40 research outputs found
Airway expression of Transient Receptor Potential (TRP) Vanniloid-1 and Ankyrin-1 channels is not increased in patients with Idiopathic Pulmonary Fibrosis
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 17/11/2017
- Field of study
Dry cough is a common symptom described in patients with Idiopathic Pulmonary Fibrosis
(IPF) and impairs quality of life. The exact mechanisms causing cough in IPF remain unclear,
however evidence suggests altered cough neurophysiology and sensitisation plays a role; IPF
patients have an enhanced cough reflex sensitivity to inhaled capsaicin. The Transient Receptor
Potential Vanniloid-1 channel (TRPV-1) has a role in the cough reflex and airway expression
is increased in patients with chronic cough. The Ankyrin-1 receptor (TRPA-1) is often coexpressed.
It was hypothesised that, like chronic cough patients, IPF patients have increased
airway TRP receptor expression. Bronchial biopsies were obtained from 16 patients with IPF,
11 patients with idiopathic chronic cough and 8 controls without cough. All other causes of
cough were rigorously excluded. Real-time quantitative Polymerase Chain Reaction was used
to detect TRPV-1 and TRPA-1 mRNA expression with Immunohistochemistry demonstrating
protein expression. Mean TRPV-1 and TRPA-1 gene expression was higher in IPF patients
compared with controls, but the difference did not reach statistical significance. Immunostaining
supported these findings. This study suggests that structural up-regulation of central airway
TRP receptors is not the key mechanism for cough in IPF patients. It is probable that IPF
cough results from altered neuronal sensitivity at multiple levels of the cough pathway
Experimental Treatment of Ebola Virus Disease with TKM-130803: A Single-Arm Phase 2 Clinical Trial.
- Author
- Arias Armando
- Brooks Timothy JG
- Carson Gail
- Castle Lyndsey
- Dunning Jake
- Ferri Mauricio
- Gandi Regina
- Gannon Fiona
- Goodfellow Ian
- Grove Jennifer
- Hope-Gill Benjamin
- Horby Peter W
- Howell-Jones Rebecca
- Idriss Baimba
- Joseph Sebatu
- Kowalski Mark
- Lang Trudie
- Massaquoi Thomas
- Merson Laura
- Olliaro Piero
- Osman Hassan K
- Pardinaz-Solis Raul
- RAPIDE-TKM trial team
- Rojek Amanda
- Sahr Foday
- Samai Mohammed
- Simpson Andrew JH
- Stepniewska Kasia
- Thorne Lucy
- Whitehead John
- Publication venue
- PLoS Med
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: TKM-130803, a small interfering RNA lipid nanoparticle product, has been developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in humans has not been evaluated. METHODS AND FINDINGS: In this single-arm phase 2 trial, adults with laboratory-confirmed EVD received 0.3 mg/kg of TKM-130803 by intravenous infusion once daily for up to 7 d. On days when trial enrolment capacity was reached, patients were enrolled into a concurrent observational cohort. The primary outcome was survival to day 14 after admission, excluding patients who died within 48 h of admission. After 14 adults with EVD had received TKM-130803, the pre-specified futility boundary was reached, indicating a probability of survival to day 14 of â€0.55, and enrolment was stopped. Pre-treatment geometric mean Ebola virus load in the 14 TKM-130803 recipients was 2.24 Ă 109 RNA copies/ml plasma (95% CI 7.52 Ă 108, 6.66 Ă 109). Two of the TKM-130803 recipients died within 48 h of admission and were therefore excluded from the primary outcome analysis. Of the remaining 12 TKM-130803 recipients, nine died and three survived. The probability that a TKM-130803 recipient who survived for 48 h will subsequently survive to day 14 was estimated to be 0.27 (95% CI 0.06, 0.58). TKM-130803 infusions were well tolerated, with 56 doses administered and only one possible infusion-related reaction observed. Three patients were enrolled in the observational cohort, of whom two died. CONCLUSIONS: Administration of TKM-130803 at a dose of 0.3 mg/kg/d by intravenous infusion to adult patients with severe EVD was not shown to improve survival when compared to historic controls. TRIAL REGISTRATION: Pan African Clinical Trials Registry PACTR201501000997429
Identification of common genetic risk variants for autism spectrum disorder
- Author
- Abdellaoui Abdel
- Adams Mark J.
- Agee Michelle
- Agerbo Esben
- Air Tracy M.
- Alipanahi Babak
- Als Thomas D.
- Andlauer Till F. M.
- Andreassen Ole A.
- Anney Richard
- Arolt Volker
- Auton Adam
- Awashti Swapnil
- Bacanu Silviu-Alin
- Baekvad-Hansen Marie
- Baune Bernhard T.
- Beekman Aartjan T. F.
- Bell Robert K.
- Belliveau Rich
- Berger Klaus
- Bettella Francesco
- Bigdeli Tim B.
- Binder Elisabeth B.
- Blackwood Douglas H. R.
- Boomsma Dorret
- Borglum Anders D.
- Breen Gerome
- Bryc Katarzyna
- Bryois Julien
- Buttenschon Henriette N.
- Buxbaum Joseph D.
- Bybjerg-Grauholm Jonas
- Byrne Enda M.
- Cai Na
- Castelao Enrique
- Cerrato Felecia
- Chambert Kimberly
- Christensen Jane H.
- Churchhouse Claire
- Cichon Sven
- Clarke Toni-Kim
- Coleman Jonathan R.
- Colodro-Conde Lucia
- Couvy-Duchesne Baptiste
- Craddock Nick
- Crawford Gregory E.
- Daly Mark J.
- Dannlowski Udo
- Davies Gail
- de Geus E. J. C.
- De Rubeis Silvia
- Deary Ian J.
- Degenhardt Franziska
- Dellenvall Karin
- Demontis Ditte
- DePaulo J. Raymond
- Derks Eske M.
- Devlin Bernie
- Direk Nese
- Djurovic Srdjan
- Dolan Conor
- Domenici Enrico
- Domschke Katharina
- dPoterba Timothy
- Dumont Ashley L.
- Dunn Erin C.
- Eley Thalia C.
- Elson Sarah L.
- Escott-Price Valentina
- Esko Tonu
- Finucane Hilary K.
- Fontanillas Pierre
- Forstner Andreas J.
- Frank Josef
- Furlotte Nicholas A.
- Gaspar Helena A.
- Geschwind Daniel H.
- Gill Michael
- Goes Fernando S.
- Goldstein Jacqueline
- Gordon Scott D.
- Grabe Hans J.
- Grove Jakob
- Hall Lynsey S.
- Hamilton Steven P.
- Hansen Christine S.
- Hansen Thomas F.
- Hauberg Mads Engel
- Hayward Caroline
- Heath Andrew C.
- Herms Stefan
- Hickie Ian B.
- Hoffmann Per
- Hollegaard Mads
- Homuth Georg
- Hope Sigrun
- Horn Carsten
- Hottenga Jouke-Jan
- Hougaard David M.
- Howrigan Daniel P.
- Hromatka Bethann S.
- Huang Hailiang
- Huber Karen E.
- Hultman Christina M.
- Ising Marcus
- Jansen Rick
- Jörgenson Eric
- Kendler Kenneth S.
- Kiadeh Farnush Farhadi Hassan
- Klei Lambertus
- Kleinman Aaron
- Kloiber Stefan
- Knowles James A.
- Kohane Isaac S.
- Kraft Julia
- Kretzschmar Warren W.
- Krogh Jesper
- Kutalik Zoltan
- Levinson Douglas F.
- Lewis Cathryn M.
- Lewis Glyn
- Li Qingqin S.
- Li Yihan
- Lind Penelope A.
- Litterman Nadia K.
- Lucae Susanne
- MacIntyre Donald J.
- MacKinnon Dean F.
- Madden Pamela A. F.
- Magnusson Patrik K.
- Maier Robert M.
- Maier Wolfgang
- Maller Julian
- Marchini Jonathan
- Martin Alicia R.
- Martin Joanna
- Martin Nicholas G.
- Mattheisen Manuel
- Mbarek Hamdi
- McGrath Patrick
- McGuffin Peter
- McIntosh Andrew M.
- McIntyre Matthew H.
- Medland Sarah E.
- Mehta Divya
- Metspalu Andres
- Middeldorp Christel M.
- Mihailov Evelin
- Milaneschi Yuri
- Milani Lili
- Mirza Saira Saeed
- Mondimore Francis M.
- Montgomery Grant W.
- Moran Jennifer L.
- Mors Ole
- Mortensen Preben Bo
- Mostafavi Sara
- Mountain Joanna L.
- Mullins Niamh
- MĂŒller-Myhsok Bertram
- Naerland Terje
- Nauck Matthias
- Neale Benjamin M.
- Ng Bernard
- Nivard Michel G.
- Noblin Elizabeth S.
- Noethen Markus M.
- Nordentoft Merete
- Northover Carrie A. M.
- Nyegaard Mette
- Nyholt Dale R.
- O'Donovan Michael C.
