Olayinka Stephen
- Ilic Irena M
- Ilic Milena D
- Islami Farhad
- Iwagami Masao
- Jahani Mohammad Ali
- Jakovljevic Mihajlo
- Javaheri Tahereh
- Jayawardena Ranil
- Jebai Rime
- Jha Ravi Prakash
- Joo Tamas
- Joseph Nitin
- Joukar Farahnaz
- Jozwiak Jacek Jerzy
- Kabir Ali
- Kalhor Rohollah
- Kamath Ashwin
- Kapoor Neeti
- Karaye Ibraheem M
- Karimi Amirali
- Kauppila Joonas H
- Kazemi Asma
- Keykhaei Mohammad
- Khader Yousef Saleh
- Khajuria Himanshu
- Khalilov Rovshan
- Khanali Javad
- Khayamzadeh Maryam
- Khodadost Mahmoud
- Kim Hanna
- Kim Min Seo
- Kisa Adnan
- Kisa Sezer
- Kolahi Ali-asghar
- Koohestani Hamid Reza
- Kopec Jacek A
- Koteeswaran Rajasekaran
- Koyanagi Ai
- Krishnamoorthy Yuvaraj
- Kumar G Anil
- Kumar Manoj
- Kumar Vivek
- La Vecchia Carlo
- Lami Faris Hasan
- Landires Iván
- Ledda Caterina
- Lee Sang-woong
- Lee Wei-chen
- Lee Yeong Yeh
- Leong Elvynna
- Li Bingyu
- Lim Stephen S
- Lobo Stany W
- Loureiro Joana A
- Lunevicius Raimundas
- Madadizadeh Farzan
- Mahmoodpoor Ata
- Majeed Azeem
- Malekpour Mohammad-reza
- Malekzadeh Reza
- Malik Ahmad Azam
- Mansour-ghanaei Fariborz
- Mantovani Lorenzo Giovanni
- Martorell Miquel
- Masoudi Sahar
- Mathur Prashant
- Meena Jitendra Kumar
- Mehrabi Nasab Entezar
- Mendoza Walter
- Mentis Alexios-fotios A
- Mestrovic Tomislav
- Miao Jonasson Junmei
- Miazgowski Bartosz
- Miazgowski Tomasz
- Mijena Gelana Fekadu Worku
- Mirmoeeni Seyyedmohammadsadeq
- Mirza-aghazadeh-attari Mohammad
- Mirzaei Hamed
- Misra Sanjeev
- Mohammad Karzan Abdulmuhsin
- Mohammadi Esmaeil
- Mohammadi Saeed
- Mohammadi Seyyede Momeneh
- Mohammadian-hafshejani Abdollah
- Mohammed Shafiu
- Mohammed Teroj Abdulrahman
- Moka Nagabhishek
- Mokdad Ali H
- Mokhtari Zeinab
- Molokhia Mariam
- Momtazmanesh Sara
- Monasta Lorenzo
- Moradi Ghobad
- Moradzadeh Rahmatollah
- Moraga Paula
- Morgado-da-costa Joana
- Mubarik Sumaira
- Mulita Francesk
- Naghavi Mohsen
- Naimzada Mukhammad David
- Nam Hae Sung
- Natto Zuhair S
- Nayak Biswa Prakash
- Nazari Javad
- Nazemalhosseini-mojarad Ehsan
- Negoi Ionut
- Nguyen Cuong Tat
- Nguyen Son Hoang
- Noor Nurulamin M
- Noori Maryam
- Noori Seyyed Mohammad Ali
- Nuñez-samudio Virginia
- Nzoputam Chimezie Igwegbe
- Oancea Bogdan
- Odukoya Oluwakemi Ololade
- Oguntade Ayodipupo Sikiru
- Okati-aliabad Hassan
- Olagunju Andrew T
- Olagunju Tinuke O
- Ong Sokking
- Ostroff Samuel M
- Padron-monedero Alicia
- Pakzad Reza
- Pana Adrian
- Pandey Anamika
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- Piracha Zahra Zahid
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- Pourshams Akram
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- Rabiee Mohammad
- Rabiee Navid
- Radfar Amir
- Rafiei Sima
- Rahman Mosiur
- Rahmani Amir Masoud
- Rahmanian Vahid
- Rajai Nazanin
- Rajesh Aashish
- Ramezani-doroh Vajiheh
- Ramezanzadeh Kiana
- Ranabhat Kamal
- Rashedi Sina
- Rashidi Amirfarzan
- Rashidi Mahsa
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- Roshandel Gholamreza
- Saber-ayad Maha Mohamed
- Saberzadeh-ardestani Bahar
- Saddik Basema
- Sadeghi Hossein
- Saeed Umar
- Sahebazzamani Maryam
- Sahebkar Amirhossein
- Salek Farrokhi Amir
- Salimi Amir
- Salimzadeh Hamideh
- Samadi Pouria
- Samaei Mehrnoosh
- Samy Abdallah M
- Sanabria Juan
- Santric-milicevic Milena M
- Saqib Muhammad Arif Nadeem
- Sarveazad Arash
- Sathian Brijesh
- Satpathy Maheswar
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- Sepanlou Sadaf G
- Seylani Allen
- Sha Feng
- Shafiee Sayed Mohammad
- Shaghaghi Zahra
- Shahabi Saeed
- Shaker Elaheh
- Sharifi-rad Javad
- Sharifian Maedeh
- Sharma Rajesh
- Sheikhbahaei Sara
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- Shirkoohi Reza
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- Silva Julian Guilherme
- Silva Diego Augusto Santos
- Singh Achintya Dinesh
- Singh Jasvinder A
- Siraj Md Shahjahan
- Sivandzadeh Gholam Reza
- Skryabin Valentin Yurievich
- Skryabina Anna Aleksandrovna
- Socea Bogdan
- Solmi Marco
