L'interès per la pràctica d'activitat físicoesportiva de temps lliure de l'alumnat de la Universitat d'Almeria. Un estudi longitudinal

Conèixer l'interès mostrat cap a la pràctica de l'activitat físicoesportiva tot analitzant l'evolució que s'ha produït, transcorreguts dos cursos acadèmics, en l'alumnat de la Universitat d'Almeria, és un dels objectius que guia aquesta investigació. D'altra banda, es pretén valorar la repercussió que ha tingut, sobre l'interès per la pràctica d'activitat físicoesportiva en el temps lliure, tant l'Educació Física rebuda com a assignatura obligatòria al col·legi i a l'institut com l'actitud dels pares/mares respecte d'aquesta mena de pràctiques. La població està formada per l'alumnat universitari d'Almeria de primer i segon cicle. La mostra de primer cicle (curs 96/97) és de 1.376, a segon cicle (curs 98/99) és de 878. L'error mostral assumit és del ±3% i un nivell de confiança del 95,5%. La recollida de dades s'ha realitzat amb metodologia quantitativa mitjançant enquestes (qüestionari autoadministrat amb aplicació massiva -per aules- i presència d'aplicador). L'anàlisi de dades, mitjançant tècniques quantitatives, amb el programa informàtic SPSS/PC + (V 7,52), ens permet de presentar resultats descriptius de les diferents variables plantejades, i també inferencials. A totes les persones objecte de la nostra investigació, prescindint de la seva situació activa o passiva (realització o no d'activitats físicoesportives en el temps de lleure) se'ls planteja una pregunta simple per determinar el seu interès sobre la pràctica d'activitat físicoesportiva: "Amb relació a la pràctica de l'activitat físicoesportiva i considerant-la en totes les seves formes, és a dir, com a espectacle, joc, exercici físic i diversió, i independentment que practiquis o no activitat física, diries que t'interesses molt, força, poc o gens, per l'activitat física i esportiva?". Les dades que es desprenen del nostre estudi coincideixen, en gran mesura, amb les aportades per altres investigacions similars, que confirmen el creixent interès per la pràctica físicoesportiva, i el lloc que aquesta va ocupant, com a una de les formes ideals, i amb més diversitat de manifestacions, entre les activitats de lleure. Es presenten també els resultats de l'anàlisi inferencial de la variable interès en relació amb les variables d'edat, sexe, estat civil, facultats, estudis, curs acadèmic, expedient acadèmic, Educació Física rebuda, experiència pràctica personal i actitud dels pares envers la pràctica físicoesportiva de temps lliure

El interés por la práctica de actividad físico-deportiva de tiempo libre del alumnado de la Universidad de Almería. Un estudio longitudinal

Conocer el interés mostrado hacia la práctica de la actividad físico-deportiva analizando la evolución que se ha producido, transcurridos dos cursos académicos, en el alumnado de la Universidad de Almería es uno de los objetivos que guía esta investigación. Por otro lado, se pretende valorar la repercusión que ha tenido, sobre el interés por la práctica de actividad físico-deportiva en el tiempo libre, tanto la Educación Física recibida como asignatura obligatoria en el colegio e instituto así como la actitud de los padres/madres con respecto a este tipo de prácticas. La población está formada por el alumnado universitario almeriense de primer y segundo ciclo. La muestra de primer ciclo (curso 96/97) es de 1.376, en segundo ciclo (curso 98/99) es de 878. El error muestral asumido es del ±3% y un nivel de confianza del 95.5 %. La recogida de datos se ha realizado con metodología cuantitativa mediante encuestas (cuestionario autoadministrado con aplicación masiva -por aulas- y presencia de aplicador). El análisis de datos mediante técnicas cuantitativas con el programa informático SPSS/PC+ (V 7.52), nos permiten presenar resultados descriptivos de las diferentes variables planteadas, así como inferenciales. A todas las personas objeto de nuestra investigación, independientemente de su situación activa o pasiva (realización o no de actividades físico-deportivas en el tiempo libre) se les plantea una pregunta simple para determinar su interés sobre la práctica de actividad físico-deportiva: "Con relación a la práctica de la actividad físico-deportiva y considerándola en todas sus formas, es decir, como espectáculo, juego, ejercicio físico y diversión, e independientemente de que practiques o no actividad física, ¿dirías que te interesas mucho, bastante, poco o nada por la actividad física y deportiva" Los datos que se desprenden de nuestro estudio vienen a coincidir en gran medida con los aportados por otras investigaciones similares, que confirman el creciente interés por la práctica físico-deportiva, y el lugar que ésta va ocupando, como una de las formas ideales y con mayor diversidad de manifestaciones entre las actividades de ocio. Se presentan también los resultados del análisis inferencial de la variable interés en relación con las variables de edad, sexo, estado civil, facultades, estudios, curso académico, expediente académico, Educación Física recibida, experiencia práctica personal y actitud de los padres hacia la práctica físico-deportiva de tiempo libre