- O'Reilly Paul F.
- Oskarsson Hogni
- Owen Michael J.
- Paciga Sara A.
- Painter Jodie N.
- Pallesen Jonatan
- Palmer Duncan S.
- Palotie Aarno
- Pedersen Carsten Bocker
- Pedersen Marianne Giortz
- Pedersen Nancy L.
- Penninx Brenda W. J. H.
- Perlis Roy H.
- Peterson Roseann E.
- Pettersson Erik
- Peyrot Wouter J.
- Pistis Giorgio
- Pitts Steven J.
- Porteous David J.
- Posthuma Danielle
- Potash James B.
- Poulsen Jesper Buchhave
- Preisig Martin
- Quiroz Jörge A.
- Qvist Per
- Rehnstrom Karola
- Reichenberg Abraham
- Reichert Jennifer
- Rice John P.
- Rietschel Marcella
- Riley Brien P.
- Ripke Stephan
- Rivera Margarita
- Robinson Elise B.
- Roeder Kathryn
- Roussos Panos
- Saemundsen Evald
- Sandin Sven
- Sathirapongsasuti J. Fah
- Satterstrom F. Kyle
- Sazonova Olga
- Schoevers Robert
- Schulte Eva C.
- Schulze Thomas G.
- SchÀfer Catherine
- Shelton Janie F.
- Shen Ling
- Shi Jianxin
- Shringarpure Suyash
- Shyn Stanley
- Sigurdsson Engilbert
- Sinnamon Grant C. B.
- Smit Johannes H.
- Smith Daniel J.
- Smith George Davey
- Smoller Jordan W.
- St Pourcain Beate
- Stefansson Hreinn
- Stefansson Kari
- Steinberg Stacy
- Stevens Christine R.
- Streit Fabian
- Strohmaier Jana
- Sullivan Patrick F.
- Tansey Katherine E.
- Teismann Henning
- Teumer Alexander
- Thompson Wesley
- Thomson Pippa A.
- Thorgeirsson Thorgeir E.
- Tiemeier Henning
- Traylor Matthew
- Treutlein Jens
- Trubetskoy Vassily
- Trzaskowski Maciej
- Tung Joyce Y.
- Turley Patrick
- Uher Rudolf
- Uitterlinden Andr G.
- Umbricht Daniel
- Vacic Vladimir
- Van Der Auwera Sandra
- van Hemert Albert M.
- Viktorin Alexander
- Visscher Peter M.
- Voelzke Henry
- Walters G. Bragi
- Walters Raymond K.
- Wang Yunpeng
- Webb Bradley T.
- Weinsheimer Shantel Marie
- Weissman Myrna M.
- Wellmann JĂŒrgen
- Werge Thomas
- Willemsen Gonneke
- Wilson Catherine H.
- Witt Stephanie H.
- Won Hyejung
- Wray Naomi R.
- Wu Yang
- Xi Hualin S.
- Xu Xinyi
- Yang Jian
- Zhang Futao
- Publication venue
- Ludwig-Maximilians-UniversitĂ€t MĂŒnchen
- Publication date
- 01/01/2019
- Field of study
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no individual variants have been robustly associated with ASD. With a marked sample-size increase from a unique Danish population resource, we report a genome-wide association meta-analysis of 18,381 individuals with ASD and 27,969 controls that identified five genome-wide-significant loci. Leveraging GWAS results from three phenotypes with significantly overlapping genetic architectures (schizophrenia, major depression, and educational attainment), we identified seven additional loci shared with other traits at equally strict significance levels. Dissecting the polygenic architecture, we found both quantitative and qualitative polygenic heterogeneity across ASD subtypes. These results highlight biological insights, particularly relating to neuronal function and corticogenesis, and establish that GWAS performed at scale will be much more productive in the near term in ASD
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
- Author
- Adams Mark J
- Adan Roger A H
- Adolfsson Annelie Nordin
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Akil Huda
- Albani Diego
- Alda Martin
- Alexander Madeline
- Alfredsson Lars
- Als Thomas D
- Andlauer Till F M
- Ando Tetsuya
- Andreassen Ole A
- Androutsos Christos
- Anjorin Adebayo
- Anney Richard J L
- Anttila Verneri
- Arking Dan E
- Arnold Paul D
- Arranz M. J.
- Artigas Maria Soler
- Aschauer Harald
- Asherson Philip
- Backlund Lena
- Baker Jessica H
- Baldursson GĂsli
- Banaschewski Tobias
- Barr Cathy L
- Barta Csaba
- Bass Nicholas
- Bauer Michael
- Baune Bernhard T
- Begemann Martin
- Belangero Sintia
- Bellgrove Mark
- Belliveau Richard A
- Bellivier Frank
- Bencko Vladimir
- Bergen Andrew W
- Bergen Sarah E
- Berger Klaus
- Berrettini Wade H
- Bettella Francesco
- Bey Katharina
- Bienvenu O Joseph
- Biernacka Joanna M
- Binder Elisabeth B
- BirgegÄrd Andreas
- Black Donald W
- Blackwood Douglas H R
- Boomsma Dorret I
- Bramon Elvira
- Brandt Harry
- Breen Gerome
- Brown Lawrence W
- Buccola Nancy G
- Budde Monika
- Budman Cathy
- Buitelaar Jan
- Bulik Cynthia M
- Bunney William
- Burghardt Roland
- Burmeister Margit
- Burton Christie L
- Buxbaum Joseph D
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M
- BĂŠkvad-Hansen Marie
- BĂžen Erlend
- BĂžrglum Anders D
- Cairns Murray J
- Campion Dominique
- Carlberg Laura
- Carr Vaughan J
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Cath Danielle
- Cerrato Felecia
- Chambert Kimberly
- Cheon Keun-Ah
- Christensen Jane H
- Churchhouse Claire
- Cichon Sven
- Ciullo Valentina
- Clarke Toni-Kim
- Clementi Maurizio
- Cloninger C Robert
- Coffey Barbara J
- Cohen David
- Coleman Jonathan R I
- Collier David A
- Collins Ryan L
- Colodro-Conde LucĂa
- Cook Edwin H
- Coon Hilary
- Coppola Giovanni
- Cormand Bru
- Corvin Aiden
- Courtet Philippe
- Craddock Nicholas
- Crawford Steven
- Crosbie Jennifer
- Crow Scott
- Crowley James J
- Curtis David
- Cusi Daniele
- Czerski Piotr M
- Dale Anders M
- Dalkner Nina
- Dalsgaard SĂžren
- Daly Mark J
- Danner Unna N
- Dannlowski Udo
- Davis Lea K
- Davis Oliver S P
- de Geus E. J. C.
