10 research outputs found
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
- Anderson C
- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
- Arawwawala D
- Ardern D
- Argue R
- Arkalaki E
- Armaganidis A
- Armstrong J
- Armstrong R
- Arnaoutoglou C
- Arnaoutoglou E
- Arnold G
- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
- Arumugam S
- Arustei M
- Arvaniti K
- Arya A
- Arya S
- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
- Attrill E
- Attwood C
- Auer P
- Avidan M
- Avila Sanchez FJ
- Avila EJD
- Avis J
- Awad H
- Axioti E
- Ayyaz H
- Azam UAA
- Azambuja P
- Azevedo C
- Aziz FZ
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- Baghirzada L
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- Bai Y
- Baillie S
- Baines D
- Baio TH
- Bairaktari A
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- Balaji P
- Balajonda N
- Balanescu A
- Balasubramaniam M
- Baldisserotto S
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- Bandeira ME
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- Bilolikar A
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- Chandrasekharan S
- Chang YH
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- Cherrett V
- Chetty RR
- Chew M
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- Chicken D-W
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- Chin II
- Chirkut S
- Chisbert Cuenca V
- Chlorou D
- Choi H-MD
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- Christiansen IC
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- Christofaki M
- Christoforidis D
- Chronis C
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- Chua P
- Chukkambotla S
- Chung CKE
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- Ciobanu C
- Ciobotaru OR
- Cirstea E
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- Comptaer N
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- Dumitrascu CO
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- Yagnik A
- Yan Y
- Yang J
- Yang L
- Yang Q
- Yang S
- Yang T
- Yang Y
- Yao S
- Yao Y
- Yap HL
- Yarwood J
- Yassaee A
- Ye H
- Ye H
- Yegnaram S
- Yeh E
- Yin N
- Yip CP
- Yong J
- Yu HC
- Yu S
- Yu T
- Yu Y
- Yuan D
- Yuan F
- Yuan J
- Yuan J
- Yuan Y
- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
- Zettergren J
- Zhang B
- Zhang E
- Zhang H
- Zhang H
- Zhang H
- Zhang J
- Zhang K
- Zhang L
- Zhang M
- Zhang M
- Zhang Q
- Zhang R
- Zhang S
- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhao B
- Zhao B
- Zhao C
- Zhao J
- Zhao J
- Zhao L
- Zhao L
- Zhao S
- Zhao T
- Zhao W
- Zhao W
- Zhao X
- Zhen J
- Zheng K
- Zheng L
- Zheng T
- Zhong Y
- Zhou C
- Zhou D
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Prospective observational cohort study of the association between antiplatelet therapy, bleeding and thrombosis in patients with coronary stents undergoing noncardiac surgery
- Author
- A. Danila
- A. Fouracres
- A. Gibson
- A. Hasani
- A. Hermina
- A. Hermina
- A. Hervias
- A. Hoeft
- A. Karbonskiene
- A. Krishnan
- A. Potter
- A. Rose
- A.-S. Dincq
- A.R. Pont
- Albaladejo
- Assali
- Austin
- B. Leva
- B. Plichon
- Barr
- Biancari
- Bittl
- Bonaca
- Bowry
- Brilakis
- C. Martac
- C. Mbongo
- C. Naylor
- C. Watremez
- C.G. Bartolo
- Capodanno
- Compton
- D. Fuller
- D. Hernando
- D. Kahn
- D. Sanchez Pérez
- D. Tomescu
- Devereaux
- E. Emre Demirel
- F. Hidalgo
- F. Kessler
- Fleisher
- Gandhi
- H. Melson
- H.M. Reyes
- Harder
- Hawn
- Ho
- Howard-Alpe
- I. Grintescu
- I. Sepulveda Gil
- Iakovou
- Iqbal
- J. Gudaityte
- J. Joscak
- J. Paddle
- J. Pettit
- J. Ryan
- J. Thompson
- Joint Formulary Committee
- K. Arnell
- K. Colling
- K. Griffiths
- K. Muhammad
- K. Simeson
- Kaluza
- Kapetanakis
- Kristensen
- L. Hollos
- L. Mirea
- L. Sarmiento
- L. Serrano
- L. Serrano
- L. Sleight
- L. Twohey
- L. Zsisku
- Layland
- Luscher
- M. Hough
- M. Momeni
- M. Nadolski
- M. Northey
- M. Orts
- M. Suñé
- M. Trashorras
- M. Tugrul
- M. Wittmann
- M. Zuleika
- Mauri
- McFadden
- N. Dunk
- N. Smith
- Nasser
- Nuttall
- O. González
- O. González
- Obi
- P. Carvalho
- P. Matsota
- P. Matute
- P. Monedero
- P. Raymode
- P. Sierra
- P. Watt
- Poldermans
- R. Fernandez-Garcia
- R. Ferreira
- R. Navarro Perez
- R. Struck
- R. Telford
- R.J. Stolker
- R.M. West
- Rabbitts
- Roffi
- Rossini
- S. Birch
- S. Bowrey
- S. Carvalho
- S. Damster
- S. Davies
- S. Dharmarajah
- S. Elliot
- S. Rasche
- S. Sabaté
- S. Varma
- S.B. Wheatcroft
- S.E. Hoeks
- S.J. Howell
- S.L. Galera
- Sheth
- Stuart
- T. Collyer
- T. Rüddel
- T. Tamm
- T. Valentijn
- The Vascular events In noncardiac Surgery patIents cOhort evaluatioN Operations Committee
- Thygesen
- V. Martinson
- Wenaweser
- Wiviott
- Z. Beardow
- Z. Coleman
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/12/2018
- Field of study
Background: The perioperative management of antiplatelet therapy in noncardiac surgery patients who have undergone previous percutaneous coronary intervention (PCI) remains a dilemma. Continuing dual antiplatelet therapy (DAPT) may carry a risk of bleeding, while stopping antiplatelet therapy may increase the risk of perioperative major adverse cardiovascular events (MACE).
Methods: Occurrence of Bleeding and Thrombosis during Antiplatelet Therapy In Non-Cardiac Surgery (OBTAIN) was an international prospective multicentre cohort study of perioperative antiplatelet treatment, MACE, and serious bleeding in noncardiac surgery. The incidences of MACE and bleeding were compared in patients receiving DAPT, monotherapy, and no antiplatelet therapy before surgery. Unadjusted risk ratios were calculated taking monotherapy as the baseline. The adjusted risks of bleeding and MACE were compared in patients receiving monotherapy and DAPT using propensity score matching.
