Sickle cell trait in association with HB H : a new patient from the Mediterranean region

Only five Hb S heterozygotes with an associated Hb H Disease i.e. the ASH condition or AS: --/-α have been defined in molecular detail. These had ancestries of Saudi-Arabian, Black or mixed Black and Chinese origin. We have studied a sixth patient who was from Turkey. The propositus was detected at birth with Hb Bart's at 27.6%. This declined to 1.6% at nine months, while the proportion of Hb S which was 5.1% at one month increased to 18.0% at one year.peer-reviewe

Atrioventricular thrombus in a 14-year-old patient: a case report

Right atrioventricular thrombus was diagnosed by echocardiography in a 14-year-old boy. Thrombus was reached through the right ventricle to the pulmonary artery and it was caused to tricuspit valve insufficiency. Surgical thrombectomy was performed and, he was treated with oral anticoagulation in postoperative period

Genetics of immunoglobulin-A vasculitis (Henoch-Schönlein purpura): An updated review

Immunoglobulin-A vasculitis (IgAV) is classically a childhood small-sized blood vessel vasculitis with predominant involvement of the skin. Gastrointestinal and joint manifestations are common in patients diagnosed with this condition. Nephritis, which is more severe in adults, constitutes the most feared complication of this vasculitis. The molecular bases underlying the origin of IgAV have not been completely elucidated. Nevertheless, several pieces of evidence support the claim that genes play a crucial role in the pathogenesis of this disease. The human leukocyte antigen (HLA) region is, until now, the main genetic factor associated with IgAV pathogenesis. Besides a strong association with HLA class II alleles, specifically HLA-DRB1 alleles, HLA class I alleles also seem to influence on the predisposition of this disease. Other gene polymorphisms located outside the HLA region, including those coding cytokines, chemokines, adhesion molecules as well as those related to T-cells, aberrant glycosylation of IgA1, nitric oxide production, neoangiogenesis, renin-angiotensin system and lipid, Pyrin and homocysteine metabolism, may be implicated not only in the predisposition to IgAV but also in its severity. An update of the current knowledge of the genetic component associated with the pathogenesis of IgAV is detailed in this review.Acknowledgements: RL-Mis supported by the Miguel Servet I programme of the Spanish Ministry of Economy and Competitiveness through the grant CP16/ 00033. FG is recipient of a Sara Borrell postdoctoral fellowship from the “Instituto Carlos III de Salud” at the Spanish Ministry of Health (Spain) (CD15/00095). SR-M is supported by funds from the RETICS Program (RIER) (RD16/0012/0009). FDC is supported by the Ramón y Cajal programme of the Spanish Ministry of Economy and Competitiveness through the grant RYC-2014-16458

Hamitabat petroleum system in the Thrace Basin, Turkey

Since the first drill in 1957, three oil, 19 gas and condensate fields have been discovered in the Thrace Basin. However, any petroleum system with its essential elements and processes has not been assigned yet. This study consists of two parts, (1) geochemical overview of the previous work in order to get a necessary help to construct a petroleum system and (2) calculation of quantitative undiscovered hydrocarbon resources generated from this system. An extensive overview study showed that the primary reservoir and source rocks in the Thrace Basin are the Middle Eocene Hamitabat sandstones and shales, respectively, hence it appears that the most effective petroleum system of the Thrace Basin becomes the Hamitabat (!) petroleum system. Currently, 18.5 billion m(3) of in-place gas, 2.0 million m(3) (12.7 million bbl) in-place waxy oil as well as minor amount of associated condensate were discovered from this system. This study showed that the regional distribution of the oil and gas fields almost overlapped with the previously constructed pod of active Hamitabat shales implying that short and up-dip vertical migration pathway of hydrocarbons from the source to trapping side was available. Thermal model demonstrated that hydrocarbon generation from the Hamitabat shales commenced in the Early Miocene. The amount of quantitative gas generation based on the mean-original TOC=0.94 wt%, mean-original HI =217 HC/g TOC and the volume of the pod of active source rock=49 km(3) is approximately 110 billion m(3) of gaseous hydrocarbons that results in a high generation-accumulation efficiency of 17% when 18.5 billion m(3) of already discovered hydrocarbons are considered. (C) 2008 Elsevier Ltd. All rights reserved

Airlines experiential marketing: gaining and retaining customers : Case studies of British Airways, SAS, Air France, Easy jet and KLM

Title: Airlines experiential marketing: gaining and retaining customers Research Question: How do airlines use the experiential marketing to gain and retain consumers? Supervisor: Venilton Reinert Course: Strategic Marketing with Independent Project Keywords: Airlines, experiential marketing, experience, loyalty, sense, emotions, feelings Purpose: The aim of this research is to understand how airlines’ users can be acquired and kept thanks to experiential marketing. This study allows analysing the news consumers’ expectations and how companies adapt their strategies to meet customers’ needs thanks to experiential marketing. All airlines mentioned in this study are European. Methodology: A qualitative research has been used for this paper. The authors of the thesis proceed choosing five European airlines: British Airways, Air France, KLM Royal Dutch Airlines, Easy Jet and Scandinavian Airlines System. The case studies have been used to describe, thanks to a number of Internet tools, how companies use the experience and feelings in marketing to urge consumers to purchase and be loyal. Then, authors used Schmitt theory to collect data. Finally, a number of frameworks have been used to analyse data. Conclusion: Airlines want to carry the customer to think and act through the experience. A successful experiential marketing occurs when the customer behaves thanks to his emotions. So, airlines’ marketers create competition, challenge, and game to remind customers. The interaction with public and internet users is necessary used in each experiential marketing event by airlines to promote the event and permeated to the customer share its experience, meet people and identify him in a group. If customers experience unique and perfectly experiential event, they will remember the service, and consequently the brand in the long-term as remarkable. In this way, the brand gain or retain customers