- De Rubeis Silvia
- Degenhardt Franziska
- Degortes Daniela
- DeLisi Lynn E
- Delorme Richard
- Demontis Ditte
- Denys Damiaan
- Depienne Christel
- Derks Eske M
- DeSocio Janiece E
- Di Florio Arianna
- Dick Danielle M
- Dietrich Andrea
- Dina Christian
- Direk Nese
- Docampo Elisa
- Docherty Anna R
- Domenici Enrico
- Domschke Katharina
- Donohoe Gary
- Doyle Alysa E
- Duan Jubao
- Dudbridge Frank
- Dumont Ashley
- Duncan Laramie E
- Dunn Erin C
- Eapen Valsamma
- Edenberg Howard J
- Egberts Karin
- Ehrenreich Hannelore
- Ehrlich Stefan
- Elia Josephine
- ElvsÄshagen TorbjÞrn
- Espeseth Thomas
- Etain Bruno
- Falkai Peter
- Fanous Ayman H
- Faraone Stephen V
- Feng Yen-Chen A
- Fernandez Thomas V
- FernĂĄndez-Aranda Fernando
- Fichter Manfred M
- Fischer Sascha B
- Foo Jerome C
- Foretova Lenka
- Forstner Andreas J
- Forty Liz
- Forzan Monica
- Frank Josef
- Franke Barbara
- Freedman Robert
- Frye Mark
- Fullerton Janice M
- Gade Katrin
- Gambaro Giovanni
- Garcia-Delgar Blanca
- Gaspar Héléna A
- Ge Tian
- Gejman Pablo V
- Gelernter Joel
- Geller Daniel A
- Gershon Elliot S
- Geschwind Daniel H
- Giegling Ina
- Gilbert Donald L
- Gill Michael
- Godard Stephanie
- Goes Fernando S
- Golimbet Vera
- Gonidakis Fragiskos
- Gordon Scott D
- Gordon-Smith Katherine
- Gorwood Philip
- Grabe Hans J
- Grados Marco A
- Green Melissa J
- Greenberg Erica
- Greenwood Tiffany A
- Grice Dorothy E
- Grigoroiu-Serbanescu Maria
- Grotzinger Andrew D
- Grove Jakob
- GrĂŒnblatt Edna
- Gudmundsson Olafur O
- Guo Yiran
- Guzman-Parra José
- Haavik Jan
- HagstrĂžm Julie
- Hakonarson Hakon
- Halmi Katherine A
- Hamilton Steven P
- Hanna Gregory L
- Hansen Christine S
- Hansen Thomas F
- Hartman Catharina A
- Hartmann Andreas
- Hartmann Annette M
- Hatzikotoulas Konstantinos
- Hauser Joanna
- Hautzinger Martin
- Hawi Ziarih
- Hebebrand Johannes
- Hedderly Tammy
- Heilbronner Urs
- Heiman Gary A
- Helder Sietske G
- Henskens Frans A
- Herms Stefan
- Herpertz-Dahlmann Beate
- HervĂĄs Amaia
- Herzog Wolfgang
- Heyman Isobel
- Hinney Anke
- Hoekstra Pieter J
- Hoffmann Per
- Holland Dominic
- Holmans Peter A
- Hong Hyun Ju
- Hope Sigrun
- Horn Carsten
- Hottenga Jouke-Jan
- Hougaard David M
- Howard David
- Howrigan Daniel P
- Huang Alden
- Huang Hailiang
- Hultman Christina M
- Huyser Chaim
- Ibanez-Gomez Laura
- Ikeda Masashi
- Imgart Hartmut
- Ising Marcus
- Iwata Nakao
- Jablensky Assen V
- Jamain Stéphane
- Jiménez-Murcia Susana
- Joa Inge
- Joachim Oedegaard Ketil
- Johnson Craig
- Jones Ian
- Jones Lisa A
- Jordan Jennifer
- JuliĂ Antonio
- Jönsson Erik G
- KaminskĂĄ Deborah
- Kandaswamy Radhika
- Kaprio Jaakko
- Karhunen Leila
- Karwautz Andreas
- Kas Martien J H
- Kaye Walter H
- Kelly Brian J
- Kelsoe John R
- Kendler Kenneth S
- Kennedy James L
- Kennedy Martin A
- Keski-Rahkonen Anna
- Khramtsova Ekaterina A
- Kim Youl-Ri
- Kim Young Key
- Kim Young-Shin
- King Robert A
- Kirov George
- Kittel-Schneider Sarah
- Klareskog Lars
- Klei Lambertus
- Kloiber Stefan
- Klump Kelly L
- Knight Jo
- Knudsen Gun Peggy S
- Kogevinas Manolis
- Koh Yun-Joo
- Koller Anna C
- Konstantinidis Anastasios
- Konte Bettina
- Kook Sodahm
- Kranzler Henry R
- Kuntsi Jonna
- Kuperman Samuel
- Ladd-Acosta Christine
- Landén Mikael
- Langley Kate
- Laurent-Levinson Claudine
- Lavebratt Catharina
- Le Hellard Stephanie
- Lee Jimmy
- Lee Phil H
- Lencz Todd
- Lerer Bernard
- Lesch Klaus-Peter
- Leung Patrick W L
- Leventhal Bennett L
- Levinson Douglas F
- Levitan Robert D
- Lewis Cathryn M
- Lewis Cathryn M
- Lewis Glyn
- Li Dong
- Li Qingqin S
- Lichtenstein Paul
- Lissowska Jolanta
- Lochner Christine
- Loo Sandra K
- Loohuis Loes M O
- Loughland Carmel M
- Lucae Susanne
- Ludolph Andrea G
- Luykx Jurjen J
- Maaser Anna
- Madruga-Garrido Marcos
- Magnusson Pall
- Magnusson Patrik K E
- Maj Mario
- Malaty Irene
- Malhotra Anil K
- Mallet Jacques
- Malt Ulrik F
- Maras Athanasios
- Marsal Sara
- Martin Alicia R
- Martin Joanna
- Martin Nicholas G
- Martinsson Lina
- Mathews Carol A
- Mattheisen Manuel
- Mayora Monica Gratacos
- Mbarek Hamdi
- McCracken James T
- McDevitt Sara
- McDonald Colm
- McElroy Susan L
- McGough James J
- McIntosh Andrew M
- McMahon Francis J
- McQuillin Andrew
- Medland Sarah E
- Meijer Inge A
- Melle Ingrid
- Metspalu Andres
- Middeldorp Christel M
- Millischer Vincent
- Mir Pablo
- Mitchell James
- Mitchell Karen S
- Mitchell Philip B
- Mitjans Marina
- Monteleone Alessio Maria
- Monteleone Palmiero
- Montgomery Grant W
- Moran Jennifer L
- Morer Astrid
- Morken Gunnar
- Morris Derek W
- Mors Ole
- Mortensen Preben B
- Mostafavi Sara
- Mowry Bryan J
- Mullins Niamh
- Munn-Chernoff Melissa A
- Murphy Kieran C
- Murphy Tara L
- Murray Robin M
- Myers Richard M
- MĂŒller-Myhsok Bertram
- MĂŒller-Vahl Kirsten R
- MĂŒnchau Alexander
- Naarden Allan
- Nacmias Benedetta
- Nagy Peter
- Navratilova Marie
- Neale Benjamin M
- Neale Michael C
- Nestadt Gerald
- Nestadt Paul S
- Nicolini Humberto
- Nievergelt Caroline M
- Nivard Michel G
- Nordentoft Merete
- Nurmi Erika L
- Nurnberger John I
- Nyegaard Mette
- Nyholt Dale R
- NĂŠrland Terje
- Nöthen Markus M
- O'Donovan Michael C
- O'Neill F Anthony
- O'Toole Julie K
- Oades Robert D
- Oh Sang-Yun
- Okun Michael S
- Ophoff Roel A
- Owen Michael J
- Paciga Sara A
- Padyukov Leonid
- Palmer Duncan S
- Palotie Aarno
- Pantel Jacques
- Pantelis Christos
- Papezova Hana
- Paschou Peristera
- Pato Carlos N
- Pato Michele T
- Pedersen Carsten B
- Pedersen Marianne G
- Penninx Brenda Wjh
- Perica Vesna Boraska
- Perlis Roy H
- Perry Amy
- Peters Triinu
- Peterson Roseann E
- Petryshen Tracey L
- Pinto Dalila
- Piras Fabrizio
- Piras Federica
- Pistis Giorgio
- Pittenger Christopher
- Plessen Kerstin J
- Porteous David J
- Posthuma Danielle
- Potash James B
- Poterba Timothy
- Poulsen Jesper B
- Preisig Martin
- Pulver Ann E
- Quested Digby J
- Quiroz Jorge A
- Qvist Per
- Rabionet Raquel
- Raevuori Anu
- Ramos-Quiroga Josep Antoni
- Ramoz Nicolas
- Rehnström Karola
- Reichborn-Kjennerud Ted
- Reichenberg Abraham
- Reichert Jennifer
- Reif Andreas
- Reinbold CĂ©line S
- Ribasés Marta
- Ricca Valdo
- Richter Margaret A
- Rietschel Marcella
- Riley Brien
- Ripke Stephan
- Rivera Margarita
- Rizzo Renata
- Roberson Mary
- Roberts Marion
- Robertson Mary
- Roeder Kathryn
- Roessner Veit
- Rohde Luis A
- Rosenthal Jacob
- Rothenberger Aribert
- Rouleau Guy A
- Rovira Paula
- Ruhrmann Stephan
- Rujescu Dan
- Rybakowski Filip
- Saemundsen Evald
- Samuels Jack F
- Sanders Alan R
- Sanders Stephan J
- Sandin Sven
- Sandor Paul
- Santangelo Susan L
- Satterstrom F Kyle
- Schachar Russell
- Schaefer Catherine
- Schall Ulrich
- Schalling Martin
- Scharf Jeremiah M
- Scherag André
- Schlögelhofer Monika
- Schmidt Ulrike
- Schofield Peter R
- Schulte Eva C
- Schulze Thomas G
- Schwab Sibylle G
- Scott Laura J
- Scott Rodney J
- Seitz Jochen
- Serretti Alessandro
- Sham Pak C
- Shi Jianxin
- Shin Eun-Young
- Sigurdsson Engilbert
- Silverman Jeremy M
- Sim Kang
- Singer Harvey
- Slachtova Lenka
- Slof-Op't Landt Margarita C T
- Slopien Agnieszka
- Smeland Olav B
- Smith Daniel J
- Smoller Jordan W
- Song Dong-Ho
- Song Jungeun
- Sorbi Sandro
- Southam Lorraine
- Spalletta Gianfranco
- St Pourcain Beate
- Stahl Eli A
- Stefansson Hreinn
- Stefansson Kari
- Stein Dan J
- Stein Murray B
- Steinberg Stacy
- Steixner Agnes A
- Stewart S Evelyn
- Storch Eric A
- Stordal Eystein
- Stranger Barbara
- Streit Fabian
- Strober Michael
- Strohmaier Jana
- Stuhrmann Manfred
- Sullivan Patrick F
- Sutcliffe James S
- SĂĄnchez-Mora Cristina
- Talkowski Michael E
- Tarnok Zsanett
- Thomson Pippa A
- Thorgeirsson Thorgeir E
- Thornton Laura M
- Tiemeier Henning
- Tischfield Jay A
- Tooney Paul A
- Tortorella Alfonso
- Tozzi Federica
- Treasure Janet
- Treutlein Jens
- Tucker-Drob Elliot M
- Turecki Gustavo
- Turley Patrick
- Tziouvas Konstantinos
- TĂŒbing Jennifer
- Uher Rudolf
- Vaaler Arne E
- van der Auwera Sandra
- van Elburg Annemarie A
- van Os Jim
- Vawter Marquis P
- Vieta Eduard
- Vincent John B
- Visscher Frank
- Vulink Nienke
- Wade Tracey D
- Wagner Gudrun
- Wagner Michael
- Walitza Susanne
- Walsh Dermot
- Walters G Bragi
- Walters James T R
- Walters Raymond K
- Walton Esther
- Wanderer Sina
- Wang Meg M-J
- Wang Yunpeng
- Watson Hunna J
- Weiser Mark
- Weiss Lauren A