Results: A total of 917 patients were recruited and 847 were eligible for inclusion. Ninety-six patients received no antiplatelet therapy, 526 received monotherapy with aspirin, and 225 received DAPT. Thirty-two patients suffered MACE and 22 had bleeding. The unadjusted risk ratio for MACE in patients receiving DAPT compared with monotherapy was 1.9 (0.93–3.88), P=0.08. There was no difference in MACE between no antiplatelet treatment and monotherapy 1.03 (0.31–3.46), P=0.96. Bleeding was more frequent with DAPT 6.55 (2.3–17.96) P=0.0002. In a propensity matched analysis of 177 patients who received DAPT and 177 monotherapy patients, the risk ratio for MACE with DAPT was 1.83 (0.69–4.85), P=0.32. The risk of bleeding was significantly greater in the DAPT group 4.00 (1.15–13.93), P=0.031.
Conclusions: OBTAIN showed an increased risk of bleeding with DAPT and found no evidence for protective effects of DAPT from perioperative MACE in patients who have undergone previous PCI
Intraoperative transfusion practices in Europe
- Author
- Ahrens N.
- Akan M.
- Aksoy O.
- Alanoğlu Z.
- Alfredo M.
- Alkis N.
- Almeida V.
- Alousi M.
- Alves C.
- Amaral J.
- Ambrosi X.
- Ana I.
- Anastase D.
- Andersson M.
- Andreou A.
- Anthopoulos G.
- Apanaviciute D.
- Arbelaez A.
- Arcade A.
- Arion Balescu C.
- Arun O.
- Azenha M.
- Bacalbasa N.
- Baeten W.
- Balandin A.
- Barquero López M.
- Barsan V.
- Bascuas B.
- Basora M.
- Baumann H.
- Bayer A.
- Bell A.
- Belmonte Cuenca J.
- Bengisun Z.
- Bento C.
- Beran M.
- Bermudez Lopez M.
- Bernardino A.
- Berthelsen K.
- Bigat Z.
- Bilshiene D.
- Bilska M.
- Bisbe Vives E.
- Biscioni T.
- Björn H.
- Blom T.
- Bogdan Prodan A.
- Bogdanovic Dvorscak M.
- Boisson M.
- Bolten J.
- Bona F.
- Borg F.
- Boros C.
- Borys M.
- Boveroux P.
- Boztug Uz N.
- Brettner F.
- Brisard L.
- Britta de W.
- Browne G.
- Budow K.
- Buerkle H.
- Buggy D.
- Cain A.
- Calancea E.
- Calarasu F.
- Calder V.
- Camci A.
- Campiglia L.
- Campos B.
- Camps A.
- Carlos D.
- Carreira C.
- Carrilho A.
- Carvalho P.
- Cassinello C.
- Cattan A.
- Cenni L.
- Cerny V.
- Ceyda Meço B.
- Chesov I.
- Chishti A.
- Chupin A.
- Cikova A.
- Cindea I.
- Cintula D.
- Ciobanasu R.
- Clements D.
- Cobiletchi S.
- Coburn M.
- Coghlan L.
- Collyer T.
- Copotoiu R.
- Copotoiu S.
- Corneci D.
- CORTEGIANI Andrea
- Coskunfirat O.
- Costea D.
- Czuczwar M.
- Davies K.
- De Baerdemaeker L.
- De Hert S.
- Debernardi F.
- Decagny S.
- Deger Coskunfirat N.
- Diana G.
- Diana T.
- Dias S.
- Dickinson M.
- Dobisova A.
- Dragan A.
- Droc G.
- Duarte S.
- Dunk N.
- Ekelund K.
- Ekmekçi P.
- Elena C.
- Ellimah T.
- Espie L.
- ETPOS collaborators: Accurso G.
- Everett L.
- Ferguson A.
- Fernandes M.
- Ferner M.
- Fernández J.
- Ferreira D.
- Ferrie R.
- Filipescu D.
- Filipescu D.
- Flassikova Z.
- Fleischer A.
- Font A.
- Galkova K.
- Garcia I.
- Garner M.
- Gasenkampf A.
- Gelmanas A.
- Gherghina V.
- Gilsanz F.
- Giokas G.
- Goebel U.
- Gomes P.
- Gonzalez Monzon V.
- Gonçalves Aguiar J.
- Gottschalk A.
- Gouraud J.
- Gramigni E.
- Grintescu I.
- Grynyuk A.
- Grytsan A.
- Guasch E.
- Gustin D.
- Hans G.
- Harazim H.
- Hervig T.
- Hidalgo F.
- Higham C.
- Hirschauer N.
- Hoeft A.
- Innerhofer Pompernigg N.
- Innerhofer P.
- Jacobs S.
- Jakobs N.
- Jamaer L.
- James S.
- Jawad M.
- Jesus J.
- Jhanji S.
- Jipa Lavina N.
- Jokinen J.
- Jovanovic G.
- Jubera M.
- Kahn D.
- Karjagin J.
- Kasnik D.
- Katsanoulas K.
- Kelle H.
- Kelleher M.
- Kessler F.
- Kirigin B.
- Kiskira O.
- Kivik P.
- Klimi P.
- Klučka J.
- Koers L.
- Kontrimaviciut E.
- Koopman van Gemert A.
- Korfiotis D.
- Kosinová M.
- Koursoumi E.
- Kozek Langenecker S.
- Kozek Langenecker S.
- Kranke P.
- Kresic M.
- Krobot R.
- Kropman L.
- Kulikov A.
- Kvolik S.
- Kvrgic I.
- Kyttari A.
- Lagarto F.
- Lance M.
- Laufenberg R.
- Lauwick S.
- Lecoq J.
- Leech L.
- Lidzborski L.
- Liliana H.
- Linda F.
- Llau Pitarch J.
- Llau Pitarch J.
- Lopes A.
- Lopez Alvarez A.
- Lopez L.
- Lorenzi I.
- Lorre G.
- Lucian H.
- Lupis T.
- Lupu M.
- Macas A.
- Macedo A.
- Maggi G.
- Mallett S.
- Mallett S.
- Mallor T.
- Manoleli A.
- Manolescu R.
- Manrique S.
- Maquoi I.
- Marios Konstantinos T.
- Markovic Bozic J.
- Markus W.
- Marques M.
- Martinez E.
- Martinez R.
- Martinho H.
- Martins D.
- Martires E.
- Martus P.
- Martus P.
- Martínez E.
- Matias F.
- Matot I.
- Matot I.
- Mauff S.
- Meale P.
- Meier J.
- Meier J.
- Merz H.
- Meybohm P.
- Militello M.
- Mincu N.
- Miranda M.
- Mirea L.
- Moghildea V.
- Moise A.
- Molano Diaz P.
- Moltó L.
- Monedero P.
- Moral V.
- Moreira Z.
- Moret E.
- Mulders F.
- Munteanu A.
- Nadia Diana K.
- Nair A.