Relation of IL28B Gene Polymorphism with Biochemical and Histological Features in Hepatitis C Virus-Induced Liver Disease

BACKGROUND/AIMS: Polymorphism at the IL28B gene may modify the course of hepatitis C virus (HCV) chronic infection. Our aim was to study the influence of IL28B rs12979860 gene polymorphism on the biochemistry and pathology of HCV-induced disease in the clinical course from mild chronic hepatitis C to hepatocellular carcinoma. METHODS: We have determined the rs12979860 single nucleotide polymorphism (SNP) upstream IL28B gene in two groups of patients with HCV-induced chronic liver disease: 1) 268 patients (159 men) with biopsy-proven chronic hepatitis C, to analyse its relation with biochemical, virological and histological features; and 2) 134 patients (97 men) with HCV-related hepatocellular carcinoma. The distribution of the analysed SNP in hepatocellular carcinoma patients was compared with that found in untreated chronic hepatitis C patients. All patients were white and most were Spaniards. RESULTS: In multivariate analysis ALT values were higher (P = 0.001) and GGT values were lower (P<0.001) in chronic hepatitis C patients homozygotes for the major rs12979860C allele as compared with carriers of the mutated rs12979860T allele. Steatosis was more frequent (Odds ratio = 1.764, 95% C.I. 1.053-2.955) and severe (P = 0.026) in carriers of the rs12979860T allele. No relation was found between the analysed SNP and METAVIR scores for necroinflammation and fibrosis, and there were no differences in the distribution of the analysed SNP between hepatocellular carcinoma and untreated chronic hepatitis C patients. CONCLUSION: The IL28B rs12979860 polymorphism correlates with the biochemical activity and the presence and severity of liver steatosis in chronic hepatitis C

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions

Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41–6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000–2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p &lt; 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 2–79 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (tMRCA) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999–2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced as a result of multiple introductions in Spain, following regional dispersal in several cases. We showed that CRF02_AG transmissions were mostly due to regional dispersal in Spain. The hot-spot for the largest CRF02_AG regional subepidemic in Spain was in Madrid associated with MSM transmission risk group. The existence of subepidemics suggest that several spillovers occurred from Madrid to other areas. CRF02_AG sequences from Hispanics were clustered in a separate subclade suggesting no linkage between the local and Hispanic subepidemics

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Mortality of emergency abdominal surgery in high-, middle- and low-income countries

Background: Surgical mortality data are collected routinely in high-income countries, yet virtually no low- or middle-income countries have outcome surveillance in place. The aim was prospectively to collect worldwide mortality data following emergency abdominal surgery, comparing findings across countries with a low, middle or high Human Development Index (HDI). Methods: This was a prospective, multicentre, cohort study. Self-selected hospitals performing emergency surgery submitted prespecified data for consecutive patients from at least one 2-week interval during July to December 2014. Postoperative mortality was analysed by hierarchical multivariable logistic regression. Results: Data were obtained for 10 745 patients from 357 centres in 58 countries; 6538 were from high-, 2889 from middle- and 1318 from low-HDI settings. The overall mortality rate was 1⋅6 per cent at 24 h (high 1⋅1 per cent, middle 1⋅9 per cent, low 3⋅4 per cent; P < 0⋅001), increasing to 5⋅4 per cent by 30 days (high 4⋅5 per cent, middle 6⋅0 per cent, low 8⋅6 per cent; P < 0⋅001). Of the 578 patients who died, 404 (69⋅9 per cent) did so between 24 h and 30 days following surgery (high 74⋅2 per cent, middle 68⋅8 per cent, low 60⋅5 per cent). After adjustment, 30-day mortality remained higher in middle-income (odds ratio (OR) 2⋅78, 95 per cent c.i. 1⋅84 to 4⋅20) and low-income (OR 2⋅97, 1⋅84 to 4⋅81) countries. Surgical safety checklist use was less frequent in low- and middle-income countries, but when used was associated with reduced mortality at 30 days. Conclusion: Mortality is three times higher in low- compared with high-HDI countries even when adjusted for prognostic factors. Patient safety factors may have an important role. Registration number: NCT02179112 (http://www.clinicaltrials.gov)

Current Options for Third-line and Beyond Treatment of Metastatic Colorectal Cancer. Spanish TTD Group Expert Opinion.