- Weissman Myrna M
- Werge Thomas
- Wichmann H-Erich
- Wildenauer Dieter B
- Williams Nigel M
- Willsey A Jeremy
- Witt Stephanie H
- Won Hyejung
- Woods Martin
- Woodside D Blake
- Worbe Yulia
- Wormley Brandon K
- Wray Naomi R
- Yu Dongmei
- Zai Clement C
- Zai Gwyneth
- Zandi Peter
- Zayats Tetyana
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Fuquan
- Zheutlin Amanda
- Zhu Zhaozhong
- Zinner Samuel H
- Zipfel Stephan
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe
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- Abbass Hakam
- Adhikari Neill
- Affleck Julia
- Agno Sathianathan Ronan
- Ahmad Norfaizan
- Ahmed Iram
- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
- Aparicio Christelle
- Appelt Peter
- Arabi Yaseen
- Arabi Yaseen
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arishi Hatim
- Arnold Donald
- Asghar Adeeba
- Ashelford Angela
- Attwood Ben
- Austin Karen
- Aysel Florescu Simin
- Azaiz Amine
- Babel JakĆĄa
- Babio-Galan Maite
- Badie Julio
- Bagshaw Sean
- Baillie Kenneth
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbazza Leanne
- Barber Russell
- Barge Deborah
- Barnes Nicky
- BarĆĄiÄ Bruno
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bates Michelle
- Bauchmuller Kris
- Bean Sarah
- Beane Abigail
- Beane Abigail
- Beasley Richard
- Begin Phillipe
- Bellemare David
- Benettaib Fatna
- Benzekri Dalila
- Berdaguer Fernando Daniel
- Bergin Colin
- Berry Lindsay
- Berry Lindsay
- Berry Scott
- Berry Scott
- Bhimani Zahra
- Bhimani Zahra
- Bihari Shailesh
- Bihari Shilesh
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- Bion Julian
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- Birch Janine
- Birch Jenny
- Birchall Katie
- Birkinshaw Isobel
- Black Ethel
- Bloos Frank
- Board Jasmin
- Bone Allsion
- Bonner Stephen
- Bonten Marc
- Bonten Marc
- Borgatta Barbara
- Borrill Zoe
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- Boschert Catherine
- Bossard Isabelle
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- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouwman Wietske
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- Bradbury Charlotte
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- Brailsford Jane
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- Breen Patrick
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- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
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- Browne Troy
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- Brunkhorst Frank
- Budd Joanna
- Buehner Ulrike
- Buhr Heidi
- Bullman Laetitia
- Burns Karen
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler M
- Buxton Meredith
- Buxton Meredith
- Buzgau Adrian
- Byrne Deborah
- Byrne Kathleen
- BĂ©lteczki JĂĄnos
- Cabreros Leilani
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- Chassé Michaël
- Chen Yan
- Cheng Allen
- Cheng Allen C
- Cherian Shiney
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- Collier Dawn
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- Collins Joanne
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- Cooper Jamie
- Cooper Melanie
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- Cort Jon
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- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craner Michelle
- Craven Thomas
- Creagh-Brown Ben
- Crisp Nikki
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- Davies Louisa
- Davies Michelle
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- De Beaux Fiona
- De Bus Liesbet
- de Courcy-Golder Kim
- de Jager P
- de Jong Menno
- De Jong Menno
- de Jonge E
- de la Fuente Martos Carmen
- de Lima Pereira Tiago Nuno Alfaro
- de Man Angelique
- De Waele Jan
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- Fitzgerald Mark
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- Forbes Loretta
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- Fowler Robert
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- Frey Anna
- Friedrich Hinrichs Carl
- Frohlich Stephen
- Fysh Ed
- Gallagher Linda Jude
- Ganguly Saibal
- Ganpat Radhika
- Garcia Rebecca
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- Goossens Herman
- Goossens Herman
- Gopal Shameer
- Gopinath Amitha
- Gordon Anthony
- Gordon Anthony C
- Gordon Elizabeth
- Gosbell Iain
- Gould Richard
- Grecu Irina
- Green Cameron
- Green Cameron
- Gregory Jane
- Gresha Rebecca
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- Grimwade Kate
- Guilder E
- Guitton Christophe
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- Hadebe Bernard
- Hagel Stefan
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- Hall Kathryn
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- Hamilton-Davies Colin
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- Hickey Naomi
- Higgins Alisa M
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- Hugill Keith
- Hullegie Sebastiaan
- Hullegie Sebastiaan J
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- Hulme Jonathan
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- Hunter Stephanie
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- Hutton Paula
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- Isgro Graziella
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- Jackson Shane
- Jackson Susan
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- Kruger Peter
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- Lamontagne Francois
- Lamontagne Francois
- Lamontagne François
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- Lane Janis-Best
- Lankester Liana
- Laver Russell
- Lawler Patrick
- Lawler Patrick R
- Lawless Patrick
- Lazaro Juan Martin
- Leaver Susannah
- Leblond Julie
- Lee Kelvin
- Lee Stephanie
- Leparco CĂ©cile
- Lesona Eden
- Leszkoven JĂĄnos
- Lewis Roger
- Lewis Roger J
- Lewis Sarah
- LeĂłn LĂłpez Rafael
- Limb James
- Linstrum Kelsey
- Linstrum Kelsey
- Litton Ed
- Litton Edward
- Litton Edward
- Lomme Kaatje
- London Emily
- Lorenzi Elizabeth
- Lorenzi Elizabeth
- Lother Sylvain
- Lowe Benjamin
- Lowrey Julie
- Luis David
- Luk Tracy
- LâHotellier Sylvie
- Mackay Callum
- Mackay Euan
- MacLennan Sheila
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- Marshall John
- Marshall John
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- Martynoga Robert
- Maselli Astrid
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- Mateo LĂłpez Maria Isabel
- Matsa Ramprasad
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- Maxime Virginie
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- McArthur Colin
- McArthur Colin
- McAuley Daniel
- McAuley Daniel
- McAuley Danny
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- McCullagh Iain
- McCullough James
- McDyer John
- McGhee Christopher
- McGlothin Anna
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- McGloughlin Steve
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- McGuinness Shay
- McGuinness Shay
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- Mercier Romain
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- Monchi Mehran
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- Montague Laura
- Montgomery Stephanie
- Montgomery Stephanie
- Moore Lorraine
- Morel Guillaume
- Moreno Cuesta Jeronimo
- Morgan Matt
- Morpeth Susan
- Morris Sheila
- Morrison Lynette
- Mouncey Paul
- Mouncey Paul
- Moviat M
- Mullan Dee
- Muller Grégoire
- Munt Sheila
- Murphy Sheenagh
- Murray Lauren
- Murthy Srinivas
- Murthy Srinivas
- Music Edvin
- Muñoz-BermĂșdez Rosana
- Mwaura Esther
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- Nichol Alistair
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- Nicholson Sarah
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- Noble Harriet
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- Nortje Jurgens
- Oakley Susan
- Oborska Aneta
- Oczkowski Simon
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- Orath Prabakaran Rajalakshmi
- Orford Neil
- Oritz-Ruiz de Gordoa Laura
- Orr Katrina
- Oza Deepali
- OâBrien Julie
- OâDywer Michael
- OâKane Cecilia
- OâKane SinĂ©ad
- OâMalley Laura
- OâNeill Aisling
- Page Valerie
- Paling A
- Panwar Rakshit
- Paramasivam Elankumaran
- Parekh Dhruv
- Parke Rachael
- Parke Rachael
- Parker Jane
- Parker Lorraine
- Parrilla GĂłmez Francisco
