Consideraciones sobre el final del relleno endorreico de las fosas de Calatayud y Teruel y su paso al exorreísmo. Implicaciones morfoestratigráficas y estructurales

[Resumen] Se pone en evidencia como la edad de la Superficie de Erosión Fundamental y el final del relleno endorreico de las fosas de Calatayud y Teruel, en la Cordillera Ibérica, no es un evento isócrono, sino variable en ambas depresiones yen. distintos sectores de una misma. La información geomorfológica y estratigráfica demuestra como la captura de una depresión endorreica y su paso al exorreismo es un proceso gradual en el espacio y en el tiempo, sin que necesariamente esté relacionado con estímulos tectónicos o climáticos. Así un intervalo de tiempo postcaptura puede estar representado en distintos sectores de una fosa por sedimentos endorreicos, hiatos erosivos o de no depósito y depósitos aluviales exorreicos. Por otra parte se cuestiona la cronoestratigrafía tradicional de los mantos aluviales depositados en condiciones exorreicas. Finalmente se esboza la evolución espacio temporal de la captura y paso al exorreismo de las fosas de Calatayud y Teruel y de las semifosas pliocuaternarias del sector central de la Cordillera Ibérica.[Abstract] It is shown how the age of the "Fundamental Erosión Surface" and the end of the endorheic infill of Calatayud and Teruel grabens, in the Iberian Range, is not isochronous, but variable between both basins and among different sectors of a certain one. Both, geomorphological and stratigraphical evidences demonstrate how the capture of an endorheic basin and its transition to exorheic conditions is a gradual process, which not necessarily has to be related with tectonic or climatic factors. A po~t-capture time span may be represented in different sectors of a graben by endorheic sediments, erosional and nondepositional hiatus and alluvial exorheic deposits. On the other hand, the traditional chronostratigraphy of the alluvial fans deposited under exorheic conditions is argued. Finally, the space and time evolution of the capture and transition to exorheic conditions in Teruel and Calatayud grabens and in the Plioquaternary halfgrabens of the central sector of the Iberian range is outlined

Retroceso de escarpes en ambientes semiáridos a partir de facetas triangulares de ladera (depresión del Ebro)

[Resumen] La evolución de las laderas en las regiones áridas puede dar lugar a la generaciónde facetas triangulares de ladera situadas al pie de relieves estructurales. Al Surde Zaragoza (Depresión del Ebro) existe un buen ejemplo de secuencias de facetas triangulares donde se pueden identificar cinco estadios de evolución de laderas (Sl a Ss' de la más reciente a la más antigua). Los depósitos de estas laderas contienen fragmentos de cerámicas, carbón vegetal y cenizas que permiten obtener dataciones relativas y absolutas. El contenido en cerámicas de las acumulaciones indica una edad final de generación posterior al siglo XIX para Sl y posterior al Bronce Medio-Final (3.500-3.100 BP) para S2. Las dataciones por Carbono-14 obtenidas son 2.529±52 BP y 2.930±60 BP para S2' 27.862±444 BP para S3 y 35.570±490 BP' para S4. La acumulación más antigua no ha podido ser datada. La extrapolación de las ecuaciones logarítmicas ajustadas a los perfiles de las facetas permite calcular los retrocesos del escarpe. Los datos obtenidos indican velocidades de retroceso del escarpe de 0.9-1 m/l.000 años para los últimos 35.000 años.[Abstract] Slope evolution in arid regions may result in the development of talus flatiron sequences at the foot of structural reliefs. A good example exists to the South of Zaragoza (Ebro Basin), where five stages of slope evolution have been identified in the talus flatiron sequences (Sl to Ss' youngest to oldest). The deposits of these slopes contain pottery remains, charcoal and ashes which permit to carry out relative and absolute datings of the slope accumulations. Based on the pottery content, the most recent accumulation stage (Sl) is post-19th century. The pottery remains of the previous one (S2) indicate an age post-Middle-Late Bronze (3.5003.100 BP) and 14C datings obtained for this accumulation are 2.529±52 BP and 2.930±60 BP. The talus flatirons S3 have provided an age of 27.862±444 BP by 14C and for S4 the age is 35.570±490 BP. The oldest accumulation has not been dated. The extrapolation of the logaritmic equation fit from the talus flatiron profiles allows to calculate the scarp retreats. The data supplied indicate rates of scarp retreat of 0.9-1 m/1.000 years over the past 35.000 years