- Soltani-zangbar Mohammad Sadegh
- Song Suhang
- Szerencsés Viktória
- Szócska Miklós
- Tabarés-seisdedos Rafael
- Tabibian Elnaz
- Taheri Majid
- Taheriabkenar Yasaman
- Taherkhani Amir
- Talaat Iman M
- Tan Ker-kan
- Tbakhi Abdelghani
- Tesfaye Bekele
- Tiyuri Amir
- Tollosa Daniel Nigusse
- Touvier Mathilde
- Tran Bach Xuan
- Tusa Biruk Shalmeno
- Ullah Irfan
- Ullah Saif
- Vacante Marco
- Valadan Tahbaz Sahel
- Veroux Massimiliano
- Vo Bay
- Vos Theo
- Wang Cong
- Westerman Ronny
- Woldemariam Melat
- Yahyazadeh Jabbari Seyed Hossein
- Yang Lin
- Yazdanpanah Fereshteh
- Yu Chuanhua
- Yuce Deniz
- Yunusa Ismaeel
- Zadnik Vesna
- Zahir Mazyar
- Zare Iman
- Zhang Zhi-jiang
- Zoladl Mohammad
- Šekerija Mario
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Funding: F Carvalho and E Fernandes acknowledge support from Fundação para a Ciência e a Tecnologia, I.P. (FCT), in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy i4HB; FCT/MCTES through the project UIDB/50006/2020. J Conde acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). V M Costa acknowledges the grant SFRH/BHD/110001/2015, received by Portuguese national funds through Fundação para a Ciência e Tecnologia (FCT), IP, under the Norma Transitória DL57/2016/CP1334/CT0006.proofepub_ahead_of_prin
The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Aali Amirali
- Abbas Qamar
- Abbasi Behzad
- Abbasi-Kangevari Mohsen
- Abbasi-Kangevari Zeinab
- Abbastabar Hedayat
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdelwahab Ahmed Abdelwahab
- Abdoli Gholamreza
- Abdulkader Rizwan Suliankatchi
- Abdulkadir Hanan Abdulkadir
- Abedi Aidin
- Abegaz Kedir Hussein
- Abidi Hassan
- Aboagye Richard Gyan
- Abolhassani Hassan
- Absalan Abdorrahim
- Abtew Yonas Derso
- Abu-Gharbieh Eman
- Achappa Basavaprabhu
- Acheson Alistair R
- Acuna Juan Manuel
- Addison Daniel
- Addo Isaac Yeboah
- Adegboye Oyelola A
- Adesina Miracle Ayomikun
- Adnan Mohammad
- Adnani Qorinah Estiningtyas Sakilah
- Advani Shailesh M
- Afrin Sumia
- Afzal Muhammad Sohail
- Aggarwal Manik
- Ahinkorah Bright Opoku
- Ahmad Araz Ramazan
- Ahmad Rizwan
- Ahmad Sajjad
- Ahmad Sohail
- Ahmadi Sepideh
- Ahmed Haroon
- Ahmed Luai A
- Ahmed Muktar Beshir
- Aiman Wajeeha
- Ajami Marjan
- Akalu Gizachew Taddesse
- Akbarzadeh-Khiavi Mostafa
- Aklilu Addis
- Akonde Maxwell
- Akunna Chisom Joyqueenet
- Al-Hanawi Mohammed Khaled
- Al-Maweri Sadeq Ali Ali
- Al-Raddadi Rajaa M
- Al-Rifai Rami H Hani
- Al-Sabah Salman Khalifah
- Al-Tammemi Ala'a B
- Alahdab Fares
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Alessy Saleh Ali
- Algammal Abdelazeem M
- Alhassan Robert Kaba
- Ali Adel Hajj
- Ali Beriwan Abdulqadir
- Ali Hiwa Abubaker
- Ali Liaqat
- Ali Syed Shujait
- Alimohamadi Yousef
- Alipour Vahid
- Aljunid Syed Mohamed
- Alkhayyat Motasem
- Almustanyir Sami
- Alonso Nivaldo
- Alqalyoobi Shehabaldin
- Altawalah Haya
- Alvis-Guzman Nelson
- Amare Firehiwot
- Ameyaw Edward Kwabena
- Amirzade-Iranaq Mohammad Hosein
- Amu Hubert
- Amusa Ganiyu Adeniyi
- Ancuceanu Robert
- Anderson Jason A
- Animut Yaregal Animut
- Anoushiravani Amir
- Anoushirvani Ali Arash
- Ansari-Moghaddam Alireza
- Ansha Mustafa Geleto
- Antony Benny
- Antwi Maxwell Hubert
- Anwar Sumadi Lukman
- Anwer Razique
- Anyasodor Anayochukwu Edward
- Arab-Zozani Morteza
- Arabloo Jalal
- Aremu Olatunde
- Argaw Ayele Mamo
- Ariffin Hany
- Aripov Timur
- Arshad Muhammad
- Artaman Al
- Arulappan Judie
- Aruleba Raphael Taiwo
- Aryannejad Armin
- Asaad Malke
- Asemahagn Mulusew A
- Asemi Zatollah
- Asghari-Jafarabadi Mohammad
- Ashraf Tahira
- Assadi Reza
- Athar Mohammad
- Athari Seyyed Shamsadin
- Atout Maha Moh'd Wahbi
- Attia Sameh
- Aujayeb Avinash
- Ausloos Marcel
- Avila-Burgos Leticia
- Avval Atlas Haddadi
- Awedew Atalel Fentahun
- Awoke Mamaru Ayenew
- Awoke Tewachew
- Ayana Tegegn Mulatu
- Ayen Solomon Shitu
- Azadi Davood
- Azadnajafabad Sina
- Azami-Aghdash Saber
- Azanaw Melkalem Mamuye
- Azangou-Khyavy Mohammadreza
- Azizi Hosein