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- Pasi John
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- Patch Sarah
- Patel Amit
- Patel Kamal
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- Paterson David
- Patterson Lisa
- Peake Sandra
- Pearson Karen
- Pegler Suzannah
- Pellicano Annamaria
- Pereira Sousa Bastos Joana Margarida
- Pereira Rita
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- Peters Marco
- Peters Svenja
- Petros Sirak
- PettilÀ Leena
- Phalod Gunjan
- Philbin Jennifer
- Phillips Barbara
- Phull Mandeep-Kaur
- Pillai Suresh
- Pinder Meredith
- Pinnell Jez
- Pitts Sally
- Pletz Mathias
- Pletz Mathias
- Plumb Benjamin
- Pogreban Tatiana
- Pogson David
- Polderman F
- Polgarova Petra
- Pomeroy Fiona
- Porteous Rebecca
- Porter David
- Potter Alison
- Pourcine Franck
- Powell Elizabeth
- Powell Matthew
- Presneill Jeffrey
- Pridee Nicole
- Prinssen Anton
- Prout Rachel
- Pugh Richard
- Pulletz Mark
- Purandare Laura
- Purohit Dharam
- Purvis Sarah
- Puthucheary Zudin
- Puxty Kathryn
- Quayle Rachael
- Quinn Kevin
- Qureshi Hafiz
- Rad Laura
- Rademaker Emma
- Rae Nicola
- Raithatha Ajay
- Ramali Mohamed
- Ramanan Mahesh
- Ramos Lidia
- Randell Georgina
- Rauniyar Rashmi
- Raymakers Kik
- Reddy Amie
- Reddy Harsha
- Rees Tabitha
- Reeve Brenda
- Regli Adrian
- Reill Lorenz
- Rengers Els
- Reschreiter Henrik
- Reynolds Claire
- Reynolds John
- Rhodes Jonathan
- Richards-Belle Alvin
- Ricketts Daniel
- Rietveld Ilse
- RistimÀki Sanna
- Ritzema Carter Jay
- Robert Alain
- Roberts David
- Robertson Yvonne
- Robinson Matt
- Robinson Philip
- Rochwerg Bram
- Rodden Natalie
- Rodriguez Fernandez Jorge
- Roedl Kevin
- Rohde Gernot
- Rojo Roceld
- Rook Clare
- Rooney Kevin
- Rosaroso Lace Paulyn
- Rose Steve
- Rostron Anthony
- Rowan Kathryn
- Rowan Kathryn
- Rowan Kathy
- Rowland Matthew
- Roy Alistair
- Roynon-Reed Anna
- Rozendaal Wim
- Russell Robert
- Ryalls Kim
- Ryan Lucy
- Sagnier Anne
- Salazar Degracia Anna
- Salerno Tania
- Salet A
- Salisbury Sarah
- Sall Jas
- Salmon Charlotte
- Sandhu Gyan
- Sanil Ashish
- Sanil Ashish
- Santamaria John
- Santos Filipa
- Santos Marlene
- Santos Marlene
- Saull Michelle
- Saunders Christina
- Saunders Christina
- Schischka Livia
- Schneider Francis
- Schotsman Joost
- Schuster-Bruce Martin
- Schutgens Roger
- Schweikert Sacha
- SchĂŒtze Bianka
- Scully Michael
- Sellers Katharine
- Selvamoni Selvin
- Senya Ho Jan
- Seppelt Ian
- Serri Karim
- Sever Helena
- Seymour Christopher
- Seymour Christopher
- Shah Asim
- Shakih Arif
- Shankar-Hari Manu
- Shaw David
- Shaw Joanne
- Shearer Audrey
- Sheffield Jonathan
- Shehabi Yahya
- Shovelton Charmaine
- Shrestha Tapaswi
- Shyamsundar Murali
- Siami Shidasp
- Silversides Jon
- Sim Malcolm
- Simmonds Catherine
- Simons Koen
- Simpson Joanne
- Simpson Scott
- Singh Vanessa
- Singleton Jo
- Sinha Pratik
- Slevin Kathryn
- Small Charlotte
- Smallwood Andrew
- Smee Joanna
- Smith Joanne
- Smith John
- Smith Judith
- Smith Julie
- Smith Kirsy
- Smith Margaret
- Smith Roger
- Smith Simon
- Smith Tim
- Smuts Sara
- Smyth Michelle
- Soar Natalie
- Somerville Alastair
- Song Rima
- Sousa Arias Sonia
- Southern David
- Southin Sara
- Spencer Thomas
- Spittle Nick
- Spivey Michael
- Stanciu Delia
- Stanworth Simon
- Sterba Martin
- Stevenson Hannah
- Stewart Richard
- Strzelecka Anna
- Sundara Raman Ajay
- Sundaran Dhinesh
- Sutherland Helen
- Sutterlin Laetitia
- Sutu Mihaela
- Sweet Katie
- Szakmany Tamas
- Szigligeti GĂĄbor
- SzĆke ViktĂłria
- Tallott Mandy
- Tatham Kate Colette
- Templeton Maie
- Thomas Amy
- Thomas Helen
- Thomas Matt
- Thomas Matthew
- Thompson Taylor
- Thomson Nicola
- Thrush Jessica
- Tilney Emma
- Tinmouth Alan
- Tong Steve
- Tooley Joe
- Touma Omar
- Trapani Tony
- Trask Kara
- Triulzi Darrell
- Trodd Dawn
- Tsang Jennifer
- Tully Redmond
- Turgeon Alexis
- Turki Salah
- Turner Anne
- Turner Anne
- Turner-Bone Ian
- Turns Margaret
- Uddin Ruzena
- Udy Andrew
- Uyeki Tim
- Vaara Suvi
- Vahtera Annukka
- Vamplew Luke
- van Bentum Puijk Wilma
- van Bentum-Puijk Wilma
- van Bentum-Puijk Wilma
- van Beurden Marloes
- van de Veerdonk Frank
- van de Veerdonk Frank
- Van Der Heyden Kym
- van der Poll Tom
- vanât Hoff Willian
- Vates Jennifer
- Vautier Sarah
- Vazquez-Grande Gloria
- Venkatesh Bala
- Venkatesh Balasubramanian
- Venz Ellen
- Verlander Mark
- Verrier Nathalie
- Victor Saji
- Vieillard-Baron Antoine
- Voicu Sebastian
- Vowell Emma
- Vujaklija BrajkoviÄ Ana
- Vuylsteke Alain
- Wagh Atul
- Walden Andrew
- Walker Rachel
- Walsh Joanne
- Walsh Tim
- Walsham James
- Ward Kathryn
- Warnock Majella
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Waugh Victoria
- Webb Steve
- Webb Steven A
- Wedd Steve
- Weismann Dirk
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Wetherill Bill
- Whelan Ruth
- Whileman Amanda
- Whitbread Jennifer
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Wibrow Bradley
- Wigbers J
- Wilby Elizabeth
- Wild Laura
- Wild Laura
- Wilding Laura
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Erin
- Williams Hannah
- Williams Karen
- Williams Patricia
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James
- Wilson Karen
- Wilson Maggie
- Wiseman Sophie
- Wong Helen
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Äimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (nâ=â143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (nâ=â152), or no hydrocortisone (nâ=â108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (nâ=â137), shock-dependent (nâ=â146), and no (nâ=â101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka â â
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safaâ
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
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- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
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- Alshawadfy Abdelrhman
- Alshawesh Aisha
- Alsheik Ahmad
- Alsori Mohamed
- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
- Alzyoud Osama
- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
- Aminu Muhammad Baffah
- Ammar Ahmed Siddique
- Amro Dana
- Ananthapadmanabhan Shravankrishna
- Anderson Paul
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- Aslan Merve
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- Asudo Felicia
- Atadag Yildiz Buyukdereli
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- Ather M Hammad
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- Atia Ahmed
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- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
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- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- âAladna âAbdallah
- âAljoumaa âAbdullah
- âNawfal âHamdi
- âNiazi âAmmar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
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- S Swann
- S Tilbey
- S Turki
- S Turney
- S Twiss
- S Wadd
- S Whiteley
- S Williams
- S Wood
- S Yussuf
- Sabino Scolletta
- Samreen Ijaz
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara McDonald
- Sarah Law
- Sarah McCafferty
- Saverio Giuseppe Parisi
- Saye Khoo
- Scott Richard
- Semple Malcolm G
- Serafina Valente
- Serena Ludovisi
- Sergio Daga
- SeĂĄn Keating
- Shankar-Hari Manu
- Shen Xia
- Shih Barbara
- Shiranee Sriskandan
- Shona C Moore
- Silvia Cappelli
- Simona Marcantonio
- Simone Furini
- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
- T Arden
- T Baird
- T Behan
- T Bemand
- T Cosier
- T Coventry
- T Duncan
- T Felton
- T Geary
- T Hazleton
- T Joefield
- T Kannan
- T Lawton
- T Marsden
- T Martin
- T McHugh
- T Newman
- T Nortcliffe
- T O Jones
- T Pogreban
- T Rees
- T Samakomva
- T Smith
- T Smith
- T Szakmany
- T Varghes
- T Williams
- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
- V Nagarajan
- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, PÂ =Â 1.65Â ĂÂ 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, PÂ =Â 2.3Â ĂÂ 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, PÂ =Â 3.98Â ĂÂ Â 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, PÂ =Â 4.99Â ĂÂ 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard VĂ©ronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
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- Baker M.
