Adolescent autonomy in anxiety disorder treatment: An exploratory study of individual therapy versus relational therapy

Adolescents, who guard their autonomy fiercely, frequently are reluctant to fully engage in family therapy. This also is true for adolescents being treated for anxiety disorders, which is the most common mental health condition in this age group, with a prevalence of 6.5%. Because anxiety disorders present young and frequently persist into adulthood, early treatment is imperative. While caregiver involvement is often an aid in therapeutic treatment, this study aims to investigate whether relational or individual therapy is more effective for adolescents being treated for anxiety disorders. The study hypothesizes that adolescents will have better outcomes in individual therapy

Utilizing evidence-based trauma trainings in the prevention of secondary trauma

Secondary trauma (ST) is a risk mental health clinicians face when treating trauma clients. To our knowledge, research has not explored how a clinician’s trauma training could protect against developing secondary trauma. We used data from a larger national project examining ST in a sample of Marriage and Family Therapists (MFTs; N = 200). A majority of the sample (n = 149; 64.5%) reported receiving specific trauma training. We explored qualitative reports of the specific trauma trainings clinicians received; the most commonly reported were Trauma Focused Cognitive Behavioral Therapy (TFCBT; n = 36) and Eye Movement Desensitization and Reprocessing (EMDR; n = 35). Future analyses will focus on whether using specific evidence-based trauma models can decrease levels of ST in clinicians

The Dependence of the Superconducting Transition Temperature of Organic Molecular Crystals on Intrinsically Non-Magnetic Disorder: a Signature of either Unconventional Superconductivity or Novel Local Magnetic Moment Formation

We give a theoretical analysis of published experimental studies of the effects of impurities and disorder on the superconducting transition temperature, T_c, of the organic molecular crystals kappa-ET_2X and beta-ET_2X (where ET is bis(ethylenedithio)tetrathiafulvalene and X is an anion eg I_3). The Abrikosov-Gorkov (AG) formula describes the suppression of T_c both by magnetic impurities in singlet superconductors, including s-wave superconductors and by non-magnetic impurities in a non-s-wave superconductor. We show that various sources of disorder lead to the suppression of T_c as described by the AG formula. This is confirmed by the excellent fit to the data, the fact that these materials are in the clean limit and the excellent agreement between the value of the interlayer hopping integral, t_perp, calculated from this fit and the value of t_perp found from angular-dependant magnetoresistance and quantum oscillation experiments. If the disorder is, as seems most likely, non-magnetic then the pairing state cannot be s-wave. We show that the cooling rate dependence of the magnetisation is inconsistent with paramagnetic impurities. Triplet pairing is ruled out by several experiments. If the disorder is non-magnetic then this implies that l>=2, in which case Occam's razor suggests that d-wave pairing is realised. Given the proximity of these materials to an antiferromagnetic Mott transition, it is possible that the disorder leads to the formation of local magnetic moments via some novel mechanism. Thus we conclude that either kappa-ET_2X and beta-ET_2X are d-wave superconductors or else they display a novel mechanism for the formation of localised moments. We suggest systematic experiments to differentiate between these scenarios.Comment: 18 pages, 5 figure

An epigenome-wide association study of total serum immunoglobulin E concentration

Immunoglobulin E (IgE) is a central mediator of allergic (atopic) inflammation. Therapies directed against IgE can alleviate hay fever and allergic asthma. Genetic association studies have not yet identified novel therapeutic targets or pathways underlying IgE regulation. We therefore surveyed epigenetic associations between serum IgE concentrations and methylation at loci concentrated in CpG islands genome wide in 95 nuclear pedigrees, using DNA from peripheral blood leukocytes. We validated positive results in additional families and in subjects from the general population. Here we show replicated associations-with a meta-analysis false discovery rate less than 10(-4)-between IgE and low methylation at 36 loci. Genes annotated to these loci encode known eosinophil products, and also implicate phospholipid inflammatory mediators, specific transcription factors and mitochondrial proteins. We confirmed that methylation at these loci differed significantly in isolated eosinophils from subjects with and without asthma and high IgE levels. The top three loci accounted for 13% of IgE variation in the primary subject panel, explaining the tenfold higher variance found compared with that derived from large single-nucleotide polymorphism genome-wide association studies. This study identifies novel therapeutic targets and biomarkers for patient stratification for allergic diseases

Numerical analysis of ship motion of crew boat with variations of wave period on ship operational speed