- Azzam Ahmed YY
- Babajani Amirhesam
- Badar Muhammad
- Badiye Ashish D
- Baghcheghi Nayereh
- Bagheri Nader
- Bagherieh Sara
- Bahadory Saeed
- Baig Atif Amin
- Bain Luchuo Engelbert
- Baker Jennifer L
- Bakhtiari Ahad
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- Banerjee Indrajit
- Bardhan Mainak
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- Bashiri Azadeh
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- Batiha Abdul-Monim Mohammad
- Begum Aeysha
- Bekele Alehegn Bekele
- Belay Alemayehu Sayih
- Belete Melaku Ashagrie
- Belgaumi Uzma Iqbal
- Bell Arielle Wilder
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- Benzian Habib
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- Bernabe Eduardo
- Bhagavathula Akshaya Srikanth
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- Bibi Sadia
- Bicer Burcu Kucuk
- Bilchut Awraris Hailu
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- Biondi Antonio
- Birega Mesfin Geremaw Birega
- Birhan Habitu Eshetu
- Bjørge Tone
- Blyuss Oleg
- Bodicha Belay Boda Abule
- Bohan Phillip M Kemp
- Bolla Srinivasa Rao
- Boloor Archith
- Bosetti Cristina
- Braithwaite Dejana
- Brauer Michael
- Brenner Hermann
- Briko Andrey Nikolaevich
- Briko Nikolay Ivanovich
- Buchanan Christina Maree
- Bulamu Norma B
- Bustamante-Teixeira Maria Teresa
- Butt Muhammad Hammad
- Butt Nadeem Shafique
- Butt Zahid A
- Cao Chao
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- Carreras Giulia
- Carvalho Márcia
- Cembranel Francieli
- Cerin Ester
- Chakraborty Promit Ananyo
- Chandrasekar Viveksandeep Thoguluva
- Charalampous Periklis
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- Culbreth Garland T
- Cámera Luis Alberto
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- Dahlawi Saad MA
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- Darwesh Aso Mohammad
- Das Saswati
- Davitoiu Dragos Virgil
- De la Hoz Fernando Pio
- Debela Sisay Abebe
- Dehghan Azizallah
- Dehkordi Javad Javad Aminian
- Demisse Biniyam
- Demisse Fitsum Wolde
- Denova-Gutiérrez Edgar
- Derakhshani Afshin
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- Deribe Kalkidan Solomon
- Desai Rupak
- Desalegn Markos Desalegn
- Desideri Lorenzo Ferro
- Dessalegn Fikadu Nugusu
- Dessalegni Samuel Abebe A
- Dessie Gashaw
- Desta Abebaw Alemayehu
- Dewan Syed Masudur Rahman
- Dharmaratne Samath Dhamminda
- Dhimal Meghnath
- Dianatinasab Mostafa
- Diao Nancy
- Diaz Daniel
- Digesa Lankamo Ena
- Dixit Shilpi Gupta
- Doaei Saeid
- Doan Linh Phuong
- Doku Paul Narh
- Dongarwar Deepa
- dos Santos Florentino Luciano Caetano
- dos Santos Wendel Mombaque
- Driscoll Tim Robert
- Dsouza Haneil Larson
- Durojaiye Oyewole Christopher
- Edalati Sareh
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- Ehsani-Chimeh Elham
- Eini Ebrahim
- Ekholuenetale Michael
- Ekundayo Temitope Cyrus
- Ekwueme Donatus U
- El-Huneidi Waseem
- Elbahnasawy Mostafa Ahmed
- Elbarazi Iffat
- Elghazaly Hesham
- Elhadi Muhammed
- Emamian Mohammad Hassan
- Enyew Daniel Berhanie
- Erkhembayar Ryenchindorj
- Eshetu Tegegne
- Eshrati Babak
- Eskandarieh Sharareh
- Esmaeili Elham Davtalab
- Espinosa-Montero Juan
- Etaee Farshid
- Etemadimanesh Azin
- Eyayu Tahir
- Ezeonwumelu Ifeanyi Jude
- Ezzikouri Sayeh
- Fagbamigbe Adeniyi Francis
- Fahimi Saman
- Fakhradiyev Ildar Ravisovich
- Faraon Emerito Jose A
- Fares Jawad
- Farmany Abbas
- Farooque Umar
- Farrokhpour Hossein
- Fasanmi Abidemi Omolara
- Fatehizadeh Ali
- Fatima Wafa
- Fattahi Hamed
- Fekadu Ginenus
- Feleke Berhanu Elfu
- Ferrari Allegra Allegra
- Ferrero Simone
- Filip Irina
- Fischer Florian
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- Fukumoto Takeshi
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- Gad Mohamed M
- Gadanya Muktar A
- Gaipov Abduzhappar
- Galehdar Nasrin
- Gallus Silvano
- Garg Tushar
- Gebremariam Yosef Haile
- Gebremeskel Teferi Gebru
- Gebremichael Mathewos Alemu
- Geda Yohannes Fikadu
- Gela Yibeltal Yismaw
- Gemeda Belete Negese Belete