Los valles tectónicos recientes de Rubielos de la Cerida (Teruel)

[Resumen] La actividad tectónica cuaternaria y reciente ha dado lugar en este área a un conjunto de depresiones alargadas de orientación submeridiana, enmarcadas por fallas, que constituyen valles tectónicos[Abstract] Quaternary and recent tectonic activity led to a series of elongated depressions in the studied area of roughly N-S orientation, framed by faults, and developping as tectonic valleys

Depósitos periglaciales en la vertiente septentrional de la Sierra de Lújar. Implicaciones neotectónicas

En la vertiente septentrional de la Sierra de Lújar afloran depósitos cuaternarios antiguos, colgados varias decenas de metros sobre los cauces actuales. Están representados por encostramientos que configuran morfológicamente un paleorelieve bien conservado, y por grèzes litées subyacentes. En esta nota se discute el origen y significado de estos depósitos periglaciales que llegan a alcanzar cotas relativamente bajas, dada la latitud del sector estudiado y su escasa distancia -sólo 20 km- de la costa mediterránea. Se plantea la hipótesis de un hundimiento importante en tiempos recientes, asociado a las fallas que jalonan el Corredor de las Alpujarras.In the northern side of Sierra de Lújar outcrop ancient quaternary deposits overhanging several tens of meters the present river system. They are represented by hardened crusts, morphologically constituting a well preserved paleotopography, and by underlying grèzes litées. In this paper we discuss the origin and meaning of these periglacial deposits occurring at rather low heights, considering the latitude of the surveyed area, located, in the other hand, at hardly 20 km from the mediterranean coast. We put forward the hypothesis of a significant subsidence in recent times, related to the fault system of the Alpujarras Corridor

Morfología de vertientes y neotectónica en el Macizo de Javalambre (provincia de Teruel)

[Resumen] El modelado actual de las vertientes del macizo de Javalambre es consecuencia de tres tipos principales de procesos que actúan a partir de su elevación a comienzos del Plioceno -superior: (a) la dinámica periglaciar, (b) una etapa de activida~ tect6nica ocurrida hacia el Pleistoceno medio-superior, y (c) deslizamientos gravitacionales, translacionales y rotacionales producidos a favor de un sustrato plástico en las áreas de mayor incisión de la red -fluvial.Abstract] The present slope form in Javalambre area results from three principal types of processes which are active after its elevation in the early Upper Pliocene: (a) periglacial dynamics, (b) a tectonic phase in Middle-Upper Pleistocene, and (c) gravitational, translational and rotational landslides generated over plastic rocks in zones with a intensive fluvial incisio

Search strategies and the automated control of plant diseases

We propose the use of the "infotaxis" search strategy as the navigation system of a robotic platform, able to search and localize infectious foci by detecting the changes in the profile of volatile organic compounds emitted by and infected plant. We builded a simple and cost effective robot platform that substitutes odour sensors in favour of light sensors and study their robustness and performance under non ideal conditions such as the exitence of obstacles due to land topology or weeds

Quantitative reconstruction of Late Cenozoic landscapes: a case study in the Sierra de Atapuerca (Burgos, Spain)