- Neskovic V.
- Ninane V.
- Nitu D.
- Oberhofer D.
- Odeberg Wernerman S.
- Oganjan J.
- Omur D.
- Orallo Moran M.
- Ozkardesler S.
- Pacasová R.
- Paklar N.
- Pandazi A.
- Papaspyros F.
- Paraskeuopoulos T.
- Parente S.
- Paunescu M.
- Pavičić Šarić J.
- Pereira E.
- Pereira F.
- Pereira L.
- Perry C.
- Petri A.
- Petrovic U.
- Pica S.
- Pinheiro F.
- Pinto F.
- Pinto J.
- Piwowarczyk P.
- Platteau S.
- Poeira R.
- Popescu R.
- Popica G.
- Poredos P.
- Prasser C.
- Preckel B.
- Prospiech A.
- Pujol R.
- Raimundo A.
- RAINERI Santi Maurizio
- Rakic D.
- Ramadan M.
- Ramazanoğlu A.
- Rantis A.
- Raquel F.
- Real C.
- Reikvam T.
- Reis L.
- Rigal J.
- Rohner A.
- Rokk A.
- Roman Fernandez A.
- Rosenberger P.
- Rossaint R.
- Rozec B.
- Rudolph T.
- Rätsep I.
- Saeed Y.
- Safonov S.
- Saka E.
- Samama C.
- Sanchez Perez D.
- Sanchez Sanchez Y.
- Sandeep V.
- Sandu M.
- Sanlı S.
- Saraiva A.
- Scarlatescu E.
- Schiraldi R.
- Schittek G.
- Schnitter B.
- Schuster M.
- Seco C.
- Selvi O.
- Senard M.
- Serra S.
- Serrano H.
- Shmigelsky A.
- Silva L.
- Simeson K.
- Singh R.
- Sipylaite J.
- Skitek K.
- Skok I.
- Smirnova N.
- Smékalová O.
- Sofia M.
- Soler Pedrola M.
- Soumelidis C.
- Spindler Yesel A.
- Stefan M.
- Stevanovic A.
- Stevikova J.
- Stivan S.
- Striteska J.
- Strys L.
- Suljevic I.
- Sánchez López Ó.
- Sõrmus A.
- Söndergaard S.
- Sørvoll I.
- Tania M.
- Tareco G.
- Tena B.
- Theodoraki K.
- Tifrea M.
- Tikuisis R.
- Tolós R.
- Tomasi R.
- Tomescu D.
- Tomkute G.
- Tormos P.
- Trepenaitis D.
- Troyan G.
- Unic Stojanovic D.
- Unterrainer A.
- Uranjek J.
- Valsamidis D.
- van Dasselaar N.
- Van Limmen J.
- van Noord P.
- van Poorten J.
- Vanderlaenen M.
- Varela Garcia O.
- Velasco A.
- Veljovic M.
- Vera Bella J.
- Vercauteren M.
- Verdouw B.
- Verenkin V.
- Veselovsky T.
- Vieira H.
- Villar T.
- Visnja I.
- Voje M.
- von Dossow Hanfstingl V.
- Von Langen D.
- Vorotyntsev S.
- Vujanovič V.
- Vukovic R.
- Watt P.
- Werner E.
- Wernerman J.
- Wittmann M.
- Wright M.
- Wunder C.
- Wyffels P.
- Yakymenko Y.
- Yıldırım Ç.
- Yılmaz H.
- Zacharowski K.
- Zarif M.
- Zielinska Skitek E.
- Zsisku L.
- Záhorec R.
- Åkeröy K.
- Štourač P.
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND:
Transfusion of allogeneic blood influences outcome after surgery. Despite widespread availability of transfusion guidelines, transfusion practices might vary among physicians, departments, hospitals and countries. Our aim was to determine the amount of packed red blood cells (pRBC) and blood products transfused intraoperatively, and to describe factors determining transfusion throughout Europe.
METHODS:
We did a prospective observational cohort study enrolling 5803 patients in 126 European centres that received at least one pRBC unit intraoperatively, during a continuous three month period in 2013.
RESULTS:
The overall intraoperative transfusion rate was 1.8%; 59% of transfusions were at least partially initiated as a result of a physiological transfusion trigger- mostly because of hypotension (55.4%) and/or tachycardia (30.7%). Haemoglobin (Hb)- based transfusion trigger alone initiated only 8.5% of transfusions. The Hb concentration [mean (sd)] just before transfusion was 8.1 (1.7) g dl(-1) and increased to 9.8 (1.8) g dl(-1) after transfusion. The mean number of intraoperatively transfused pRBC units was 2.5 (2.7) units (median 2).
CONCLUSION:
Although European Society of Anaesthesiology transfusion guidelines are moderately implemented in Europe with respect to Hb threshold for transfusion (7-9 g dl(-1)), there is still an urgent need for further educational efforts that focus on the number of pRBC units to be transfused at this threshold.