- Getachew Melaku
- Getachew Motuma Erena
- Ghaffari Kazem
- Ghafourifard Mansour
- Ghamari Seyyed-Hadi
- Ghassemi Fariba
- Ghimire Ajnish
- Ghith Nermin
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- Gill Paramjit Singh
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- Godos Justyna
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- Golechha Mahaveer
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- Goulart Bárbara Niegia Garcia
- Grosso Giuseppe
- Guadie Habtamu Alganeh
- Gubari Mohammed Ibrahim Mohialdeen
- Gudayu Temesgen Worku
- Guerra Maximiliano Ribeiro
- Gunawardane Damitha Asanga
- Gupta Bhawna
- Gupta Sapna
- Gupta Veer Bala
- Gupta Vivek Kumar
- Gurara Mekdes Kondale
- Guta Alemu
- Habibzadeh Parham
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- Halboub Esam S
- Halimi Aram
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- Hamad Hanadi Al
- Hamadeh Randah R
- Hameed Sajid
- Hamidi Samer
- Hanif Asif
- Hariri Sanam
- Harlianto Netanja I
- Haro Josep Maria
- Hartono Risky Kusuma
- Hasaballah Ahmed I
- Hasan SM Mahmudul
- Hasani Hamidreza
- Hashemi Seyedeh Melika
- Hassan Abbas M
- Hassanipour Soheil
- Hay Simon I
- Hayat Khezar
- Heidari Golnaz
- Heidari Mohammad
- Heidarymeybodi Zahra
- Henrikson Hannah Jacqueline
- Herrera-Serna Brenda Yuliana
- Herteliu Claudiu
- Hezam Kamal
- Hiraike Yuta
- Hlongwa Mbuzeleni Mbuzeleni
- Holla Ramesh
- Holm Marianne
- Horita Nobuyuki
- Hoseini Mohammad
- Hossain Mahbub
- Hossain Mohammad Bellal Hossain
- Hosseini Mohammad-Salar
- Hosseinzadeh Ali
- Hosseinzadeh Mehdi
- Hostiuc Mihaela
- Hostiuc Sorin
- Househ Mowafa
- Huang Junjie
- Hugo Fernando N
- Humayun Ayesha
- Hussain Salman
- Hussein Nawfal R
- Hwang Bing-Fang
- Ibitoye Segun Emmanuel
- Iftikhar Pulwasha Maria
- Ikuta Kevin S
- Ilesanmi Olayinka Stephen
- Ilic Irena M
- Ilic Milena D
- Immurana Mustapha
- Innos Kaire
- Iranpour Pooya
- Irham Lalu Muhammad
- Isfahani Haleh Mousavi
- Islam Rakibul M
- Islam Shariful
- Islami Farhad
- Ismail Nahlah Elkudssiah
- Isola Gaetano
- Iwagami Masao
- J Linda Merin
- Jabbari Seyed Hossein Yahyazadeh
- Jafari Amirhossein Azari
- Jaiswal Abhishek
- Jakovljevic Mihajlo
- Jalili Mahsa
- Jalilian Shahram
- Jamshidi Elham
- Jang Sung-In
- Jani Chinmay T
- Javaheri Tahereh
- Jayarajah Umesh Umesh
- Jayaram Shubha
- Jazayeri Seyed Behzad
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- Kebede Abinet Gebremickael
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- Kejela Gemechu Gemechu
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- Khaneghah Amin Mousavi
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- Mirza-Aghazadeh-Attari Mohammad
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- Misganaw Abay Sisay
- Misra Sanjeev
- Mohammad Karzan Abdulmuhsin
- Mohammadi Esmaeil
- Mohammadi Mokhtar
- Mohammadian-Hafshejani Abdollah
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- Tiyuri Amir
- Tollosa Daniel Nigusse
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- Woldemariam Melat
- Woldu Berhanu
- Xiao Hong
- Xu Rixing
- Xu Suowen
- Xu Xiaoyue
- Yadav Lalit
- Yang Lin
- Yazdanpanah Fereshteh
- Yeshaw Yigizie
- Yismaw Yazachew
- Yonemoto Naohiro
- Younis Mustafa Z
- Yousefi Zabihollah
- Yousefian Fatemeh
- Yu Chuanhua
- Yu Yong
- Yunusa Ismaeel
- Zahir Mazyar
- Zaki Nazar
- Zaman Burhan Abdullah
- Zangiabadian Moein
- Zare Fariba
- Zare Iman
- Zareshahrabadi Zahra
- Zarrintan Armin
- Zastrozhin Mikhail Sergeevich
- Zeineddine Mohammad A
- Zhang Dongyu
- Zhang Jianrong
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhou Linghui
- Zodpey Sanjay
- Zoladl Mohammad
- Šekerija Mario
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
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- Publication venue
- Oxford University Press (OUP)
- Publication date
- 01/07/2023
- Field of study
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
- Author
- Aanniz Tarek
- Abar Aden Elmi
- Abbad Anass
- Abdelfattah May
- Abdelhamid W.
