412 research outputs found
Human Dental Microwear From Ohalo II (22,500–23,500 cal BP), Southern Levant
Dietary hardness and abrasiveness are inferred from human dental microwear at Ohalo II, a late Upper Palaeolithic site (22,500–23,500 cal BP) in the southern Levant. Casts of molar grinding facets from two human skeletons were examined with a scanning electron microscope. The size and frequency of microwear was measured, counted, and compared to four prehistoric human groups from successive chronological periods in the same region: pre-pottery Neolithic A, Chalcolithic (this study); Natufian, pre-pottery Neolithic B (Mahoney: Am J Phys Anthropol 130 (2006) 308–319). The Ohalo molars had a high frequency of long narrow scratches, and a few small pits, suggesting a tough abrasive diet that required more shearing rather than compressive force while chewing. These results imply that the diet of the two late Upper Palaeolithic hunter-gatherers did not focus on very hard foods. Aquatic foods with adherent contaminants, as well as grit from plant grinding tools seemed likely causal agents. The size of the pits and scratches on the Ohalo molars were most similar to microwear from the pre-pot- tery Neolithic A period, though they also compared well to the Chalcolithic period. These results contrasted with the larger pits and scratches from the Natufian hunter-gath- erers and pre-pottery Neolithic B farmers, implying that there is no simple increase or decrease in dietary hard- ness and abrasiveness across the late Upper Palaeolithic to Chalcolithic development in the Southern Levant
Disease manifestations and X inactivation in heterozygous females with Fabry disease
Abstract Aim: Fabry disease is an X-linked lysosomal storage disorder characterized by an accumulation of neutral glycosphingolipids in multiple organ systems caused by a-galactosidase A deficiency due to mutations in the GLA gene. The majority of heterozygous females show the characteristic signs and symptoms of the disease, and some of them are severely affected. The current hypothesis for the occurrence of disease manifestations in females is skewed X inactivation favouring the mutant GLA allele. Method: We analyzed the patterns of X inactivation in the leukocytes of 28 biochemically and genetically characterized symptomatic Fabry disease heterozygotes and their correlation with clinical and biochemical disease expression. Results: X inactivation patterns in symptomatic females who are heterozygous for Fabry disease did not differ from those of female controls of the same age (p0/ 0.669). Thirteen (46%) of the 28 females with Fabry disease showed random X inactivation, ten (36%) moderate skewing, and five (18%) highly skewed X inactivation. Segregation analysis was performed in the families of six females who had highly or moderately skewed X inactivation. In four of these females, skewing favoured the wild-type GLA allele and in the other two skewing favoured the mutant allele. Patterns of X inactivation or the extent of skewing were not related to the severity of clinical manifestations or to residual enzyme activity. Conclusion: In this study we provide evidence that heterozygous females with Fabry disease show random X inactivation. Our data do not support the hypothesis that the occurrence and severity of disease manifestations in the majority of Fabry heterozygotes are related to skewed X inactivation
OGLE-2009-BLG-092/MOA-2009-BLG-137: A Dramatic Repeating Event With the Second Perturbation Predicted by Real-Time Analysis
We report the result of the analysis of a dramatic repeating gravitational
microlensing event OGLE-2009-BLG-092/MOA-2009-BLG-137, for which the light
curve is characterized by two distinct peaks with perturbations near both
peaks. We find that the event is produced by the passage of the source
trajectory over the central perturbation regions associated with the individual
components of a wide-separation binary. The event is special in the sense that
the second perturbation, occurring days after the first, was
predicted by the real-time analysis conducted after the first peak,
demonstrating that real-time modeling can be routinely done for binary and
planetary events. With the data obtained from follow-up observations covering
the second peak, we are able to uniquely determine the physical parameters of
the lens system. We find that the event occurred on a bulge clump giant and it
was produced by a binary lens composed of a K and M-type main-sequence stars.