CLINICAL TRIAL REGISTRATION: NCT 01604083
Kuluttajabarometri maakunnittain 2000, 2. neljännes
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
- Anderson C
- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
- Arawwawala D
- Ardern D
- Argue R
- Arkalaki E
- Armaganidis A
- Armstrong J
- Armstrong R
- Arnaoutoglou C
- Arnaoutoglou E
- Arnold G
- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
- Arumugam S
- Arustei M
- Arvaniti K
- Arya A
- Arya S
- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
- Attrill E
- Attwood C
- Auer P
- Avidan M
- Avila Sanchez FJ
- Avila EJD
- Avis J
- Awad H
- Axioti E
- Ayyaz H
- Azam UAA
- Azambuja P
- Azevedo C
- Aziz FZ
- Baas P
- Baghirzada L
- Bai H-P
- Bai Y
- Baillie S
- Baines D
- Baio TH
- Bairaktari A
- Baker G
- Baker K-A
- Baker P
- Balain B
- Balaji P
- Balajonda N
- Balanescu A
- Balasubramaniam M
- Baldisserotto S
- Baldwin J
- Baldwin M
- Balfoussia D
- Bali C
- Bandeira ME
- Banerjee R
- Bankewitz C
- Banner-Goodspeed V
- Bao Q
- Barcraft-Barnes H
- Barneto L
- Barnett A
- Baroselli A
- Barraclough J
- Barras J-P
- Barrett S
- Barrett WJ
- Basanth S
- Batchelor N
- Bateman B
- Bates A
- Bates S
- Batista HD
- Bauchmuller K
- Bauer M
- Baumgarten G
- Baxter L
- Beaton C
- Beattie S
- Beavis V
- Bechan S
- Bejia T
- Belciu I
- Belda MT
- Bell G
- Bell R
- Bell S
- Bellandi M
- Bello J
- Beloeil H
- Belskiy V
- Ben-Menachem E
- Benavent P
- Benevento A
- Bengeri S
- Bennett C
- Bennett M
- Bennett R
- Bennett V
- Bentley C
- Beretta L
- Berg A
- Bergin C
- Bernard A
- Berntsen E
- Bertram W
- Bester D
- Bester M
- Bettega F
- Bettinelli A
- Bhardwaj N
- Bhatia K
- Bhula C
- Bi Y
- Biais M
- Biccard BM
- Bidd H
- Bidgoli J
- Biffen A
- Bignami E
- Bilolikar A
- Bin Mustapha MT
- Birch J
- Bishop DG
- Biyase T
- Bizios C
- Blackwell C
- Blackwood D
- Blaj M
- Blakemore SP
- Bland M
- Blunt M
- Blyth K
- Bocchino S
- Bodansky D
- Bodger P
- Boer C
- Boereboom C
- Boggiano V
- Bogner G
- Bolaji B
- Bolton D
- Boone M
- Boschi L
- Boshier P
- Botes M
- Botis I
- Bottini C
- Bottrill F
- Bouchez S
- Boulton K
- Bouris V
- Bourner L
- Boutsikos G
- Bouwman A
- Bouwman RA
- Bowrey S
- Boxall L
- Boyd C
- Bradburn M
- Bradley J
- Branagan G
- Branco T
- Brand B
- Brandsborg B
- Breitenstein S
- Brennan A
- Brennan E
- Brenner L
- Brincat M
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- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
- Zettergren J
- Zhang B
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- Zhao L
- Zhao L
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- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
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- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- Tilastokeskus
- Publication date
- 11/07/2000
- Field of study
Suomen virallinen tilasto (SVT
Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: a 7-day cohort study of elective surgery
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
- Anderson C
- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
- Arawwawala D
- Ardern D
- Argue R
- Arkalaki E
- Armaganidis A
- Armstrong J
- Armstrong R
- Arnaoutoglou C
- Arnaoutoglou E
- Arnold G
- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
- Arumugam S
- Arustei M
- Arvaniti K
- Arya A
- Arya S
- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
- Attrill E
- Attwood C
- Auer P
- Avidan M
- Avila Sanchez FJ
- Avila EJD
- Avis J
- Awad H
- Axioti E
- Ayyaz H
- Azam UAA
- Azambuja P
- Azevedo C
- Aziz FZ
- Baas P
- Baghirzada L
- Bai H-P
- Bai Y
- Baillie S
- Baines D
- Baio TH
- Bairaktari A
- Baker G
- Baker K-A
- Baker P
- Balain B
- Balaji P
- Balajonda N
- Balanescu A
- Balasubramaniam M
- Baldisserotto S
- Baldwin J
- Baldwin M
- Balfoussia D
- Bali C
- Bandeira ME
- Banerjee R
- Bankewitz C
- Banner-Goodspeed V
- Bao Q
- Barcraft-Barnes H
- Barneto L
- Barnett A
- Baroselli A
- Barraclough J
- Barras J-P
- Barrett S
- Barrett WJ
- Basanth S
- Batchelor N
- Bateman B
- Bates A
- Bates S
- Batista HD
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- Zamudio D
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- Zbitnew G
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2017
- Field of study
This was an investigator-initiated study funded by Nestle Health Sciences through an unrestricted research grant and by a National Institute for Health Research (UK) Professorship held by R.P. The study was sponsored by Queen Mary University of London
Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study
- Author
- Abad Gurumeta A.
- Abernethy C.
- Abigail P.
- Achaibar K.
- Adam E.
- Afshari A.
- Agudelo Montoya M. E.
- Akgun F. N.
- Aletti G.
- Alkis N.
- Allan A.
- Allan K.
- Allaouchiche B.
- Allcock C.
- Almasy E.
- Amey I.
- Amigoni M.
- Andersen E.
- Andersson P.
- Anipchenko N.
- Antunes P.
- Armstrong E.
- Aslam T. N.
- Aslin B.
- Assuncao J. P.
- Ausserer J.
- Avvai M.
- Awad N.
- Ayas Montero B.
- Ayuso M.
- Azevedo P.
- Badarau V.
- Badescu R.
- Baiardo Redaelli M.
- Baird C.
- Baird Y.
- Baker T.
- Balaji P.
- Balan C.
- Balandin A.
- Balescu-Arion C.
- Baliuliene V.
- Baltasar Isabel J.
- Baluch S. N.
- Bandrabur D.
- Bankewitz C.
- Barber K.
- Barbera F.
- Barcraft-Barnes H.
- Barletti V.
- Barnett G.
- Baron K.
- Barros A.
- Barsan V.
- Bartlett P.
- Batistaki C.
- Baumgarten G.
- Baytas V.
- Beauchamp N.
- Becerra Cayetano I. A.
- Bell S.
- Bellandi M.
- Belletti A.
- Belmonte Cuenca J.
- Benitez-Cano A.
- Beretta L.
- Berger M.
- Bergmann N.
- Bergmark K.
- Bermudez Lopez M.
- Bernotaite M.
- Beurskens C.
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- Zuleika M.