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- Banerjee Ruby
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- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
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- Barker Darren
- Barker Gary
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- Beasley Helen
- Beasley Oliver
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- Beck Alfred
- Beck Stephen
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- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
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- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
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- Bercovitz John
- Berghoff Amy
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- Berkowicz Nicolas
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- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
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- Bieri Tamberlyn
- Bimage Kesha E.
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- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
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- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
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- Bray Jason
- Bray-Allen Sarah
- Brettin Thomas
- Bridgeman Anne
- Bridgers Michael
- Brimhall Angela K.
- Brokstein Peter
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- Campbell Evelyn W.
- Campbell Mary I.
- Campbell Mary L.
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- Chan Yee Man
- Chang Jean L.
- Chapman Jarrod
- Chapman Joanna
- Chapple Jeffrey
- Charles Rachel
- Chasteen Leslie A.
- Chavarria Simeon
- Chazaro Bruno
- Chen Baoxian
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- Chen Zhu
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- Chen Zhu
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- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
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- Chinwalla Asif
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- Christensen Mari
- Christopoulos Constantine
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- Chung A
- Cinkowsky Michael J.
- Citroen Mieke
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- Dathorne Stephanie R.
- Daum Christopher
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- Dawson Elisabeth
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- DeArellano Kurt
- Deaven Larry I.
- Deaven Larry L.
- Deere Kerry
- DeGray Stewart
- Degusta David
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- Delgado Marcos
- Delgado Oliver
- Delhaunty Kimberley
- Deloukas Panos
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- Desai Anu
- Detter John C.
- Devlin Laurie
- Dewar Ken
- Dhami Pawandeep
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- Dias Jennifer
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- Dibling Catherine
- Dickson Mark
- Diekhans Mark
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- Ding Li
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- Horne Jennifer
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- Howden Philip
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- Huang Wei
- Huang Wei
- Huang Zhengping
- Hubbard Timothy
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- Huckle Elizabeth
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- Hupman Matt
- Huynh Sandy
- Hyde David
- Hynds Christopher
- Idlebird Devincent G.
- Iliev Ilian
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- Imo Kelvin C.
- Inacio Nicole
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- Ince Michael
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- Ishibashi Akiko
- Ishikawa Sabine K.
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- Izumiyama Tomohiro
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- Jackson Terri
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- Jaeger Sara
- Jaffe David B.
- Jahn Niels
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- Jaklevic Michael
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- Madabhushi Ramki
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- Nakato Eriko
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- Nandkeshwar Richard
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- Naranjo Cleo M.
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- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
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- Olson Maynard V.
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- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
- Author
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- Ridgway P. F.
- Righini E. (Azienda UnitĂ Sanitaria Locale di Ferrara
- Riley C.
- Rimonda R.
- Ringressi M. N.
- Ripollés-Melchor J.
- Risaliti M.
- Rizzi A. (ASST Sette Laghi-Varese)
- Robinson A.
- Rodimov S.
- Rodrigo V. S. D. (District General Hospital Chilaw)
- Rodriguez J. L.
- RodrĂguez GĂłmez L. (Severo Ochoa University Hospital)
- Rogers L. (Derriford Hospital)
- Rojo LĂłpez J. A.
- Romano M.
- Romero de Diego A.
- Ronellenfitsch U. (University Hospital Halle (Saale))
- Rooney S.
- Rosa F.
- Rose J.
- Roslani A. C. (University Malaya Medical Centre). Mexico: Buerba G. A.
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- Rottoli M.
- Roy Mahapatra S.
- Royle T.
- Rozzano (Mi) and Humanitas University
- Rubio-Perez I.
- Ruivo A.
- Ruiz Escobar A. (Infanta Leonor University Hospital)
- Ruiz Soriano M.
- Ruiz-MarĂn M.
- Russ J.
- RutegÄrd M. (Umea University Hospital). Switzerland: Arigoni M.
- Rutherford D.
- Ruzzenente A.
- Ryan M. (University Hospital Waterford/University College Cork). Italy: Macina S. (ASST Mantua)
- Ryan Ă. (University Hospital Galway)
- Ryska O. (Royal Lancaster Infirmary)
- RĂo Lafuente F. D.
- Saad M. M.
- Saafan T.
- Saavedra J.
- Sabah)
- Sabratha)
- Sabry A.
- Saeed S.
- Saez Carlin P.
- Sagar J.
- Sagnotta A. (Ospedale San Filippo Neri)
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- Salazar A.
- Saleem A.
- Salem H.
- Salgado-Nesme N.
- SalimoÄlu S.
- Salindera S.
- Sallam I.
- Samih A.
- Samir Abdelaal A.
- Samison L. H. (Joseph Ravoahangy Andrianavalona Hospital). Malaysia: Hamdan K. H.
- Samkari A.
- Sammarco G.
- Sammour T. (Royal Adelaide Hospital)
- Sampaio da NĂłvoa Gomes Miguel I. I. (Centro Hospitalar UniversitĂĄrio do Algarve â Unidade de PortimĂŁo)
- Sampietro G. M. (Ospedale di Rho â ASST Rhodense)
- San Francisco (UCSF))
- Sanchez Cabezudo Noguera F.
- Sanchez Gonzalez J.
- Sanchez Jimenez R.
- Sanchez-Pelaez D. (Hospital General Universitario de Ciudad Real)
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- Sanli A. N.
- Santanach C.
- Santarrufina Martinez S.
- Santero-Ramirez M. S.
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- Saraiva P.
- Sarantitis I.
- Sarigul M.
- Sarin A.
- Sarjanoja E. (LĂ€nsi-Pohja Central Hospital)
- Sarma D. R.
- Sarre C. (Instituto Nacional de Ciencias MĂ©dicas y NutriciĂłn âSalvador ZubirĂĄnâ). Morocco: Amrani L.
- Sartarelli L.
- Sarveswaran J.
- Sasapu K. (Diana Princess of Wales Hospital Grimsby)
- Sasia D.
- SaudĂ S. (Hospital Universitario Miguel Servet)
- Sauvain M. (Pourtales Neuchatel Hospital)
- Sauvat F. (CHU RĂ©union). Romania: Bezede C.
- SavkoviÄ N.
- Sayyed R. (Patel Hospital)
- Scabini S.
- Scalabre A. (Chu Saint Etienne)
- Scanu A. M. (Cliniche San Pietro
- Schiavo M. (Ospedale Vittorio Emanuele III â Carate Brianza)
- Schiergens T.
- Schineis C. (Charité University Medicine
- Schizas D.
- Schlesinger N.
- Schwartz P.
- Scott L. (Pinderfields Hospital)
- Scotton G. (St Moritz Hospital)
- Scrima O.
- Sechenov Medical State University)
- Seebah K.
- Seeliger B. (Strasbourg University Hospitals/IHU-Strasbourg)
- Seguin-Givelet A.
- Sehgal T.
- Selmani J.
- Semina E. (Moscow Research and Educational Center
- Senossi O.
- Serevina O. L.
- Serralta de Colsa D. (Infanta SofĂa University Hospital)
- Serrano GonzĂĄlez J. (Hospital Universitario de TorrejĂłn de Ardoz)
- Serrano-Navidad M.
- Sert Ä°.
- Seymour Z. (Ysbyty Gwynedd). USA: Haynes A.
- Sganga G. (Fondazione Policlinico Universitario Agostino Gemelli IRCCS)
- SgrĂČ A.
- Shah J. (North Manchester General Hospital)
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- Shah Z. A.
- Shaikh I.
- Shaikh S.
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- Sharma P. (Aberdeen Royal Infirmary)
- Shehata S.
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- Sheridan K.
- Sherief M.
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- Shokuhi P.
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- Sibilla M. G.
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- Silva M.
- Silva N.
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- Silveira Nunes I.
- SimÔes J. (Centro Hospitalar e Universitårio de Coimbra)
- Singh A.
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- Smith H. (Bispebjerg Hospital). Egypt: Al Sayed M.
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- Soares A. P.
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- Solari F.
- Soriero D. (IRCCS Ospedale Policlinico San Martino)
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- Sorribas Grifell M.
- Soto Montesinos C. (FundaciĂł Althaia â Xarxa Assistencial UniversitĂ ria de Manresa)
- Souadka A. (Institut National dâOncologie
- Soulikia K.
- Sousa Fernandes M. (Hospital Beatriz Angelo)
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- Spartalis E.
- Spencer N.
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- Sreedharan L.
- Sriram R. K.
- Srishankar S. (Teaching Hospital Anuradhapura). Sudan Ali Adil A. K. (Al-Rajhi). COVIDSurg COllabOratIVe | 17 Sweden: ĂlgĂ„ A.
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- Stafford J. (George Eliot Hospital)
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- Stylianidis G. (Evaggelismos General Hospital)
- Subhi M. T. (Alkhadra Hospital)
- Subocius A.