Inhibition of decomposition of sodium metaborate 1-peroxohydrate 3-hydrate in aqueous solution by montmorillonitic and sepiolitic clays. Part II

Rodopman K., Gurgey I. Inhibition of decomposition of sodium metaborate 1-peroxohydrate 3-hydrate in aqueous solution by montmorillonitic and sepiolitic clays. Part II. In: Bulletin du Groupe français des argiles. Tome 26, fascicule 2, 1974. pp. 181-191

Inhibition of decomposition of sodium metaborate 1-peroxohydrate in aqueous solution by montmorillonitic. and sepiolitic clays. Part I

In this part, the authors present a study upon the inhibition effect of montmorillonitic and sepiolitic clays with low MgO content on the decomposition of sodium metaborate 1-peroxohydrate 3-hydrate.Dans cette partie, les auteurs présentent une étude sur l'effet inhibiteur d'argiles de type montmorillonite et sépiolite à faible teneur en MgO sur la décomposition du métaborate 1-peroxohydrate 3-hydrate de sodium.Rodopman K., Gurgey I. Inhibition of decomposition of sodium metaborate 1-peroxohydrate in aqueous solution by montmorillonitic. and sepiolitic clays. Part I. In: Bulletin du Groupe français des argiles. Tome 26, fascicule 2, 1974. pp. 173-179

Airlines experiential marketing: gaining and retaining customers : Case studies of British Airways, SAS, Air France, Easy jet and KLM

Title: Airlines experiential marketing: gaining and retaining customers Research Question: How do airlines use the experiential marketing to gain and retain consumers? Supervisor: Venilton Reinert Course: Strategic Marketing with Independent Project Keywords: Airlines, experiential marketing, experience, loyalty, sense, emotions, feelings Purpose: The aim of this research is to understand how airlines’ users can be acquired and kept thanks to experiential marketing. This study allows analysing the news consumers’ expectations and how companies adapt their strategies to meet customers’ needs thanks to experiential marketing. All airlines mentioned in this study are European. Methodology: A qualitative research has been used for this paper. The authors of the thesis proceed choosing five European airlines: British Airways, Air France, KLM Royal Dutch Airlines, Easy Jet and Scandinavian Airlines System. The case studies have been used to describe, thanks to a number of Internet tools, how companies use the experience and feelings in marketing to urge consumers to purchase and be loyal. Then, authors used Schmitt theory to collect data. Finally, a number of frameworks have been used to analyse data. Conclusion: Airlines want to carry the customer to think and act through the experience. A successful experiential marketing occurs when the customer behaves thanks to his emotions. So, airlines’ marketers create competition, challenge, and game to remind customers. The interaction with public and internet users is necessary used in each experiential marketing event by airlines to promote the event and permeated to the customer share its experience, meet people and identify him in a group. If customers experience unique and perfectly experiential event, they will remember the service, and consequently the brand in the long-term as remarkable. In this way, the brand gain or retain customers

Cohort Study: Central Venous Catheter-Related Complications In Children With Hematologic Diseases At A Single Center

Objective: This study aims to document and analyze the central venous catheter (CVC)-related complications in children with hematological diseases who were treated within a single institution. Materials and Methods: A retrospective investigation was conducted in 106 pediatric patients in whom 203 CVCs were inserted. A total of 175 catheter-related complications occurred in 5 years. Results: The rates of clinical catheter infections, local catheter infections, venous thromboembolism, bleeding, and mechanical complications were 2.6, 1.1, 0.2, 0.2, and 0.2 per 1000 catheter days. Methicillin-resistant Staphylococcus epidermidis was the predominant infectious organism in blood and catheter cultures. The children with leukemia had a significantly higher frequency of clinical catheter infections (p=0.046). The children who underwent bone marrow transplantation had a significantly lower frequency of clinical catheter infections (p=0.043) and higher frequency of local catheter infections (p=0.003). The children with implanted catheters had a significantly lower frequency of clinical catheter infections (p=0.048). The children with thrombocytopenia had significantly fewer local catheter infections and significantly more clinical catheter infections and catheter-related bleeding (respectively p=0.001, p=0.042, and p=0.024). Conclusion: Leukemia, bone marrow transplantation, and thrombocytopenia are risk factors for CVC-associated complications. The relatively higher number of interventions performed via permanent catheters may be responsible for the significantly increased incidence of systemic infections and mechanical injury.PubMedWoSScopu