Seakeeping is influenced by several factors such as speed, ship hull shape, and the direction of the waves (heading angle). In this research, the crew boat is analyzed using the 3D Diffraction method to obtain the response of the ship's motion at regular waves. The study focused on analyzing the sea motion of the crew boat at different wave periods (2.58 s, 4.12 s, 5.67 s, and 7.22 s) and variation of ship speeds (0 Knot, 3 knots, 6 knots, 9 knots, 12 knots, 15 knots, and 18 knots). It used input data including the heading angle of the wave (μ) which is 180°and at a wave height of 0.5 m. The numerical analysis was carried out to determine the ship's seakeeping and compare it with NORDFORSK 1987 criteria, and also to identify the Motion Sickness Incidence (MSI) of the crews onboard. Based on the results obtained, the seakeeping value of the ship accepted the criteria of NORDFORSK 1987 up to a speed of 9 knots, starting at a speed of 12 knots it does not accept the criteria. As for the operability, the comfort level of the crewwhile on board has an MSI index of 0% for 0 Knot, and an MSI index for 18 knots is 4.46% of the total crew of the ship namely only 1 person from 25 persons will likely feel sea sickness.Keywords:CFD; Crew Boat;Numerical Analysis; Seakeeping; MSI1.IntroductionCrew boats are very important in the shipping industry because they are a means of connecting onshore and offshore installations such as drilling activities, or port destinations that serve hundreds of ships at once[1]. Crew boatsrequire only small construction or minor modificationson the platform, so this crew boat is used to move a team of workers with their equipment[2].As one of the types of fast boats, it is necessary to pay attention to the level of comfort and safety of the passengers. Today, ship safety is a top priority in the maritime industry[3,4]. In general, the ship serves as a means of transportation fortransporting goods or passengers. As a form of floating media, the ship will experience movement caused byinternal factors due to the ship itself or external factors such as *Corresponding author.E-mail address: [email protected](I Ketut Aria Pria Utama)https://doi.org/10.37934/cfdl.16.4.115<br/

Human mast cells and basophils-How are they similar how are they different?

Mast cells and basophils are key contributors to allergies and other inflammatory diseases since they are the most prominent source of histamine as well as numerous additional inflammatory mediators which drive inflammatory responses. However, a closer understanding of their precise roles in allergies and other pathological conditions has been marred by the considerable heterogeneity that these cells display, not only between mast cells and basophils themselves but also across different tissue locations and species. While both cell types share the ability to rapidly degranulate and release histamine following high-affinity IgE receptor cross-linking, they differ markedly in their ability to either react to other stimuli, generate inflammatory eicosanoids or release immunomodulating cytokines and chemokines. Furthermore, these cells display considerable pharmacological heterogeneity which has stifled attempts to develop more effective anti-allergic therapies. Mast cell- and basophil-specific transcriptional profiling, at rest and after activation by innate and adaptive stimuli, may help to unravel the degree to which these cells differ and facilitate a clearer understanding of their biological functions and how these could be targeted by new therapies

Coronal Heating as Determined by the Solar Flare Frequency Distribution Obtained by Aggregating Case Studies

Flare frequency distributions represent a key approach to addressing one of the largest problems in solar and stellar physics: determining the mechanism that counter-intuitively heats coronae to temperatures that are orders of magnitude hotter than the corresponding photospheres. It is widely accepted that the magnetic field is responsible for the heating, but there are two competing mechanisms that could explain it: nanoflares or Alfv\'en waves. To date, neither can be directly observed. Nanoflares are, by definition, extremely small, but their aggregate energy release could represent a substantial heating mechanism, presuming they are sufficiently abundant. One way to test this presumption is via the flare frequency distribution, which describes how often flares of various energies occur. If the slope of the power law fitting the flare frequency distribution is above a critical threshold, $\alpha=2$ as established in prior literature, then there should be a sufficient abundance of nanoflares to explain coronal heating. We performed $>$600 case studies of solar flares, made possible by an unprecedented number of data analysts via three semesters of an undergraduate physics laboratory course. This allowed us to include two crucial, but nontrivial, analysis methods: pre-flare baseline subtraction and computation of the flare energy, which requires determining flare start and stop times. We aggregated the results of these analyses into a statistical study to determine that $\alpha = 1.63 \pm 0.03$. This is below the critical threshold, suggesting that Alfv\'en waves are an important driver of coronal heating.Comment: 1,002 authors, 14 pages, 4 figures, 3 tables, published by The Astrophysical Journal on 2023-05-09, volume 948, page 7

Students' participation in collaborative research should be recognised

Letter to the editor