- Subramaniam S. (Queen Elizabeth Hospital and Universiti Malaysia Sabah
- Sundaram Venkatesan G. (Glan Clwyd Hospital)
- SusztĂĄk N. (Szent BorbĂĄla KĂłrhĂĄz). India: Bhat G. A.
- Sutherland A. (Coffs Harbour Health Campus)
- Swinson B. (Royal Brisbane and Womenâs Hospital). Austria: Messner F.
- Syed W. A. S.
- Syllaios A.
- Szatmary P.
- Szubota I. (Hospital and Oncological Centre Novy Jicin). Denmark: EbbehĂžj A. L.
- SĂĄnchez del Pueblo C.
- SĂĄnchez Fuentes N.
- SĂĄnchez- Pernaute A.
- SĂĄnchez- Rubio M.
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- Tanal M.
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- Tanzanu M.
- Tartaglia D. (Azienda Ospedaliero Universitaria Pisana)
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- Teixeira J. (Centro Hospitalar UniversitĂĄrio do Algarve â Unidade de Faro)
- Teixeira M. (Centro Hospitalar do Tamega e Sousa)
- Tejero- Pintor F. J. (Hospital Universitario RĂo Hortega)
- Testa V. (Santa Croce E. Carle Hospital
- Tewari N. (University Hospitals Coventry and Warwickshire NHS Trusts)
- Tezas S. (Furness General Hospital)
- Thaha M.
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- Theodosopoulos T.
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- Thrumurthy S. (Epsom and St Helier University Hospitals NHS Trust)
- Thulasiraman S. V.
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- Titu S. (Prof. Dr. Ion Chiricuta Institute of Oncology). Russia: Garmanova T.
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- Torres Arcos C.
- Townson A.
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- Travaglio E. (Regina Montis Regalis Hospital
- Tribillon E. (Institut Mutualiste Montsouris)
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- Tsiamalou I.
- Tsiaoussis I.
- TU Dresden)
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- Universiti Sains Malaysia)
- University of Amsterdam)
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- Uslu G.
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- Valbuena Jabares V. (Marqués de Valdecilla University Hospital)
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- Vieira B. (Centro Hospitalar de TrĂĄs-Os-Montes e Alto Douro
- Vieira Caroço T. (IPO Coimbra)
- Vieira Paiva Lopes A. C. (Hospital de Torres Vedras â Centro Hospitalar do Oeste)
- Vignali A. (San Raffaele Scientific Institute
- Vigorita V. (Ălvaro Cunqueiro Hospital)
- Vijayan D. (Queen Elizabeth Hospital Birmingham)
- Villalabeitia Ateca I. (Hospital Universitario Cruces)
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- Viswanath Y. K. S. (James Cook University Hospital)
- Vitali A. (Ospedale San Giovanni di Dio)
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- Von Papen M.
- Vovola F. (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia)
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- Walkes K. (Queen Elizabeth Hospital). Belgium: Flamey N.
- Wani R. (Sher-I-Kashmir Institute of Medical Sciences)
- Waqar S. H. (Pakistan Institute of Medical Sciences). Poland: Major P. (Jagiellonian University Medical College). Portugal: Azevedo C.
- Warren O. (Chelsea and Westminster Hospital)
- Watson L. J. (Sunderland Royal Hospital)
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- Weitz J.
- Welsch T. (Carl-Gustav-Carus University Hospital
- Werner J. (LMU Klinikum Campus Innenstadt)
- Westwood E. (James Paget University NHS Foundation Trust Hospital)
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- Whitmore H. (Torbay and South Devon NHS Trust)
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- Williams G. (Royal Gwent Hospital)
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- Wong M.
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- Yang W.
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- Ye G.
- Yesantharao P.
- Yetkin S. G. (Sisli Hamidiye Etfal Training and Research Hospital)
- YeĆilyurt D. (University of Health Sciences Tepecik Training and Research Hospital)
- Yiallourou A. (Nicosia General Hospital). Czechia: Martinek L.
- Yıldırım A.
- Yildiz A. (Yildirim Beyazit University Yenimahalle Training and Research Hospital). Uganda: Lule H.
- Young R. (York Teaching Hospitals NHS Trust)
- Yousof E. A. (Assiut University Hospital)
- Youssef M. (Norfolk and Norwich University Hospital)
- Yurttas C. (University Hospital Tuebingen)
- YĂĄnez C. (Royo Villanova)
- YĂŒksel E. (Kocaeli University Teaching Hospital)
- Zafar S. N. (University of Wisconsin)
- Zakaria A. D.
- Zakaria Z. (School of Medical Sciences and Hospital
- Zambon M. (Policlinico Umberto I Sapienza University of Rome)
- Zanus G. (Caâ Foncello Treviso â DISCOG â UniversitĂ di Padova)
- Zegarac M. (Institute for Oncology and Radiology of Serbia)
- ZeliÄ M. (University Hospital Center Rijeka)
- Zengin A. K. (Istanbul Universty â CerrahpaĆa Medical Faculty)
- Zerbib P. (CHU Lille)
- Zervas K.
- Zese M. (Santa Maria degli Angeli Hospital ULSS 5 â Adria)
- Zhang H. (Concord Repatriation General Hospital)
- Zizzo M. (Azienda UnitĂ Sanitaria Locale â IRCCS di Reggio Emilia)
- Zografos C. (Laiko University Hospital)
- Zorrilla OrtĂșzar J. (Hospital General Universitario Gregorio Marañón)
- Zourntou S. (General Hospital of Larissa âKoutlimpaneio and Triantafylleioâ)
- Zubaidi A. M. (King Saud University). Serbia: AleksiÄ L.
- Ăngelo M.
- Ăelebi F.
- Ăolak E.
- Ăfner D. (Medical University of Innsbruck)
- Ăhlberger L.
- Ăzçelık M. F.
- ĂÄĂŒcĂŒ H.
- ĂberrĂŒck L.
- Äoza I.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study
- Author
- Aanensen David
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad
- Aigrain Louise
- Alam Mohammad
- Alcolea-Medina Adela
- Alderton Alex
- Aliabadi Shirin
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ash Amy
- Ashcroft Fiona
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali
- Aydin Alp
- Baker David
- Baker Paul
- Balcazar Carlos
- Ball Jonathan
- Barrett Jeff
- Barton Edward
- Bashton Matthew
- Bassett Andrew
- Batra Rahul
- Baxter Laura
- Bayzid Nadua
- Beale Mathew
- Beaver Charlotte
- Beckett Angela
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine
- Berry Lisa
- Berry Louise
- Best Angus
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- BoYes John
- Bradley Amanda
- Bradley Declan
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah
- Bronner Iraad
- Brooks Ellena
- Broos Alice
- Brown Julianne
- Brown Paul
- Brown Rebecca
- Bucca Giselda
- Buck David
- Bull Matthew
- Burton-Fanning Shirelle
- Campbell Sharon
- Carabelli Alessandro
- Carden Holli
- Carlile Matthew
- Carmichael Stephen
- Casey Anna
- Cerda Alberto
- Chalker Vicki
- Chand Meera
- Chapman Michael
- Chappell Joseph
- Charalampous Themoula
- Charlett Andre
- Chatterton Wendy
- Chaudhry Yasmin
- Chauhan Anoop
- Cheng Jeffrey
- Churcher Carol
- Clark Gemma
- Cogger Benjamin
- Coll Francesc
- Collins Jennifer
- Connor Thomas
- Constantinidou Chrystala
- Cook Kate
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nick
- Cotic Marius
- Cottrell Simon
- Coupland Lindsay
- Cowell Angela
- Cox Alison
- Craine Noel
- Crawford Liam
- Cronin Michelle
- Crook Derrick
- Cumley Nicola
- Curran Martin
- Curran Tanya
- da Silva Filipe Ana
- Dabrera Gavin
- Dabrera Gavin
- Dadrah Ashok
- Danesh John
- Darby Alistair
- Davidson Rose
- Davies Alisha
- Davies Robert
- Davis Thomas
- De Angelis Daniela
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan
- Debebe Johnny
- Dent Hannah
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Dorman Matthew
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Durham Jillian
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Ensell Leah
- Escalera Zamudio Marina
- Essex Sarah
- Evans Cariad
- Evans Johnathan
- Eyre David
- F. Nascimento Fabricia
- Fairley Derek
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Fearn Christopher
- Fenton Melisa
- Fina Laia
- Fisher Chloe
- Flaviani Flavia
- Fleming Vicki
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy
- Frost Lucy
- Fuller William
- Galai Katerina
- Gallagher Eileen
- Gallagher Eileen
- Gallagher Michael
- Gallis Marta
- Gaskin Amy
- Gatica-Wilcox Bree
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet
- Girgis Sophia
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodwin Scott
- Goudarzi Salman
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Green Angie
- Green Luke
- Greenaway Jane
- Gregory Richard
- Groves Danielle
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gunson Rory
- Gupta Ravi
- Gutierrez Bernardo
- Hadjirin Nazreen
- Haldenby Sam
- Hale Antony
- Hall Grant
- Halstead Fenella
- Hamilton William
- Haque Tanzina
- Harper Katherine