- Abdella Saro
- Abdellah Faouzi
- Abdelmjid El Oualid
- Abdelmoula Fatma
- Abdelmoulah F.
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- Abdillahi Idil Salah
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- Fares Wasfi
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- Fekkak Jamal
- Femi Ayoade
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- Gevao Sahr
- Gharmaz Hamza
- Ghassan Adib
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- Gismondo Maria Rita
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- Howard Julia
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- Lahlou Amine Idriss
- Lahlou Idriss-Amine
- Lahlou Kitane Driss
- Lako Richard Lino Loro
- Lalemi Mary
- Lambisia Arnold W.
- Lamboni Lallepak
- Lamiae Belayachi
- Langat Sombo
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- Laryea Dennis
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- Layibo Yasser
- Le Viet Thanh
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- Lee Justin
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- Lefrançois Louise
- Lekana-Douki Bernard
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- Lo Gora
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- Lontchi Roméo Aimé Laclong
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- Lutalo Tom
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- Webby Richard
- Weldemariam A.G.
- Weldemariam Atsbeha G.
- Werno Anja
- Wiley Michael R.
- Wilkinson David
- Wilkinson Eduan
- Williamson Carolyn
- Wilson Shannon
- Woelfel R.
- Wohl Shirlee
- Wolh S.
- Wolter Nicole
- Wuduri Zara
- Wulf Ben
- Wurie I.
- Wurie Isatta
- Xavier Joicymara S.
- Xiang Zuzheng
- Xie Hong
- Yadouleton Anges
- Yadouleton Yahya
- Yakout Mostfa
- Yandoko Rivalyn Nakoune
- Yang Qi
- Yao Kouadio T.
- Yassine Kasmi
- Yassine Zouheir
- Yasuda Jiro
- Yatassaye Bouna
- Yeboah C.
- Yeboah Richmond
- Yeboah-Manu Dorothy
- Yemi Bright K.
- Yiaba Cyrus
- Yiaba Warren Cyrus
- Yu Popova A.
- Yusuf Nyam Itse
- Yusuf Yacob Mohamed
- Zablon J. Matoke D.
- Zablon J.O.
- Zaher Tarek Refaat Elnagdy Raafat
- Zahra El Ansari Fatima
- Zahran Manal Hamdy
- Zekri Abdel-Rahman N.
- Zhang J.
- Zhou Pei
- Zinyowera Sekesai
- Zong Minko O.
- Zongo Arsène
- Zorgani A.
- Zouaki Amal
- Zulu P.
- Zumla Ali
- Zumla Alimuddin
- Zuze Boitumelo
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 07/10/2022
- Field of study
INTRODUCTION
Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic.
RATIONALE
We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs).
RESULTS
Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants.
CONCLUSION
Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019
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- Unnikrishnan B.
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- Violante F.S.
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- Vlassov V.
- Vo B.
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- Vu L.G.
- Wadood A.W.
- Waheed Y.
- Walde M.T.
- Wamai R.G.
- Wang C.
- Wang F.
- Wang N.
- Wang Y.
- Ward P.
- Waris A.
- Westerman R.
- Wickramasinghe N.D.
- Woldemariam M.
- Woldu B.
- Xiao H.
- Xu R.
- Xu S.
- Xu X.
- Yadav L.
- Yahyazadeh Jabbari S.H.
- Yang L.
- Yazdanpanah F.
- Yeshaw Y.
- Yismaw Y.
- Yonemoto N.
- Younis M.Z.
- Yousefi Z.
- Yousefian F.
- Yu C.
- Yu Y.
- Yunusa I.
- Zahir M.
- Zaki N.
- Zaman B.A.
- Zangiabadian M.
- Zare F.
- Zare I.
- Zareshahrabadi Z.
- Zarrintan A.
- Zastrozhin M.S.
- Zeineddine M.A.
- Zhang D.
- Zhang J.
- Zhang Y.
- Zhang Z.J.
- Zhou L.
- Zodpey S.
- Zoladl M.
- Šekerija M.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
BACKGROUND: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. METHODS: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. FINDINGS: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01–4·94) deaths and 105 million (95·0–116) DALYs for both sexes combined, representing 44·4% (41·3–48·4) of all cancer deaths and 42·0% (39·1–45·6) of all DALYs. There were 2·88 million (2·60–3·18) risk-attributable cancer deaths in males (50·6% [47·8–54·1] of all male cancer deaths) and 1·58 million (1·36–1·84) risk-attributable cancer deaths in females (36·3% [32·5–41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6–28·4) and DALYs by 16·8% (8·8–25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9–42·8] and 33·3% [25·8–42·0]). INTERPRETATION: The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
- Arif Tahera
- Arkani Samara
- Armatura Giulia
- Armijos Daniel
- Arnaout Ali
- Arnaoutoglou Eleni
- Arnaud Alexis P.