- Zupaneie D.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background: Results from retrospective studies suggest that use of neuromuscular blocking agents during general anaesthesia might be linked to postoperative pulmonary complications. We therefore aimed to assess whether the use of neuromuscular blocking agents is associated with postoperative pulmonary complications. Methods: We did a multicentre, prospective observational cohort study. Patients were recruited from 211 hospitals in 28 European countries. We included patients (aged ≥18 years) who received general anaesthesia for any in-hospital procedure except cardiac surgery. Patient characteristics, surgical and anaesthetic details, and chart review at discharge were prospectively collected over 2 weeks. Additionally, each patient underwent postoperative physical examination within 3 days of surgery to check for adverse pulmonary events. The study outcome was the incidence of postoperative pulmonary complications from the end of surgery up to postoperative day 28. Logistic regression analyses were adjusted for surgical factors and patients' preoperative physical status, providing adjusted odds ratios (ORadj) and adjusted absolute risk reduction (ARRadj). This study is registered with ClinicalTrials.gov, number NCT01865513. Findings: Between June 16, 2014, and April 29, 2015, data from 22 803 patients were collected. The use of neuromuscular blocking agents was associated with an increased incidence of postoperative pulmonary complications in patients who had undergone general anaesthesia (1658 [7·6%] of 21 694); ORadj 1·86, 95% CI 1·53–2·26; ARRadj −4·4%, 95% CI −5·5 to −3·2). Only 2·3% of high-risk surgical patients and those with adverse respiratory profiles were anaesthetised without neuromuscular blocking agents. The use of neuromuscular monitoring (ORadj 1·31, 95% CI 1·15–1·49; ARRadj −2·6%, 95% CI −3·9 to −1·4) and the administration of reversal agents (1·23, 1·07–1·41; −1·9%, −3·2 to −0·7) were not associated with a decreased risk of postoperative pulmonary complications. Neither the choice of sugammadex instead of neostigmine for reversal (ORadj 1·03, 95% CI 0·85–1·25; ARRadj −0·3%, 95% CI −2·4 to 1·5) nor extubation at a train-of-four ratio of 0·9 or more (1·03, 0·82–1·31; −0·4%, −3·5 to 2·2) was associated with better pulmonary outcomes. Interpretation: We showed that the use of neuromuscular blocking drugs in general anaesthesia is associated with an increased risk of postoperative pulmonary complications. Anaesthetists must balance the potential benefits of neuromuscular blockade against the increased risk of postoperative pulmonary complications. Funding: European Society of Anaesthesiology
Mortality after surgery in Europe: a 7 day cohort study
- Author
- Aakeroey K
- Acan I
- Adams D
- Adams T
- Adanic M
- Adolfsson A
- Afonso O
- Afshari A
- Agarwal B
- Agnic I
- Aguado DN
- Ahern R
- Ahonen T
- Aignatoaie M
- Akotia N
- Akouds E
- Al Abdaly A
- Al Subaie N
- Alagarsamy F
- Alameda LE
- Alaspää A
- Albalad DD
- Albaladejo P
- Albante A
- Alberdi F
- Albu C
- Alcaide CM
- Alcantud JF
- Aldecoa C
- Aldecoa C
- Alderson L
- Aleixandre IS
- Aleksic D
- Aleman M
- Alexander D
- Alexander P
- Algarra RR
- Ali ZS
- Aliste P
- Allué RM
- Almeida E
- Almeida IM
- Almeras L
- Alonso AE
- Alonso E
- Alvarez AA
- Alvarez LR
- Amaniti E
- Amatya S
- Ampuero MS
- Anchuelo AH
- Andabaka T
- Andersen JD
- Anderson H
- Andresen B
- Angulo GO
- Anna US
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- Bonet A
- Boninsegna D
- Bonnet A
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- Bonnington S
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- Borchers F
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- Borrat X
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- Candi GM
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- Capone M
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- Castiñeiras AP
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- Catalán M
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- Christopoulos C
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- Ciobanu A
- Cirillo V
- Ciubotaru R
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- Clausen NG
- Clauwaert C
- Claxton A
- Clouva Molyvdas PM
- Cocu S
- Codreanu M
- Collantes E
- Collard E
- Collareta M
- Collates AF
- Collin V
- Collins D
- Collins H
- Collyer T
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- Conway D
- Copley E
- Copotoiu R
- Copotoiu SM
- Coppini R
- Corneci D
- Corner V
- Corradetti F
- Correia C
- Corsini LM
- Cortes JG
- Cortés AF
- Costagliola R
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- Crespo BI
- Crespo Mdel R
- Crespo P
- Cristina MV
- Crooks N
- Crowley S
- Csomos A
- Csüllög E
- Cuarental A
- Cubillos DN
- Cupitt J
- Currie V
- Cvachovec K
- Czeslick E
- Cíková A
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- Damster S
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- de Almeida J
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- de la Lastra M
- de la Torre PA
- de Maeyer AG
- de Meneses H
- De Michele M
- De Neve N
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- de Quevedo SA
- de Rabago RB
- De Rudnicki S
- De Simone M
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- de Sousa M
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- de Zayas RS
- Debelic D
- Debernardi F
- Del Olmo M
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- Delgado TR
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- Dell'unto S
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- Della Rocca G
- Della Rocca G
- Demars N
- Dempsey G
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- Dennesen P
- Derumeaux P
- Desbordes J
- Desikan S
- Deutsch PA
- Di Mauro P
- Di Noto A
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- Diaz A
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- Dokka V
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- Drab M
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- Dragulescu D
- Dražen B
- Drenjancevic IH
- Drescher J
- Dresden C
- Dropulic N
- Druwé P
- Dubois Vallaud D
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- Dunne K
- Duque P
- Durán MV
- Duzel V
- Dušanka K
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- Díaz TD
- Díez EP
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- Elisei D
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- Ellermaa J
- ElMiloudi F
- Elomaa E
- Elson MZ
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- Elósegui I
- Engelen WC
- Epure F
- Ercole A
- Erkens U
- Erler I
- Ernst S
- Espinosa E
- Espinosa N
- Esteruelas JA
- Esteva GE
- Esteves F
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- Farnia A
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- Fernández LF
- Fernández PT
- Fernández SR
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- Galambos Z
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- Gandolfi A
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- García PD
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- García Sanz M
- García V
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- Gardin C
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
Background: Clinical outcomes after major surgery are poorly described at the national level. Evidence of heterogeneity between hospitals and health-care systems suggests potential to improve care for patients but this potential remains unconfirmed. The European Surgical Outcomes Study was an international study designed to assess outcomes after non-cardiac surgery in Europe.Methods: We did this 7 day cohort study between April 4 and April 11, 2011. We collected data describing consecutive patients aged 16 years and older undergoing inpatient non-cardiac surgery in 498 hospitals across 28 European nations. Patients were followed up for a maximum of 60 days. The primary endpoint was in-hospital mortality. Secondary outcome measures were duration of hospital stay and admission to critical care. We used χ² and Fisher’s exact tests to compare categorical variables and the t test or the Mann-Whitney U test to compare continuous variables. Significance was set at p<0·05. We constructed multilevel logistic regression models to adjust for the differences in mortality rates between countries.Findings: We included 46 539 patients, of whom 1855 (4%) died before hospital discharge. 3599 (8%) patients were admitted to critical care after surgery with a median length of stay of 1·2 days (IQR 0·9–3·6). 1358 (73%) patients who died were not admitted to critical care at any stage after surgery. Crude mortality rates varied widely between countries (from 1·2% [95% CI 0·0–3·0] for Iceland to 21·5% [16·9–26·2] for Latvia). After adjustment for confounding variables, important differences remained between countries when compared with the UK, the country with the largest dataset (OR range from 0·44 [95% CI 0·19 1·05; p=0·06] for Finland to 6·92 [2·37–20·27; p=0·0004] for Poland).Interpretation: The mortality rate for patients undergoing inpatient non-cardiac surgery was higher than anticipated. Variations in mortality between countries suggest the need for national and international strategies to improve care for this group of patients.Funding: European Society of Intensive Care Medicine, European Society of Anaesthesiology
Mortality after surgery in Europe: a 7 day cohort study.
