A thorough study of the intriguing X-ray emission from the Cartwheel ring

We present the results from the high resolution Chandra observation of the Cartwheel galaxy. Many individual sources are resolved in the image, mostly associated with the outer ring. All detected sources have a very high X-ray luminosity ($\geq 10^{39}$ erg s$^{-1}$)that classifies them as Ultra Luminous X-ray sources (ULX). The brightest of them is possibly the most luminous individual non-nuclear source observed so far, with L$_X \sim 10^{41}$ erg s$^{-1}$ (at D=122 Mpc). The spatial extent of this source is consistent with a point source at the Chandra resolution. The luminosity function of individual X-ray sources extends about an order of magnitude higher than previously reported in other galaxies. We discuss this in the context of the "universal" luminosity function for High Mass X-ray Binaries and we derive a Star Formation Rate higher than in other starburst galaxies studied so far. A diffuse component, associated with hot gas, is present. However, deeper observations that we will obtain with XMM-Newton are needed to constrain its properties.Comment: 14 pages; accepted for publication in A&

Homogeneous percolation versus arrested phase separation in attractively-driven nanoemulsion colloidal gels

We elucidate mechanisms for colloidal gelation of attractive nanoemulsions depending on the volume fraction (ϕ) of the colloid. Combining detailed neutron scattering, cryo-transmission electron microscopy and rheological measurements, we demonstrate that gelation proceeds by either of two distinct pathways. For ϕ sufficiently lower than 0.23, gels exhibit homogeneous fractal microstructure, with a broad gel transition resulting from the formation and subsequent percolation of droplet–droplet clusters. In these cases, the gel point measured by rheology corresponds precisely to arrest of the fractal microstructure, and the nonlinear rheology of the gel is characterized by a single yielding process. By contrast, gelation for ϕ sufficiently higher than 0.23 is characterized by an abrupt transition from dispersed droplets to dense clusters with significant long-range correlations well-described by a model for phase separation. The latter phenomenon manifests itself as micron-scale “pores” within the droplet network, and the nonlinear rheology is characterized by a broad yielding transition. Our studies reinforce the similarity of nanoemulsions to solid particulates, and identify important qualitative differences between the microstructure and viscoelastic properties of colloidal gels formed by homogeneous percolation and those formed by phase separation.United States. Army Research Office (Institute for Collaborative Biotechnologies. Grant W911NF- 09-0001)National Science Foundation (U.S.) (Grants CMMI-1120724 and DMR-1006147

Damage analysis and fracture toughness evaluation in a thin woven composite laminate under static tension using infrared thermography

This work deals with the issue of damage growth in thin woven composite laminates subjected to tensile loading. The conducted tensile tests were monitored on-line with an infrared camera, and tested specimens were analysed using Scanning Electron Microscopy (SEM). Combined with SEM micrographs, observation of heat source fields enabled us to assess the damage sequence. Transverse weft cracking was confirmed to be the main damage mode and fiber breakage was the final damage leading to failure. For cracks which induce little variation of specimen stiffness, the classic “Compliance method” could not be used to compute energy release rate. Hence, we present here a new procedure based on the estimation of heat source fields to calculate the energy release rate associated with transverse weft cracking. The results are then compared to those computed with a simple 3D inverse model of the heat diffusion problem and those presented in the literature

Physics of Bubble-Propelled Microrockets

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim A popular method to induce synthetic propulsion at the microscale is to use the forces created by surface-produced gas bubbles inside the asymmetric body of a catalytic swimmer (referred to in the literature as microrocket). Gas bubbles nucleate and grow within the swimmer and migrate toward one of its openings due to asymmetric geometric confinement, generating a net hydrodynamic force which propels the device. Here, numerical simulations are used to develop a joint chemical (diffusive) and hydrodynamic (Stokes) analysis of the bubble growth within a conical catalytic microrocket and of the associated bubble and microrocket motion. With this computational model, the bubble dynamics are solved for over one bubble cycle ranging from its nucleation to its exiting the conical rocket, and the propulsion characteristics are identified as a function of all design parameters (geometry and chemical activity of the motor, surface tension, physicochemical constants). The results suggest that hydrodynamics and chemistry partially decouple in the motion of the bubbles, with hydrodynamics determining the distance travelled by the microrocket over each cycle while chemistry sets the bubble ejection frequency. This numerical model allows for the identification of an optimal microrocket shape and size for which the distance travelled per cycle duration is maximized

Malonyl-CoA Mediates Leptin Hypothalamic Control of Feeding Independent of Inhibition of CPT-1a

Hypothalamic fatty acid metabolism is involved in central nervous system controls of feeding and energy balance. Malonyl-CoA, an intermediate of fatty acid biosynthesis, is emerging as a significant player in these processes. Notably, hypothalamic malonyl-CoA has been implicated in leptin's feeding effect. Leptin treatment increases malonyl-CoA level in the hypothalamic arcuate nucleus (Arc), and this increase is required for leptin-induced decrease in food intake. However, the intracellular downstream mediators of malonyl-CoA's feeding effect have not been identified. A primary biochemical action of malonyl-CoA is the inhibition of the acyltransferase activity of carnitine palmitoyltransferase-1 (CPT-1). In the hypothalamus, the predominant isoform of CPT-1 that possesses the acyltransferase activity is CPT-1 liver type (CPT-1a). To address the role of CPT-1a in malonyl-CoA's anorectic action, we used a recombinant adenovirus expressing a mutant CPT-1a that is insensitive to malonyl-CoA inhibition. We show that Arc overexpression of the mutant CPT-1a blocked the malonyl-CoA-mediated inhibition of CPT-1 activity. However, the overexpression of this mutant did not affect the anorectic actions of leptin or central cerulenin for which an increase in Arc malonyl-CoA level is also required. Thus, CPT-1a does not appear to be involved in the malonyl-CoA's anorectic actions induced by leptin. Furthermore, long-chain fatty acyl-CoAs, substrates of CPT-1a, dissociate from malonyl-CoA's actions in the Arc under different feeding states. Together, our results suggest that Arc intracellular mechanisms of malonyl-CoA's anorectic actions induced by leptin are independent of CPT-1a. The data suggest that target(s), rather than CPT-1a, mediates malonyl-CoA action on feeding

Diverse histologic appearances in pulmonary mucinous cystic neoplasia: A case report

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

A Pickering Emulsion Route to Swimming Active Janus Colloids

The field of active colloids is attracting significant interest to both enable applications and allow investigations of new collective colloidal phenomena. One convenient active colloidal system that has been much studied is spherical Janus particles, where a hemispherical coating of platinum decomposes hydrogen peroxide to produce rapid motion. However, at present producing these active colloids relies on a physical vapor deposition (PVD) process, which is difficult to scale and requires access to expensive equipment. In this work, it is demonstrated that Pickering emulsion masking combined with solution phase metallization can produce self-motile catalytic Janus particles. Comparison of the motion and catalytic activity with PVD colloids reveals a higher catalytic activity for a given thickness of platinum due to the particulate nature of the deposited coating. This Pickering emulsion based method will assist in producing active colloids for future applications and aid experimental research into a wide range of active colloid phenomena