- Arneja Jugpal
- Arrangoiz Rodrigo
- Arshad Muhammad
- Arthur Joshua
- Ashcroft James
- Ashford Bruce
- Ashraf Fariha
- Asiimwe Daniel
- Asirifi Samuel Amoako
- Asla Amir
- Aslam Ramisha
- Aspide Raffaele
- Ataya Karim
- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
- Awad Rabih
- Awad Selmy
- Ayad Kusay
- Ayana Birhanu
- Aydin Yener
- Ayeni Funbi
- Aytac Erman
- Azab Ahmed
- Azami Rizwan
- Azize Diallo Abdoul
- Azzam Ahmed Y.
- Azzis Olivier
- Baba Yabasin Iddrisu
- Babis George
- Bacalbasa Nicolae
- Badiani Sarit
- Badran Saif
- Baduell Albert
- Baeesa Saleh
- Baertschiger Reto
- Bafaquh Mohammed
- Bahassan Omar Mohammed
- Bahrami-Hessari Michael
- Baia Marco
- Baidoo Ebikela Ivie
- Bailey Karen
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Baiocchi Glauco
- Baiyewu Lateef Ayodele
- Bajaj Ankur
- Bajunaid Khalid
- Balagobi Balasingam
- Balasubramanian Ishwarya
- Balduzzi Alberto
- Baldwin Alexander
- Balla Andrea
- Balogh Zsolt J.
- Balogun James A.
- Balogun Simon
- Baloyiannis Ioannis
- Ban Vin Shen
- Bandyopadhyay Samik Kumar
- Bandyopadhyay Soham
- Banerjee Sumit
- Banipal Gurpreet Singh
- Banky Balazs
- Bannone Elisa
- Bansal Sujesh
- Barberis Andrea
- Barbosa-Breda Joao
- Bareka Metaxia
- Barišić Tatjana
- Barlas Aziz Mutlu
- Barlow Ciaran
- Barmayehvar Behrad
- Baroffio Paolo
- Barone Mirko
- Barra Fabio
- Barranquero Alberto G.
- Barugola Giuliano
- Basendowah Mohammed
- Bashir Mahmod
- Basnayake Oshan
- Bass Gary Alan
- Basu Somprakas
- Bateman Antony
- Bateman Kellie
- Batista Sylvia
- Batstone Martin
- Bauer Marlies
- Bauset Juan Carlos Catalá
- Bawa Ashvind
- Bawa Sayesha
- Bayhan Hüseyin
- Bayo Heura Llaquet
- Bazzi Nagham
- Beamish Andrew
- Beasley Nigel
- Beatty Jasmine Winter
- Becerra Angel
- Bedada Alemayehu Ginbo
- Bedzhanyan Arkady
- Begum Farzana
- Beisenov Bekzat
- Bellio Gabriele
- Bello Usman Mohammed
- Bellés Ana Ciscar
- Belzile Etienne
- Benamar Safia
- Bence Matthew
- Benshetrit Guy
- Bensoltane Khadidja
- Bergkvist David Julià
- Beristain-Hernandez Jose-Luis
- Bernante Paolo
- Bernardi Daniele
- Beron Reinaldo Isaacs
- Berselli Bruno
- Berselli Mattia
- Bertelli Giacomo
- Bertoglio Pietro
- Bertolaccini Luca
- Beswick Daniel
- Bette Birgit
- Bezirci Rifat
- Bhangu Aneel
- Bharathan Rasiah
- Bhat Vivek
- Bhatti Khalid
- Bianchi Valentina
- Bianco Francesco
- Bianco Giuseppe
- Bijou Walid
- Bilfaqirah Majed
- Biloslavo Alan
- Bin Alhassan Baba Alhaji
- Binnawara Muhannud
- Bissacco Daniele
- BİŞGİN TAYFUN
- Blair James
- Blanco Jose
- Blencowe Natalie
- Bloemers Frank
- Board Timothy
- Bobak Peter
- Boccalatte Luis
- Boedo Maria Jesus Maroño
- Bohmer Rob
- Boira Mar Achalandabaso
- Boisson Matthieu
- Boligo Sofia
- Bolton William
- Bombardini Cristina
- Bonavina Luigi
- Bonci Eduard-Alexandru
- Bondurri Andrea
- Bonilla Antonio Ramos
- Bonsaana Gilbert Batieka
- Booth L.