- Author
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- \u160aric JP
- \u160eric J
- \u160imic-Korac N
- \u160imurina T
- \u160ribar A
- \u17dilic A
- \u17dilinc\ue1rov\ue1 V
- \u17duni J
- \u17dupcic M
- \uc1lvaro JL
- \uc5lvarez JT
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- Thorup L
- Thuet V
- Thwaites A
- Tiainen P
- Tibblin AO
- Tikkerberi A
- Timms G
- Timoneda FL
- Tincu E
- Tindall L
- Tinti C
- Toft P
- Toft P
- Toha AC
- Toivonen J
- Toma\u161evic A
- Tomasevic B
- Tomescu D
- Tomkute G
- Tommasino C
- Tompsett L
- Tomulic K
- Topic J
- Toplice K
- Toretti I
- Tormena M
- Toro JP
- Torrente FM
- Torres BF
- Tosi M
- Tot OK
- Tounou-Akue F
- Tredici S
- Trenkler S
- Triltsch A
- Trodd D
- Tsakas P
- Tsirogianni A
- Tucker K
- Tufano R
- Turcanu R
- Turi S
- Turina M
- Turner A
- Tzani V
- Ubre M
- Ungureanu L
- Unterberg M
- Untergehrer G
- Unz\ufae CL
- Ursic T
- Ursu I
- Utrera FA
- V\ue4\ue4r\ue4niemi H
- Vaccarisi E
- Vainio K
- Vajter J
- Vakkala M
- Valc\ue1rcel IE
- Vallejo A
- Vallet B
- van Acker G
- van Bommel J
- van den Berg R
- van der A M
- van der Hoven B
- van Duijn D
- van Klei W
- Van Mossevelde V
- van Obbergh L
- Vanlinthout L
- Vaquer S
- Varela IP
- Vargas MJ
- Vasan R
- Vasanth S
- Vasian H
- Vega JL
- Velasco AR
- Veld B
- Velzeboer F
- Venema A
- Venkatesh S
- Venzera- Azenic D
- Verbeke A
- Vercauteren M
- Verdenelli P
- Verhamme B
- Vezzoli D
- Viarengo V
- Vicari L
- Vicente R
- Vidal FG
- Vidal SG
- Viitanen M
- Vijar K
- Vilardi A
- Villach IR
- Villagran J
- Villen LM
- Vincent JL
- Vincent JL
- Vingsnes SO
- Vinnal M
- Visentin R
- Visk E
- Viskovic N
- Vitor P
- Vizca\uedno M
- Vizcaychipi M
- Vojinovic R
- von Heymann C
- Voulas A
- Vrankovic S
- Vrbanovic V
- Vrettou E
- Vymazal T
- Wadams B
- Wagner B
- Wagner J
- Waife N
- Walder B
- Walker E
- Walker R
- Wallet F
- Walsh H
- Ward G
- Ward S
- Warde B
- Wasmund C
- Waton K
- Watters M
- Webb S
- Weber M
- Weda T
- Wepler U
- Wernerman J
- Wessels K
- Westbrook A
- Westbrook A
- Weyland A
- White N
- White S
- Wickboldt N
- Wiegand-L\uf6hnert C
- Wiese O
- Wigmore T
- Wilde J
- Willars C
- Williams C
- Williams M
- Wilson J
- Wilson R
- Wilson S
- Windsor D
- Winsser L
- Wintzheimer S
- Wittmann M
- Wollaston J
- Wong K
- Wong P
- Woolhead A
- Worton R
- Wright C
- Wright M
- Wyldbore M
- Yemnga B
- Yepes MJ
- Yeung J
- Ytrebo LM
- Zaballos J
- Zabarte M
- Zacharouli D
- Zacharovska A
- Zadrazilova K
- Zafiridis T
- Zahorec R
- Zahorec R
- Zaldibar E
- Zamora JF
- Zandvliet R
- Zantua K
- Zearo E
- Zeba S
- Ziekenhuis A
- Zittling R
- Zocca E
- Zoltowski MK
- Zompanti V
- Zsisku L
- Zunic F
- Zuzan O
- Publication venue
- Publication date
- 01/01/2012
- Field of study
Intraoperative transfusion practices in Europe
- Author
- Accurso G
- Ahrens N
- Akan M
- Akeroy K
- Aksoy O
- Alanoglu Z
- Alfredo M
- Alkis N
- Almeida V
- Alousi M
- Alves C
- Amaral J
- Ambrosi X
- Ana I
- Anastase D
- Andersson M
- Andreou A
- Anthopoulos G
- Apanaviciute D
- Arbelaez A
- Arcade A-L
- Arion-Balescu C
- Arun O
- Azenha M
- Bacalbasa N
- Baeten W
- Balandin A
- Barquero Lopez M
- Barsan V
- Bascuas B
- Basora M
- Baumann H
- Bayer A
- Bell A
- Belmonte Cuenca J
- Bengisun ZK
- Bento C
- Beran M
- Bermudez Lopez M
- Bernardino A
- Berthelsen KG
- Bigat Z
- Bilshiene D
- Bilska M
- Bisbe Vives E
- Biscioni T
- Bjorn H
- Blom T
- Bogdan Prodan A
- Bogdanovic Dvorscak M
- Boisson M
- Bolten J
- Bona F
- Borg F
- Boros C
- Borys M
- Boveroux P
- Boztug Uz N
- Brettner F
- Brisard L
- Britta DW
- Browne G
- Budow K
- Buerkle H
- Buggy D
- Cain A
- Calancea E
- Calarasu F
- Calder V
- Camci AE
- Campiglia L
- Campos B
- Camps A
- Carlos D
- Carreira C
- Carrilho A
- Carvalho P
- Cassinello C
- Cattan A
- Cenni L
- Cerny V
- Ceyda Meco B
- Chesov I
- Chishti A
- Chupin A-M
- Cikova A
- Cindea I
- Cintula D
- Ciobanasu R
- Clements D
- Cobiletchi S
- Coburn M
- Coghlan L
- Collyer T
- Copotoiu R
- Copotoiu SM
- Corneci D
- Cortegiani A
- Coskunfirat OK
- Costea D
- Czuczwar M
- Davies K
- De Baerdemaeker L
- De Hert S
- Debernardi F
- Decagny S
- Deger Coskunfirat N
- Diana GM
- Diana T
- Dias S
- Dickinson M
- Dobisova A
- Dragan A
- Droc G
- Duarte S
- Dunk N
- Ekelund K
- Ekmekci P
- Elena C
- Ellimah T
- Espie L
- Everett L
- Ferguson A
- Fernandes M
- Fernandez JA
- Ferner M
- Ferreira D
- Ferrie R
- Filipescu D
- Filipescu D
- Flassikova Z
- Fleischer A
- Font A
- Galkova K
- Garcia I
- Garner M
- Gasenkampf A
- Gelmanas A
- Gherghina V
- Gilsanz F
- Giokas G
- Goebel U
- Gomes P
- Goncalves Aguiar JM
- Gonzalez Monzon V
- Gottschalk A
- Gouraud J-P
- Gramigni E
- Grintescu I
- Grynyuk A
- Grytsan A
- Guasch E
- Gustin D
- Hans G
- Harazim H
- Hervig T
- Hidalgo F
- Higham C
- Hirschauer N
- Hoeft A
- Innerhofer P
- Innerhofer-Pompernigg N
- Jacobs S
- Jakobs N
- Jamaer L
- James S
- Jawad M
- Jesus J
- Jhanji S
- Jipa Lavina N
- Jokinen J
- Jovanovic G
- Jubera MP
- Kahn D
- Karjagin J
- Kasnik D
- Katsanoulas K
- Kelle H
- Kelleher M
- Kessler F
- Kirigin B
- Kiskira O
- Kivik P
- Klimi P
- Klucka J
- Koers L
- Kontrimaviciut E
- Koopman-Van Gemert AWMM
- Korfiotis D
- Kosinova M
- Koursoumi E
- Kozek Langenecker S
- Kozek-Langenecker S
- Kranke P
- Kresic M
- Krobot R
- Kropman L
- Kulikov A
- Kvolik S
- Kvrgic I
- Kyttari A
- Lagarto F
