Caracterizaci?n de pacientes con infecci?n por Klebsiella pneumoniae productora de Carbapenemasa en la unidad de cuidado intensivo adulto de la Cl?nica Avidanti sede Ibagu?, periodo junio 2020 a junio 2021.

83 p.Introducci?n: Las infecciones causadas por enterobacterias productoras de carbapenemasa como Klebsiella pneumoniae, presentan gran importancia cl?nica debido a su r?pida diseminaci?n e incremento de su incidencia, se han convertido en un problema de salud p?blica por su capacidad de causar infecciones intrahospitalarias de dif?cil tratamiento ocasionando proporciones altas de fallas terap?uticas y mortalidad. Objetivo: Describir las caracter?sticas demogr?ficas, cl?nicas y microbiol?gicas de los pacientes con infecciones por Klebsiella pneumoniae productora de carbapenemasa, hospitalizados en las unidades de cuidado intensivo adulto en Ibagu?- Tolima, en el periodo de junio 2020 a junio 2021. Materiales y M?todos: Estudio observacional, descriptivo, transversal. Resultados: De los 38 pacientes hospitalizados en la unidad de cuidados intensivos el 60,5% fueron mujeres, la edad promedio fue de 67,3 a?os, el 86,8% proven?an de la zona urbana. El 68,4% presentaban hipertensi?n arterial y el 50% diabetes mellitus tipo 2. El 97,4% utiliz? ventilaci?n mec?nica invasiva y el 100% uso cat?ter central y urinario. La complicaci?n cl?nica presentada con mayor frecuencia fue el choque s?ptico con el 73,7%. El 76,3% de los pacientes falleci?. Existe un alto porcentaje de resistencia a los carbapen?micos superior al 89%. Conclusi?n: los datos obtenidos en este estudio coinciden con la literatura revisada, la infecci?n por KPC se present? con mayor frecuencia en pacientes en edades avanzadas y con antecedente de comorbilidades. Se presentaron elevados porcentajes de resistencia a los antibi?ticos carbapen?micos limitando las opciones terap?uticas. Por lo tanto, se recomienda a la instituci?n socializar los resultados de este estudio con el fin de implementar con rigurosidad las precauciones est?ndar de bioseguridad y mejorar el uso adecuado de antibi?ticos. Palabras claves: Klebsiella pneumoniae, farmacorresistencia microbiana, carbapen?micos, infecci?n hospitalaria.Introduction: Infections caused by carbapenemase-producing Enterobacteriaceae such as Klebsiella pneumoniae, have great clinical importance due to their rapid spread and increase in incidence, they have become a public health problem due to their ability to cause intrahospital infections that are difficult to treat, causing high proportions of therapeutic failures and mortality. Objective: To describe the demographic, clinical and microbiological characteristics of patients with carbapenemase-producing Klebsiella pneumoniae infections. hospitalized in adult intensive care units in a fourth level institution in Ibagu?-Tolima in the period from June 2020 to June 2021. Materials and Methods: observational, descriptive, cross-sectional study. Results: Of the 38 patients hospitalized in the intensive care unit, 60.5% were women, the average age was 67.3 years, 86.8% came from the urban area. 68.4% had hypertension and 50% had type 2 diabetes mellitus. 97.4% used invasive mechanical ventilation and 100% used central and urinary catheters. The most frequently presented clinical complication was septic shock with 73.7%. 76.3% of the patients died. There is a high percentage of resistance to carbapenems greater than 89%. Conclusion: The data obtained in this study coincide with the literature reviewed. KPC infection occurred more frequently in patients of advanced age and with a history of comorbidities. There were high percentages of resistance to carbapenemic antibiotics, limiting the therapeutic options. Therefore, the institution is recommended to socialize the results of this study in order to rigorously implement standard biosafety precautions and improve the appropriate use of antibiotics. Keywords: Klebsiella pneumoniae, drug resistance microbial, carbapenems, Cross infection

Measurement of charged particle spectra in minimum-bias events from proton-proton collisions at root s =13 TeV

Pseudorapidity, transverse momentum, and multiplicity distributions are measured in the pseudorapidity range vertical bar eta vertical bar 0.5 GeV in proton-proton collisions at a center-of-mass energy of root s = 13 TeV. Measurements are presented in three different event categories. The most inclusive of the categories corresponds to an inelastic pp data set, while the other two categories are exclusive subsets of the inelastic sample that are either enhanced or depleted in single diffractive dissociation events. The measurements are compared to predictions from Monte Carlo event generators used to describe high-energy hadronic interactions in collider and cosmic-ray physics.Peer reviewe