Protocolo de uso de Albumina Humana al 20%

1 recurso en línea 3 p.Se entiende por MEDICAMENTO DE USO RESTRINGIDO a aquel para el que, mediante un procedimiento participativo, multidisciplinar y representativo del hospital, su uso ha sido restringido a determinados grupos de pacientes o a determinadas situaciones clínicas para asegurar una mayor eficacia, evitar efectos adversos, por motivos epidemiológicos o por motivos económicos. El Hospital Nacional de Clínicas (HNC) cuenta con un listado de medicamentos de uso restringido entre los que se encuentra la Albúmina Humana al 20% (AH).Fil: Bustos Fierro, Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Hospital Nacional de Clínicas; Argentina.Fil: Gavelli, María Emilia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Hospital Nacional de Clínicas; Argentina.Fil: Herrera Comoglio, Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Hospital Nacional de Clínicas; Argentina.Fil: Calantoni, Miguel Alberto. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Hospital Nacional de Clínicas; Argentina.Fil: Breda, Susana Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Hospital Nacional de Clínicas; Argentina.FIl: Bosio Beatriz. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Hospital Nacional de Clínicas; Argentina.Fil: Alesso, Luis. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Hospital Nacional de Clínicas; Argentina.Fil: Rueda, María José. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Hospital Nacional de Clínicas; Argentina.Fil: Kasparian, Andrés. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Hospital Nacional de Clínicas; Argentina.Fil: Zuázaga, Mariano. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Hospital Nacional de Clínicas; Argentina.Fil: Soria, Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Hospital Nacional de Clínicas; Argentina.Fil: Ojeda, Verónica. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Hospital Nacional de Clínicas; Argentina.Fil: Arguello, Pablo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Hospital Nacional de Clínicas; Argentina

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at root s(NN)=2.76TeV

Peer reviewe

Caracterización antropométrica en una población de hipertensos esenciales

This research work  is focussed on identifing the anthropological features on patients suffering from hipertensión, and to evaluate its relationship with the development of the hypertension illness.We used common methods the ammounts of central tendency, the "t" test, to compare groups of cases, control groups and gender. We used a correlation analysis to determine the degree of correspondence between the anthropometrical values, and the blood pressure filtres (systolic and diastolic).The ratio odds were calculated, and their reliance intervals to evalúate the association strenght between the risk factors selected, total body fat, waist, wrist measure, body mass indicator, and blood pressure. The logistic test was applied to evaluate the contribution of the selected variables to the development of hipertensión.  The variables that showed significant correspondence were age an suprailaic folds. In women suffering from hipertensión the fat distribution pattem remained constant and under normal tensión.In men with normal tensión and hipertensión the behavior of these patterns was constant, so there is an unusual bio-homogenity in the group of study, thi scan be due to the features of the sample.  A simple model to predict Hta. is proposed.

Caracterización antropométrica en una población de hipertensos esenciales

This research work  is focussed on identifing the anthropological features on patients suffering from hipertensión, and to evaluate its relationship with thedevelopment of the hypertension illness.We used common methods the ammounts of central tendency, the "t" test, to compare groups of cases, control groups and gender. We used a correlation analysis to determine the degree of correspondence between the anthropometrical values, and the blood pressure filtres (systolic and diastolic).The ratio odds were calculated, and their reliance intervals to evalúate the association strenght between the risk factors selected, total body fat, waist, wrist measure, body mass indicator, and blood pressure. The logistic test was applied to evaluate the contribution of the selected variables to the development of hipertensión.  The variables that showed significantcorrespondence were age an suprailaic folds. In women suffering from hipertensión the fat distribution pattem remained constant and under normal tensión.In men with normal tensión and hipertensión the behavior of these patterns was constant, so there is an unusual bio-homogenity in the group of study, thi scanbe due to the features of the sample.  A simple model to predict Hta. is proposed.El trabajo se enfoca a identificar las características antropométricas del sujeto hipertenso y a evaluar su eventual asociación con el desarrollo de la enfermedad hipertensiva

Protein Hydrolysis by Subcritical Water: A New Perspective on Obtaining Bioactive Peptides

The importance of bioactive peptides lies in their diverse applications in the pharmaceutical and food industries. In addition, they have been projected as allies in the control and prevention of certain diseases due to their associated antioxidant, antihypertensive, or hypoglycemic activities, just to mention a few. Obtaining these peptides has been performed traditionally by fermentation processes or enzymatic hydrolysis. In recent years, the use of supercritical fluid technology, specifically subcritical water (SW), has been positioned as an efficient and sustainable alternative to obtain peptides from various protein sources. This review presents and discusses updated research reports on the use of subcritical water to obtain bioactive peptides, its hydrolysis mechanism, and the experimental designs used for the study of effects from factors involved in the hydrolysis process. The aim was to promote obtaining peptides by green technology and to clarify perspectives that still need to be explored in the use of subcritical water in protein hydrolysis

Effect of Supercritical Fluid Extraction Process on Chemical Composition of <i>Polianthes tuberosa</i> Flower Extracts

Supercritical fluid extracts from flowers of Polianthes tuberosa var. double were ob tained using carbon dioxide as a solvent. Yield extract obtained was 2.5%. The effects of the pressure process (18 MPa, 28 MPa, and 38 MPa) and temperature process (313 K, 323 K, and 333 K) on the volatile composition of tuberose flowers extracts were evaluated, and a significant variation in chemical composition was found. Characteristic compounds of tuberose as methyl isoeugenol, benzyl benzoate, methyl anthranilate, pentacosene, and heptacosene were obtained mainly at 18 MPa and 333 K process conditions, and could be used in the perfume or fragrance industry. Components such as geraniol, farnesol, and methyl eugenol were also obtained, these extracts could be used in the development of cosmeceutical products. This work allowed to identification of the chemical composition profile and evaluation of the changes in tuberose extracts due to the extraction process