- Lance MD
- Laufenberg R
- Lauwick S
- Lecoq J-P
- Leech L
- Lidzborski L
- Liliana H
- Linda F
- Llau Pitarch J
- Llau Pitarch JV
- Lopes A
- Lopez Alvarez A
- Lopez L
- Lorenzi I
- Lorre G
- Lucian H
- Lupis T
- Lupu MN
- Macas A
- Macedo A
- Maggi G
- Mallett S
- Mallett S
- Mallor T
- Manoleli A
- Manolescu R
- Manrique S
- Maquoi I
- Marios-Konstantinos T
- Markovic Bozic J
- Markus HW
- Marques M
- Martinez E
- Martinez E
- Martinez R
- Martinho H
- Martins D
- Martires E
- Martus P
- Martus P
- Matias F
- Matot I
- Matot I
- Mauff S
- Meale P
- Meier J
- Meier J
- Merz H
- Meybohm P
- Militello MG
- Mincu N
- Miranda ML
- Mirea L
- Moghildea V
- Moise A
- Molano Diaz P
- Molto L
- Monedero P
- Moral V
- Moreira Z
- Moret E
- Mulders F
- Munteanu AM
- Nadia Diana K
- Nair A
- Neskovic V
- Ninane V
- Nitu D
- Oberhofer D
- Odeberg-Wernerman S
- Oganjan J
- Omur D
- Orallo Moran MA
- Ozkardesler S
- Pacasova R
- Paklar N
- Pandazi A
- Papaspyros F
- Paraskeuopoulos T
- Parente S
- Paunescu MA
- Pavicic Saric J
- Pereira E
- Pereira F
- Pereira L
- Perry C
- Petri A
- Petrovic U
- Pica S
- Pinheiro F
- Pinto F
- Pinto J
- Piwowarczyk P
- Platteau S
- Poeira R
- Popescu R
- Popica G
- Poredos P
- Prasser C
- Preckel B
- Prospiech A
- Pujol R
- Raimundo A
- Raineri SM
- Rakic D
- Ramadan M
- Ramazanoglu A
- Rantis A
- Raquel F
- Ratsep I
- Real C
- Reikvam T
- Reis L
- Rigal J-C
- Rohner A
- Rokk A
- Roman Fernandez A
- Rosenberger P
- Rossaint R
- Rozec B
- Rudolph T
- Saeed Y
- Safonov S
- Saka E
- Samama CM
- Sanchez Lopez O
- Sanchez Perez D
- Sanchez Sanchez YE
- Sandeep V
- Sandu MN
- Sanll S
- Saraiva A
- Scarlatescu E
- Schiraldi R
- Schittek G
- Schnitter B
- Schuster M
- Seco C
- Selvi O
- Senard M
- Serra S
- Serrano H
- Shmigelsky A
- Silva L
- Simeson K
- Singh R
- Sipylaite J
- Skitek K
- Skok I
- Smekalova O
- Smirnova N
- Sofia M
- Soler Pedrola M
- Sondergaard S
- Sormus A
- Sorvoll IH
- Soumelidis C
- Spindler Yesel A
- Stefan M
- Stevanovic A
- Stevikova J
- Stivan S
- Stourac P
- Striteska J
- Strys L
- Suljevic I
- Tania M
- Tareco G
- Tena B
- Theodoraki K
- Tifrea M
- Tikuisis R
- Tolos R
- Tomasi R
- Tomescu D
- Tomkute G
- Tormos P
- Trepenaitis D
- Troyan G
- Unic-Stojanovic D
- Unterrainer A
- Uranjek J
- Valsamidis D
- Van Dasselaar N
- Van Limmen J
- Van Noord P
- Van Poorten JF
- Vanderlaenen M
- Varela Garcia O
- Velasco A
- Veljovic M
- Vera Bella J
- Vercauteren M
- Verdouw B
- Verenkin V
- Veselovsky T
- Vieira H
- Villar T
- Visnja I
- Voje M
- Von Dossow-Hanfstingl V
- Von Langen D
- Vorotyntsev S
- Vujanovic V
- Vukovic R
- Watt P
- Werner E
- Wernerman J
- Wittmann M
- Wright M
- Wunder C
- Wyffels P
- Yakymenko Y
- Ylldlrlm C
- Yllmaz H
- Zacharowski K
- Zahorec R
- Zarif M
- Zielinska-Skitek E
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study
- Author
- A. M. Leonardi
- A. M. Varsani
- A. W. M. M. Kopp
- A. Abernethy
- A. Allaouchiche
- A. Balescu-Arion
- A. Barsan
- A. Beretta
- A. Bilskiene
- A. Bowen
- A. Bucolo
- A. Calhau
- A. Cammu
- A. Carise
- A. Casal
- A. Chinery
- A. Chondhury
- A. Costa
- A. Cox
- A. Curley
- A. Danninger
- A. Dinic
- A. f Hollmann
- A. Ferrando
- A. Filipescu
- A. Floris
- A. Georghiou
- A. Gibson
- A. Gievski
- A. Giovannoni
- A. Granell
- A. Grassetto
- A. Greenwood
- A. Grigoras
- A. Gritsan
- A. Guadagnin
- A. Hagau
- A. Hribar
- A. Humphreys
- A. Hussein
- A. Hyams
- A. Kumar
- A. Landoni
- A. Lišková
- A. Loganathan
- A. Luippold
- A. Macas
- A. Macgregor
- A. Margalef
- A. Melia
- A. Melotti
- A. Minto
- A. Moise
- A. Mokini
- A. Moltó
- A. Moura
- A. Negri
- A. Nicholas
- A. Novillo
- A. Oliveira
- A. Ovezov
- A. Ozbilgin
- A. Papapostolou
- A. Pasin
- A. Paunescu
- A. Petta
- A. Rato
- A. Razaque
- A. Schiavone
- A. Soro
- A. Spadaro
- A. Spindler-Vesel
- A. Stamelos
- A. Standl
- A. Sultanpori
- A. Toretti
- A. Tudor
- A. Turan
- A. Vissicchio
- A. Voje
- A. Vrecic-Slabe
- A. Wallberg
- A. Weller
- A. Zani
- A. Zieglerder
- Abad Gurumeta
- Agudelo Montoya
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- B. Ayuso
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- B. Franke
- B. Gferer
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- B. Hestenes
- B. Iannuccelli
- B. Jankovic
- B. Joachim
- B. Junke
- B. Kadaoui
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- B. Kyttari
- B. Levstek
- B. Malewski
- B. Marcu
- B. Mccourt
- B. Stourac
- B. Tsaousi
- B. Verheyen
- B. Vizcaychipi
- B. Wilson
- Baiardo Redaelli
- Baltasar Isabel
- Becerra Cayetano
- Belmonte Cuenca
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- C. Morri
- C. Nightingale
- C. Reid
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- C. Schopflin
- C. Schreiber
- C. Schönberg
- C. Spada
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- C. Stevens
- C. Swan
- C. Toni
- C. Unzueta
- C. Uranjek
- C. Werkmann
- C. Zambon
- Cabrera Díaz
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- Correia de Barros
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- D. Bischoff
- D. Buhre
- D. Damster
- D. Fleischer
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- Danguy des Déserts
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- G. Godoroja
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- G. Perez-Cerda
- G. Tsiftsi
- G. Turhan
- G. Vecchiatini