Colorectal cancer (CRC) is a public health problem: it is the third most common cancer in men (746,000 new cases/year) and the second in women (614,000 new cases/year), representing the second leading cause of death by cancer worldwide. The survival of patients with metastatic CRC (mCRC) has increased prominently in recent years, reaching a median of 25 to 30 months. A growing number of patients with mCRC are candidates to receive a treatment in third line or beyond, although the optimal drug regimen and sequence are still unknown. In this situation of refractoriness, there are several alternatives: (1) To administer sequentially the 2 oral drugs approved in this indication: trifluridine/tipiracil and regorafenib, which have shown a statistically significant benefit in progression-free survival and overall survival with a different toxicity profile. (2) To administer cetuximab or panitumumab in treatment-naive patients with RAS wild type, which is increasingly rare because these drugs are usually indicated in first- or second-line. (3) To reuse drugs already administered that were discontinued owing to toxicity or progression (oxaliplatin, irinotecan, fluoropyrimidine, antiangiogenics, anti-epidermal growth factor receptor [if RAS wild-type]). High-quality evidence is limited, but this strategy is often used in routine clinical practice in the absence of alternative therapies especially in patients with good performance status. (4) To use specific treatments for very selected populations, such as trastuzumab/lapatinib in mCRC human epidermal growth factor receptor 2-positive, immunotherapy in microsatellite instability, intrahepatic therapies in limited disease or primarily located in the liver, although the main recommendation is to include patients in clinical trials

La Constitución Política de los Estados Unidos Mexicanos 1917-2017 a 100 años

resultado de la primera revolución social del siglo XX fue la Constitución Política de los Estados Unidos Mexicanos, documento que plasmó las aspiraciones de toda una nación, marcando el rumbo de nuestro país hacia la democracia. Gracias a la Carta Magna hoy tenemos garantizados amplios derechos y podemos ejercer plenamente nuestras libertades. Celebro que la Universidad Autónoma del Estado de México conmemore los cien años de nuestra Constitución con la publicación de este libro, elaborado por un grupo multidisciplinario de investigadores, pertenecientes a diversas instituciones educativas del país, que analizan los diferentes artículos de la Constitución de 1917, desde los ámbitos histórico, filosófico, jurídico, educativo y social. Para el Gobierno del Estado de México, un libro conmemorativo de nuestra Carta Magna es invitación a reflexionar sobre las características de nuestras instituciones, así como la conveniencia de mantener o reformar sus artículos para continuar respondiendo a las necesidades de la ciudadanía. En cada propuesta de este libro, desde sus respectivos campos de estudio, los autores analizan los retos de la sociedad actual; además en su lectura e interpretación demuestran que los 136 artículos no son letra muerta, siguen vigentes

Discovering HIV related information by means of association rules and machine learning

Acquired immunodeficiency syndrome (AIDS) is still one of the main health problems worldwide. It is therefore essential to keep making progress in improving the prognosis and quality of life of affected patients. One way to advance along this pathway is to uncover connections between other disorders associated with HIV/AIDS-so that they can be anticipated and possibly mitigated. We propose to achieve this by using Association Rules (ARs). They allow us to represent the dependencies between a number of diseases and other specific diseases. However, classical techniques systematically generate every AR meeting some minimal conditions on data frequency, hence generating a vast amount of uninteresting ARs, which need to be filtered out. The lack of manually annotated ARs has favored unsupervised filtering, even though they produce limited results. In this paper, we propose a semi-supervised system, able to identify relevant ARs among HIV-related diseases with a minimal amount of annotated training data. Our system has been able to extract a good number of relationships between HIV-related diseases that have been previously detected in the literature but are scattered and are often little known. Furthermore, a number of plausible new relationships have shown up which deserve further investigation by qualified medical experts