362 research outputs found
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Russian racial logic : examining white nationalism and narratives of race in Russia
This thesis uses qualitative content and historical analysis to understand the narratives of race and racism in the Russian Federation. It analyzes the history of race as a concept and the racialization of collective identities to challenge a common Russian trope that âthere is no racism in Russia.â It reveals that Russia has a history of racism that it actively supports within its own society, but that this racism is cloaked behind nationalist rhetoric and does not use the terminology commonly administered to describe global racisms. As a result, white nationalist organizations that openly advocate for the superiority of the Russian ethnicity over others and commit violence against minorities are able to publicly do so without earning the label of âracistâRussian, East European, and Eurasian StudiesGlobal Policy Studie
Whose Land Is It Anyway? Navigating Ghana\u27s Complex Land System
This Article dives into Ghanaâs complex land-registration system, which is influenced by both statutory and customary law. Section II discusses Ghanaâs statutory land laws. Section III provides a brief overview of Ghanaâs customary land laws. Section IV discusses several obstacles within Ghanaâs land-administration system
Medial temporal lobe activity during complex discrimination of faces, objects, and scenes: Effects of viewpoint
ABSTRACT: The medial temporal lobe (MTL), a set of heavily interconnected structures including the hippocampus and underlying entorhinal, perirhinal and parahippocampal cortex, is traditionally believed to be part of a unitary system dedicated to declarative memory. Recent studies, however, demonstrated perceptual impairments in amnesic individuals with MTL damage, with hippocampal lesions causing scene discrimination deficits, and perirhinal lesions causing object and face discrimination deficits. The degree of impairment on these tasks was influenced by the need to process complex conjunctions of features: discriminations requiring the integration of multiple visual features caused deficits, whereas discriminations that could be solved on the basis of a single feature did not. Here, we address these issues with functional neuroimaging in healthy participants as they performed a version of the oddity discrimination task used previously in patients. Three different types of stimuli (faces, scenes, novel objects) were presented from either identical or different viewpoints. Consistent with studies in patients, we observed increased perirhinal activity when participants distinguished between faces and objects presented from different, compared to identical, viewpoints. The posterior hippocampus, by contrast, showed an effect of viewpoint for both faces and scenes. These findings provide convergent evidence that the MTL is involved in processes beyond longterm declarative memory and suggest a critical role for these structures in integrating complex features of faces, objects, and scenes into viewinvariant, abstract representations. V V C 2009 Wiley-Liss, Inc
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LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock.
INTRODUCTION: Sepsis is a life-threatening, dysregulated response to infection. Both high-density lipoprotein and low-density lipoprotein cholesterol should protect against sepsis by several mechanisms; however, for partially unknown reasons, cholesterol levels become critically low in patients with early sepsis who experience poor outcomes. An anti-inflammatory lipid injectable emulsion containing fish oil is approved by the Food and Drug Administration as parenteral nutrition for critically ill patients and may prevent this decrease in serum cholesterol levels by providing substrate for cholesterol synthesis and may favourably modulate inflammation. This LIPid Intensive Drug therapy for Sepsis Pilot clinical trial is the first study to attempt to stabilise early cholesterol levels using lipid emulsion as a treatment modality for sepsis. METHODS AND ANALYSIS: This is a two-centre, phase I/II clinical trial. Phase I is a non-randomised dose-escalation study using a Bayesian optimal interval design in which up to 16 patients will be enrolled to evaluate the safest and most efficacious dose for stabilising cholesterol levels. Based on phase I results, the two best doses will be used to randomise 48 patients to either lipid injectable emulsion or active control (no treatment). Twenty-four patients will be randomised to one of two doses of the study drug, while 24 control group patients will receive no drug and will be followed during their hospitalisation. The control group will receive all standard treatments mandated by the institutional sepsis alert protocol. The phase II study will employ a permuted blocked randomisation technique, and the primary endpoint will be change in serum total cholesterol level (48âhours - enrolment). Secondary endpoints include change in cholesterol level from enrolment to 7 days, change in Sequential Organ Failure Assessment score over the first 48âhours and 7 days, in-hospital and 28-day mortality, lipid oxidation status, inflammatory biomarkers, and high-density lipoprotein function. ETHICS AND DISSEMINATION: Investigators are trained and follow good clinical practices, and each phase of the study was reviewed and approved by the institutional review boards of each institution. Results of each phase will be disseminated through presentations at national meetings and publication in peer-reviewed journals. If promising, data from the pilot study will be used for a larger, multicentre, phase II clinical trial. TRIAL REGISTRATION NUMBER: NCT03405870