- G. Vitković
- G. Zavackiene
- Gecaj Gashi
- Gilsanz Rodriguez
- Guerrero Diez
- H. Barletti
- H. Bifulco
- H. Blethyn
- H. Buggy
- H. Harlet
- H. Leuvrey
- H. Maciariello
- H. Murthy
- H. Poldermann
- H. Rial
- H. Spielmann
- H. Tiganiuc
- H. Tomescu
- H. Wallden
- H. Wikström
- H. Zsisku
- Herrera Hueso
- I. A. Bell
- I. Amigoni
- I. Blunt
- I. Calderon
- I. Cascella
- I. Cinnella
- I. Dascalu
- I. Garcia-Perez
- I. Grintescu
- I. Gritsan
- I. Ionițăv
- I. Maitan
- I. O'Reilly
- I. Ologoiu
- I. Townley
- I. Volta
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- J. P. Ausserer
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- J. Jonikaite
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- J. Montgomery
- J. Norrie
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- J. Stefan
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- J. Wallner
- Jiménez Gomez
- Jonsson Fagerlund
- K. Adam
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- K. b Blobner
- K. Barbera
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- K. Blincoe
- K. Borys
- K. Czuczwar
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- L. Mirea
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- L. Palugniok
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- L. Pitterle
- L. Pompei
- L. Popescu
- L. Rimaitis
- L. Scanlon
- L. Stanculescu
- L. Syrogianni
- L. Telford
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- L. Watson
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- Lewald H. A
- Lluch Oltra
- Lopez Rodríguez
- M. C. Montalto
- M. C. Sörmus
- M. E. Akgün
- M. I. Reavley
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- M. Andersen
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- Martin Ayuso
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- Rushton A.
- Russotto V.
- Rypulak E.
- Ryszka M.
- Ródenas F.
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- S. Bellandi
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- S. Garlak
- S. Gottfridsson
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- S. Henderson
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- S. Legrottaglie
- S. Leong
- S. Lopez
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- S. Metterlein
- S. Midgley
- S. Milić
- S. Moore
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- W. A.
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- Walther Sturesson
- Wegiel Leskiewiq
- Y. Baker
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- Z. Gavrilov
- Z. Molin
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- Zupanĕiĕ D.
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- Şanli Karip
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Background Results from retrospective studies suggest that use of neuromuscular blocking agents during general anaesthesia might be linked to postoperative pulmonary complications. We therefore aimed to assess whether the use of neuromuscular blocking agents is associated with postoperative pulmonary complications.Methods We did a multicentre, prospective observational cohort study. Patients were recruited from 211 hospitals in 28 European countries. We included patients (aged >= 18 years) who received general anaesthesia for any in-hospital procedure except cardiac surgery. Patient characteristics, surgical and anaesthetic details, and chart review at discharge were prospectively collected over 2 weeks. Additionally, each patient underwent postoperative physical examination within 3 days of surgery to check for adverse pulmonary events. The study outcome was the incidence of postoperative pulmonary complications from the end of surgery up to postoperative day 28. Logistic regression analyses were adjusted for surgical factors and patients' preoperative physical status, providing adjusted odds ratios (ORadj) and adjusted absolute risk reduction (ARR(adj)). This study is registered with ClinicalTrials. gov, number NCT01865513.Findings Between June 16, 2014, and April 29, 2015, data from 22 803 patients were collected. The use of neuromuscular blocking agents was associated with an increased incidence of postoperative pulmonary complications in patients who had undergone general anaesthesia (1658 [7.6%] of 21 694); ORadj 1.86, 95% CI 1.53-2.26; ARR(adj) -4.4%, 95% CI -5.5 to -3.2). Only 2.3% of high-risk surgical patients and those with adverse respiratory profiles were anaesthetised without neuromuscular blocking agents. The use of neuromuscular monitoring (ORadj 1.31, 95% CI 1.15-1.49; ARR(adj) -2.6%, 95% CI -3.9 to -1.4) and the administration of reversal agents (1.23, 1.07-1.41; -1.9%, -3.2 to -0.7) were not associated with a decreased risk of postoperative pulmonary complications. Neither the choice of sugammadex instead of neostigmine for reversal (ORadj 1.03, 95% CI 0.85-1 center dot 25; ARR(adj) -0.3%, 95% CI -2.4 to 1.5) nor extubation at a train-of-four ratio of 0.9 or more (1.03, 0.82-1.31; -0.4%, -3.5 to 2.2) was associated with better pulmonary outcomes.Interpretation We showed that the use of neuromuscular blocking drugs in general anaesthesia is associated with an increased risk of postoperative pulmonary complications. Anaesthetists must balance the potential benefits of neuromuscular blockade against the increased risk of postoperative pulmonary complications