- Borg Elaine
- Borges Miguel Fróis
- Borges Nuno
- Bork Ulrich
- Borselle Dominika
- Bortul Marina
- Botelho Pedro
- Bottari Andrea
- Bouchagier Konstantinos
- Bouliaris Konstantinos
- Bowan Antoinette Bediako
- Bowen Joel
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bramis Konstantinos
- Branagan Graham
- Branzan Daniela
- Brasset Camille
- Bratus Dejan
- Bravo Ana Maria Minaya
- Bravo Sybil Lizanne
- Bright Tim
- Brisinda Giuseppe
- Brodkin Edgar
- Broglia Alessandro
- Brolese Alberto
- Browning Rebecca
- Bruzzaniti Placido
- Brzeszczyński Filip
- Bsisu Isam
- Bua Emmanuel
- Budd Gabrielle
- Bukhari Syed Imran
- Bulian Dirk Rolf
- Bumbasirevic Uros
- Bumber Boris
- Burgos-Blasco Barbara
- Burlov Nikita
- Bussu Francesco
- Bàmbina Fabrizio
- Börner Nikolaus
- Böttcher Arne
- Cabeza Leticia
- Cabrera Marino
- Cais Simon
- Cakmak Guldeniz Karadeniz
- Calabretto Francesca
- Calabrò Marcello
- Calavia Pablo
- Calculli Federica
- Calini Giacomo
- Callan Rory
- Callcut Rachael
- Calu Valentin
- Calvache Jose Andres
- Calvache Nieto
- Calvo Francisco Javier Redondo
- Cama Jitoko
- Camacho Barbosa
- Camarena Ana Isabel Avellaneda
- Camargo-Parra Katherin
- Cammarata Emanuele
- Cammarata Francesco
- Cammarata Roberto
- Campagnaro Tommaso
- Campanelli Michela
- Campennì Paola
- Campisi Giuseppina
- Campo Flaminia
- Campuzano Nicolas
- Cano-Trigueros Emiliano
- Capella Stefano
- Capitan-Morales Luis-Cristobal
- Capobianco Mattia
- Capolupo Gabriella Teresa
- Capozzi Enrico
- Cappuccio Micaela
- Capuano Marianna
- Carannante Filippo
- Carbone Fabio
- Carbone Ludovico
- Caretto Marta
- Caricato Chiara
- Caricato Marco
- Carpenter Holly
- Carreras-Castañer Anna
- Carretero Manuel Moriche
- Caruana Edward J.
- Carvello Michele
- Casagranda Biagio
- Cassese Gianluca
- Cassinotti Elisa
- Castagnini Francesco
- Castaldi Antonio
- Castaño Mario
- Castaño-Leon Ana M.
- Castillo Dayan Fanery Campino
- Castillo Monica Noguez
- Castro Ernes John
- Catarzi Lisa
- Caubet Maria Mercedes
- Caziuc Alexandra
- Ceelen Wim
- Celik Burak
- Cerovac Anis
- Cerovac Elmedina
- Chamakhi Amine
- Champagne Pierre-Olivier
- Chan Albert
- Chan Linda
- Chan Matthew
- Chaplin Helen
- Charalabopoulos Alexandros
- Chatzikomnitsa Paraskevi
- Chaudhary Muhammad Amjad
- Chaudhary Muhammad Hamid
- Chauhan Govind Singh
- Chauhan Munish
- Chean Chung Shen
- Cheetham Mark
- Cherbanyk Floryn
- Cheung Lok Ka
- Chevallay Mickael
- Chiaradia Angela
- Chin Synn Lynn
- Ching Laine Valerie Kongsun
- Chirca Alexandru
- Chisthi Meer
- Choong Peter
- Chopra Sharat
- Choron Rachel
- Choudhry Asad
- Chouliaras Christos
- Chowdhury Mahbub
- Chowdhury Sharfuddin
- Chowdhury Subhadip Pal
- Christidis Panagiotis
- Christodoulidis Gregory
- Christodoulou Prokopis
- Chrysovitsiotis Georgios
- Chu Michael Jen Jie
- Chukwu Isaac
- Chwat Carina
- Cianci Pasquale
- Cicerchia Pierfranco Maria
- Ciftci Ahmet Burak
- Cil Aylin Pelin
- Cillara Nicola
- Cina Caterina
- Ciniero Valeria
- Cioffi Stefano Piero Bernardo
- Cipolla Calogero
- Cisneros Juan Roberto Torres
- Ciubotaru Cezar
- Claireaux Henry
- Clancy Cillian
- Claret Guillem
- Clegg Rachael
- Clementi Marco
- Clerc Daniel
- Clune Edward
- Coates Amy
- Cobianchi Lorenzo
- Coccolini Federico
- Cockbain Andrew J.
- Cohnert Tina
- Coimbra Fernandez
- Cokan Andrej
- Colak Elif
- Colasanti Roberto
- Cole Simon
- Collins Michelle L.
- Colombari Renan Carlo
- Colombo Francesco
- Colucci Nicola
- Colás-Ruiz Enrique
- Consani Heitor
- Conso Christel
- Consorti Giuseppe
- Conte Luigi Eduardo
- Conti Alfredo
- Conti Luigi
- Contreras Sergio Marcos
- Coppola Alessandro
- Coppola Federico
- Corallino Diletta
- Cordova Adriana
- Cormio Gennaro
- Correia Inês
- Corte Emanuele La
- Costantino Andrea
- Costas-Chavarri Ainhoa
- Costea Radu
- Cotovio Manuel Damasio
- Coughlin Patrick
- Cox Daniel
- Cozens Joanne
- Creavin Ben
- Crichton Robert
- Critchley Rebecca
- Croghan Stefanie M.
