Occurrence and correction of copper deficiency of sheep in north-Western Queensland

The occurrence and correction of copper deficiency in Merino sheep on an affected property in north-western Queensland were studied in three trials in successive years. The effects of copper supplementation on growth of weaner sheep, wool production, wool quality and reproductive performance were examined. From these studies recommended treatments to prevent copper deficiency in sheep in this locality are (a) establish a good initial liver copper concentration by three treatments at fortnightly or monthly intervals and then maintain these reserves by 3-monthly treatments; and (b) treat lambs at marking and thereafter at about 3-monthly intervals

Localisation and mass generation for non-Abelian gauge fields

It has been suggested recently that in the presence of suitably "warped" extra dimensions, the low-energy limit of pure gauge field theory may contain massive elementary vector bosons localised on a "brane", but no elementary Higgs scalars. We provide non-perturbative evidence in favour of this conjecture through numerical lattice measurements of the static quark-antiquark force of pure SU(2) gauge theory in three dimensions, of which one is warped. We consider also warpings leading to massless localised vector bosons, and again find evidence supporting the perturbative prediction, even though the gauge coupling diverges far from the brane in this case.Comment: 27 pages; small clarifications adde

Transient domain walls and lepton asymmetry in the Left-Right symmetric model

It is shown that the dynamics of domain walls in Left-Right symmetric models, separating respective regions of unbroken SU(2)_L and SU(2)_R in the early universe, can give rise to baryogenesis via leptogenesis. Neutrinos have a spatially varying complex mass matrix due to CP-violating scalar condensates in the domain wall. The motion of the wall through the plasma generates a flux of lepton number across the wall which is converted to a lepton asymmetry by helicity-flipping scatterings. Subsequent processing of the lepton excess by sphalerons results in the observed baryon asymmetry, for a range of parameters in Left-Right symmetric models.Comment: v2 version accepted for publication in Phys. Rev. D. Discussion in Introduction and Conclusion sharpened. Equation (12) corrected. 16 pages, 3 figure files, RevTeX4 styl

Leptogenesis through direct inflaton decay to light particles

We present a scenario of nonthermal leptogenesis following supersymmetric hybrid inflation, in the case where inflaton decay to both heavy right handed neutrino and SU(2)_L triplet superfields is kinematically disallowed. Lepton asymmetry is generated through the decay of the inflaton into light particles by the interference of one-loop diagrams with right handed neutrino and SU(2)_L triplet exchange respectively. We require superpotential couplings explicitly violating a U(1) R-symmetry and R-parity. However, the broken R-parity need not have currently observable low-energy signatures. Also, the lightest sparticle can be stable. Some R-parity violating slepton decays may, though, be detectable in the future colliders. We take into account the constraints from neutrino masses and mixing and the preservation of the primordial lepton asymmetry.Comment: 11 pages including 3 figures, uses Revtex, minor corrections, references adde

Complex structure moduli stability in toroidal compactifications

In this paper we present a classification of possible dynamics of closed string moduli within specific toroidal compactifications of Type II string theories due to the NS-NS tadpole terms in the reduced action. They appear as potential terms for the moduli when supersymmetry is broken due to the presence of D-branes. We particularise to specific constructions with two, four and six-dimensional tori, and study the stabilisation of the complex structure moduli at the disk level. We find that, depending on the cycle on the compact space where the brane is wrapped, there are three possible cases: i) there is a solution inside the complex structure moduli space, and the configuration is stable at the critical point, ii) the moduli fields are driven towards the boundary of the moduli space, iii) there is no stable solution at the minimum of the potential and the system decays into a set of branes.Comment: 24 pages, JHEP3.cls, 19 figures. A few references adde

Baryon number violation, baryogenesis and defects with extra dimensions

In generic models for grand unified theories(GUT), various types of baryon number violating processes are expected when quarks and leptons propagate in the background of GUT strings. On the other hand, in models with large extra dimensions, the baryon number violation in the background of a string is not trivial because it must depend on the mechanism of the proton stabilization. In this paper we argue that cosmic strings in models with extra dimensions can enhance the baryon number violation to a phenomenologically interesting level, if the proton decay is suppressed by the mechanism of localized wavefunctions. We also make some comments on baryogenesis mediated by cosmological defects. We show at least two scenarios will be successful in this direction. One is the scenario of leptogenesis where the required lepton number conversion is mediated by cosmic strings, and the other is the baryogenesis from the decaying cosmological domain wall. Both scenarios are new and have not been discussed in the past.Comment: 20pages, latex2e, comments and references added, to appear in PR