We have developed a method to reconstruct palaeorelief by means of detailed geomorphological and geological studies, geostatistical tools, GIS and a DEM. This method has been applied to the Sierra de Atapuerca (NE Duero Basin, Burgos, Spain), allowing us to model a three-dimensional reconstruction of the relief evolution from the Middle Miocene to the present. The modelling procedure is based on geostatistical recovery of the palaeosurfaces characteristic of each geomorphological evolution stage, using polynomial regressions, trend surfaces and kriging. The modelling of morphology trends has been useful in establishing new geological and geomorphological relationships in the geodynamic evolution of this basin, such as uplift quantification, correlation of erosion surfaces and sedimentary units, and the evolution of fluvial base levels. The palaeosurface reconstruction together with an analysis of the slope retreat have allowed us to reconstruct the palaeoreliefs that define the Late Cenozoic landscape evolution of this area, where the Lower and Middle Pleistocene archaeopalaeontological sites of the Sierra de Atapuerca are located. Copyright © 2007 John Wiley & Sons, Ltd.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/57912/1/1534_ftp.pd

Potent Anticancer Activity of CXCR4-Targeted Nanostructured Toxins in Aggressive Endometrial Cancer Models

Patients with advanced endometrial cancer (EC) show poor outcomes. Thus, the development of new therapeutic approaches to prevent metastasis development in high-risk patients is an unmet need. CXCR4 is overexpressed in EC tumor tissue, epitomizing an unexploited therapeutic target for this malignancy. The in vitro antitumor activity of two CXCR4-targeted nanoparticles, including either the C. diphtheriae (T22-DITOX-H6) or P. aeruginosa (T22-PE24-H6) toxin, was evaluated using viability assays. Apoptotic activation was assessed by DAPI and caspase-3 and PARP cleavage in cell blocks. Both nanotoxins were repeatedly administrated to a subcutaneous EC mouse model, whereas T22-DITOX-H6 was also used in a highly metastatic EC orthotopic model. Tumor burden was assessed through bioluminescence, while metastatic foci and toxicity were studied using histological or immunohistochemical analysis. We found that both nanotoxins exerted a potent antitumor effect both in vitro and in vivo via apoptosis and extended the survival of nanotoxin-treated mice without inducing any off-target toxicity. Repeated T22-DITOX-H6 administration in the metastatic model induced a dramatic reduction in tumor burden while significantly blocking peritoneal, lung and liver metastasis without systemic toxicity. Both nanotoxins, but especially T22-DITOX-H6, represent a promising therapeutic alternative for EC patients that have a dismal prognosis and lack effective therapies

A Collaborative Effort to Define Classification Criteria for ATM Variants in Hereditary Cancer Patients

Background Gene panel testing by massive parallel sequencing has increased the diagnostic yield but also the number of variants of uncertain significance. Clinical interpretation of genomic data requires expertise for each gene and disease. Heterozygous ATM pathogenic variants increase the risk of cancer, particularly breast cancer. For this reason, ATM is included in most hereditary cancer panels. It is a large gene, showing a high number of variants, most of them of uncertain significance. Hence, we initiated a collaborative effort to improve and standardize variant classification for the ATM gene. Methods Six independent laboratories collected information from 766 ATM variant carriers harboring 283 different variants. Data were submitted in a consensus template form, variant nomenclature and clinical information were curated, and monthly team conferences were established to review and adapt American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP) criteria to ATM, which were used to classify 50 representative variants. Results Amid 283 different variants, 99 appeared more than once, 35 had differences in classification among laboratories. Refinement of ACMG/AMP criteria to ATM involved specification for twenty-one criteria and adjustment of strength for fourteen others. Afterwards, 50 variants carried by 254 index cases were classified with the established framework resulting in a consensus classification for all of them and a reduction in the number of variants of uncertain significance from 58% to 42%. Conclusions Our results highlight the relevance of data sharing and data curation by multidisciplinary experts to achieve improved variant classification that will eventually improve clinical management.FEDER funds-a way to build Europe PI19/00553 PI16/00563 PI16/01898 SAF2015-68016-RGeneralitat de Catalunya 2017SGR1282 2017SGR496CERCA Program: Government of CataloniaXunta de GaliciaInstituto de Salud Carlos III. AES PI19/00340Spanish Government SAF2016-80255-REuropean Commission EFA086/15Instituto de Salud Carlos III European Commissio