- Cross George W. V.
- Cruz Ricardo Pedrini
- Cucinella Giuseppe
- Cullinane Carolyn
- Cullis Paul
- Cunha Miguel F.
- Cunningham Brian
- Currò Giuseppe
- Cuthbert Rory
- Cutmore Carina
- Czako Ladislav
- Cáceres Freud
- D'Acapito Fabrizio
- D'Addino José Luis
- D'Amico Alessia
- D'Amore Anna
- D'Andrea Giancarlo
- D'Archi Sabatino
- D'Oria Mario
- D'Sa Prashanth
- Daddi Niccolo'
- Dagklis Themistoklis
- Dajani Khaled
- Dajti Irida
- Daketsey Elorm
- Daley Brian
- Dare Anna
- Daruwalla Jurstine
- Das Sunit
- Dasa Michael
- Dasanayake Lanka
- Davidescu Mihnea
- Davies Jessica
- Davies Mark
- Davies Richard Justin
- Davis Amelia
- Dawson Amanda Caroline
- Dawson Jonathon
- Dbouk Samer
- De Alarcón Jaime Rodríguez
- De Andrés-Asenjo Beatriz
- De Bacco Marangon Gustavo
- De Campos Prado Caio Antonio
- De Cillia Michael
- De Haro Jorge Irene
- De Haro Joaquin
- De Jesus Labrador Hernandez Gregorio
- De La Infiesta García Carlos
- De La Medina Antonio Ramos
- De La Rosa-Estadella Marta
- De Nardi Paola
- De Oliveira Gabriel Paiva
- De Pastena Matteo
- De Simone Veronica
- De Sousa Álvaro Francisco Lopes
- De Vega Sánchez Blanca
- De Virgilio Armando
- De Zuanni Marco
- Dean Yomna
- Degarege Dawit
- Degener Stephan
- Dejeu George
- Del Amo María Dolores Arribas
- Dell Angela
- Demetrashvili Zaza
- Demetriades Andreas K
- Demetriou Charis
- Demir Sebahattin
- Dennis Rory
- Deputy Mohammed
- Derilo Habtamu
- Des Déserts Marc Danguy
- Desai Chaitya
- Desio Matteo
- Dessalegn Megbar
- Devarakonda Sreekar
- Dewan Michael
- Dewan Varun
- Dhaity Guipson Dhaity
- Dhondt Bert
- Di Bartolomeo Mattia
- Di Franco Gregorio
- Di Lascio Pierpaolo
- Di Martino Marcello
- Di Nuzzo Maria Michela
- Diaconescu Bogdan
- Dickson Kathryn
- Diehl Thomas
- Dif Elmes Saoussene
- Dimas Angelos
- Dimitrokallis Nikolaos
- Dincer Müserref Beril
- Dindyal Shiva
- Djama Zakarya
- Djedovic Gabriel
- Doerner Johannes
- Doherty Daniel
- Dolci Giampiero
- Domanin Maurizio
- Domingo Marta María Arroyo
- Dominguez-Rosado Ismael
- Don Cristine Pathirannehalage
- Donkin Ian
- Donmez Emin Erhan
- Donoghue Sophie
- Donovan Richard
- Dornseifer Mamun David
- Dorovinis Panagiotis
- Douglas Deborah
- Downey Candice
- Doyle Alex
- Doǧan Lütfi
- Dragisic Vedran
- Draman Mohd Rusdi
- Drasovean Radu
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- Vincent Elizabeth
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- Vázquez Gil
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- Wade Ryckie
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- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
- Watson David
- Watson Matthew
- Weber Clemens
- Wheatstone P.
- Wheeler James
- Wheldon Luke
- White Michelle
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- Williams Shekinah
- Windsor John
- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on CD11b-expressing cells
- Publication venue
- American Chemical Society (United States)
- Publication date
- 01/01/2005
- Field of study
The Bordetella adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) forms cation-selective membrane channels and delivers into the cytosol of target cells an adenylate cyclase domain (AC) that catalyzes uncontrolled conversion of cellular ATP to cAMP. Both toxin activities were previously shown to depend on post-translational activation of proCyaA to CyaA by covalent palmitoylation of the internal Lys983 residue (K983). CyaA, however, harbors a second RTX acylation site at residue Lys860 (K860), and the role of K860 acylation in toxin activity is unclear. We produced in E. coli the CyaA-K860R and CyaA-K983R toxin variants having the Lys860 and Lys983 acylation sites individually ablated by arginine substitutions. When examined for capacity to form membrane channels and to penetrate sheep erythrocytes, the CyaA-K860R acylated on Lys983 was about 1 order of magnitude more active than CyaA-K983R acylated on Lys 860, although, in comparison to intact CyaA, both monoacylated constructs exhibited markedly reduced activities in erythrocytes. Channels formed in lipid bilayers by CyaA-K983R were importantly less selective for cations than channels formed by CyaA-K860R, intact CyaA, or proCyaA, showing that, independent of its acylation status, the Lys983 residue may play a role in toxin structures that determine the distribution of charged residues at the entry or inside of the CyaA channel. While necessary for activity on erythrocytes, acylation of Lys983 was also sufficient for the full activity of CyaA on CD11b+ J774A.1 monocytes