Decay of Unstable D-branes with Electric Field

Using the techniques of two dimensional conformal field theory we construct time dependent classical solutions in open string theory describing the decay of an unstable D-brane in the presence of background electric field, and explicitly evaluate the time dependence of the energy momentum tensor and the fundamental string charge density associated with this solution. The final decay product can be interpreted as a combination of stretched fundamental strings and tachyon matter.Comment: 35 pages, LaTe

Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

Mutations in leucine-rich repeat kinase 2 (LRRK2) are an established cause of inherited Parkinson's disease (PD). LRRK2 is expressed in both neurons and glia in the central nervous system, but its physiological function(s) in each of these cell types is uncertain. Through sequential screens, we report a functional interaction between LRRK2 and Clathrin adaptor protein complex 2 (AP2). Analysis of LRRK2 KO tissue revealed a significant dysregulation of AP2 complex components, suggesting LRRK2 may act upstream of AP2. In line with this hypothesis, expression of LRRK2 was found to modify recruitment and phosphorylation of AP2. Furthermore, expression of LRRK2 containing the R1441C pathogenic mutation resulted in impaired clathrin-mediated endocytosis (CME). A decrease in activity-dependent synaptic vesicle endocytosis was also observed in neurons harboring an endogenous R1441C LRRK2 mutation. Alongside LRRK2, several PD-associated genes intersect with membrane-trafficking pathways. To investigate the genetic association between Clathrin-trafficking and PD, we used polygenetic risk profiling from IPDGC genome wide association studies (GWAS) datasets. Clathrin-dependent endocytosis genes were found to be associated with PD across multiple cohorts, suggesting common variants at these loci represent a cumulative risk factor for disease. Taken together, these findings suggest CME is a LRRK2-mediated, PD relevant pathway.Neurological Motor Disorder

Using the past to constrain the future: how the palaeorecord can improve estimates of global warming

Climate sensitivity is defined as the change in global mean equilibrium temperature after a doubling of atmospheric CO2 concentration and provides a simple measure of global warming. An early estimate of climate sensitivity, 1.5-4.5{\deg}C, has changed little subsequently, including the latest assessment by the Intergovernmental Panel on Climate Change. The persistence of such large uncertainties in this simple measure casts doubt on our understanding of the mechanisms of climate change and our ability to predict the response of the climate system to future perturbations. This has motivated continued attempts to constrain the range with climate data, alone or in conjunction with models. The majority of studies use data from the instrumental period (post-1850) but recent work has made use of information about the large climate changes experienced in the geological past. In this review, we first outline approaches that estimate climate sensitivity using instrumental climate observations and then summarise attempts to use the record of climate change on geological timescales. We examine the limitations of these studies and suggest ways in which the power of the palaeoclimate record could be better used to reduce uncertainties in our predictions of climate sensitivity.Comment: The final, definitive version of this paper has been published in Progress in Physical Geography, 31(5), 2007 by SAGE Publications Ltd, All rights reserved. \c{opyright} 2007 Edwards, Crucifix and Harriso

Thermal leptogenesis in a model with mass varying neutrinos

In this paper we consider the possibility of neutrino mass varying during the evolution of the Universe and study its implications on leptogenesis. Specifically, we take the minimal seesaw model of neutrino masses and introduce a coupling between the right-handed neutrinos and the dark energy scalar field, the Quintessence. In our model, the right-handed neutrino masses change as the Quintessence scalar evolves. We then examine in detail the parameter space of this model allowed by the observed baryon number asymmetry. Our results show that it is possible to lower the reheating temperature in this scenario in comparison with the case that the neutrino masses are unchanged, which helps solve the gravitino problem. Furthermore, a degenerate neutrino mass patten with $m_i$ larger than the upper limit given in the minimal leptogenesis scenario is permitted.Comment: 18 pages, 7 figures, version to appear in PR