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Analyzing food value chains for nutrition goals
First proposed in 2010, the use of âvalue chain analysisâ to identify opportunities for targeted nutrition interventions in food systems is still an emerging method. This review explores and summarizes the application of value chain analysis to nutrition and from this provides five insights into how to more effectively conduct value chain analysis for nutrition: 1) use a consumer perspective to inform selection of foods and chains; 2) consider the research question, available resources, and the type of chain; 3) situate consumer research at the center of the analysis; 4) assess economic trade-offs; and 5) pay attention to governance and stakeholdersâ capacity for and incentives to change
Researching outside the box: Welcoming innovative qualitative inquiry to nurse education today
I would like to begin by thanking Billy Lauder for inviting me to write this editorial, following my recent appointment to the NET International Advisory Board. My first aim in what follows is to make some critical comments about trends I have seen in published qualitative research articles over the years of my involvement with NET and other mainstream international nursing journals. In this regard, I speak as a qualitative research teacher, supervisor, article and book writer, and peer reviewer and past editorial board member of journals in and beyond the discipline of nursing. On the basis of these critical comments, my second aim is to argue the need for an increase in innovative qualitative articles in NET. This will bring our journal more into line with the developing state of the art global picture of qualitative inquiry, evident in recent years in journals informing wider interdisciplinary fields in the social and human sciences and the humanities. I believe that such a broadening of scope can only enhance the status of NET as a world leader in creative nurse educational research and scholarship. In the light of these two aims, again responding to a request from Billy, I will end my editorial by describing related amendments to the journalâs article guidelines for authors on structuring innovative qualitative articles, and a corresponding increase in peer reviewers, appropriate for the task ahead
A Digital Public Archaeology?
Digital Public Archaeology is a very new label for a contemporary practice, and as such has been subject to a limited amount of theoretical scrutiny. The rapid pace of change within Internet technologies has significantly expanded potential for this âdigitalâ form of Public Archaeology practice. Internet technologies can be used to gather contributions of âcrowd-sourcedâ archaeological content; to share and discuss archaeological news and discoveries; foster online community identity, situated around the topic of archaeology and wider heritage issues, or to elicit financial support. Expectations of and opportunities for social, collaborative and individual participation and interaction with cultural heritage have grown accordingly. Professional archaeological organisations are increasingly encouraged, if not required, to disseminate their grey literature reports, publications, educational resources, data-sets, images and other archaeological informatics through digital means, frequently as mandatory outputs for impact assessment and public accountability. Real-time sharing, comment and feedback of archaeological information online and via mobile technologies stand in contrast to lengthy waits for publication and wider dissemination. This paper will explore the literature on the practice of Public Archaeology in the UK, and issues associated with the development of digital public engagement in the heritage sector
Ecological and Evolutionary Benefits of Temperate Phage: What Does or Doesn't Kill You Makes You Stronger
Infection by a temperate phage can lead to death of the bacterial cell, but sometimes these phages integrate into the bacterial chromosome, offering the potential for a more long-lasting relationship to be established. Here we define three major ecological and evolutionary benefits of temperate phage for bacteria: as agents of horizontal gene transfer (HGT), as sources of genetic variation for evolutionary innovation, and as weapons of bacterial competition. We suggest that a coevolutionary perspective is required to understand the roles of temperate phages in bacterial populations
A role for calreticulin in the pathogenesis of rheumatoid arthritis
Calreticulin (CRT) plays a role in the clearance of dying cells and has been implicated in autoimmunity. Recent evidence indicates that cell surface CRT (csCRT) acts as a signal transducing receptor for the rheumatoid arthritis (RA) shared epitope (SE). The SE binding site on CRT has been mapped to amino acid residues 217â223 in the P-domain. Upon interaction with dendritic cells (DCs), the SE activates potent immune regulatory events. In CD8α + DCs, which express higher abundance of csCRT, the SE inhibits the tolerogenic enzyme indoleamine 2,3 dioxygenase with resultant inhibition of regulatory T (Treg) cell differentiation. In CD8α â DCs, the SE ligand increases secretion of IL-6 and IL-23 and facilitates generation of Th17 cells, a T cell subset known to play a role in autoimmunity. On the basis of these recent findings, we discuss the possibility that the csCRT may play a pathogenic role in RA by transducing SE-activated Th17-polarizing signals.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79357/1/j.1749-6632.2010.05745.x.pd
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