The estimated masses of the binary components are
and , respectively, and they are separated in
projection by . The measured distance to the
lens is . We also detect the orbital motion
of the lens system.Comment: 18 pages, 5 figures, 1 tabl
MOA-2009-BLG-387Lb: A massive planet orbiting an M dwarf
We report the discovery of a planet with a high planet-to-star mass ratio in
the microlensing event MOA-2009-BLG-387, which exhibited pronounced deviations
over a 12-day interval, one of the longest for any planetary event. The host is
an M dwarf, with a mass in the range 0.07 M_sun < M_host < 0.49M_sun at 90%
confidence. The planet-star mass ratio q = 0.0132 +- 0.003 has been measured
extremely well, so at the best-estimated host mass, the planet mass is m_p =
2.6 Jupiter masses for the median host mass, M = 0.19 M_sun. The host mass is
determined from two "higher order" microlensing parameters. One of these, the
angular Einstein radius \theta_E = 0.31 +- 0.03 mas, is very well measured, but
the other (the microlens parallax \pi_E, which is due to the Earth's orbital
motion) is highly degenate with the orbital motion of the planet. We
statistically resolve the degeneracy between Earth and planet orbital effects
by imposing priors from a Galactic model that specifies the positions and
velocities of lenses and sources and a Kepler model of orbits. The 90%
confidence intervals for the distance, semi-major axis, and period of the
planet are 3.5 kpc < D_L < 7.9 kpc, 1.1 AU < a < 2.7AU, and 3.8 yr < P < 7.6
yr, respectively.Comment: 20 pages including 8 figures. A&A 529 102 (2011
Surgical management of pulmonary inflammatory pseudotumors: A single center experience
<p>Abstract</p> <p>Background</p> <p>The pulmonary inflammatory pseudotumor (PIP) is a rare disease. It is still debated whether it represents an inflammatory lesion characterized by uncontrolled cell growth or a true neoplasm. PIP is characterized by a cellular polymorphism.</p> <p>Methods</p> <p>We retrospectively analyzed 8 patients with PIP treated by surgery between 2001 and 2009. Preoperative thoracic computed tomography (CT) scan was performed in all cases. All patients underwent preoperative bronchoscopy with washing and brushing and/or transbronchial biopsy and preoperative cytology examination</p> <p>Results</p> <p>There were 5 men and 3 women, aged between 38 and 69 years (mean of 58 years). 3 patients (37%) were asymptomatic. The others had symptoms characterized by chest pain, shortness of breath and persistent cough or hemoptysis. 5 patients had neutrophilic leucocytosis. CT scan demonstrated solitary nodules (maximum diameter <3 cm) in 5 patients (62%) and lung masses (maximum diameter >3 cm) in 3 patients (37%). In 2 patients there were signs of pleural infiltration. Distant lesions were excluded in all cases. A preoperative histology examination failed to reach a definitive diagnosis in all patients. At surgery, we performed two lobectomies, one segmentectomy and five wedge resections, these being performed with videothoracoscopy (VATS), except for one patient where open surgery was used. Complete tumor resection was obtained in all patients. According to the Matsubara classification, there were 2 cases of organizing pneumonia, 5 cases of fibrous histiocytoma and one case of lymphoplasmacytoma. All patients were discharged alive from hospital between 4 and 7 days after surgery. At follow-up CT scan performed annually (range 11 to 112 months) (mean 58 months), there were no residual lesions, neither local nor distant recurrences.</p> <p>Conclusions</p> <p>PIP is a rare disease. Many synonyms have been used for this disease, usually in relation to the most represented cell type. The true incidence is unclear. Preoperative diagnosis is difficult to reach, despite performing a bronchoscopy or a transparietal needle aspiration. Different classifications have been proposed for PIP. Either medical, radiation or surgical therapy has been used for PIP. Whenever possible, surgery should be considered the standard treatment. Complete surgical resection is advocated to prevent recurrence.</p
A Small Chloroplast-Encoded Protein as a Novel Architectural Component of the Light-Harvesting Antenna
An optical group catalogue to z = 1 from the zCOSMOS 10k sample