- Harris Kathryn
- Harris Ross J
- Harrison Ewan
- Harrison Ian
- Harrison James
- Hart Jennifer
- Hartley John
- Hartman Hassan
- Hassan-Ibrahim Mohammed
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew
- Heyburn David
- Higginson Ellen
- Hill Verity
- Hilvers Ember
- Hiscox Julian
- Hogsden Wendy
- Holden Matthew
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hope Russell
- Hopes Richard
- Hosmillo Myra
- Howe Robin
- Howson-Wells Hannah
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hutchings Stephanie
- Illingworth Chris
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Chris
- Jackson David
- Jackson Kathryn
- Jackson Leigh
- Jahun Aminu
- James Keith
- Jamrozy Dorota
- Jannoo Riaz
- Jeffries Aaron
- Jeremiah Sarah
- Jesudason Natasha
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnston Ian
- Jones Carl
- Jones Christopher
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Karamani Angeliki
- Kay Gemma
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander
- Kenyon Anita
- Kermack Leanne
- Khakh Manjinder
- Kidd Stephen
- Kitchen Christine
- Knight Bridget
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-SummerhaYes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Ledesma Juan
- Lee David
- Lee Jack
- Leek Danielle
- Lensing Stefanie
- Leonard Steven
- Letchford Laura
- Levene Nick
- Levett Lisa
- Lewis Kevin
- Li Kathy
- Liddle Jennifier
- Liggett Steven
- Lindsey Benjamin
- Lister Michelle
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loman Nicholas
- Loose Matthew
- Lopez-Bernal Jamie
- Louka Stavroula
- Loveson Katie
- Lowe Hannah
- Lowe Helen
- Lucaci Anita
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan
- Macfarlane-Smith Louissa
- Machin Nicholas
- MacIntyre-Cockett George
- Maclean Alasdair
- Madona Pinglawathee
- Maes Mailis
- Mahanama Adhyana
- Mahungu Tabitha
- Mair Daniel
- Maksimovic Joshua
- Makunin Alex
- Malone Cassandra
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez Nunez Rocio
- Masoli Jane
- Mason Jenifer
- Mather Alison
- Mayhew Megan
- Mbisa Tamyo
- McCann Clare
- McCarthy Shane
- McCluggage Kathryn
- McClure Patrick
- McGuigan Samantha
- McHugh Martin
- McKenna James
- McKerr Caoimhe
- McManus Georgina
- McMurray Claire
- McNally Alan
- Meader Emma
- Meadows Lizzie
- Megram Oliver
- Menegazzo Mirko
- Merrick Ian
- Merrill Tammy
- Miah Shahjahan
- Michell Stephen
- Michelsen Michelle
- Mirza Jeremy
- Moles-Garcia Emma
- Moll Robin
- Mollett Guy
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nichols Jenna
- Nickbakhsh Seema
- Niebel Marc
- Nomikou Kyriaki
- Nyberg Tommy
- O'Brien Sarah
- O'Grady Justin
- O'Toole Elaine
- O'Toole Ăine
- Oliver Karen
- Orton Richard
- Osman Husam
- Ott Sascha
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew
- Palmer Sophie
- Palmer Steve
- Pandey Sarojini
- Park Naomi
- Parker Matthew
- Parmar Surendra
- Parsons Paul
- Partridge David
- Patel Amita
- Patel Minal
- Patel Vineet
- Paterson Steve
- Paul Hannah
- Payne Brendan
- Peacock Sharon
- Pearson Clare
- Pelosi Emanuela
- Percival Benita
- Perry Malorie
- Peto Timothy
- Pinckert Malte
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Presanis Anne M
- Prestwood Liam
- Price Anna
- Price James
- Prieto Jacqui
- Puethe Christoph
- Pusok Monika
- Pybus Oliver
- Pymont Hannah
- Quail Michael
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Rambaut Andrew
- Ramsay Mary
- Randell Paul
- Ratcliffe Liz
- Raviprakash Veena
- Raza Mohammad
- Redshaw Nicholas
- Rey Sara
- Reynolds Nicola
- Richter Alex
- Robertson David
- Robinson Esther
- Robinson Trevor
- Robson Samuel
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Saeed Kordo
- Saluja Tranprit
- Samaraweera Buddhini
- Sambles Christine
- Sang Fei
- Scarlett Garry
- Schaefer Ulf
- Scott Carol
- Scott Garren
- Seaman Shaun R
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shankar Giri
- Shepherd James
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian
- Sillitoe John
- Silveira Siona
- Simpson David
- Singer Joshua
- Sinnathamby Mary A
- Sivaprakasam Venkat
- Siveroni Igor
- Sloan Tim
- Sluga Graciela
- Smith Colin
- Smith Darren
- Smith Kim
- Smith Louise
- Smith Nikki
- Smith Wendy
- Smollett Katherine
- Snell Luke
- Southgate Joel
- Spellman Karla
- Spencer Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David
- Swindells Emma
- Symmonds Amanda
- Taha Yusri
- Tang Julian
- Taylor Ben
- Taylor Graham
- Taylor Sarah
- Taylor-Joyce Grace
- Temperton Ben
- Templeton Kate
- Thelwall Simon
- Thompson Thomas
- Thomson Emma
- Thornton Alicia
- Thurston Scott
- Todd John
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Tovar-Corona Jaime
- Trebes Amy
- Trotter Alexander
- Tsoleridis Theocharis
- Tucker Rachel
- Turtle Lance
- Twohig Katherine
- Twohig Katherine A
- Underwood Anthony
- Unnikrishnan Meera
- Vamos Edith
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vernet Gabrielle
- Vipond Ian
- Volz Erik
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webster Hermione
- Weldon Danni
- Westhorpe Adam
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Williams Charlotte
- Williams Chris
- Williams David
- Williams Lesley-Anne
- Williams Rachel
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen
- Willingham Iona
- Wilson Harry
- Wilson Rebekah
- Wilson-Davies Eleri
- Wise Emma
- Witele Eric
- Workman Trudy
- Wright Victoria
- Wyatt Tim
- Wyles Matthew
- Wyllie Sarah
- Xu-McCrae Li
- Yeats Corin
- Yew Wen
- Young Gregory
- Young Jamie
- Zaidi Asad
- Zarebski Alex
- Zhang Peijun
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background:
The SARS-CoV-2 delta (B.1.617.2) variant was first detected in England in March, 2021. It has since rapidly become the predominant lineage, owing to high transmissibility. It is suspected that the delta variant is associated with more severe disease than the previously dominant alpha (B.1.1.7) variant. We aimed to characterise the severity of the delta variant compared with the alpha variant by determining the relative risk of hospital attendance outcomes.
Methods:
This cohort study was done among all patients with COVID-19 in England between March 29 and May 23, 2021, who were identified as being infected with either the alpha or delta SARS-CoV-2 variant through whole-genome sequencing. Individual-level data on these patients were linked to routine health-care datasets on vaccination, emergency care attendance, hospital admission, and mortality (data from Public Health England's Second Generation Surveillance System and COVID-19-associated deaths dataset; the National Immunisation Management System; and NHS Digital Secondary Uses Services and Emergency Care Data Set). The risk for hospital admission and emergency care attendance were compared between patients with sequencing-confirmed delta and alpha variants for the whole cohort and by vaccination status subgroups. Stratified Cox regression was used to adjust for age, sex, ethnicity, deprivation, recent international travel, area of residence, calendar week, and vaccination status.
Findings:
Individual-level data on 43â338 COVID-19-positive patients (8682 with the delta variant, 34â656 with the alpha variant; median age 31 years [IQR 17â43]) were included in our analysis. 196 (2·3%) patients with the delta variant versus 764 (2·2%) patients with the alpha variant were admitted to hospital within 14 days after the specimen was taken (adjusted hazard ratio [HR] 2·26 [95% CI 1·32â3·89]). 498 (5·7%) patients with the delta variant versus 1448 (4·2%) patients with the alpha variant were admitted to hospital or attended emergency care within 14 days (adjusted HR 1·45 [1·08â1·95]). Most patients were unvaccinated (32â078 [74·0%] across both groups). The HRs for vaccinated patients with the delta variant versus the alpha variant (adjusted HR for hospital admission 1·94 [95% CI 0·47â8·05] and for hospital admission or emergency care attendance 1·58 [0·69â3·61]) were similar to the HRs for unvaccinated patients (2·32 [1·29â4·16] and 1·43 [1·04â1·97]; p=0·82 for both) but the precision for the vaccinated subgroup was low.
Interpretation:
This large national study found a higher hospital admission or emergency care attendance risk for patients with COVID-19 infected with the delta variant compared with the alpha variant. Results suggest that outbreaks of the delta variant in unvaccinated populations might lead to a greater burden on health-care services than the alpha variant.
Funding:
Medical Research Council; UK Research and Innovation; Department of Health and Social Care; and National Institute for Health Research