We present a galaxy group catalogue spanning the redshift range 0.1 <~ z <~ 1
in the ~1.7 deg^2 COSMOS field, based on the first ~10,000 zCOSMOS spectra. The
performance of both the Friends-of-Friends (FOF) and Voronoi-Delaunay-Method
(VDM) approaches to group identification has been extensively explored and
compared using realistic mock catalogues. We find that the performance improves
substantially if groups are found by progressively optimizing the group-finding
parameters for successively smaller groups, and that the highest fidelity
catalogue, in terms of completeness and purity, is obtained by combining the
independently created FOF and VDM catalogues. The final completeness and purity
of this catalogue, both in terms of the groups and of individual members,
compares favorably with recent results in the literature. The current group
catalogue contains 102 groups with N >= 5 spectroscopically confirmed members,
with a further ~700 groups with 2 <= N <= 4. Most of the groups can be assigned
a velocity dispersion and a dark-matter mass derived from the mock catalogues,
with quantifiable uncertainties. The fraction of zCOSMOS galaxies in groups is
about 25% at low redshift and decreases toward ~15% at z ~ 0.8. The zCOSMOS
group catalogue is broadly consistent with that expected from the semi-analytic
evolution model underlying the mock catalogues. Not least, we show that the
number density of groups with a given intrinsic richness increases from
redshift z ~ 0.8 to the present, consistent with the hierarchical growth of
structure.Comment: 20 pages, 19 figures, accepted for publication in Ap
Characterizing Lenses and Lensed Stars of High-Magnification Single-lens Gravitational Microlensing Events With Lenses Passing Over Source Stars
We present the analysis of the light curves of 9 high-magnification
single-lens gravitational microlensing events with lenses passing over source
stars, including OGLE-2004-BLG-254, MOA-2007-BLG-176,
MOA-2007-BLG-233/OGLE-2007-BLG-302, MOA-2009-BLG-174, MOA-2010-BLG-436,
MOA-2011-BLG-093, MOA-2011-BLG-274, OGLE-2011-BLG-0990/MOA-2011-BLG-300, and
OGLE-2011-BLG-1101/MOA-2011-BLG-325. For all events, we measure the linear
limb-darkening coefficients of the surface brightness profile of source stars
by measuring the deviation of the light curves near the peak affected by the
finite-source effect. For 7 events, we measure the Einstein radii and the
lens-source relative proper motions. Among them, 5 events are found to have
Einstein radii less than 0.2 mas, making the lenses candidates of very low-mass
stars or brown dwarfs. For MOA-2011-BLG-274, especially, the small Einstein
radius of mas combined with the short time scale of
days suggests the possibility that the lens is a
free-floating planet. For MOA-2009-BLG-174, we measure the lens parallax and
thus uniquely determine the physical parameters of the lens. We also find that
the measured lens mass of is consistent with that of a
star blended with the source, suggesting that the blend is likely to be the
lens. Although we find planetary signals for none of events, we provide
exclusion diagrams showing the confidence levels excluding the existence of a
planet as a function of the separation and mass ratio.Comment: 14 pages, 12 figures, 5 table
Modelling of the effect of ELMs on fuel retention at the bulk W divertor of JET
Effect of ELMs on fuel retention at the bulk W target of JET ITER-Like Wall was studied with multi-scale calculations. Plasma input parameters were taken from ELMy H-mode plasma experiment. The energetic intra-ELM fuel particles get implanted and create near-surface defects up to depths of few tens of nm, which act as the main fuel trapping sites during ELMs. Clustering of implantation-induced vacancies were found to take place. The incoming flux of inter-ELM plasma particles increases the different filling levels of trapped fuel in defects. The temperature increase of the W target during the pulse increases the fuel detrapping rate. The inter-ELM fuel particle flux refills the partially emptied trapping sites and fills new sites. This leads to a competing effect on the retention and release rates of the implanted particles. At high temperatures the main retention appeared in larger vacancy clusters due to increased clustering rate
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